Physiology pp 37-56 | Cite as

Regulation of Mononuclear Phagocyte Proliferation

  • Carleton C. Stewart


The diversity of functions assigned to mononuclear phagocytes (MNP) leads to the view that either the system is composed of multiple functionally distinct subpopulations (Walker, 1976; Walker et al., 1981) or that expression of a particular function represents differentiation states through which all cells pass as they mature. Superimposed on either developmental sequence, environmental stimuli may modulate the expression fo MNP function. For example, surface markers such as Ia or C3b receptors might be the result of clonal expansion of a subpopulation (Walker et al, 1981). The expression of Ia could also be a modulatable activity. Several investigators have shown that incubation of macrophages with mitogen-stimulated lymphocyte products can induce Ia on the surface membrane of macrophages (Farr et al, 1979; Beller and Unanue, 1981).


Bone Marrow Cell Colony Formation Adherent Cell Mononuclear Phagocyte Nonadherent Cell 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Carleton C. Stewart
    • 1
  1. 1.Experimental Pathology GroupLos Alamos National LaboratoryLos AlamosUSA

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