Immunobiology of African Trypanosomiasis

  • Georges E. Roelants
  • Margaret Pinder
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 12)


African trypanosomes are flagellated Protozoa that include the causative agents of important human and animal diseases (Table I) and are fascinating biologically.


Spleen Cell Mixed Lymphocyte Reaction Trypanosoma Brucei Variant Surface Glycoprotein Zebu Cattle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Agabian, H., Thompson, L., Milhausen, M., and Stuart, K., 1980, Structural analysis of variant and invariant genes, Am. J. Trop. Med. Hyg. 29: 1043–1052.PubMedGoogle Scholar
  2. Albright, J. W., and Albright, J. F., 1981, Basis of the specificity of rodent trypanosomes for their natural host, Infect. Immun. 33: 355–363.PubMedGoogle Scholar
  3. Allsopp, B. A., Njogu, A. R., and Humphryes, K. E., 1971, Nature and location of Trypanosoma brucei subgroup exoantigen and the relationship to 4S antigen, Exp. Parasitol. 29: 271–284.PubMedGoogle Scholar
  4. Askonas, B. A., Corsini, A. C., Clayton, C. E., and Ogilvie, B. M., 1979, Functional depletion of T- and B-memory cells and other lymphoid cell subpopulations during trypanosomiasis, Immunology 36: 313–321.PubMedGoogle Scholar
  5. Barbet, A. F., and McGuire, T. C., 1978, Crossreacting determinants in variant-specific surface antigens of African trypanosome, Proc. Natl. Acad. Sci. USA 75: 1989–1993.PubMedGoogle Scholar
  6. Barry, J. D., Hajduk, S. L., Vickerman, K., and Le Ray, D., 1979, Detection of multiple variable antigen types in metacyclic populations of Trypanosoma brucei, Trans. R. Soc. Trop. Med. Hyg. 73: 205–208.PubMedGoogle Scholar
  7. Boothroyd, J. C., Cross, G. A. M., Hoeijmakers, J. H. J., and Borst, P., 1980, A variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic “tail” absent from purified glycoproteins, Nature (Lond.) 288: 624–626.Google Scholar
  8. Boothroyd, J. C., Paynter, C. A., Cross, G. A. M., Bernards, A., and Borst, P., 1981, Variant surface glycoproteins of Trypanosoma brucei are synthesized with cleavable hydrophobic sequences at the carboxy-and aminotermini, Nucl. Ac. Res. 9: 4735–4744.Google Scholar
  9. Borst, P., Fase-Fouler, F., Frasch, A. C. C., Hoeijmakers, J. H. J., and Weijers, P. J., 1980a, Characterization of DNA from Trypanosoma brucei and related trypanosomes by restriction endonuclease digestion, Mol. Biochem. Parasitol. 1: 221–246.Google Scholar
  10. Borst, P., Frasch, A. C. C., Bernards, A., Hoeijmakers, J. H. J., Van der Ploeg, L. H. T., and Cross, G. A. M., 1980b, The genes for variant antigens in trypanosomes, Am. J. Trop. Med. Hyg. 29: 1033–1036.PubMedGoogle Scholar
  11. Borst, P., Frasch, A. C. C., Bernards, A., Van der Ploeg, L. H. T., Hoeijmakers, J. H. J., Ann-berg, A. C., and Cross, G. A. M., 1981, DNA rearrangements involving the genes for variant antigens in Trypanosoma brucei, Cold Spring Harbor Symp. Quant. Biol. 45: 935–944.PubMedGoogle Scholar
  12. Bridgen, P. J., Cross, G. A. M., and Bridgen, J., 1976, N-terminal amino acid sequences of variant specific surface antigens from Trypanosoma brucei,Nature (Lund.) 263: 613–614.Google Scholar
  13. Browning, C. H., and Gulbransen, R., 1936, Immunity following cure of experimental Trypanosoma brucei infection by a chemotherapeutic agent, J. Pathol. Bacteriol. 43: 479–486.Google Scholar
  14. Campbell, G. H., and Phillips, S. M., 1976, Adoptive transfer of variant-specific resistance to Trypanosoma rhodesiense with B lymphocytes and serum, Infect. Immun. 14: 1144–1150.PubMedGoogle Scholar
  15. Campbell, G. H., Esser, K. M., and Weinbaum, F. J., 1977, Trypanosoma rhodesiense infection in B cell deficient mice, Infect. Immun. 18: 434–438.PubMedGoogle Scholar
  16. Campbell, G. H., Esser, K. M., and Phillips, S. M., 1978, Trypanosoma rhodesiense infection in congenitally athymic (nude) mice, Infect. Immun. 20: 714–720.PubMedGoogle Scholar
  17. Capbern, A., Giroud, C., Baltz, T., and Mattem, P., 1977, Trypanosoma equiperdum: Etude des variations antigéniques au cours de la trypanosomose expérimentale du lapin, Exp. Parasitol. 42: 6–13.Google Scholar
  18. Carr, W. R., Macleod, J., Woolf, B., and Spooner, R. L., 1974, A survey of the relationship of genetic markers, tick-infestation level and parasitic diseases in Zebu cattle in Zambia, Trop. Anim. Health Prod. 6: 203–214.PubMedGoogle Scholar
  19. Chandler, R. L., 1952, Comparative tolerance of West African N’Dama cattle to trypanosomiasis, Ann. Trop. Med. Parasit. 46: 127–134.PubMedGoogle Scholar
  20. Chandler, R. L., 1958, Studies on the tolerance of N’Dama cattle to trypanosomiasis, J. Comp. Pathol. 68: 253–260.PubMedGoogle Scholar
  21. Clarkson, M. J., and Penhale, W. J., 1973, Serum protein changes in trypanosomiasis in cattle, Trans. Soc. Trop. Med. Hyg. 62: 273.Google Scholar
  22. Clayton, C. E., 1978, Trypanosoma brucei: Influence of host strains and parasite antigenic type in infection in mice, Exp. Parasitol. 44: 202–208.PubMedGoogle Scholar
  23. Clayton, C. E., Sacks, D. L., Ogilvie, B. M., and Askonas, B. A., 1979a, Membrane fractions of trypanosomes mimic the immunosuppressive and mitogenic effects of living parasites on the host, Parasite Immunol. 1: 241–249.PubMedGoogle Scholar
  24. Clayton, C. E., Ogilvie, B. M., and Askonas, B. A., 1979b, Trypanosoma brucei infection in nude mice: B lymphocyte function is suppressed in the absence of T lymphocytes, Parasite Immunol. 1: 39–48.PubMedGoogle Scholar
  25. Clayton, C. E., Selkirk, M. E., Corsini, C. A., Ogilvie, B. M., and Askonas, B. A., 1980, Mu-sine trypanosomiasis: Cellular proliferation and functional depletion in the blood, peritoneum and spleen related to changes in bone marrow stem cells, Infect. Immun. 28: 824–831.PubMedGoogle Scholar
  26. Cohen, C., and Phillips, G. N., 1981, Spikes and fimbriae: a-helical proteins from surface projections on microorganisms, Proc. Natl. Acad. Sci. USA 78: 5303–5304.PubMedGoogle Scholar
  27. Cook, R. M., 1981, Attachment of Trypanosoma brucei to rabbit peritoneal exudate cells, Int. J. Parasitol. 11: 149–156.PubMedGoogle Scholar
  28. Corsini, A. C., Clayton, C. E., Askonas, B. A., and Ogilvie, B. M., 1977, Suppressor cells and loss of B-cells potential in mice infected with 7rypanosma brucei, Clin. Exp. Immunol. 29: 122–131.PubMedGoogle Scholar
  29. Coulomb, J. Gruvel, J., Morel, P. C., Perreau, P., Quéval, R., Tibayrenc, R., and Provost, A., 1977, La Trypanotolérance. Synthèse Bibliographique des Connaissances Actuelles, Institut d’Elévage et de Médecine Vétérinaire des Pays Tropicaux, Paris.Google Scholar
