Cerebral Subsystems as Biological Entities
  • Henry McIlwain


Sixty years ago, preparing sections of the brain with investigative intent was carried out mainly by anatomists and neuropathologists in search of normal or abnormal structures visible to the eye or through a microscope. Having been obtained postmortem, the organ or its sections were not expected to show functional alterations and indeed were “fixed” with reactive chemicals to minimize endogenous changes.


Rest Membrane Potential Cerebral Tissue Cerebral Neuron Lateral Olfactory Tract Endogenous Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Anguiano, G. and Mcllwain, H., 1951, Convulsive agents and the phosphates of brain examined in vitro, Br. J. Pharmacol. 6:448–453.Google Scholar
  2. Buchel, L. and Mcllwain, H., 1950, Narcotics and the inorganic and creatine phosphates of mammalian brain, Br. J. Pharmacol. 5:465–473.Google Scholar
  3. Forda, O. and Mcllwain, H., 1953, Anticonvulsants on electrically stimulated metabolism of separated mammalian cerebral cortex, Br. J. Pharmacol. 8:225–229.Google Scholar
  4. Gibson, I. M. and Mcllwain, H., 1965, Continuous recording of changes in membrane potential in mammalian cerebral tissues in vitro. Recovery after depolarization by added substances, J. Physiol 176:261–283.PubMedGoogle Scholar
  5. Greengard, O. and Mcllwain, H., 1955, Anticonvulsants and the metabolism of separated mammalian cerebral tissues, Biochem. J. 61:61–68.PubMedGoogle Scholar
  6. Heller, I. H. and Mcllwain, H., 1973, Release of adenine derivatives from isolated subsystems of the guinea pig brain: Actions of electrical stimulation and of papaverine, Brain Res. 53:105–116.PubMedCrossRefGoogle Scholar
  7. Hillman, H. H., Campbell, W. J., and Mcllwain, H., 1963, Membrane potentials in isolated and electrically stimulated mammalian cerebral cortex. Effects of chlorpromazine, cocaine, phenobarbitone and protamine on the tissue’s electrical and chemical responses to stimulation, J. Neurochem. 10:325–339.CrossRefGoogle Scholar
  8. Kakiuchi, S., Rail, T. W., and Mcllwain, H., 1969, The effect of electrical stimulation on the accumulation of adenosine 3:5-phosphate in isolated cerebral tissue, J. Neurochem. 16:485–491.PubMedCrossRefGoogle Scholar
  9. Krebs, H. A., 1981, Otto Warburg. Cell Physiologist, Biochemist and Eccentric, Clarendon Press, Oxford.Google Scholar
  10. Li, C-L. and Mcllwain, H., 1957, Maintenance of resting membrane potentials in slices of mammalian cerebral cortex and other tissues in vitro, J. Physiol. 139:178–190.PubMedGoogle Scholar
  11. Mcllwain, H., 1951, Metabolic response in vitro to electrical stimulation of sections of mammalian brain, Biochem. J. 49:382–393.Google Scholar
  12. Mcllwain, H., 1952, Phosphates and nucleotides of the central nervous system, Biochem. Soc. Symp. 8:27–43.Google Scholar
  13. Mcllwain, H., 1953, Substances which support respiration and metabolic response to electrical impulses in human cerebral tissues, J. Neurol. Neurosurg. Psychiatry 16:257–266.CrossRefGoogle Scholar
  14. Mcllwain, H., 1956, Electrical influences and the speed of chemical change in the brain, Physiol Rev. 36:355–375.Google Scholar
  15. Mcllwain, H., 1964, Actions of haloperidol, meperidine and related compounds on the excitability and ion content of isolated cerebral tissue, Biochem. Pharmacol. 13:523–529.CrossRefGoogle Scholar
  16. Mcllwain, H., 1975, Cerebral isolates and neurochemical discovery, Biochem. Soc. Trans. 3:579–590.Google Scholar
  17. Mcllwain, H., 1981a, Brain: Intracellular and extracellular purinergic receptor-systems, in: Purinergic Receptors (G. Burnstock, ed.) Chapman and Hall, London, pp. 163–198.CrossRefGoogle Scholar
  18. Mcllwain, H., 1981b, The flow of thought and the flow of substance in the brain, Biol Psychol 12:147–169.CrossRefGoogle Scholar
  19. Mcllwain, H. and Greengard, O., 1957, Excitants and depressants of the central nervous system, on isolated electrically stimulated cerebral tissues, J. Neurochem. 1:348–357.CrossRefGoogle Scholar
  20. Mcllwain, H. and Snyder, S. H., 1970, Stimulation of piriform and neocortical tissues in an in vitro flow-system: Metabolic properties and relase of putative neurotransmitters, J. Neurochem. 17:521–530.CrossRefGoogle Scholar
  21. Mcllwain, H., Ayres, P. J. W., and Forda, O., 1952, Metabolic response to electrical stimulation in separated portions of human cerebral tissues, J. Ment. Sci. 98:265–272.Google Scholar
  22. Pull, I. and Mcllwain, H., 1972, Adenine derivatives as neurohumoral agents in the brain. Quantities liberated on excitation of superfused cerebral tissues, Biochem. J. 130:975–981.PubMedGoogle Scholar
  23. Sattin, A. and Rail, T. W., 1970, The effect of adenosine and adenine nucleotides on the cyclic adenosine 3′: 5′-monophosphate content of guinea pig cerebral cortex slices, Mol Pharmacol 6:13–23.PubMedGoogle Scholar
  24. Warburg, D., Posener, K., and Negelein, E., 1924, Über den Stoffwechsel der Carcinomzelle, Biochem. Z. 152:309.Google Scholar
  25. Yamamoto, C. and Mcllwain, H., 1966, Electrical activities in thin sections from the mammalian brain maintained in chemically defined media in vitro, J. Neurochem. 13:1333–1343.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Henry McIlwain
    • 1
  1. 1.Department of BiochemistrySt. Thomas’s Hospital Medical SchoolLondonEngland

Personalised recommendations