Advertisement

Physiology pp 37-56 | Cite as

Regulation of Mononuclear Phagocyte Proliferation

  • Carleton C. Stewart

Abstract

The diversity of functions assigned to mononuclear phagocytes (MNP) leads to the view that either the system is composed of multiple functionally distinct subpopulations (Walker, 1976; Walker et al., 1981) or that expression of a particular function represents differentiation states through which all cells pass as they mature. Superimposed on either developmental sequence, environmental stimuli may modulate the expression fo MNP function. For example, surface markers such as Ia or C3b receptors might be the result of clonal expansion of a subpopulation (Walker et al, 1981). The expression of Ia could also be a modulatable activity. Several investigators have shown that incubation of macrophages with mitogen-stimulated lymphocyte products can induce Ia on the surface membrane of macrophages (Farr et al, 1979; Beller and Unanue, 1981).

Keywords

Bone Marrow Cell Colony Formation Adherent Cell Mononuclear Phagocyte Nonadherent Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Beller, D. I., and Unanue, E. R., 1981, Regulation of macrophage populations. II. Synthesis and expression of Ia antigens by peritoneal exudate macrophage is a transient event, J. Immunol. 126:263.PubMedGoogle Scholar
  2. Bradley, P. A., Telfer, P. A., and Fry, P., 1971, The effect of erythrocytes on mouse bone marrow colony development in vitro, Blood 38:353.PubMedGoogle Scholar
  3. Chen, D., and Lin, H., 1981a, Differential enhancement of the clonal growth of various mononuclear phagocytes by hemolysates, J. Reticuloendothelial Soc. 29:465.Google Scholar
  4. Chen, D., and Lin, H., 1981b, Inhibitor of peritoneal mononuclear phagocyte colony forming cells, Exp. Hematol. 9:240.PubMedGoogle Scholar
  5. Cole, P., 1975, Activation of mouse peritoneal cells to kill Listeria monocytogenes by T-lymphocyte products, Infect. Immun. 12:35.Google Scholar
  6. Erb, P., Stern, A. C., Alkan, S. S., Studer, S., Zoombou, E., and Gissler, R. H., 1980, Characterization of accessory cells required for helper T-cell induction in vitro: Evidence for a phagocytic F—receptor and la-bearing cell type, J. Immunol. 125:2504.PubMedGoogle Scholar
  7. Farr, A. G., Kiely, J., and Unanue, E. R., 1979, Macrophage T-cell interactions involving Listeria monocytogenes—Role of the H-2 gene complex, J. Immunol. 122:2395.PubMedGoogle Scholar
  8. Gordon, S., and Werb, Z., 1976, Secretion of macrophage neutral proteinase is enhanced by colchicine, Proc. Natl. Acad. Sci. USA 73:872.PubMedCrossRefGoogle Scholar
  9. Hayflick, L., 1973, The biology of human aging, Am. J. Med. Sci. 265:433.CrossRefGoogle Scholar
  10. Kurland, J. I., Bockman, R. S., Broxmeyer, H., and Moore, M. A. S., 1978, Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E, Science 199:552.PubMedCrossRefGoogle Scholar
  11. Kurland, J. I., Pelus, L. M., Ralph, P., Bockman, R. S., and Moore, M. A. S., 1979, Induction of prostaglandin E synthesis in normal and neoplastic macrophages: Role for colony-stimulating factor(s) distinct from effects on myeloid progenitor cell proliferation, Proc. Natl. Acad. Sci. USA 76:2326.PubMedCrossRefGoogle Scholar
  12. Lee, K.-C., and Wong, M., 1980, Functional heterogeneity of culture-grown bone marrow-derived macrophages. I. Antigen presenting function, J. Immunol. 125:86.PubMedGoogle Scholar
  13. Leonard, E. J., Ruco, L. P., and Meltzer, M. S., 1978, Characterization of macrophage activation factor: A lymphokine that causes macrophages to become cytotoxic for tumor cells, Cell. Immunol. 41:347.PubMedCrossRefGoogle Scholar