  30. Cross, G. A. M., 1975, Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei, Parasitology 71: 393–417.PubMedGoogle Scholar
  31. Cross, G. A. M., 1979a, Immunochemical aspects of antigenic variation in trypanosomes, J. Gen. Micro biol. 113: 1–12.Google Scholar
  32. Cross, G. A. M., 1979b, Crossreacting determinants in the C-terminal region of trypanosome variant surface antigens, Nature (Lond.) 227: 310–312.Google Scholar
  33. Cross, G. A. M., Holder, A. A., Allen, G., and Boothroyd, J. C., 1980, An introduction to antigenic variation in trypanosomes, Am. J. Trop. Med. Hyg. 29: 1027–1032.PubMedGoogle Scholar
  34. D’Alesandro, P. A., 1972, Trypanosoma lewisi: Production of exoantigens during infection in the rat, Exp. Parasitol. 32: 149–164.PubMedGoogle Scholar
  35. Dar, R. K., Paris, J., and Wilson, A. J., 1973, Serological studies on trypanosomiasis in East Africa. IV. Comparison of antigenic types of Trypanosoma vivax group organisms, Ann. Trop. Med. Parasitol. 67: 319–329.PubMedGoogle Scholar
  36. Dargie, J. D., Murray, P. K., Murray, M., Grimshaw, W., and McIntyre, W. I. M., 1979, Bovine trypanosomiasis: The red cell kinetics of N’Dama and Zebu cattle infected with Trypanosoma congolense, Parasitology 78: 271–286.Google Scholar
  37. Desowitz, R. S., 1959, Studies on immunity and host parasite relationships. I. The immunological response of resistant and susceptible breeds of cattle to trypanosomal challenge, Ann. Trop. Med. Parasitol. 53: 293–313.PubMedGoogle Scholar
  38. Desowitz, R. S., and Watson, H. C. J., 1952, Studies on Trypanosoma vivax. III. Observations on the maintenance of a strain in white rats, Ann. Trop. Med. Parasitol. 46: 92–100.PubMedGoogle Scholar
  39. Desowitz, R. S., and Watson, H. C. J., 1953, Studies on Trypanosoma vivax. IV. The maintenance of a strain in white rats without sheep-serum supplementation, Ann. Trop. Med. Parasitol. 47: 62–67.PubMedGoogle Scholar
  40. D’Hondt, J., Van Meirvenne, N., Moens, L., and Kondo, M., 1979, Cat+ is essential cofactor for trypanocidal activity of normal human serum, Nature (Lond.) 282: 613–615.Google Scholar
  41. Diggs, C., Flemmings, B., Dillon, J., Snodgrass, R., Campbell, G., and Esser, K., 1976, Immune serum-mediated cytotoxicity against Trypanosoma rhodesiense, J. Immunol. 116: 1005–1009.PubMedGoogle Scholar
  42. Dodin, A., Fromentin, H., and Gleye, M., 1962, Mise en évidence d’un antigène vaccinant dans le plasma de souris expérimentalement infectées par diverses espèces de trypanosomes, Bull. Soc. Pathol. Exot. 55: 291–299.Google Scholar
  43. Doyle, J. J., 1977, Antigenic variation in the salivarian trypanosomes, Adv. Exp. Med. Bio. 93: 31–63.Google Scholar
  44. Eardley, D. D., and Jayawardena, A. N., 1977, Suppressor cells in mice infected with Trypanosoma brucei, J. Immunol. 119: 1029–1033.Google Scholar
  45. Ehrlich, P., Rochl, W., and Gulbransen, R., 1909, Ueber serum feste Trypanosomenstaemme, Z. Immunitaetforsch. 3: 296–299.Google Scholar
  46. Emery, D. L., and Moloo, S. K., 1981, The dynamics of the cellular reactions elicited in the skin of goats by Glossina morsitans morsitans infected with Trypanosoma (Nannomonas) congolense or T. (Duttonella) vivax, Acta Trop. 38: 15–28.Google Scholar
  47. Emery, D. L., Wells, P. W., and Tenywa, T., 1980a, Trypanosoma congolense: specific transformation in vitro of leukocytes from infected or immunized cattle, Exp. Parasitol. 50: 358–368.PubMedGoogle Scholar
  48. Emery, D. L., Akol, G. W. O., Murray, M., Morrison, W. I., and Moloo, S. K., 1980b, The chancre-Early events in the pathogenesis of African trypanosomiasis in domestic livestock, in: The Host-Invader Interplay ( H. Van den Bossche, ed.), pp. 345–356, Janssen Research Foundation, Elsevier/North-Holland Biomedical Press, Amsterdam.Google Scholar
  49. Faghihi Shirazi, M., Holman, M., Hudson, K. M., Klaus, G. G. B., and Terry, R. J., 1980, Complement (C3) levels and the effect of C3 depletion in infections of Trypanosoma brucei in mice, Parasite Immunol. 2: 155–161.Google Scholar
  50. Finerty, J. F., Krehl, E. P., and McKevin, R. L., 1978, Delayed-type hypersensitivity in mice immunized with Trypanosoma rhodesiense antigens, Infect. Immun. 20: 464–467.PubMedGoogle Scholar
  51. Fruit, J., Santoro, F., Afchain, D., Duvallet, G., and Capron, A., 1977, Lesimmuncomplexes circulants dans la trypanosomiase africaine humaine et expérimentale, Ann. Soc. Belge Med. Trop. 57: 257–266.Google Scholar
  52. Fulton, J. D., and Lourie, E. M., 1946, The immunity of mice cured of trypanosome infections, Ann. Trop. Med. Parasitol. 40: 1–9.PubMedGoogle Scholar
  53. Galvao-Castro, B., Hochmann, A., and Lambert, P.-H., 1978, The role of the host immune response in the development of tissue lesions associated with African trypanosomiasis in mice, Clin. Exp. Immunol. 33: 12–24.PubMedGoogle Scholar
  54. Gasbarre, L.C., Hug, K., and Louis, J. A., 1980, Murine T lymphocyte specificity for African trypanosomes. I. Induction of a T lymphocyte-dependent proliferative response to Trypanosoma brucei, Clin. Exp. Immunol. 41: 97–106.Google Scholar
  55. Gasbarre, L. C., Hug, K., and Louis, J. A., 1981a, Murine T lymphocyte specificity for African trypanosomes. II. Suppression of the lymphocyte proliferative response to Trypanosoma brucei by systemic trypanosome infection, Clin. Exp. Immunol. 45: 165–172.PubMedGoogle Scholar
  56. Gasbarre, L. C., Finerty, J. F., and Louis, J. A., 1981 b, Nonspecific immune responses in CBA/N mice infected with Trypanosoma brucei, Parasite Immunol 3: 273–282.Google Scholar
  57. Gibson, W. C., Marshall, T. F. de C., and Godfrey, D. C., 1980, Numerical analysis of enzyme polymorphism: A new approach to the epidemiology and taxonomy of trypanosomes of the subgenus Trypanozoon,Adv. Parasitol. 18: 175–246.Google Scholar
  58. Gidel, R., 1962, Etude électrophorétique quantitative en gélose des protéines sériques de bovins, Rev. Elev. Med. Vét. Pays Trop. 15: 259–263.Google Scholar
  59. Gray, A. R., 1965, Antigenic variation in a strain of Trypanosma brucei transmitted by Glossina morsitans and G. palpalis, J. Gen. Microbiol. 41: 195–214.PubMedGoogle Scholar
  60. Gray, A. R., 1966, The antigenic relationship of strains of Trypanosoma brucei isolated in Nigeria, J. Gen. Microbiol. 44: 263–271.PubMedGoogle Scholar
  61. Gray, A. R., 1970, A study of the antigenic relationships of isolates of Trypanosoma brucei collected from a herd of cattle kept in one locality for five years, J. Gen. Microbiol. 62: 301–313.PubMedGoogle Scholar
