Physiology pp 353-377 | Cite as

Iron Metabolism

  • Farid I. Haurani
  • Samir K. Ballas


The bone marrow of an average person needs about 30 mg of iron per day. Approximately 1 to 2 mg of iron is absorbed daily from a diet that contains roughly 10 mg of iron, in order to keep up with an equal daily loss of iron. This means that the daily needs of iron by the bone marrow are met primarily by the reutilization of iron from the RES. Therefore, this system plays a very important role in iron metabolism on a daily basis. Figure 1 attempts to depict the relationship of the RES to iron metabolism in its proper perspective as it relates to the other two major systems involved in iron metabolism, namely, the bone marrow and the gastrointestinal tract. However, this chapter deals primarily with the RE aspects of iron metabolism. First, the uptake of the iron carriers, red blood cells and hemoglobin or heme, by the RES is presented. This is followed by the processing in the RES and the release of iron from the RES back to the circulation. Finally, we conclude with iron storage. Figure 2 highlights these events of iron metabolism.


Serum Ferritin Human Erythrocyte Iron Metabolism Iron Release Plasma Iron 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Farid I. Haurani
    • 1
  • Samir K. Ballas
    • 1
  1. 1.Cardeza Foundation for Hematologic Research, Department of MedicineThomas Jefferson UniversityPhiladelphiaUSA

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