  14. Lin, H., and Stewart, C., 1973, Colony formation by mouse peritoneal exudate cells in vitro, Nature New Biol. 243:176.PubMedGoogle Scholar
  15. Lin, H., Kuhn, C., and Stewart, C. C., 1978, Peritoneal exudate cells. V. Influence of age, sex, strain and species on the induction and the growth of macrophage colony forming cells, J. Cell. Physiol. 96:133.PubMedCrossRefGoogle Scholar
  16. Morton, H. J., and Isacs, R., 1967, Cultivation of rat bone marrow. I. Preliminary studies and some effects of hemolyzed blood as nutrient, J. Natl. Cancer Inst. 39:796.Google Scholar
  17. Nacy, C. A., Leonard, E. J., and Meltzer, M. S., 1981, Macrophages in resistance to rickettsial infections: Characterization of lymphokines that induce rickettsiacidal activity in macrophages, J. Immunol. 126:204.PubMedGoogle Scholar
  18. Parish, C., Kirov, C. S., Bowern, N., and Blanden, R., 1974, A one step procedure for separating mouse T and B lymphocytes, Eur. J. Immunol. 4:808.CrossRefGoogle Scholar
  19. Rabellino, E. M., and Metcalf, D., 1975, Receptors for C3 and IgG on macrophage, neutrophil and eosinophil colony cells grown in vitro, J. Immunol. 115:688.PubMedGoogle Scholar
  20. Ruco, L. P., and Meltzer, M. S., 1977, Macrophage activation for tumor cytotoxicity: Induction of tumoricidal macrophages by supernatants of PPD-stimulated bacillus Calmette-Guerin-immune spleen cell culture, J. Immunol. 119:889.PubMedGoogle Scholar
  21. Stanley, E. R., 1979, Colony-stimulating factor (CSF) radioimmunoassay: Detection of a CSF subclass stimulating macrophage production, Proc. Natl. Acad. Sci. USA 76:2969.PubMedCrossRefGoogle Scholar
  22. Stanley, E. R., 1981, Colony stimulating factors, in: The Lymphokines (R. Stewart and J. Haddon, eds.), Humana Press, Clifton, N.J.Google Scholar
  23. Stanley, E. R., Cifone, M., Heard, P. M., and Defendi, V., 1976, Factors regulating macrophage production and growth: Identity of colony-stimulating factor and macrophage growth factor, J. Exp. Med. 143:631.PubMedCrossRefGoogle Scholar
  24. Steinman, R. M., Nogueira, N., Witmer, M. D., Tydings, J. D., and Mellman, I. S., 1980, Lymphokine enhances the expression and synthesis of Ia antigens on cultured mouse peritoneal macrophages, J. Exp. Med. 152:1248.PubMedCrossRefGoogle Scholar
  25. Stern, A. C., Erb, P., and Gisler, R. H., 1979, la-bearing bone marrow-cultured macrophages induce antigen-specific helper T cells for antibody synthesis, J. Immunol. 123:612.PubMedGoogle Scholar
  26. Stewart, C. C., 1979, The use of cloned mononuclear phagocytes to study immunoregulation, in: Regulatory Roles of Mononuclear Phagocytes in Immunity (A. S. Rosenthal and E. R. Unanue, eds.), p. 455, Academic Press, New York.Google Scholar
  27. Stewart, C. C., 1980, Formation of colonies of mononuclear phagocytes outside the bone marrow, in: Mononuclear Phagocytes: Functional Aspects (R. van Furth, ed.), p. 377, Nijhoff, The Hague.Google Scholar
  28. Stewart, C. C., 1981, Murine mononuclear phagocytes from bone marrow, in: Methods for Studying Mononuclear Phagocytes (D. O. Adams, H. Koren, and P. Edelson, eds.), p. 5, Academic Press, New York.CrossRefGoogle Scholar
  29. Stewart, C. C., and Lin, H., 1978, Macrophage growth factor and its relationship to colony stimulating factor, J. Reticuloendothelial Soc. 23:269.Google Scholar
  30. Stewart, C. C., Yen, S., and Senior, R. M., 1981, Colony-forming ability of mononuclear phagocytes, in: Manual of Macrophage Methodology (H. B. Herscowitz, H. T. Holden, J. A. Bellanti, and A. Ghaffer, eds.), p. 171, Dekkar, New York.Google Scholar