  62. Gray, A. R., and Luckins, A. G., 1980, Features of epidemiological importance in the development of cyclically transmitted stocks of Trypanosoma congolense in vertebrate hosts, Insect. Sci. 1: 69–72.Google Scholar
  63. Greenblatt, C. L., 1975, Nutritional and immunological factors in the control of infections with Trypanosoma lewisi, Exp. Parasitol. 38: 342–349.PubMedGoogle Scholar
  64. Greenblatt, C. L., and Lincicombe, D. R., 1966, Identity of trypanosome growth factors in serum. II. Active globulin components, Exp. Parasitol. 19: 139–150.PubMedGoogle Scholar
  65. Greenblatt, C. L., and Sheldon, E., 1968, Mouse serum as an environment for the growth of Trypanosoma lewisi, Exp. Parasitol. 22: 187–200.Google Scholar
  66. Greenblatt, C. L., Joni, L. A., and Cahnman, H. J., 1969, Chromatographic separation of a rat growth factor required by Trypanosoma lewisi, Exp. Parasitol. 24: 228–242.PubMedGoogle Scholar
  67. Greenwood, B. M., 1974a, Possible role of a B-cell mitogen in hypergammaglobulinaemia in malaria ani trypanosomiasis, Lancet 16: 435–436.Google Scholar
  68. Greenwood, B. M., 1974b, Immunosuppression in patients with malaria and sleeping sickness, in: Parasites in the Immunised Host: Mechanisms of Survival, Ciba Foundation Symposium, North-Holland, Amsterdam, 25: 138–146.Google Scholar
  69. Greenwood, B. M., and Whittle, H. C., 1976, Complement activation in patients with Gambian sleeping sickness, Clin. Exp. Immunol. 24: 133–138.PubMedGoogle Scholar
  70. Greenwood, B. M., Whittle, H. C., and Molyneux, D. H., 1973, Immunosuppression in Gambian trypanosomiasis, Trans. R. Soc. Med. Hyg. 67: 846–850.Google Scholar
  71. Grosskinsky, C. M., and Askonas, B. A., 1981, Macrophages as primary target cells and mediators of immune dysfunction in African trypanosomiasis, Infect. Immun. 33: 149–155.PubMedGoogle Scholar
  72. Guidot, G., and Roelants, G. E., 1982, Compared susceptibility of Zebu and Baoulé cattle to seringe infection with Trypanosoma (Duttonella) vivax and T. (Nannomonas) congolense, Rev. Med. Vét. Pays Trop. 35: 233–244.Google Scholar
  73. Hawking, F., 1979, The action of human serum upon Trypanosoma brucei, Protozool. Abst. 3: 199–206.Google Scholar
  74. Hawking, F., Ramsden, D. B., and Whytock, S., 1973, The trypanocidal action of human serum and of baboon plasma, Trans. R. Soc. Trop. Med. Hyg. 71: 427–430.Google Scholar
  75. Herbert, W. J., Parratt, D., Van Meirvenne, N., and Lennox, B., 1980, An accidental laboratory infection with trypanosomes of a defined stock. II. Studies on the serological response of the patient and the identity of the infecting organism, J. Infect. 2: 113–124.PubMedGoogle Scholar
  76. Hoeijmakers, J. H. J., Frasch, A. C. C., Bernards, A., Borst, P., and Cross, G. A. M., 1980a, Novel expression-linked copies of the genes for variant surface antigens in trypanosomes, Nature (Lond.) 284: 78–80.Google Scholar
  77. Hoeijmakers, J. H. J., Borst, P., Van den Burg, J., Weissmann, C., and Cross, G. A. M., 1980b, The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei, Gene 8: 391–417.PubMedGoogle Scholar
  78. Holder, A. A., and Cross, G. A. M., 1981, Glycopeptides from variant surface glycoproteins of Trypanosoma brucei. C-terminal location of antigenically cross-reacting carbohydrate moieties, Mol. Biochem. Parasitol. 2: 135–150.PubMedGoogle Scholar
  79. Holmes, P. H., Mammo, C., Thomson, A., Knight, P. A., Lucken, R., Murray, P. K., Murray, M., Jennings, F. W., and Urquhart, G. M., 1974, Immunosuppression in bovine trypanosomiasis, Vet. Rec. 95: 86–87.PubMedGoogle Scholar
  80. Holmes, P. H., Macaskill, J. A., Whitelaw, D. D., Jennings, F. W., and Urquhart, G. M., 1979, Immunological clearance of 75Se-labelled Trypanosoma brucei in mice. I. Aspects of the radiolabelling technique, Immunology 36: 415–420.PubMedGoogle Scholar
  81. Hornby, H. E., 1921, Trypanosomes and trypanosomiasis of cattle, J. Comp. Pathol. 34: 211–240.Google Scholar
  82. Hornby, H. E., 1941, Immunisation against bovine trypanosomiasis, Trans. Soc. Trop. Med. Hyg. 35: 165–176.Google Scholar
  83. Houba, V., Brown, K. N., and Allison, A. C., 1969, Heterophile antibodies, M-anti-globulins and immunoglobulins in experimental trypanosomiasis, Clin. Exp. Immunol. 4: 113–123.PubMedGoogle Scholar
  84. Hudson, K. M., Byner, C., Freeman, J., and Terry, R. J., 1976, Immunodepression, high IgM levels and evasion of the immune response in murine trypanosomiasis, Nature (Lond.) 264: 256–258.Google Scholar
  85. Hudson, K. M., Taylor, A. E. R., and Elce, B. J., 1980, Antigenic changes in Trypanosoma brucei on transmission by tsetse fly, Parasite Immunol. 2: 57–69.Google Scholar
  86. ILCA, 1979, Trypanotolerant Livestock in West and Central Africa, International Livestock Center for Africa, Addis Ababa, Ethiopia.Google Scholar
  87. Ishizaka, S., Otani, S., and Morisawa, S., 1977, Effect of carrageenan on immune response. I. Studies on the macrophage dependency of various antigens after treatment with carrageenan, J. Immunol. 18: 1213–1218.Google Scholar
  88. Jayawardena, A. N., and Waksman, B H., 1977, Suppressor cells in experimental trypanosomiasis, Nature (Land.) 265: 539–541.Google Scholar
  89. Jayawardena, A. N., Waksman, B. H., and Eardley, D. D., 1978, Activation of distinct helper and suppressor T cells in experimental trypanosomiasis, J. Immunol. 121: 622–628.PubMedGoogle Scholar
  90. Jenni, L., 1977a, Comparisons of antigenic types of Trypanosoma (T) brucei strains transmitted by Glossina m. morsitans, Acta Trop. 34: 35–41.PubMedGoogle Scholar
  91. Jenni, L., 1977b, Antigenic variants in cyclically transmitted strains of the T. brucei complex, Ann. Soc. Belge Med. Trop. 57: 383–386.Google Scholar
  92. Jenni, L., Molyneux, D. H., Livesey, J. L., and Galun, R., 1980, Feeding behavior of tsetse flies infected with salivarian trypanosomes, Nature (Lond.) 283: 383–385.Google Scholar
  93. Jennings, F. W., Whitelaw, D. D., Holmes, P. H., and Urquhart, G. M., 1978, The susceptibility of strains of mice to infection with Trypanosoma congolense, Res. Vet. Sci. 25: 399–400.PubMedGoogle Scholar
  94. Johnson, J. G., and Gross, G. A. M., 1977, Carbohydrate composition of variant-specific surface antigen glycoproteins for Trypanosoma brucei, J. Protozool. 24: 587–591.PubMedGoogle Scholar
  95. Johnson, J. G., and Gross, G. A. M., 1979, Selective cleavage of variant surface glycoproteins from Trypanosoma brucei, Biochem. J. 178: 689–697.PubMedGoogle Scholar
