Rodent Models of Filariasis

  • Mario Philipp
  • M. J. Worms
  • R. M. Maizels
  • Bridget M. Ogilvie
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 12)


Filariasis is one of the most challenging problems for immunoparasitology today. This long-term chronic infection in humans causes extensive morbidity but little mortality (Nelson, 1979; Ottesen, 1980; Ogilvie and Mackenzie, 1981). Existing chemotherapeutic regimens suffer from inefficacy against mature parasites and may incur unpleasant side effects; control of the arthropod vectors has not yet proved sufficiently effective to interrupt transmission. For these reasons, immunologic analysis, directed toward both detection and prophylaxis of infection, may play a major role in controlling a disease currently afflicting some 300 million people (Sasa, 1976).


Adult Worm Inbred Strain Infective Larva Female Worm Filarial Parasite 
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  1. Ah, H. S., and Thompson, P. E., 1973, Brugia pahangi infections and their effect on the lymphatic systems of Mongolian jirds, Exp. Parasitol. 34: 393.PubMedCrossRefGoogle Scholar
  2. Ahmed, S. S., 1966, Location of developing and adult worms of Brugia ssp. in naturally and experimentally infected animals, J. Trop. Med. Hyg. 69: 291.Google Scholar
  3. Ahmed, S. S., 1967a, Studies on the laboratory transmission of sub-periodic Brugia malayi and B. pahangi. II. Transmission to intact and splenectomized rats and cotton rats, Ann. Trop. Med. Parasitol. 61: 432.PubMedGoogle Scholar
  4. Ahmed, S. S., 1967b, Studies on the laboratory transmission of sub-periodic Brugia malayi and B. pahangi. I. The resistance of guinea pigs, rabbits and white mice to infection, Ann. Trop. Med. Parasitol. 61: 93.PubMedGoogle Scholar
  5. Amsbaugh, D. F., Hausen, C. T., Prescott, B., Stashak, P. W., Barthold, D. R., and Baker, P. S., 1972, Genetic control of the antibody response to Type III pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness, J. Exp. Med. 136: 931.PubMedCrossRefGoogle Scholar
  6. Anderson, R. C., and Bain, O., 1976, Keys to the genera of the order Spirurida Part 3. Filarioidea, Aproctoidea and Diplotriaenoidea in: Keys to the Nematode Parasites of Vertebrates. No. 3. (Anderson, R. C., Chabaud, A. G., and Willmott, S., eds.), pp. 39–116, Commonwealth Agricultural Bureau, Farnham Royal, Slough.Google Scholar
  7. Aoki, Y., Recinos, M. M., and Hashiguchi, Y., 1980, Life span and distribution of Onchocerca volvulus microfilariae in mice, J. Parasitol. 66: 797.PubMedCrossRefGoogle Scholar
  8. Ash, L. R., 1971, Preferential susceptibility of male jirds (Meriones unguiculatus) to infection with Brugia pahangi, J. Parasitol. 57: 777.PubMedCrossRefGoogle Scholar
  9. Ash, L. R., 1973a, Life cycle of Brugia patei (Buckley, Nelson and Heisch 1958) in the jird Meriones unguiculatus, J. Parasitol. 59: 692.PubMedCrossRefGoogle Scholar
  10. Ash, L. R., 1973b, Chronic Brugia pahangi and Brugia malayi infections in Meriones unguiculatus, J. Parasitol. 59: 442.PubMedCrossRefGoogle Scholar
  11. Ash, L. R., and Riley, J. M., 1970e, Development of Brugia pahangi in the jird Meriones unguiculatus, with notes on infections in other rodents, J. Parasitol. 56: 962.PubMedCrossRefGoogle Scholar
  12. Ash, L. R., and Riley, J. M., 1970b, Development of subperiodic Brugia malayi in the jird Meriones unguiculatus, with notes on infections in other rodents, J. Parasitol. 56: 969.PubMedCrossRefGoogle Scholar
  13. Ash, L. R., and Schacher, J. F., 1971, Early life cycle and larval morphogenesis of Wuchereria bancrofti in the jird Meriones unguiculatus, J. Parasitol. 57: 1043.PubMedCrossRefGoogle Scholar
  14. Bagai, R. C., and Subrahmanyam, D., 1970, Nature of acquired resistance to filarial infection in albino rats, Nature (Lond.) 228: 682.CrossRefGoogle Scholar
  15. Beaver, P. C., 1970, Filariasis without microfilaraemia, Am. J. Trop. Med. Hyg. 19: 181.PubMedGoogle Scholar
  16. Benjamin, D. B., and Soulsby, E. J. L., 1976, The homocytotrophic and hemagglutinating antibody responses to Brugia pahangi infection in the multimammate rat (Mastomys natalensis), Am. J. Trop. Med. Hyg. 25: 266.PubMedGoogle Scholar
  17. Beveridge, I., Kummerow, E., and Wilkinson, P., 1980, Experimental infection of laboratory rodents and calves with microfilariae of Onchocerca gibsoni, Tropenmed. Parasitol. 31: 82.PubMedGoogle Scholar
  18. Bianco, A. E., 1975, A new rodent filaria: A possible model for onchocerciasis, Trans. R. Soc. Trop. Med. Hyg. 69: 429.PubMedGoogle Scholar
  19. Brinkmann, U. K., Krämer, P., Presthus, G. T., and Sawadogo, B., 1976, Transmission in utero of microfilariae of Onchocerca volvulus, Bull. WHO 54: 708.PubMedGoogle Scholar
  20. Brug, S. L., 1927, Genuieuwe Filaria-soort (Filaria malayi parasiteerende bij den rueesch (voorloo-pige mededeeling), Geneesk. Tijdschr. Ned. Indie 67: 750.Google Scholar
  21. Buck, A. A., 1974, Onchocerciasis. Symptomatology, Pathology, Diagnosis, World Health Organization, Geneva.Google Scholar
  22. Buckley, J. J. C., 1958, Occult filarial infections of animal origin as a cause of tropical pulmonary eosinophilia, East Afr. Med. J. 35: 493.Google Scholar
  23. Camus, D., Dessaint, J-P., Fischer, E., and Capron, A., 1979, Non-specific suppressor cell activity and specific cellular unresponsiveness in rat schistosomiasis, Eur. J. Immunol. 9: 341.PubMedCrossRefGoogle Scholar