  31. Stewart, C. C., Lin, H., and Adles, C., 1975, Proliferation and colony-forming ability of peritoneal exudate cells in liquid culture, J. Exp. Med. 141:1114.PubMedCrossRefGoogle Scholar
  32. Stewart, C. C., Skamene, E., and Kongshaun, P. H. L., 1980, The genetic basis of macrophage colony formation, in: Genetic Control of Natural Resistance to Infection and Malignancy (E. Skamene and P. Kongshaun, eds.), Academic Press, New York.Google Scholar
  33. van der Zeijst, B. A. M., Stewart, C. C., and Schlesinger, S., 1978, Proliferative capacity of mouse peritoneal macrophages in vitro, J. Exp. Med. 147:1253.PubMedCrossRefGoogle Scholar
  34. van Furth, R. (ed.), 1980, Cells of the mononuclear phagocyte system: Nomenclature in terms of sites and conditions, in: Mononuclear Phagocytes: Functional Aspects, p. 1, Nijhoff, The HagueGoogle Scholar
  35. van Furth, R., Cohn, Z. A., Hirsch, J. G., Humphry, J. H., Spector, W. G., and Langewoort, H. L., 1972, The mononuclear phagocyte system: A new classification of macrophages, monocytes and their precursors, Bull. W. H. O. 46:845.PubMedGoogle Scholar
  36. van Furth, R., Diesselhoff-dendulk, and Mattie, H., 1973, Quantitative study on the production and kinetics of mononuclear phagocytes during an acute inflammatory reaction, J. Exp. Med. 138:1314.PubMedCrossRefGoogle Scholar
  37. van Furth, R., Raeburn, J. A., and van Zwet, T. L., 1979, Characteristics of human mononuclear phagocytes, Blood 54:485.PubMedGoogle Scholar
  38. Vassalli, J., and Reich, E., 1977, Macrophage plasminogen activator: Induction by products of activated lymphoid cells, J. Exp. Med. 145:429.PubMedCrossRefGoogle Scholar
  39. Vassalli, J., Hamilton, J., and Reich, E., 1977, Macrophage plasminogen activator: Induction by concanavalin A and phorbol myristate acetate, Cell 11:695.PubMedCrossRefGoogle Scholar
  40. Virolainen, M., and Defendi, V., 1967, Dependence of macrophage growth in vitro upon interaction with other cell types, Wistar Inst. Symp. Monogr. 7:67.PubMedGoogle Scholar
  41. Volkman, A., 1976a, Monocyte kinetics and their changes in infection, in: Immunobiology of the Macrophage (D. S. Nelson, ed.), p. 291, Academic Press, New York.Google Scholar
  42. Volkman, A., 1976b, Disparity in origin of mononuclear phagocyte populations, J. Reticuloendothelial Soc. 19:249.Google Scholar
  43. Wahl, L. M., Wahl, S. M., Mergenhagen, S. E., and Martin, G. R., 1975, Collagenase production by lymphokine-activated macrophages, Science 187:261.PubMedCrossRefGoogle Scholar
  44. Walker, W. S., 1976, Functional heterogeneity of macrophages, in: Immunobiology of the Macrophage (D. S. Nelson, ed.), p. 91, Academic Press, New York.Google Scholar
  45. Walker, W. S., Hester, R. B., Gandour, D. M., and Stewart, C. C., 1981, Evidence of a distinct progenitor for the la-bearing (Ia +) murine bone-marrow-derived mononuclear phagocyte (MNP), in: Heterogeneity of Mononuclear Phagocytes (Z. Cohn, D. Foester, and M. Landy, eds.), p. 229 Academic Press, New York.Google Scholar
  46. Williams, N., 1979, Preferential inhibition of murine macrophage colony formation by prostaglandin E, Blood 53:1089.PubMedGoogle Scholar
  47. Yen, S.-E., and Stewart, C. C., 1981, Macrophage growth inhibitors derived from the murine peritoneal cavity, In Vitro 17:871.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Carleton C. Stewart
    • 1
  1. 1.Experimental Pathology GroupLos Alamos National LaboratoryLos AlamosUSA

Personalised recommendations