Physiology pp 103-113 | Cite as

Vascular Clearance of Microorganisms

  • R. J. Moon


Approximately 15 to 20 years ago there was a substantial outpouring of information regarding the nature and mechanisms of vascular clearance of microorganisms and inert particles from the circulation. The single most substantial influence which spurred these investigations seemed to be the studies by Biozzi et al. (1955) describing the use of carbon to study the kinetics of the clearance of microorganisms from the blood. There ensued numerous studies aimed at describing the nature of RES clearance by using a variety of microorganisms and inert colloids as tools (Benacerraf and Miescher, 1960; Benacerraf et al., 1957, 1959; Biozzi et al., 1955, 1957, 1960; Jenkin and Rowley, 1961; Rowley, 1962) and review articles are available which describe the early development of this research field with respect to microbial clearance (Rowley, 1962; Merigan, 1974) and inert particle clearance (Saba, 1970). More recently, the appearance of new information relating to the clearance of microorganisms has been rather sporadic. The objective of this chapter is to discuss some of the more recent contributions relating to clearance of a variety of microorganisms in vivo as well as in perfused organ models and to suggest some future directions for this research area.


Kupffer Cell Clearance Rate Reticuloendothelial System Perfuse Liver Aortic Insufficiency 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • R. J. Moon
    • 1
  1. 1.Division of Basic Sciences, School of MedicineMercer UniversityMaconUSA

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