  24. Capron, A., Dessaint, J-P., Capron, M. and Bazin, H., 1975, Specific IgE antibodies in immune adherence of normal macrophages to Schistosoma monsoni schistosomules, Nature (Lond.) 253: 474.CrossRefGoogle Scholar
  25. Capron, A., Dessaint, J-P., Capron, M., Joseph, M. and Pestel, J., 1980, Role of anaphylactic antibodies in immunity to schistosomes, Am. J. Trop. Med. Hyg. 29: 849.PubMedGoogle Scholar
  26. Capron, A., Dessaint, J. P., Capron, M., Joseph, M., and Torpier, G., 1982, Effector mechanisms of immunity to schistosomes and their regulation, Immun. Rev. 61: 41.PubMedCrossRefGoogle Scholar
  27. Capron, M., Capron, A., Torpier, G., Bazin, H., Bout, D., and Joseph, M., 1978, Eosinophildependent cytotoxicity in rat schistosomiasis: Involvement of IgG2a antibody and role of mast cells, Eur. J. Immunol. 8: 127.PubMedCrossRefGoogle Scholar
  28. Capron, M., Capron, A., Goetzl, E. J., and Austen, K. F., 1981, Tetrapeptides of the eosinophil chemotactic factor of anaphylaxis (ECF-A) enhance eosinophil Fc receptor, Nature (Lond.) 289: 71.CrossRefGoogle Scholar
  29. Chabaud, A. G., 1954, Sur le cycle evolutif des spirurides et de nematodes ayant une biologie comparable, Ann. Parasitol. Hum. Comp. 29: 238.Google Scholar
  30. Chandrasoma, P. T., and Mendis, K. N., 1978, Filarial infections of the breast, Am. J. Trop. Med. Hyg. 26: 570.Google Scholar
  31. Chong, L. K., and Wong, M. M., 1967, Experimental infection of laboratory mice with Brugia pahangi, Med. J. Malaya 21: 382.Google Scholar
  32. Connor, D. H., Morrison, N. E., Kerdelvegas, F., Berkoff, H. A., Johnson, F., Tunnicliffe, R., Failing, C. F., Hale, L. N., Lindquist, K., Thornbloom, W., McCormick, J. B., and Anderson, S. L., 1970, Onchocerciasis, onchoceral dermatitis, lymphadenitis and elephantiasis in the Ubango territory, Hum. Pathol. 1: 553.PubMedCrossRefGoogle Scholar
  33. Cross, J. H., Partono, F., Hsu, M-Y. K., Ash, L. R., and Oemijati S., 1981, Further studies on the development of Wuchereria bancrofti in laboratory animals, Southeast Asian J. Trop. Med. Public Health 12: 114.PubMedGoogle Scholar
  34. Cruickshank, J. K., Price, K. M., MacKenzie, C. D., Denham, D. A., and Spry, C. J., 1982, Eosinophil and antibody responses in an inbred rat model of Brugian filariasis: Their modulation by cyclosporin A, Parasitology Abst. 85: X VI.Google Scholar
  35. Danaraj, T. J., da Silva, L. S., and Schacher, J. F., 1959, The serological diagnosis of eosinophilic lung (tropical eosinophilia) and its etiological implications, Am. J. Trop. Med. Hyg. 8: 151.PubMedGoogle Scholar
  36. Danaraj, T. J., Pacheco, G., Shanmugaratnam, K., and Beaver, P. C., 1966, The etiology and pathology of eosinophilic lung (tropical eosinophilia), Am. J. Trop. Med. Hyg. 15: 183.PubMedGoogle Scholar
  37. Dasgupta, A., Bala, S., Banerjee, A., and Chaudhury, A., 1980, Immunodiagnosis of human filariasis by counter-immunoelectrophoresis using Litomosoides carinii antigens, J. Helminthol. 54: 83.PubMedCrossRefGoogle Scholar
  38. David, H. L., and Edeson, J. F. B., 1965, Filariasis in Portuguese Timor, with observations on a new microfilaria found in man, Ann. Trop. Med. Paraistol. 59: 193.Google Scholar
  39. Denham, D. A., 1980, Vaccination against filarial worms using radiation-attenuated vaccines, Int. J. Nucl. Med. Biol. 7: 105.PubMedCrossRefGoogle Scholar
  40. Denham, D. A., and McGreevy, P. B., 1977, Brugian filariasis: Epidemiological and experimental studies, Adv. Parasitol. 15: 243.PubMedCrossRefGoogle Scholar
  41. Denham, D. A., and Nelson, G. S., 1976, Pathology and pathophysiology of nematode infections of the lymphatic system and blood vessels, in: Pathophysiology of Parasitic Infections ( Soulsby, E. J. L., ed.), pp. 115–132, Academic Press, New York.Google Scholar
  42. Dessaint, J. P., Camus, D., Fisher, E., and Capron, A., 1977, Inhibition of lymphocyte proliferation by factors produced by Schistosoma mansoni, Eur. J. Immunol. 7: 624.PubMedCrossRefGoogle Scholar
  43. Dessaint, J-P., Capron, A., Joseph, M., and Bazin, H., 1979, Cytophilic binding of IgE to the macrophage. II. Immunologic release of lysosomal enzyme from macrophages by IgE and anti-IgE in the rat: A new mechanism of macrophage activation, Cell Immunol. 46: 24.PubMedCrossRefGoogle Scholar
  44. Dissanaike, S., and Ismail, M. M., 1980, Antigens of Setaria digitata: Cross reaction with surface antigens of Wuchereria bancrofti microfilariae and serum antibodies of W. bancrofti-infected subjects, Bull WHO 58: 649.Google Scholar
  45. Duke, B. O. L., 1962, Experimental transmission of Onchocerca volvulus to a chimpanzee, Trans. R. Soc. Trop. Med. Hyg. 56: 571.Google Scholar
  46. Edeson, J. F. B., Ramachandran, C. P., Zaini, M. A., Nai, R. S., and Kershaw, W. E., 1962, The transmission of Malayan filariasis to rodents (Demonstration), Trans. R. Soc. Trop. Med. Hyg. 56: 269.Google Scholar
  47. El Bihari, S., and Hussein, H. S., 1975, Location of the microfilariae of Onchocerca armillata, J. Parasitol. 61: 656.CrossRefGoogle Scholar
  48. Fanning, M. M., and Kazura, J. W., 1983, Genetic association of murine susceptibility to Brugia malayi microfilaraemia, Parasite Immunol. 5: 305.PubMedCrossRefGoogle Scholar
  49. Festing, M. F. W., 1979, Inbred Strains in Biomedical Research, Macmillan, London.Google Scholar
  50. Fox, E. G., and Schacher, J. F., 1976, A comparison of syngeneic laboratory rat strains as hosts for Brugia pahangi, Trans. R. Soc. Trop. Med. Hyg., 70: 523.PubMedCrossRefGoogle Scholar