  96. Kar, S. K., Roelants, G. E., Mayor-Withey, K. S. and Pearson, T. W., 1981, Immune depression in trypanosome-infected mice. VI. Comparison of immune responses of different lymphoid organs, Eur. J. Immunol. 11: 100–105.PubMedGoogle Scholar
  97. Kar, S. K., Murray, M., Roelants, G. E., Logan, D. S., and Morrison, W. I., 1983, Immune depression in trypanosome-infected mice. VII. Comparison of the immune suppression generated in spleen and lymph nodes by T. brucei and T. congolense in two strains of mice (submitted).Google Scholar
  98. Kempt, J., Louis, D., Nattingly, J., Bennet, J., Higuchi, C., Horowitz, M., and Gershon, R. K., 1980, Suppressor cells in vitro: Differential Effects of Indomethacin and related compounds, J. Immunopharmacol. 2: 471–489.Google Scholar
  99. Ketteridge, D., 1970, The presence of host serum components on the surface of rodent adapted Trypanosoma vivax, J. Protozool. 17 (Suppl): 24.Google Scholar
  100. Klaus, G. G. B., Pepys, M. B., Kitajima, K., and Askonas, B. A., 1979, Activation of mouse complement by different classes of mouse antibody, Immunology 38: 687–695.PubMedGoogle Scholar
  101. Klein, F., Mattern, P., and Korman-Bosch, H. J., 1970, Experimental induction of rheuma- toid factor-like substances in animal trypanosomiasis, Clin. Exp. Immunol. 7: 851–863.PubMedGoogle Scholar
  102. Kobayakawa, T., Louis, J., Izui, S., and Lambert, P.-H., 1979, Autoimmune response to DNA, red blood cells, and thymocyte antigens in association with polyclonal antibody synthesis during experimental African trypanosomiasis, J. Immunol. 122: 296–301.PubMedGoogle Scholar
  103. Kosinski, R. J., 1980 Antigenic variation in trypanosomes: A computer analysis of variant order, Parasitology 80: 343–357.PubMedGoogle Scholar
  104. Lambert, P.-H., and Galvao-Castro, B., 1977, Rôle de la réponse immune dans la pathogénie de la trypanosomiase africaine, Ann. Soc. Belge Med. Trop. 57: 267.Google Scholar
  105. Laveran, A., and Mesnil, F., 1902, Recherches sur le traitement et la prevention du Nagana, Ann. Inst. Pasteur 16: 785–817.Google Scholar
  106. Leeflang, P., Buys, J., and Blotkamp, J., 1976, Studies on Trypanosoma vivax infectivity and serial maintenance of natural bovine isolates in mice, Int. J. Parasitol. 6: 413–417.PubMedGoogle Scholar
  107. Le Ray, D., Barry, J. D., and Vickerman, K., 1978, Antigenic heterogeneity of metacyclic forms of Trypanosoma brucei, Nature (Lond.) 273: 300–302.Google Scholar
  108. Levaditi, C., and McIntosh, J., 1910, Le mécanisme de la création des variétés de trypanosomes résistants aux anticorps, C. R. Soc. Biol. 66: 49–51.Google Scholar
  109. Levine, R. F., and Mansfield, J. M., 1981, Genetics of resistance to African trypanosomes: Role of the H-2 locus in determining resistance to infection with Trypanosoma rhodesiense, Infect. Immun. 34: 513–518.PubMedGoogle Scholar
  110. Libeau, G., and Pinder, M., 1981, Effet néfaste du lévamisole sur la trypanosomose expérimentale de la souris, Rev. Elev. Med. Vet. Pays Trop. 34: 339–404.Google Scholar
  111. Lincicombe, D. R., 1958, Growth of Trypanosoma lewisi in the heterologous mouse host, Exp. Parasitol. 7: 1–13.Google Scholar
  112. Lincicombe, D. R., and Francis, E. M., 1961, Quantitative studies on heterologous sera inducing development of Trypanosoma lewisi in mice, Exp. Parasitol. 11: 68–76.Google Scholar
  113. Lindsley, H. B., Janecek, L. L., Gilmansa, A. M., and Hassanei, K. M., 1981, Detection and composition of immune-complexes in experimental African trypanosomiasis, Infect. Immun. 33: 407–414.PubMedGoogle Scholar
  114. Lotzsch, R., and Deindl, G., 1974, Trypanosoma congolense. III. Serological responses of experimentally infected cattle, Exp. Parasitol. 36: 27–33.PubMedGoogle Scholar
  115. Luckins, A. G., 1972, Studies on bovine trypanosomiasis. Serum immunoglobulin levels in Zebu cattle exposed to natural infection in East Africa, B. Vet. J. 128: 523–528.Google Scholar
  116. Luckins, A. G., 1977, Detection of antibodies in trypanosome infected cattle by means of a microplate linked immunosorbent assay, Trop. Anim. Health Prod. 9: 53–62.PubMedGoogle Scholar
  117. Lumsden, W. H. R., and Evans, D. A., 1979, Biology of the Kinetoplastida, Academic Press, London.Google Scholar
  118. Lumsden, W. H. R., and Herbert, W. J., 1967, Phagocytosis of trypanosomes by mouse peritoneal macrophages, Trans. R. Soc. Trop. Med. Hyg. 61: 142.Google Scholar
  119. Lumsden, W. H. R., Herbert, W. J., and McNeillage, G. J. C., 1973, Techniques with Trypanosomes, Churchill Livingstone, Edinburgh.Google Scholar
  120. Lyon, J. A., Pratt, J. M., Travis, R. W., Doctor, B. P., and Olenick, J. G., 1981, Use of monoclonal antibody to immunochemically characterize variant-specific surface coat glycoprotein from Trypanosoma rhodesiense, J. Immunol. 126: 134–137.PubMedGoogle Scholar
  121. Macaskil, J. A., Holmes, P. H., Whitelaw, D. D., McConnel, I., Jennings, F. W., and Urquhart, G. M., 1980, Immunological clearance of 7S Se-labeled Trypanosoma brucei in mice. 2. Mechanisms in immune animals, Immunology 40: 629–635.Google Scholar
  122. MacKenzie, A. R., and Boreham, P. F. L., 1971, The possible involvement of autoimmunity in Trypanosoma brucei infections of the rabbit, Trans. R. Soc. Trop. Med. Hyg. 65: 23–50.Google Scholar
  123. MacKenzie, P. K. I., Boyt, W. P., and Nesham, V. W., 1979, Serum immunoglobulin levels in sheep during the course of naturally acquired and experimentally induced trypanosomiasis, Br. Vet. J. 135: 178–184.PubMedGoogle Scholar
  124. Magnus, E., Vervoort, T., and Van Meirvenne, N., 1978, A card-agglutination test with stained trypanosomes (C.A.T.T.) for the serological diagnosis of T. b. gambiense trypanosomiasis, Ann. Soc. Belge Med. Trop. 58: 169–176.Google Scholar
  125. Majumder, H. K., Boothroyd, J.-C., and Weber, H., 1981, Homologous 3’-terminal regions of m RNAs for surface antigens of different antigenic variants of Trypanosoma brucei, Nucl. Ac. Res. 9: 4745–4754.Google Scholar
  126. Mangenot, M., Chaize, J., Desfontaine, M., Duvallet, G., and Moreau, J.-P., 1979, Intérêt de la technique ELISA pour le dépistage dans les foyers de trypanosomiase humaine africaine. Comparaison avec l’immunofluorescence, Med. Trop. 39: 527–530.Google Scholar
  127. Mansfield, J. M., and Bagasra, O., 1978, Lymphocyte function in experimental African trypanosomiasis. I. B cell responses to helper T-cell-independent and -dependent antigens, J. Immunol. 120: 759–765.PubMedGoogle Scholar
