Abstract
Leishmanias are protozoan parasites transmitted to mammalian hosts by the bite of sandflies. After injection into the skin, the flagellate forms (promastigotes) are taken up by macrophages, where they transform into the aflagellate form (amastigotes). Cutaneous leishmaniasis is caused by parasites belonging to the L. tropica (Old World), L. mexicana and L. brasiliensis complex (New World) Mucocutaneous forms of the disease usually result from infection with L. brasiliensis and visceral leishmaniasis, commonly named kala-azar, is caused by L. donovani The clinical manifestations observed in patients infected with these parasites form a spectrum of diseases similar to that described in leprosy. The types of pathologic changes observed in infected human subjects appear to be dependent on factors related to both the parasite and the host response. Furthermore, observations that the development of parasite-specific delayed-type hypersensitivity (DTH) responses are often concommitant with the resolution of cutaneous human lesions point to a major role played by cell-mediated immunity in the healing of cutaneous lesions (Alder, 1964). The absence of specific DTH reactions during the active phase of visceral leishmaniasis support this hypothesis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adler, S., 1964, in: Advances in Parasitology (B. Dawes, ed.), vol. 2, pp. 35 - 96, Academic Press, London.
Behin, R., Mauel, J., and Sordat, B., 1979, Leishmania tropica: Pathogenicity and in vitro macrophage function in strains of inbred mice, Exp. Parasitol 48: 81.
Bianchi, A. T. J., Hooijkaas H., Benner, R., Tees, R., Nordin, A. A., and Schreier, M. H., 1981, Clones of helper T cells mediate antigen-specific, H2 restricted DTH, Nature 290: 62.
Bryceson, A. D. M., Bray, R. S., Wolstencroft, R. A., and Dumonde, D. C., 1970, Immunity in cutaneous leishmaniasis of the guinea-pig, Clin. Exp. Immunol 7: 301.
Buchmüller, Y., and Mauel, J., 1979, Studies on the mechanisms of macrophage activation. II. Parasite destruction in macrophages activated by supernates from concanavalin A-stimulated lymphocytes, J. Exp. Med 150: 359.
Butterworth, A. E., Vadas, M. A., Martz, E., and Sher, A., 1979, Cytolytic T lymphocytes recognize alloantigens on schistosomula of Schistosoma mansoni, but fail to induce damage, J. Immunol 122: 1314.
Butterworth, A. E., Vadas, M. A., and David, J. R., 1980, Mechanisms of eosinophil mediated helminthotoxicity, in: The Eosinophil in Health and Disease ( A. A. F. Mahmoud and F. F. Austen, eds.), pp. 253 - 272, Grune & Stratton, New York.
Capron, A., and Dessaint, J. P., 1982, Schistosomes as potential source of immunopharmacological agents, in: Clinics in Immunology and Allergy ( A. Capron, ed.), vol. 2, pp. 613 - 619, W.B. Saunders, Philadelphia.
Capron, A., Biguet, J., Vernes, A., and Afchain, D., 1968, Structures antigéniques des helminthes. Aspects immunologiques des relations hôte-parasite, Pathol. Biol 16: 121.
Capron, A., Dessaint, J. P., Hague, A., and Capron, M., 1982, Antibody dependent cell-mediated cytotoxicity against parasites, in: Immunity and Concomitant Immunity in Infectious Diseases ( G. Kallos, ed.), pp. 234 - 267, S. Karger, Basel.
Chensue, S. W., Wellhausen, S. R., and Bows, D. L., 1981, Modulation of granulomatous hypersensitivity II. Participation of Lyl and Ly 2* T lymphocytes in the suppression of granuloma formation and lymphokine production in Schistosoma mansoni infected mice, J. Immunol 127: 363.
Corradin, G., Edinger, H. M., and Chiller, J. M., 1977, Lymphocyte specificity to protein antigens. I. Characterization of the antigen-induced in vitro T cell-dependent proliferative response with lymph node cells from primed mice, J. Immunol 119: 1048.
Dessaint, J. P., Capron, A., Joseph, M., Auriault, C., and Pestel, J,1982, Macrophage-mediated IgE antibody-dependent cellular cytotoxicity to helminth parasites and IgE dependent macrophage activation, in: Macrophage-Mediated Antibody-Dependent Cellular Cytotoxicity (H. S. Koren, ed.), Dekker, New York (in press).
