Rodent Models of Filariasis

  • Mario Philipp
  • M. J. Worms
  • R. M. Maizels
  • Bridget M. Ogilvie
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 12)

Abstract

Filariasis is one of the most challenging problems for immunoparasitology today. This long-term chronic infection in humans causes extensive morbidity but little mortality (Nelson, 1979; Ottesen, 1980; Ogilvie and Mackenzie, 1981). Existing chemotherapeutic regimens suffer from inefficacy against mature parasites and may incur unpleasant side effects; control of the arthropod vectors has not yet proved sufficiently effective to interrupt transmission. For these reasons, immunologic analysis, directed toward both detection and prophylaxis of infection, may play a major role in controlling a disease currently afflicting some 300 million people (Sasa, 1976).

Keywords

Arthritis Resis Cyclosporin Cyclophosphamide Eosin 

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Mario Philipp
    • 1
  • M. J. Worms
    • 1
  • R. M. Maizels
    • 1
  • Bridget M. Ogilvie
    • 2
  1. 1.Division of ParasitologyNational Institute for Medical ResearchLondonEngland
  2. 2.The Wellcome TrustLondonEngland

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