  128. Mansfield, J. M., and Kreier, J. P., 1972a, Tests for antibody-and cell-mediated hypersensitivity to trypanosome antigens in rabbit infected with Trypanosoma congolense, Infect. Immun. 6: 62–67.PubMedGoogle Scholar
  129. Mansfield, J. M., and Kreier, J. P., 1972b, Autoimmunity in experimental Trypanosoma congolense infections of rabbits, Infect. Immun. 5: 648–656.PubMedGoogle Scholar
  130. Mansfield, J. M., Levine, R. F., Dempsey, W. L., Wellhausen, S. R., and Hansen, C. T., 1981, Lymphocyte function in experimental African trypanosomiasis. IV. Immunosuppression and suppressor cells in the athymic nu/nu mouse, Cell. Immunol 63: 210–215.PubMedGoogle Scholar
  131. Marcu, K. B., and Williams, R. O., 1981, Microbial surface elements: The case of variant surface glycoproteins (VSG) genes of African trypanosomes, in: Genetic Engineering, Vol. 3 ( J. K. Setlow and A. Hollaender, eds.), pp. 129–155, Plenum, New York.Google Scholar
  132. Masake, R. A., 1980, The pathogenesis of infection with Trypanosoma vivax in goats and cattle, Vet. Rec. 107: 551–557.PubMedGoogle Scholar
  133. Masake, R. A., and Morrison, W. I., 1981, An evaluation of the structural and functional changes in the lymphoid organs of boran cattle infected with Trypanosoma vivax, 42: 1738–1746.Google Scholar
  134. Masake, R. A., Pearson, T. W., Wells, P., and Roelants, G. E., 1981, The in vitro response to mitogens of leukocytes from cattle infected with Trypanosoma congolense, Clin. Exp. Immunol 43: 583–589.PubMedGoogle Scholar
  135. Mattem, P., Masseyeff, R., Michel, R., and Peretti, P., 1978, Etude immunochimique de la 2-macroglobuline des sérums de malades atteints de trypanosomiase africaine à T. gambienne, Ann. Immunol. 101: 382–393.Google Scholar
  136. Matthysen, G., Michiels, F., Hamers, R., Pays, E., and Steinert, M., 1981, Two variant surface glycoproteins of Trypanosoma brucei have a conserved C-terminus, Nature (Lond.) 293: 230–233.Google Scholar
  137. Mayor-Withey, K. S., Clayton, C. E., Roelants, G. E., and Askonas, B. A., 1978, Trypanosomiasis leads to extensive proliferations of B, T and null cells in spleen and bone marrow, Clin. Exp. Immunol. 34: 359–363.PubMedGoogle Scholar
  138. McNeillage, G. J. C., and Herbert, W. J., 1968, Infectivity and virulence of Trypanosoma (Trypanozoon) brucei for mice. II. Comparison of closely related antigenic types, J. Comp. Pathol. 78: 345–349.PubMedGoogle Scholar
  139. Mesnil, E., and Brimont, E., 1909, Propriétés protectrices du sérum des animaux trypanosomés: Races résistantes à ces sérums, Ann. Inst. Pasteur 23: 129–154.Google Scholar
  140. Mitry-Martin, L., Hudson, K. M., and Terry, R. J., 1979, Autoantibodies to splenocytes in murine trypanosomiasis, Trans. R. Soc. Trop. Med. Hyg. 73: 98.Google Scholar
  141. Morrison, W. 1., and Murray, M., 1979, Trypanosoma congolense: Inheritance of the susceptibility to infection in inbred strains of mice, Exp. Parasitol. 48: 364–374.Google Scholar
  142. Morrison, W. I., Roelants, G. E., Mayor-Withey, K. S., and Murray, M., 1978, Susceptibility of inbred strains of mice to Trypanosoma congolense: Correlation with changes in spleen lymphocyte populations, Clin. Exp. Immunol. 32: 25–40.PubMedGoogle Scholar
  143. Mouton, M., Stiffel, C., and Biozzi, G., 1981, Genetic regulation of high and low immunoresponsiveness, in: Immunologic Defects in Laboratory Animals ( M. E. Gershwin and B. Merchant, eds.), Vol. 1, pp. 19–47, Plenum, New York.Google Scholar
  144. Mulligan, H. W., 1970, The African Trypanosomiasis, Allen and Unwin, London.Google Scholar
  145. Murray, M., 1974, The pathology of African trypanosomiasis, in: Progress in Immunology ( L. Brent and J. Holborow, eds.), pp. 181–192, North-Holland, Amsterdam.Google Scholar
  146. Murray, M., and Morrison, W. I., 1979a, Parasitemia and host susceptibility to African trypanosomiasis, in: Pathogenicity of Trypanosomes ( G. Losos and A. Chouinard, eds.), pp. 71–81, International Development Research Centre, Ottawa.Google Scholar
  147. Murray, M., and Morrison, W. I., 1979b, Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei by immunostimulants, Parasitology 79: 349–366.PubMedGoogle Scholar
  148. Murray, M., Morrison, W. I., Emery, D. L., Akol, G. W. O., Masake, R. A., and Moloo, S. K., 1980, Pathogenesis of trypanosome infections in cattle, in: Isotope and Radiation Research on Animal Diseases and their Vectors, pp. 15–30, IAEA, Vienna.Google Scholar
  149. Murray, M., Cliffort, D. J., Gettinby, G., Snow, W. F. and McIntyre, W. I. M., 1981, Susceptibility to African trypanosomiasis of Ndama and Zebu cattle in an area of Glossina morsitans submorsitans challenge, Vet. Rec. 109: 503–510.PubMedGoogle Scholar
  150. Murray, P. K., Murray, M., Wallace, M., Morrison, W. I., and McIntire, W. I. M., 1979a, Trypanosomiasis in Ndama and Zebu cattle. An experimental investigation of susceptibility to Trypanosoma brucei, T. congolense and mixed infections, in: International Scientific Council for Trypanosomiasis Research and Control, Proceedings of the 15th Meeting, The Gambia, Eliza Services, Nairobi. pp. 470–481.Google Scholar
  151. Murray, P. K., Murray, M., Wallace, M., Morrison, W. I., and McIntire, W. I. M., 1979b, Trypanosomiasis in Ndama and Zebu cattle. The influence of the weight of infection on the severity of the disease, in: International Scientific Council for Trypanosomiasis Research and Control, Proceedings of the 15th Meeting, The Gambia, Eliza Services, Nairobi, pp. 482–487.Google Scholar
  152. Musoke, A. J., Nantulya, V. M., Barbet, A. E., Kironde, F., and McGuire, T. C., 1981, Bovine immune response to African trypanosomes: Specific antibodies to variant surface glycoproteins of Trypanosoma brucei, Parasite Immunol. 3: 97–106.PubMedGoogle Scholar
  153. Nagle, R. B., Ward, P. A., Lindsley, H. B., Sadun, E. H., Johnson, A. J., Berkow, R. E., and Hildebrandt, P. K., 1974, Experimental infections with African trypanosomes. VI. Glomerulonephritis involving the alternate pathway of complement activation. Am. J. Trop. Med. Hyg. 23: 15–22.PubMedGoogle Scholar
  154. Nantulya, V. M., Musoke, A. J., Barbet, A. F., and Roelants, G. E., 1979, Evidence for reappearance of Trypanosoma brucei variable antigen types in relapse populations, J. Parasitol. 65: 673–679.PubMedGoogle Scholar
  155. Nantulya, V. M., Doyle, J. J., and Jenni, L., 1980e, Studies on Trypanosoma (Nannomonas) congolense. III. Antigenic variation in three cyclically transmitted stocks, Parasitology 80: 123–131.PubMedGoogle Scholar