  51. Fujita, K., and Kobayashi, J., 1969, The development of antibodies in the cotton rat transplanted with the adult cotton rat Maria, Litomosoides carinii, Jap. J. Exp. Med. 39: 586.Google Scholar
  52. Gass, R. F., Tanner, M., and Weiss, N., 1979, Development of Dipetalonema viteae third stage larvae (Nematoda-Filarioidea) in micropore chambers transplanted into jirds, hamsters, normal and immunized mice, Z. Parasitenkd. 61: 73.PubMedCrossRefGoogle Scholar
  53. Geigy, R., Deschlimann, A., and Weiss, N., 1967, Transplacentare Ubertragung von Mikrofilarien der Art Dipetalonema witeae bei Meriones libycus, Acta Trop. 24: 266.PubMedGoogle Scholar
  54. Grove, D. I., and Davis, R. S., 1978, Serological diagnosis of Bancroftian and Malayan filariasis, Am. J. Trop. Med. Hyg. 27: 508.PubMedGoogle Scholar
  55. Grove, D. I., Davis, R. S., and Warren, K. S., 1979, Brugia malayi microfilaraemia in mice: A model for the study of the host response to microfilariae, Parasitology 79: 303.PubMedCrossRefGoogle Scholar
  56. Gusmao, D’ A. R., Stanley, A. H.. and Ottesen, E. A., 1981, Brugia pahangi: Immunologic evaluation of the differential susceptibility to filarial infection in inbred Lewis rats, Exp. Parasitol. 52: 147.CrossRefGoogle Scholar
  57. Haas, B., and Wenk, P., 1981, Elimination of microfilariae (Litomosoides carinii, Filarioidea) in the patent and in the immunized cotton rat, Trans. R. Soc. Trop. Med. Hyg. 75: 143.PubMedCrossRefGoogle Scholar
  58. Hague, A., and Capron, A., 1982, Transplacental transfer of rodent microfilariae induces antigen-specific tolerance in rats, Nature (Lond.) 299: 361.CrossRefGoogle Scholar
  59. Hague, A., Lefebvre, M. N., Ogilvie, B. M., and Capron, A., 1978a, Dipetalonema viteae in hamsters: Effect of antiserum or immunization with parasite extracts on production of microfilariae, Parasitology 76: 61.CrossRefGoogle Scholar
  60. Hague, A., Chassoux, D., Ogilvie, B. M., and Capron, A., 1978b, Dipetalonema viteae infection in hamsters: enhancement and suppression of microfilariaemia, Parasitology 76: 77.CrossRefGoogle Scholar
  61. Hague, A., Worms, M. J., Ogilvie, B. M., and Capron, A., 1980a, Dipetalonema viteae: Microfilariae production in various mouse strains and in nude mice, Exp. Parasitol. 49: 398.CrossRefGoogle Scholar
  62. Hague, A., Joseph, M., Ouaissi, M. A., Capron, M., and Capron, A., 1980b, IgE antibody-mediated cytotoxicity of rat macrophages against microfilariae of Dipetalonema viteae in vitro, Clin. Exp. Immunol. 40: 487.Google Scholar
  63. Hague, A., Camus, D., Ogilvie, B. M., Capron, M., Bazin, H., and Capron, A., 1981a, Dipetalonema viteae infective larvae reach reproductive maturity in rats immunodepressed by prior exposure to Schistosoma mansoni or its products and in congenitally athymic rats, Clin. Exp. Immunol. 43: 1.Google Scholar
  64. Hague, A., Ouassi, M. A., Joseph, M., Capron, M., and Capron, A., 1981b, IgE antibody in eosinophil-and macrophage-mediated in vitro killing of Dipetalonema viteae microfilariae, J. Immunol. 127: 716.Google Scholar
  65. Harbut, C. L., 1973, The white rat and golden hamster as experimental hosts for Brugia pahangi and subperiodic Brugia malayi, Southeast Asian J. Trop. Med. Public Health 4: 487.PubMedGoogle Scholar
  66. Hawking, F., and Sewell, P., 1948, The maintenance of a filarial infection (Litomosoides carinii) for chemotherapeutic investigations, Br. J. Pharmacol. Chemother. 3: 285.PubMedGoogle Scholar
  67. Hedge, E. C., and Ridley, D. S., 1977, Immunofluorescent reactions with microfilariae. I. Diagnostic evaluation, Trans. R. Soc. Trop. Med. Hyg. 71: 304.PubMedCrossRefGoogle Scholar
  68. Ho, B. C., Singh, M., Yap, E. H., and Lim, B. L., 1976a, Studies on the Malayan forest rat filaria Breinlia booliati (Filarioidea, Onchocercidae): Transmission to laboratory rats, Int. J. Parasitol. 6: 113.PubMedCrossRefGoogle Scholar
  69. Ho, B. C., Singh, M., Yap, E. H., and Lim, E. P. C., 1976b, Studies on the Malayan forest rat filariae Breinlia booliati (Filarioidea, Onchocercidae): relative susceptibility of various species of mosquitoes, J. Med. Entomol. 13: 531.Google Scholar
  70. Ishizaka, T., Soto, C. S., and Ishizaka, K., 1972, Characteristics of complement fixation by aggregated IgE, J. Immunol. 19: 65.Google Scholar
  71. Ismail, M. M., and Nagaratnam, N., 1973, Arthritis, possibly due to filariasis, Trans. R. Soc. Trop. Med. Hyg. 67: 405.PubMedCrossRefGoogle Scholar
  72. Joe, L. K., 1962, Occult filariasis: Its relationship with tropical pulmonary eosinophilia, Am. J. Trop. Med. Hyg. 11: 646.Google Scholar
  73. Joseph, M., Dessaint, J-P., and Capron, A., 1977, Characteristics of macrophages cytoxicity induced by IgE immune complexes, Cell. Immunol. 34: 247.PubMedCrossRefGoogle Scholar
  74. Joseph, M., Capron, A., Butterworth, A. E., Sturrock, R. F., and Houba, V., 1978, cytotoxicity of human and baboon mononuclear phagocytes against schistosomula in vitro: Induction by immune complexes containing IgE and Schistosoma mansoni antigens, Clin. Exp. Immunol. 33: 48.Google Scholar
  75. Joseph, M., Tonnel, A. B., Capron, A., and Voisin, C., 1980, Enzyme release and superoxide anion production by human alveolar macrophages stimulated with immunoglobulin E, Clin. Exp. Immunol. 40: 416.PubMedGoogle Scholar
  76. Karavodin, L. M., and Ash, L. R., 1980, Circulating immunocomplexes in experimental filariasis, Clin. Exp. Immunol. 40: 312.PubMedGoogle Scholar
