Physiology pp 73-101 | Cite as

Kinetics of Vascular Clearance of Particles by Phagocytes

  • Sigurd J. Normann


There are several good reasons for studying the kinetics of vascular clearance of intravenously administered particles. The primary objectives are to identify those parameters which limit the rate of vascular clearance, show how these parameters interact, and determine at which points control of vascular clearance occurs. At present, the kinetics of phagocytosis are best studied in vivo and the descriptions of the process have been largely achieved based on in vivo measurements. In vivo, there is an adequate number of cells to ensure measurable uptake over a sustained period of time, cell-associated particles are readily separable from those in the fluid phase, measurement of removal is readily achieved, and the conditions of flow, particle availability, and media are biologically relevant. The insights gained from the study of vascular clearance with model particles are presumably relevant to the basic issues of how macrophages recognize nonself and of how things get into cells.


Particle Concentration Clearance Rate Reticuloendothelial System Lipid Emulsion Liver Blood Flow 


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© Plenum Press, New York 1984

Authors and Affiliations

  • Sigurd J. Normann
    • 1
  1. 1.Department of Pathology, College of MedicineUniversity of FloridaGainesvilleUSA

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