  156. Nantulya, V. M., Doyle, J. J., and Jenni, L., 1980b, Studies on Trypanosoma (Nannomonas) congolense. IV. Experimental immunization of mice against tsetse fly challenge, Parasitology 80: 133–137.PubMedGoogle Scholar
  157. Nielsen, K., and Sheppard, J., 1977, Activation of complement by trypanosomes; Experientia 33: 769–771.PubMedGoogle Scholar
  158. Oka, M., Osaki, H., Furuya, M., Ito, Y., and Oka, Y., 1981, Agglutination antibody responses to Trypanosoma gambienne homogenate in mice treated with dextran sulfate and carrageenan, Zentralbi. Bakteriol. Parasitenkd. Infectionskr. Hyg. Abt. I. 250: 173–181.Google Scholar
  159. Olenick, J. G., Travis, R. W., and Garson, S., 1981, Trypanosoma rhodesiense: Chemical and immunological characterization of variant-specific surface coat glycoproteins, Mol. Biochem. ParasitoL 3: 227–238.Google Scholar
  160. Onodera, M., Rosen, N. L., Lifter, J., Hotez, P. J., Bogucki, M. S., Davis, G., Patton, C. L., Konigsberg, W. H., and Richards, F. F., 1981, Trypanosoma congolense: Surface glycoproteins of two early bloodstream variants. II. Purification and partial chemical characterization, Exp. ParasitoL 52: 427–439.Google Scholar
  161. Osier, G., 1971, Weight estimates of antibody on antigen binding capacity, in: Methods Immunol. Immunochem. 3: 73–85.Google Scholar
  162. Pagot, J., 1974, Les races trypanotolérantes, in: Control Programme for Trypanosomes and Their Vectors (Inst. Elev. Méd. Vét. Pays Trop.), pp. 235–248, Actes du Colloque, Paris.Google Scholar
  163. Pays, E., Lheureux, M., and Steinert, M., 1981a, Analysis of the DNA and RNA changes associated with the expression of isotypic variant-specific antigens of trypanosomes, NucL Ac. Res. 9: 4225–4238.Google Scholar
  164. Pays, E., Lheureux, M., and Steinert, M., 1981b, The expression-linked copy of surface antigen gene in Trypanosoma is probably to one transcribed, Nature (Lond.) 292: 265–267.Google Scholar
  165. Pearson, T. W., Roelants, G. E., Lundin, L. B., and Mayor-Withey, K. S., 1978, Immune depression in trypanosome-infected mice. I. Depressed T lymphocyte responses, Eur. J. Immunol. 8: 723–727.PubMedGoogle Scholar
  166. Pearson, T. W., Roelants, G. E., Pinder, M., Lundin, L. B., and Mayor-Withey, K. S., 1979, Immune depression in trypanosome-infected mice. III. Suppressor cells, Eur. J. Immunol. 9: 200–204.PubMedGoogle Scholar
  167. Pearson, T. W., Pinder, M., Roelants, G. E., Kar, J. K., Lundin, L. B., Mayor-Withey, K. S., and Hewett, R. S., 1980, Method for derivation and detection of anti-parasite monoclonal antibodies, J. Immunol. Methods 34: 141–154.PubMedGoogle Scholar
  168. Pearson, T. W., Kar, S. K., McGuire, T. C., and Lundin, L. B., 1981, Trypanosome variable surface antigens: Studies using two-dimensional gel electrophoresis and monoclonal antibodies, J. Immunol. 126: 823–828.PubMedGoogle Scholar
  169. Pearson, T. W., Morrison, W. I., Roelants, G. E., Lundin, L. B., and Mayor-Withey, K. S., 1983, Immune depression in trypanosome-infected mice. V. Correlation of immune suppression with susceptibility to disease in various inbred strains of mice (submitted).Google Scholar
  170. Pierre, C., 1906, L’élevage dans l’Afrique Occidentale Française. Gouvernement Général de l’A.O.F. ( Inspection de l’Agriculture ), Paris.Google Scholar
  171. Pinder, M., 1983, Trypanosoma congolense: Genetic control of resistence to African trypanosome infection in mice (submitted).Google Scholar
  172. Pinder, M., Libeau, G., Hirsch, W., Tamboura, I., Hauck-Bauer, R., and Roelants, G. E., 1983, Anti-trypanosome-specific immune responses in bovids of differing susceptibility to African trypanosomiasis, Immunology (in press).Google Scholar
  173. Quéval, R., 1982a, Le défaut érythrocytaire de la G6PD dans les races bovines trypanosensibles et trypanotolérantes de l’ouest africain, Rev. Elev. Méd. Vét. Pays Trop. 35: 131–136.PubMedGoogle Scholar
  174. Quéval, R., 1982b, Polymorphisme de la transferrine chez les bovins. Répartition et fréquence des alléles dans les populations bovines trypanotolérantes et trypanosensibles de l’ouest africain, Rev. Elev. Méd. Vét. Pays Trop. 35: 373–380.PubMedGoogle Scholar
  175. Quéval, R., and Petit, J.-P., 1982, Polymorphisme biochimique de l’hémoglobine de populations bovines trypanosensibles et trypanotolérantes et de leur croisement dans l’ouest africain, Rev. Elev. Méd. Vét. Pays Trop. 35: 137–146.PubMedGoogle Scholar
  176. Quéval, R., Poivey, J.-P., and Hoste, C., 1983, Blood grouping of West African cattle breeds (in preparation).Google Scholar
  177. Rice-Ficht, A. C., Chen, K. K., and Donelson, J. E., 1981, Sequence homologies near the C-terminus of the variable surface glycoproteins of Trypanosoma brucei, Nature (Lond.) 294: 53–57.Google Scholar
  178. Rickman, W. J., Cox, H. W., and Thoongsu, S., 1981, Interaction of immunoconglutinins and immune complexes in cold auto-hemagglutination associated with African trypanosomiasis, J. Parasitol. 67: 159–163.PubMedGoogle Scholar
  179. Rifkin, M. R., 1978a, Identification of the trypanocidal factor in normal human serum: high density lipoprotein, Proc. Natl. Acad. Sci. USA 75: 3450–3454.PubMedGoogle Scholar
  180. Rifkin, M. R., 1978b, Trypanosoma brucei: Some properties of the cytotoxic reaction induced by normal human serum, Exp. Parasitol. 46: 189–206.Google Scholar
  181. Roberts, C. J., and Gray, A. R., 1973, Studies on trypanosome resistant cattle. II. The effect of trypanosomiasis on N’Dama, Muturu and Zebu cattle, Trop. Anim. Health Prod. 5: 220–233.PubMedGoogle Scholar
  182. Roelants, G. E., and Pinder, M., 1981, Application of monoclonal antibody technology to parasite immunology, in: The Immune System ( C. M. Steinberg and I. Lefkovist, eds.), Vol. 2, pp. 446–453. S. Karger, Basel.Google Scholar
  183. Roelants, G. E., and Williams, R. 0., 1982, African trypanosomiasis, Crit. Rev. Trop. Med. 1: 31–75.Google Scholar
  184. Roelants, G. E., Pearson, T. W., Tyrer, H. W., Mayor-Withey, K. S., and Lundin, L. B., 1979a, Immune depression in trypanosome-infected mice. II. Characterization of the spleen cells involved, Eur. J. Immunol. 9: 195–199.PubMedGoogle Scholar
  185. Roelants, G. E., Pearson, T. W., Morrison, W. I., Mayor-Withey, K. S., and Lundin, L. B., 1979b, Immune depression in trypanosome infected mice. IV. Kinetics of suppression and alleviation by the trypanocidal drug Berenil, Clin. Exp. Immunol. 37: 457–469PubMedGoogle Scholar