  77. Karavodin, L. M., and Ash, L. R., 1981, Sequential determination of circulating immune complexes in experimental filariasis, Infect. Immun. 34: 105.PubMedGoogle Scholar
  78. Karavodin, L. M., and Ash, L. R., 1982, Inhibition of adherence and cytotoxicity by circu- lating immune complexes formed in experimental filariasis, Parasite Immunol. 4: 1.PubMedCrossRefGoogle Scholar
  79. Kazura, J. W., and Davis, R. S., 1982, Soluble Brugia malayi microfilarial antigens protect mice against challenge by an antibody-dependent mechanism, J. Immunol. 128: 1792.PubMedGoogle Scholar
  80. Klei, T. R., and Crowell, W. A., 1981, Pathological changes in kidneys, livers and spleens of Brugia pahangi-infected jirds (Meriones unguiculatus), J. Helminthol. 55: 123.PubMedGoogle Scholar
  81. Klei, T. R., McCall, J. W., and Malone, J. B., 1980, Evidence for increased susceptibility of Brugia pahangi-infected jirds (Meriones unguiculatus) to subsequent homologous infections, J. Helminth. 54: 161.PubMedCrossRefGoogle Scholar
  82. Klei, T. R., Enright, F. M., Blanchard, D. P., and Uhl, S. A., 1981, Specific hypo-responsive granulomatous tissue reactions in Brugia pahangi-infected jirds,Acta Trop. 38: 267.Google Scholar
  83. Klei, T. R., Enright, F. M., Blanchard, D. P., and Uhl, S. A., 1982, Effects on presensitization on the development of lymphatic lesions in Brugia pahangi-infected jirds, Am. J. Trop. Med. Hyg. 31: 280.PubMedGoogle Scholar
  84. Kowalski, J. C., and Ash, L. R., 1975, Repeated infections of Brugia pahangi in the jird, Meriones unguiculatus, Southeast Asian J. Trop. Med. Public Health. 6: 195.PubMedGoogle Scholar
  85. Laing, A. B. G., Edeson, J. F. B., and Wharton, R. F., 1961, Studies on filariasis in Malaya: Further experiments on the transmission of Brugia malayi and Wuchereria bancrofti, Ann. Trop. Med. Parasitol. 55: 86.PubMedGoogle Scholar
  86. Lämmler, G., Saupe, E., and Herzoy, H., 1968, Infektions-versuche mit der Baumwollratten -filariae Litomosoides carinii bei Mastomys natalensis, Z. Parasitenkd. 32: 281.Google Scholar
  87. Lichtenberg, F. von, 1957, The early phase of endemic bancroftian filariasis in the male. Pathological study, J. Mount Sinai Hosp. 26: 983.Google Scholar
  88. Lichtenstein, A., 1927, Filaria-onderzoek te Birenen, Geneesk. Tijdschr. Ned. Indie 67: 742.Google Scholar
  89. MacDonald, E. M., and Scott, J. A., 1953, Experiments on immunity in the cotton rat to the filarial worm Litomosoides carinii, Exp. Parasitol. 2: 174.CrossRefGoogle Scholar
  90. MacDonald, E. M., and Scott, J. A., 1958, The persistence of acquired immunity to the filarial worm of the cotton rat, Am. J. Trop. Med. Hyg. 7: 419.PubMedGoogle Scholar
  91. Maizels, R. M., Philipp, M., Denham, D. A., Partono, F., Oemijati, S., and Ogilvie, B. M., 1981, Antigenic analysis in Brugian filariasis: Cross reactive and restricted antigens on the surface of Brugia of different stages and species, Parasitology 84: xxxi.Google Scholar
  92. Maizels, R. M., Philipp, M., and Ogilvie, B. M., 1982, Molecules on the surface of parasitic nematodes as probes of the immune response in infection, Immunol. Rev. 61: 109.PubMedCrossRefGoogle Scholar
  93. Maizels, R. M., Partono, F., Oemijati, S., Denham, D. A. and Ogilvie, B. M. 1983, Cross-reactive surface antigens on three stages of Brugi malayi, Brugia pahangi and Brugia timori, Parasitology (in press).Google Scholar
  94. Maizels, R. M., Philipp, M., Daseupta, A., and Partono, F., 1983a, Human serum albumen is a major component on the surface of microfiliariae of Wuchereria bancrofti, Parasite Immunol. (in press).Google Scholar
  95. Mak, J. W., and Lim, B. L., 1974, New hosts of Breinlia booliati in wild rats from Sarawak, with further observations on its morphology, Southeast Asian J. Trop. Med. Public Health. 5: 22.Google Scholar
  96. Malone, J. B., and Thompson, P. E., 1975, Brugia pahangi: Susceptibility and macroscopic pathology in golden hamsters, Exp. Parasitol. 38: 279.PubMedCrossRefGoogle Scholar
  97. Malone, J. B., Leininger, J. R., and Thompson, P. E., 1974, Brugia pahangi in golden hamsters, Trans. R. Soc. Trop. Med. Hyg. 68: 170.PubMedCrossRefGoogle Scholar
  98. Mantovani, A., and Jackson, R. F., 1966, Transplacental transmission of microfilariae of Dirofilaria immitis in the dog, J. Parasitol. 52: 116.CrossRefGoogle Scholar
  99. Martinez-Baez, M., 1978, La oncocercosis en Mexico, Symp. Gac. Med. de Mex. 114: 525.Google Scholar
  100. McCall, J. W., Malone, J. B., Ah, H., and Thompson, P. E., 1973, Mongolian jirds (Meriones unguiculatus) infected with Brugia pahangi by the intraperitoneal route: A rich source of developing larvae, adult filariae and microfilariae, J. Parasitol. 59: 436.PubMedCrossRefGoogle Scholar
  101. McGreevy, P. B., Ratiwayanto, S., Tuti, S., McGreevy, M. M., and Dennis, D. T., 1980, Brugia malayi: Relationship between anti-sheath antibodies and amicrofilaraemia in natives living in an endemic area of South Kalimantan, Borneo, Am. J. Trop. Med. Hyg. 29: 553.Google Scholar
  102. Mehta, K., Sindhu, R. K., Subrahamanyam, D., and Nelson, D. S., 1980, IgE-dependent adherence and cytotoxicity of rat spleen and peritoneal cells to Litomosoides carinii microfilariae, Clin. Exp. Immunol. 41: 107.PubMedGoogle Scholar
  103. Mehta, K., Subrahmanyam, D., and Sindhu, R. K., 1981, Immunogenicity of homogenates of the developmental stages of Litomosoides carinii in albino rats, Acta Trop. 38: 319.PubMedGoogle Scholar