  186. Roelants, G. E., Tamboura, I., Sidiki, D. B., Bassinga, A., and Pinder, M., 1983. Trypanotolerance: An individual not a breed character, Acta Tropica 40: 99–104.PubMedGoogle Scholar
  187. Roffi, J., Deranin, F., and Diallo, P. B., 1978, Application d’une méthode immuno-enzymatique (ELISA) au dépistage de la trypanosomiase humaine africaine a Trypanosoma brucei gambiense, Me’d. Mal. Infect. 8: 9–14.Google Scholar
  188. Rovis, L., Barbet, A. F., and Williams, R. O., 1978, Characterization of the surface coat of Trypanosoma congolense, Nature (Lond.) 271: 654–656.Google Scholar
  189. Rurangirwa, F. R., Tabel, H., Losos, G., Masiga, W. N., and Mwambu, P., 1978, Immunosuppressive effect of Trypanosoma congolense and Trypanosoma vivax on the secondary immune response of cattle to Mycoplasma mycoides subsp mycoides, Res. Vet. Sci. 25: 395–397.PubMedGoogle Scholar
  190. Rurangirwa, F. R., Tabel, H., Losos, G. J., and Tizard, I. R., 1979, Suppression of antibody response to Leptospira biflexa and Brucella abortus and recovery from immunosuppression after Berenil treatment, Infect. Immun. 26: 822–826.Google Scholar
  191. Rurangirwa, R. R., Mushi, E. Z., Tabel, H., Tizard, J. R., and Losos, G. J., 1980a, The effect of Trypanosoma congolense and T. vivax infections on the antibody response of cattle to live rinderpest virus vaccine, Res. Vet. Sci. 28: 264–266.PubMedGoogle Scholar
  192. Rurangirwa, F. R., Tabel, H., Losos, G. J., and Tizard, I. R., 1980b, Immunosuppression in bovine trypanosomiasis. The establishment of “memory” in cattle infected with T. congolense and the effect of post infection serum on in vitro 3H-thymidine uptake by lymphocytes and on leukocyte migration, Tropenmed. Parasitol. 31: 105–110.PubMedGoogle Scholar
  193. Sacks, D. L., and Askonas, B. A., 1980, Trypanosome induced suppression of antiparasite responses during experimental African trypanosomiasis, Eur. J. Immunol. 10: 971–974.PubMedGoogle Scholar
  194. Sacks, D. L., Selkirk, M., Ogilvie, B. M., and Askonas, B. A., 1980, Intrinsic immunosuppressive activity of different trypanosome strains varies with parasite virulence, Nature (Lond.) 283: 476–478.Google Scholar
  195. Scher, I., 1981, B-lymphocyte development and heterogeneity. Analysis with the immune-defective CBA/N mouse strain, in: Immunologic Defects in Laboratory Animals ( M. E. Gershwin and B. Merchant, eds.), Vol. 1, pp. 163–190, Plenum, New York.Google Scholar
  196. Scott, J. M., Pegram, R. G., Holmes, P. H., Pays, T. W., Knight, D. A., Jennings, F. W., and Urquhart, G. M., 1977, Immunosuppression in bovine trypanosomiasis: Field studies in using foot-and-month disease vaccine and clostridial vaccine, Trop. Anim. Health Prod. 9: 159–165.PubMedGoogle Scholar
  197. Scott, J. M., Holmes, P. H., Jennings, F. W., and Urquhart, G. M., 1978, Attempted protection of Zebu cattle against trypanosomiasis using a multistabilate vaccine, Res. Vet. Sci. 25: 115–117.PubMedGoogle Scholar
  198. Seed, J. R., and Gam, A. A., 1966, Passive immunity to experimental trypanosomiasis, J. Parasitol. 52: 1134–1140.PubMedGoogle Scholar
  199. Seed, J. R., and Gam, A. A., 1967, The presence of antibody to a normal rabbit liver antigen in rabbits infected with Trypanosoma gambiense, J. Parasitol. 53: 946–950.PubMedGoogle Scholar
  200. Seed, J. R., Cornille, R. L., Risby, E. L., and Gam, A. A., 1969, The presence of agglutinating antibody in the IgM immunoglobulin fractions of rabbit antiserum during experimental African trypanosomiasis, Parasitology 59: 283–292.PubMedGoogle Scholar
  201. Selkirk, M. E., Ogilvie, B. M.. and Platts-Mills, T. A. E., 1981, Activation of human peripheral blood lymphocytes by a trypanosome-derived mitogen, Clin. Exp. Immunol. 45: 615–620.PubMedGoogle Scholar
  202. Sollod, A. E., and Frank, G. H., 1979, Bovine trypanosomiasis effect on the immune response of the infected host, Am. J. Vet. Res. 40: 658–664.PubMedGoogle Scholar
  203. Soltys, M. A., 1955, Studies on resistance to T. congolense developed by Zebu cattle treated prophylactically with Antrycide prosalt in an enzootic area of East Africa, Ann. Trop. Med. Parasitol. 49: 1–8.PubMedGoogle Scholar
  204. Soltys, M. A., 1957, Immunity in trypanosomiasis. I. Neutralization reactions, Parasitology 47: 375–389.PubMedGoogle Scholar
  205. Stephen, L. E., 1966, Observations on the resistance of West African N’Dama and Zebu cattle to trypanosomiasis following challenge by wild Glossina morsitans from an early age, Ann. Trop. Med. Parasitol 60: 230–246.PubMedGoogle Scholar
  206. Stevens, D. R., and Moulton, J. E., 1978, Ultrastructural and immunological aspects of the phagocytosis of Trypanosoma brucei by mouse peritoneal macrophages, Infect. Immun. 19: 972–982.PubMedGoogle Scholar
  207. Tait, A., 1980, Evidence for diploidy and mating in trypanosomes, Nature (Lond.) 287: 536–538.Google Scholar
  208. Takayanagi, T., and Enriquez, G. L., 1973, Effects of the IgG and IgM immunoglobulins in Trypanosoma gambiense infection in mice, J. Parasitol. 59: 644–647.PubMedGoogle Scholar
  209. Takayanagi, T., Nakatake, Y., and Enriquez, G. L., 1974a, Attachment and ingestion of Trypanosoma gambiense to the rat macrophage by specific antiserum, J. Parasitol. 60: 336–339.PubMedGoogle Scholar
  210. Takayanagi, T., Nakatake, Y., and Enriquez, G. L., 1974b, Trypanosoma gambiense: Phagocytosis in vitro, Exp. Parasitol 36: 106–113.PubMedGoogle Scholar
  211. Takayanagi, T., Nakatake, Y., and Kato, H., 1977, Trypanosoma gambiense: Antigens involved in phagocytosis, Exp. Parasitol. 43: 414–422.Google Scholar
  212. Takayanagi, T., Takayanagi, M., Yabu, Y., and Kato, H., 1978, Trypanosoma gambiense: Immune responses of neonatal rats receiving antibodies from the female, Exp. Parasitol. 44: 82–91.PubMedGoogle Scholar
  213. Terry, R. J., 1976, Innate resistance to trypanosome infections, in: Biology of the Kinetoplastida ( W. H. R. Lumsden and D. A. Evans, eds.), Vol. 1, pp. 477–489, Academic Press, London.Google Scholar
  214. Tizard, I. R., and Soltys, M. A., 1970, Macrophage cytophilic antibodies to Trypanosoma brucei in rabbits, Trans. R. Soc. Trop. Med. Hyg. 65: 407–408.Google Scholar
  215. Tizard, I. R., and Soltys, M. A., 1971, Cell mediated hypersensitivity in rabbits infected with Trypanosoma brucei and Trypanosoma rhodesiense, Infect. Immun. 4: 674–677.PubMedGoogle Scholar
  216. Touré, S. M., Gueye, A., Seye, M., Ba, M. A., and Mane, A., 1978, Expérience de pathologie comparée entre bovins Zébus et Ndamas soumis à l’infection naturelle par des trypanosomes pathogènes, Rev. Elev. Med. Vét. Pays. Trop. 31: 293–313.PubMedGoogle Scholar