  104. Mehta, K., Sindhu, R. K., Subrahmanyam, D., Hopper, K., and Nelson, D. S., 1982, IgEdependent cellular adhesion and cytotoxicity to Litomosoides carinii microfilariaeNature of effector cells, Clin. Exp. Immunol. 48: 477.PubMedGoogle Scholar
  105. Meyers, F. M., and Kunwenaar, W., 1939, Over hypereosinophilie en overeen werkwaardigen vorm van filariassis, Geneesk. Tijdsch. Ned. Indie 79: 853.Google Scholar
  106. Mitchell, G. F., Anders, R. F., Brown, G. V., Handman, E., Roberts-Thomson, I. C., Chapman, C. B., Forsyth, K. P., Kahl, L. P., and Cruise, K. M., 1982, Analysis of infection characteristics and antiparasite immune responses in resistant compared with susceptible hosts, Immunol. Rev. 61: 137.PubMedCrossRefGoogle Scholar
  107. Muller, R. L., and Nelson, G. S., 1975, Ackertia globulosa sp. n. (Nematoda, Filarioidea) from rodents in Kenya, J. Parasitol. 61: 606.PubMedCrossRefGoogle Scholar
  108. Neilson, J. T. M., 1976, A comparison of the acquired resistance to Dipetalonema viteae stimulated in hamsters by trickle vs tertiary infections, Z. Tropenmed. Parasitol. 27: 233.Google Scholar
  109. Neilson, J. T. M., 1978, Primary infections of Dipetalonema viteae in an outbred and five inbred strains of golden hamsters, J. Parasitol. 64: 378.PubMedCrossRefGoogle Scholar
  110. Neilson, J. T. M., 1979, Kinetics of Dipetalonema viteae infections established by surgical implantation of adult worms into hamsters, Am. J. Trop. Med. Hyg. 28: 216.PubMedGoogle Scholar
  111. Neilson, J. T. M., Crandall, C. A., and Crandall, R. B., 1981, Serum immunoglobulin and antibody levels and the passive transfer of resistance in hamsters infected with Dipetalonema viteae, Acta Trop. 38: 309.PubMedGoogle Scholar
  112. Nelson, G. S., 1979, Current concepts in parasitology. Filariasis, N. Engl. J. Med. 300: 1136.PubMedCrossRefGoogle Scholar
  113. Nelson, G. S., Amin, M. A., Blackie, E. J., and Robson, N., 1966, The maintenance of Onchocerca gutturosa microfilariae in vivo and in vitro, Trans. R. Soc. Trop. Med. Hyg. 60: 17.CrossRefGoogle Scholar
  114. Neva, F. A., Kaplan, A. P., Pacheco, G., Gray, L., and Danaraj, T. J., 1975, A human model of parasitic immunopathology, with observations on serum IgE levels before and after treatment, J. Allergy Clin. Immunol. 55: 422.PubMedCrossRefGoogle Scholar
  115. Ogilvie, B. M., and MacKenzie, C. D., 1981, Immunology and immunopathology of infections caused by filarial nematodes, in: Parasitic Diseases. The Immunology ( J. Mansfield, ed.) pp. 227–289, Marcel Dekker, New York.Google Scholar
  116. Olson, L. J., 1959, The survival of migratory and post-migratory stages of Litomosoides carinii in white rats, J. Parasitol. 45: 182.PubMedCrossRefGoogle Scholar
  117. Olson, L. J., Scott, J. A., and MacDonald, E. M., 1954, Factors in the racial immunity of the white rat to cotton rat filarial worms, J. Parasitol. 40 (Suppl.): 14.Google Scholar
  118. Olson, L. J., Scott, J. A., and MacDonald, E. M., 1955, Infection of white rats with the filarial worm of cotton rats, J. Parasitol. 41 (Suppl.): 44.Google Scholar
  119. Ottesen, E. A., 1980, Immunopathology of lymphatic filariasis in man, Springer Sem. Immunopathol. 2: 373.CrossRefGoogle Scholar
  120. Ottesen, E. A., Weller, P. F., and Heck, L., 1977, Specific cellular immune unresponsiveness in human filariasis, Immunology 33: 413.PubMedGoogle Scholar
  121. Ottesen, E. A., Neva, F. A., Paranjape, R. S., Tripathy, S. P., Thiruvengadam, K. V., and Beaven, M. A., 1979, Specific allergic sensitisation to filarial antigens in tropical eosinophilic syndrome, Lancet 1: 1158.PubMedCrossRefGoogle Scholar
  122. Ouaissi, M. A., Hague, A., and Capron, A., 1981, Dipetalonema viteae: Ultrastructural study on the in vitro interaction between rat macrophages and microfilariae in the presence of IgE antibody, Parasitology 82: 55.PubMedCrossRefGoogle Scholar
  123. Palmieri, J. R., Purnomo, Dennis, D. T., and Marwoto, H. A., 1980, Filarid parasites of South Kalimantan (Borneo) Indonesia. Wuchereria kalimantani sp. n. (Nematoda, Filarioidea) from the Silver Leaf monkey Presbytis cristatus Eschscholtz 1921, J. Parasitol. 66: 645.Google Scholar
  124. Partono, F., Dennis, D. T., Purnomo, and Atmosoedjono, S., 1977, Brugia timori: Experimental infection in some laboratory animals, Southeast Asian J. Trop. Med. Public Health 8: 155.Google Scholar
  125. Perlmutter, R. M., Nahm M., Stein, K. E., Slack, J., Zitron, I., Paul, W. E., and Davie, J. M., 1979, Immunoglobulin subclass-specific immunodeficiency in mice with an X-linked B-lymphocyte defect, J. Exp. Med. 149: 993.PubMedCrossRefGoogle Scholar
  126. Petrânyi, G., Mieth, H., and Leitner, I., 1975, Mastomys natalensis as an experimental host for Brugia malayi subperiodic, Southeast Asian J. Trop. Med. Public Health 6: 328.PubMedGoogle Scholar
  127. Philipp, M., Denham, D. A., Maizels, R. M., Ogilvie, B. M., Parkhouse, R. M. E., Taylor, P. M., and Worms, M. J., 1980, The antigens on the surface of parasitic nematodes: Studies on Litomosoides carinii, Brugia pahangi and Trichinella spiralis, Parasitology 81: xxx.Google Scholar
  128. Philipp, M., Worms, M. J., McLaren, D. J., Oglivie, B. M., Parkhouse, R. M. E., and Taylor, P. M., 1983, Surface proteins of a filarial nematode: a major soluble antigen and a host component on the cuticle of Litomosoides carinii, Parasite Immunol. (in press).Google Scholar