  217. Van Hoeve, K., 1971, Some observations on the performance of Ndama and Muturu cattle under natural conditions in Northern Nigeria in Report of the International Scientific Council for Trypanosomiasis Research, Thirteenth Meeting, Lagos, OAU/STRC Publication 105, Elisa Services, Nairobi, pp. 103–106.Google Scholar
  218. Van Marck, E. A. E., and Vervoort, T., 1980, Trypanosoma brucei: Detection of antigen deposits in glomeruli of mice vaccinated with purified variable antigen, Trans. R. Soc. Med. Hyg. 74: 666–667.Google Scholar
  219. Van Meirvenne, N., Magnus, E., and Janssens, P. G., 1976, The effect of normal human serum on trypanosomes of distinct antigenic type (ETAT 1 to 12) isolated from a strain of Trypanosoma brucei rhodesiense, Ann. Soc. Belge Med. Trop. 56: 55–63.Google Scholar
  220. Vervoort, T., Magnus, E., and Van Meirvenne, N., 1978, Enzyme-linked immunosorbent assay (ELISA) with variable antigens for serodiagnosis of T. b. gambiense trypanosomiasis, Ann. Soc. Belge. Med. Trop. 58: 177–183.Google Scholar
  221. Vickerman, K., 1969, On the surface coat and flagellar adhesion in trypanosomes, J. Cell. Sci. 5: 163–194.PubMedGoogle Scholar
  222. Vickerman, K., 1978, Antigenic variation in trypanosomes, Nature (Lond.) 273: 613–617.Google Scholar
  223. Vickerman, K., and Luckins, A. G., 1969, Localization of variable antigens in the surface coat of Trypanosoma brucei using ferritin conjugated antibody, Nature (Lond.) 224: 1125–1126.Google Scholar
  224. Viens, P., Targett, G. A. T., and Lumsden, W. H. R., 1975, The immunological response of CBA mice to Trypanosoma musculi: Mechanisms of protective immunity, Int. J. Parasitol 5: 235–239.PubMedGoogle Scholar
  225. Voller, A., and De Savigny, D., 1981, Diagnostic serology of tropical parasitic diseases, J. Immunol. Methods. 46: 1–29.PubMedGoogle Scholar
  226. Voller, A., Bidwell, D. E., and Bartlett, A., 1975, A serological study on human. T. rhodesiense infections using a microscale ELISA, Tropenmed. ParasitoL 26: 247–251.PubMedGoogle Scholar
  227. Wellde, B. T., Duxbury, R. E., Sadun, E. H., Lanbehn, H. R., Lotzsch, R., Deindl, G., and Warni, G., 1973, Experimental infections with African trypanosomes. IV. Immunization of cattle with gamma-irradiated Trypanosoma rhodesiense, Exp. ParasitoL 34: 62–68.PubMedGoogle Scholar
  228. Wellde, B. T., Schoenbechler, M. J., Diggs, C. L., Langbehn, H. R., and Sadun, E. H., 1975, Trypanosoma rhodesiense: Variant specificity of immunity induced by irradiated parasites, Exp. Parasitol. 37: 125–129.Google Scholar
  229. Wellde, B. T., Hockmeyer, W. T., Kovatch, R. M., Bhogal, M. S., and Diggs, C. L., 1981, Trypanosoma congolense: Natural and acquired resistance in the bovine, Exp. ParasitoL 52: 219–232.Google Scholar
  230. Wellhausen, S. R., and Mansfield, J. M., 1979, Lymphocyte function in experimental African trypanosomiasis. II. Splenic suppressor cell activity, J. Immunol 122: 818–824.PubMedGoogle Scholar
  231. Wellhausen, S. R., and Mansfield, J. D., 1980a, Lymphocyte function in experimental African trypanosomiasis. III. Loss of lymph node cell responsiveness, J. Immunol. 124: 1183–1186.PubMedGoogle Scholar
  232. Wellhausen, S. R., and Mansfield, J. M., 1980b, Characteristics of splenic suppressor celltarget cell interaction in experimental African trypanosomiasis, CelL ImmunoL 54: 414–424.PubMedGoogle Scholar
  233. Whitelaw, D. D., Macaskill, J. A., Holmes, P. H., Jennings, F. W., and Urquhart, G. M., 1980, Genetic resistance to Trypanosoma congolense infections in mice, Infect. Immun. 27: 707–713.PubMedGoogle Scholar
  234. Wiesenhutter, Von E., 1970, Immunity experiments in Zebu against a Trypanosoma congolense infection, Berl. Munch. Tierarztl. Eschr. 83: 218–220.Google Scholar
  235. Williams, R O., Marcu, K. B., Young, J. R., Rovis, L., and Williams, S. C., 1978, A characterization of m RNA activities and their sequence complexities in Trypanosoma brucei: Partial purification and properties of the VSSA m RNA, Nuc. Ac. Res. 5: 3171–3182.Google Scholar
  236. Williams, R O., Young, J. R., and Majiwa, P. A. O., 1979, Genomic rearrangements correlated with antigenic variation in Trypanosoma brucei, Nature (Lond.) 282: 847–849.Google Scholar
  237. Williams, R. O., Young, J. R., Majiwa, P. A. O., Doyle, J. J., and Shapiro, S. Z., 1980, Analysis of variable antigen gene rearrangements in Try panosoma brucei, Am. J. Hyg. Trop. Med. 29: 1037–1042.Google Scholar
  238. Williams, R. O., Young, J. R., Majiwa, P. A. O., Doyle, J. J., and Shapiro, S. Z., 1981, Contextural genomic rearrangements of variable antigen genes in Trypanosoma brucei, Cold Spring Harbor Symp. Quant. Biot 45: 945–950.Google Scholar
  239. Wilson, A. J., and Cunningham, M. P., 1972, Immunological aspects of bovine trypanosomiasis. I. Immune response of cattle to infection with Trypanosoma congolense and the antigenic variation of the infecting organisms, Exp. Parasitol 32: 165–173.PubMedGoogle Scholar
  240. Wilson, A. J., Paris, J., and Dar, F. K., 1975a, Maintenance of a herd of breeding cattle in an area of high trypanosome challenge, Trop. Anim. Health. Prod. 7: 63–71.Google Scholar
  241. Wilson, A. J., Le Roux, J. G., Paris, J. Davidson, C. R., and Gray, A. R., 1975b, Observations on a herd of beef cattle maintained in a tsetse area. I. Assessment of chemotherapy as a method for the control of trypanosomiasis, Trop. Anim. Health. Prod. 7: 187–199.Google Scholar
  242. Wilson, A. J., Paris, J., Luckins, A. G., Dar, F. K., and Gray, A. R., 1976, Observations on a herd of beef cattle maintained in a tsetse area. II. Assessment of the development of immunity in association with trypanocidal during treatment, Trop. Anim. Health. Prod. 8: 1–12.PubMedGoogle Scholar
  243. Yorke, W., Adams, A. R. D., and Murgatroyd, D. F., 1930, Studies in chemotherapy: The action in vitro of normal human serum on the pathogenic trypanosomes and its significance, Ann. Trop. Med. Parasitol. 24: 115–163.Google Scholar
  244. Zahalsky, A. C., and Weinberg, R. L., 1976, Immunity to monomorphic Trypanosoma brucei: Humoral response, J. Parasitol. 62: 15–19.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Georges E. Roelants
    • 1
  • Margaret Pinder
    • 1
  1. 1.Centre de Recherches sur les Trypanosomoses Animales (C.R.T.A.)Bobo-Dioulasso, Upper VoltaWest Africa

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