  129. Piessens, W. F., McGreevy, P. B., Piessens, P. W., McGreevy, M., Koiman, I., Saroso, J. S., and Dennis, D. T., 1980a, Immune responses in human infections with Brugia malayi: Specific cellular unresponsiveness to filarial antigen, J. Clin. Invest. 65: 172.PubMedCrossRefGoogle Scholar
  130. Piessens, W. F., Ratiwayanto, S., Tuti, S., Palmieri, J. H., Piessens, P. W., Koiman, I., and Dennis, D. T., 1980b, Antigen-specific suppressor cells and suppressor factors in human filariasis with Brugia malayi, N. Engl. J. Med. 302: 833.PubMedCrossRefGoogle Scholar
  131. Piessens, W. F., McGreevy, P. B., Ratiwayanto, S., McGreevy, M., Piessens, P. W., Koiman, I., Saroso, J. S., and Dennis, D. T., 1980c, Immune responses in human infections with Brugia malayi: correlation of cellular and humoral reactions to microfilarial antigens with clinical status, Am. J. Trop. Med. Hyg. 29: 563.PubMedGoogle Scholar
  132. Piessens, W. F., Partono, F., Hoffman, S. L., Ratiwayanto, S., Piessen, P. W., Palmieri, J. R., Koiman, I., Dennis, D. T. and Carney, W. P., 1982, Antigen-specific suppressor T-lymphocytes in human lymphatic filariasis, N. Engl. J. Med. 307: 144.PubMedCrossRefGoogle Scholar
  133. Ponnudurai, T., Denham, D. A., Nelson, G. S., and Rogers, R., 1974, Studies with Brugia pahangi. 4. Antibodies against adult and microfilarial stages, J. Helminthol. 48: 107.PubMedCrossRefGoogle Scholar
  134. Portaro, J. K., Britton, S., and Ash, L. R., 1976, Brugia pahangi: Depressed mitogen reac- tivity in filarial infections in the jird,Meriones unguiculatus, Exp. Parasitol. 40: 438.PubMedCrossRefGoogle Scholar
  135. Pringle, G., and King, D. F., 1968, Some developments in techniques for the study of the rodent filarial parasite Litomosoides carinii. I. A preliminary comparison of the host efficiency of the multimammate rat Praomys (Mastomys) natalensis with that of the cotton rat (Sigmodon hispidus), Ann. Trop. Med. Parasitol. 62: 462.PubMedGoogle Scholar
  136. Rabalais, F. C., 1974, Studies on Onchocerca cervicalis Railliet and Henry, 1910, microfilariae in the jird Meriones unguiculatus, J. Helminthol. 48: 125.PubMedCrossRefGoogle Scholar
  137. Ramachandran, C. P., and Pacheco, G., 1965, American cotton rat (Sigmodon hispidus) as an experimental host for Brugia pahangi, J. Parasitol. 51: 722.PubMedCrossRefGoogle Scholar
  138. Ramachandran, C. P., Sandosham, A. A., and Sivanandam, S., 1966, Development of Wuchereria bancrofti in the domestic cat (Laboratory meeting), Med. J. Malaya 20: 333.PubMedGoogle Scholar
  139. Ramakrishnan, S. P., Singh, D., Bhatnagar, V. N., and Raghavan, N. G. S., 1961, Infection of the albino rat with the filarial parasite Litomosoides carinii of cotton rats, Ind. J. Malariol. 15: 255.Google Scholar
  140. Ramakrishnan, S. P., Singh, D., and Krishnaswamy, A. K., 1962, Evidence of acquired immunity against microfilariae of Litomosoides carinii in albino rats with mite-induced infections, Ind. J. Malariol. 16: 263.Google Scholar
  141. Rao, Y. V. B. G., Mehta, K., and Subrahamanyam, D., 1977, Litomosoides carinii: Effect of irradiation on the development and immunogenicity of the larval forms, Exp. Parasitol. 43: 39.CrossRefGoogle Scholar
  142. Rao, Y. V. B. G., Mehta, K., Subrahmanyam, D., and Venkatarao, S., 1980, Effect of irradiation on the infectivity and immunogenicity of larvae of Litomosoides carinii, Ind. J. Med. Res. 72: 42.Google Scholar
  143. Rogers, R., Davis, R., and Denham, D. A., 1975, A new technique for the study of changes in lymphatics induced by filarial worms, J. Helminthol. 49: 31.PubMedGoogle Scholar
  144. Rousseaux-Prevost, R., Chassoux, D., Bazin, H., and Capron, A., 1979, Serum IgE levels in rats infected with D. viteae L3 larvae, Clin. Exp. Immunol. 38: 389.PubMedGoogle Scholar
  145. Rudin, W., Tanner, M., Bauer, P., and Weiss, N., 1980, Studies on Dipetalonema viteae (Filarioidea). 5. Ultrastructural aspects of the antibody-dependent cell-mediated destruction of microfilariae, Tropenmed. Parasitol. 31: 194.PubMedGoogle Scholar
  146. Sanger, I., Lämmler, G., and Kimmig, P., 1981, Filarial infection of Mastomys natalensis and their relevance for experimental chemotherapy,Acta Trop. 38: 277.Google Scholar
  147. Sasa, M., 1976, Human Filariasis: A Global Survey of Epidemiology and Control, University Park Press, Baltimore.Google Scholar
  148. Schacher, J. F., 1973, Laboratory models in filariasis: A review of filarial life-cycle patterns, Southeast Asian J. Trop. Med. Public Health 4: 336.PubMedGoogle Scholar
  149. Schacher, J. F., and Sahyoun, P. F., 1967, A chronological study of the histopathology of filarial disease in cats and dogs caused by Brugia pahangi (Buckley and Edeson 1956), Trans. R. Soc. Trop. Med. Hyg. 61: 234.PubMedCrossRefGoogle Scholar
  150. Schrater, A. F., and Piessens, W. F., 1982, Antigens present on early larval stages induce carrier-specific suppression in Brugia malayi infected jirds, Fed. Proc. 41: 371.Google Scholar
  151. Scott, J. A., and MacDonald, E. M., 1958, Immunity to challenging infections of Litomosoides carinii produced by transfer of developing worms, J. Parasitol. 44: 187.PubMedCrossRefGoogle Scholar
  152. Scott, J. A., MacDonald, E. M., and Olson, L. J., 1958a, The early induction in cotton rats of immunity to their filarial worms, J. Parasitol. 44: 507.PubMedCrossRefGoogle Scholar
  153. Scott, J. A., MacDonald, E. M., and Olson, L. J., 1958b, Attempts to produce immunity against the filarial worms of cotton rats by transfer of developing worms, Am. J. Trop. Med. Hyg. 7: 70.PubMedGoogle Scholar
  154. Siddiqui, M. A., 1979, Host-parasite relations in cotton rat filariasis. III. The quantitative transmission of Litomosoides carinii to unirradiated or irradiated golden hamsters and white mice, Ann. Trop. Med. Parasitol. 73: 377.PubMedGoogle Scholar
  155. Singh, M., and Cheong, C. H., 1971, On a collection of nematode parasites from Malayan rats, Southeast Asian J. Trop. Med. Public Health 2: 516.PubMedGoogle Scholar
  156. Singh, M., and Ho, B. C., 1973, Breinlia booliati sp. n. (Filarioidea, Onchocercidae), a Filaria of the Malayan forest rat, Rattus sabanus (Thos), J. Helminthol. 47: 127.PubMedCrossRefGoogle Scholar
  157. Singh, M., Ho, B. C., and Lim, B. L., 1972, Preliminary results on experimental transmission of a new filarial parasite, Breinlia booliati sp. n. Singh and Ho, 1973, from Malayan wild rats to laboratory albino rats, Southeast Asian J. Trop. Med. Public Health 3: 622.Google Scholar
  158. Singh, M., Yap, E. H., Ho, B. C., Kang, K. L., and Lim, E. P. C., 1976, Studies on the Malayan forest rat Maria Breinlia booliati (Filarioidea, Onchocercidae). Course of development in rat host, J. Helminthol. 50: 103.PubMedCrossRefGoogle Scholar
  159. Spry, C. J. F., 1980, Alterations in blood eosinophil morphology, binding capacity for complexed IgG and kinetics in patients with tropical (filarial) eosinophilia, Parasite Immunol. 3: 1.CrossRefGoogle Scholar
  160. Spry, C. J. F., and Kumaraswami, V., 1982, Tropical eosinophilia, Semin. Haematol. 19: 107.Google Scholar
  161. Storey, D. M., and Al-Mukhtar, A. S., 1982, Vaccination of jirds, Meriones unguiculatus against Litomosoides carinii and Brugia pahangi using irradiated larvae of L. carinii, Tropenmed. Parasitol. 33: 23.PubMedGoogle Scholar
  162. Storey, D. M. and Al-Mukhtar, A. S., 1983, The survival of adult Litomosoides carinii in cotton rats previously injected with irradiated stage 3 larvae, Tropenmed. Parasitol. 34: 24.Google Scholar
  163. Subrahmanyam, D., Chaudbury, S., and Jain, S., 1974, Immunological investigations on filariasis, Ind. J. Bacteriol Pathol. 17: 135.Google Scholar
  164. Subrahmanyam, D., Rao, Y. V. B. G., Mehta, K., and Nelson, D. S., 1976, Serum dependent adhesion and cytotoxicity of cells to Litomosoides carinii microfilariae, Nature (Lond) 260: 5–29.CrossRefGoogle Scholar
  165. Subrahmanyam, D., Mehta, K., Nelson, D. S., Rao, Y. B. V. G., and Rao, C. K., 1978, Immune responses in human filariasis, J. Clin. Microbiol. 8: 228.PubMedGoogle Scholar
  166. Sucharit, S., and MacDonald, W. W., 1972, Brugia pahangi in small laboratory animals: The screening of infected rats, Southeast Asian J. Trop. Med. Public Health 3: 347.PubMedGoogle Scholar
  167. Sucharit, S., and MacDonald, W. W., 1973, Brugia pahangi in small laboratory animals: Attempts to increase susceptibility of white rats to Brugia pahangi by host selection, Southeast Asian J. Trop. Med. Public Health 4: 71.PubMedGoogle Scholar
  168. Suswillo, R. R., Nelson, G. S., Muller, R.., McGreevy, P. B., Duke, B. O. L., and Denham, D. A., 1977, Attempts to infect jirds (Meriones unguiculatus) with Wuchereria bancrofti, Onchocerca volvulus, Loa loa and Mansonella ozzardi, J. Helminthol. 51: 132.PubMedCrossRefGoogle Scholar
  169. Suswillo, R. R., Owen, D. G., and Denham, D. A., 1980, Infections of Brugia pahangi in conventional and nude (athymic) mice, Acta Trop. 37: 327.PubMedGoogle Scholar
  170. Suswillo, R. R., Doenhoff, M. J., and Denham, D. A., 1981, Successful development of Brugia pahangi in T-cell-deprived CBA mice, Acta Trop. 38: 305.PubMedGoogle Scholar
  171. Tanner, M., 1981, Dipetalonema viteae (Filarioidea): Development of the infective larvae in vitro, Acta Trop. 38: 241.PubMedGoogle Scholar
  172. Tanner, M., and Weiss, N., 1978, Studies on Dipetalonema viteae (Filarioidea). II. Antibody-dependent adhesion of peritoneal exudate cells to microfilariae in vitro, Acta Trop. 35: 151.PubMedGoogle Scholar
  173. Tanner, M., and Weiss, N., 1979, Studies on Dipetalonema viteae (Filarioidea). 4. Passive transfer of immunity to circulating microfilariae by spleen cells, Tropenmed. Parasitol. 30: 371.Google Scholar
  174. Tanner, M., and Weiss, N., 198la, Dipetalonema viteae (Filarioidea): Development of the infective larvae in micropore chambers implanted into normal, infected and immunized jirds, Trans. R. Soc. Trop. Med. Hyg. 75: 173.PubMedCrossRefGoogle Scholar
  175. Tanner, M., and Weiss, N., 1981b, Dipetalonema viteae (Filarioidea): Evidence for a serum dependent cytotoxicity against developing third and fourth stage larvae in vitro, Acta Trop. 38: 325.PubMedGoogle Scholar
  176. Townson, S., and Bianco, A. E., 1982, Experimental infection of mice with the microfilariae of Onchocerca lienalis, Parasitology 85: 283.PubMedCrossRefGoogle Scholar
  177. Townson, S., Bianco, A. E., and Owen, D., 1981, Attempts to infect small laboratory animals with the infective larvae of Onchocerca lienalis, J. Helminthol. 55: 247.PubMedCrossRefGoogle Scholar
  178. Thompson, J. P., Crandall, R. B., Crandall, C. A., and Neilson, J. T., 1979, Clearance of microfilariae of Dipetalonema viteae in CBA/N and CBA/H mice, J. Parasitol. 65: 966.PubMedCrossRefGoogle Scholar
  179. Thompson, J. P., Crandall, R. B., and Crandall, C. A., 1981, Microfilaremia and antibody responses in CBA/H and CBA/N mice following injection of microfilariae of Brugia malayi, J. Parasitol. 67: 728.PubMedCrossRefGoogle Scholar
  180. Vincent, A. L., and Ash, L. R., 1978, Splenomegaly in jirds (Meriones unguiculatus) infected with Brugia malayi and related species, Am. J. Trop. Med. Hyg. 27: 514.PubMedGoogle Scholar
  181. Vincent, A. L., Frommes, S. P., and Ash, L. R., 1976, Brugia malayi, B. pahangi, B. patei: Pulmonary pathology in jirds Meriones unguiculatus, Exp. Parasitol. 40: 330.PubMedCrossRefGoogle Scholar
  182. Vincent, A. L., Ash, L. R., Rodrick, G. E., and Sodeman, W. A., 1980a, The lymphatic pathology of Brugia pahangi in the Mongolian jird, J. Parasitol. 66: 613.PubMedCrossRefGoogle Scholar
  183. Vincent, A. L., Sodeman, W. A., Jr., and Winters, A., 1980b, Development of Brugia pahangi in normal and nude mice, J. Parasitol. 66: 448.PubMedCrossRefGoogle Scholar
  184. Vincent, A. L., Vickery, A. C., and Winters, A., 1982a, Life cycle of Brugia pahangi in nude (congenitally athymic) mice, C3H/HeN (nu/nu), J. Parasitol. 68: 553.PubMedCrossRefGoogle Scholar
  185. Vincent, A. L., Vickery, A. C., Nayar, J. K., Sauerman, D., and Yangco, B. G., 1982b, Non-development of Wuchereria bancrofti in nude (congenitally athymic) mice, Am. J. Trop. Med. Hyg. 31: 1062.PubMedGoogle Scholar
  186. Warren, K. S., 1971, Worms, in: Immunological Diseases ( M. Samter, ed.), pp. 668–686, Little, Brown, Boston.Google Scholar
  187. Weiner, D. J., and Soulsby, E. J. L., 1975, Fate of Litomosoides carinii adults transferred into infected and naive Mongolian jirds (Meriones unguiculatus), in: Nuclear Techniques in Helminthology Research, pp. 85–89, International Atomic Energy Agency, Vienna.Google Scholar
  188. Weiner, D. J., and Soulsby, E. J. L., 1976, Fate of Litomosoides carinii adults transplanted into the pleural or peritoneal cavity of infected and naive multimammate rats (Mastomys natalensis), J. Parasitol. 62: 886.PubMedCrossRefGoogle Scholar
  189. Weiner, D. J., and Soulsby, E. J. L., 1978, Litomosoides carinii: Effect of splenectomy on the ability of naive Mastomys natalensis to accept transplanted worms, Exp. Parasitol. 45: 241.PubMedCrossRefGoogle Scholar
  190. Weiss, N., 1970, Parasitologische und immunobiologische Untersuchungen über die durch Dipetalonema viteae erzeugte Nagertierfilariose, Acta Trop. 35: 137.Google Scholar
  191. Weiss, N., 1978a, Studies on Dipetalonema viteae (Filarioidea). I. Microfilaraemia in ham- sters in relation to worm burden and humoral immune response, Acta Trop. 35: 137.PubMedGoogle Scholar
  192. Weiss, N., 1978b, Dipetalonema viteae: In vitro blastogenesis of hamster spleen and lymph node cells to phytohaemagglutinin and filarial antigens, Exp. Parasitol. 46: 283.PubMedCrossRefGoogle Scholar
  193. Weiss, N., and Tanner, M., 1979, Studies on Dipetalonema viteae (Filarioidea). 3. Antibody-dependent cell-mediated destruction of microfilariae in vivo, Tropenmed. Parastiol. 30: 73.Google Scholar
  194. Weiss, N., and Tanner, M., 1981, Immunogenicity of the surface of filaria: larvae (Dipetalonema viteae), Trans. R. Soc. Trop. Med. Hyg. 75: 179.PubMedCrossRefGoogle Scholar
  195. Weller, P. F., 1978, Cell-mediated immunity in experimental filariasis: Lymphocyte reactivity to filarial stage-specific antigens and to B-and T-cell mitogens during acute and chronic infection, Cell. Immunol. 37: 369.PubMedCrossRefGoogle Scholar
  196. Wharton, D. B. A., 1946, Transplantation of adult filarial worms: Litomosoides carinii in cotton rats, Science 104: 30.CrossRefGoogle Scholar
  197. Williams, R. W., and Brown, H. W., 1945, The development of Litomosoides carinii filarid parasite of the cotton rat in the tropical mite, Science 102: 482.PubMedCrossRefGoogle Scholar
  198. Wong, M. M., and Guest, M. F., 1969, Filarial antibodies and eosinophilia in human subjects in an endemic area, Trans. R. Soc. Trop. Med. Hyg. 63: 796.PubMedCrossRefGoogle Scholar
  199. Wong, M. M., and Suter, M. F., 1979, Indirect fluorescent antibody test in occult dirofilariasis, Am. J. Vet. Res. 40: 414.PubMedGoogle Scholar
  200. Worms, M. J., Terry, R. J., and Terry, A., 1961, Dipetalonema witei, filarial parasite of the jird, Meriones libycus. 1. Maintenance in the laboratory, J. Parasitol. 47: 963.CrossRefGoogle Scholar
  201. Yap, E. H., Ho, B. C., Singh, M., Kang, K. L., and Lim, B. L., 1975, Studies on the Malayan forest rat filaria Breinlia booliati (Filarioidea, Onchocercidae): Periodicity and microfilaraemic patterns during the course of infection, J. Helminthol. 49: 263.PubMedCrossRefGoogle Scholar
  202. Yogogawa, S., 1939, Studies on the mode of transmission of Wuchereria bancrofti, Trans. R. Soc. Trop. Med. Hyg. 32: 653.CrossRefGoogle Scholar
  203. Zein-Eldin, E. A., 1965, Experimental infection of gerbils with Litomosoides carinii via intravenous injections, Texas Rep. Biol. Med. 23: 530.Google Scholar
  204. Zielke, E., 1979, Attempts to infect Meriones unguiculatus and Mastomys natalensis with Wuchereria bancrofti from West Africa, Tropenmed. Parasitol. 30: 466.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Mario Philipp
    • 1
  • M. J. Worms
    • 1
  • R. M. Maizels
    • 1
  • Bridget M. Ogilvie
    • 2
  1. 1.Division of ParasitologyNational Institute for Medical ResearchLondonEngland
  2. 2.The Wellcome TrustLondonEngland

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