Doughty, B. L., and Phillips, S. M., 1982, Delayed hypersensitivity granuloma formation and modulation around Schistosoma mansoni eggs in vitro. II. Regulatory T cell subset, J. Immunol 128: 37.
Golub, E. S., Mishell, R. I., Weigle, W. O., and Dutton, R. W., 1968, A modification of the hemolytic plaque assay for use with protein antigens, J. Immunol 100: 133.
Gorczynski, R. M., 1982, Nature of resistance to leishmaniasis in experimental rodents, Dev. Comp. Immunol 6: 199.
Gorczynski, R. M., and MacRae, S., 1982, Analysis of subpopulation of glass-adherent mouse skin cells controlling resistance/susceptibility to infection with Leishmania tropica, and correlation with the development of independent proliferative signals to Lyt 1 +/Lyt 2+ lymphocytes, Cell. Immunol 67: 74.
Handman, E., Ceredig, R., and Mitchell, G. F., 1979, Murine cutaneous leishmaniasis: Disease patterns in intact and nude mice of various genotypes and examination of some differences between normal and infected macrophages, Aust. J. Exp. Biol. Med. Sci 57: 9.
Howard, J. G., Hale, C., and Liew, F. Y., 1980, Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica, J. Exp. Med 152: 594.
Howard, J G., Hale, C., and Liew, F. Y., 1981, Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to Leishmania tropica, J. Exp. Med 153:557.
Joseph, M., 1982, Phagocytes against helminths, in: Clinics in Immunology and Allergy ( A., Capron, ed.), vol. 2, pp. 567 - 596, W. B. Saunders, Philadelphia.
Kappler, J. W., and Marrack, P., 1977, The role of H-2 linked genes in helper T-cell function. I. In vitro expression in B cells of immune response genes controlling helper T cell activity, J. Exp. Med 146:1977.
Katz, D. H., Hamaoka, T., and Benacerraf, B., 1973, Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates, J. Exp. Med 137: 1045.
Kurnick, J. T., Gronvik, K. O., Kimura, A. K., Linblon, J. B., Skoog, V. T., Sjosberg, O., and Wigzell, H., 1979, Long term growth in vitro of human T cell blasts with maintenance for specificity and function, J. Immunol. 122: 1255.
Liew, F. Y., and Simpson, E., 1980, Delayed-type hypersensitivity responses to H-Y: Characterization and maping of Ir genes, Immunogenetics 11: 255.
Liew, F. Y., Hale, C., and Howard, J. C., 1982, Immunological regulation of experimental cutaneous leishmaniasis. V. Characterization of effector and specific suppressor T cells, J. Immunol. 128: 1917.
Lin, L. Y. and Askonas, B. A., 1980, Cross-reactivity for different type A influenza viruses of a cloned T-killer cell line, Nature (Lond.) 288: 164.
Louis, J. A., Moedder, E., Behin, R., and Engers, H. D., 1979, Recognition of protozoan parasite antigens by murine T lymphocytes. I. Induction of specific T lymphocyte-dependent proliferative response to Leishmania tropica, Eur. J. Immunol 9: 841.
Louis, J. A., Moedder, E., MacDonald, H. R., and Engers, H. D., 1981, Recognition of protozoan parasites by murine T lymphocytes. II. Role of the H-2 gene complex in interactions between antigen-presenting macrophages and Leishmania-immune T lymphocytes, J. Immunol 126: 1661.
Louis, J. A., Zubler, R. H., Coutinho, S-G., Lima, B., Behin, R., Mauel, J., and Engers, H. D., 1982, The in vitro generation and functional analysis of murine T cell populations and clones specific for a protozoan parasite, Leishmania tropica, Immunol. Rev 61: 215.
Loveland, B. E., Hogarth, P. M., Ceredig, R., and McKenzie, I. F. C., 1981, Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection, J. Exp. Med 153: 1044.
Mauel, J., Buchmüller, Y., and Behin, R., 1978, Studies on the mechanisms of macrophage activation. I. Destruction of intracellular Leishmania enriettii in macrophages activated by cocultivation with stimulated lymphocytes, J. Exp. Med 148: 393.
Mauel, J., Behin, R., and Louis, J. A., 1981, Leishmania enriettii: Immune induction of macrophage activation in an experimental model of immunoprophylaxis in the mouse, Exp. Parasitol 52: 331.
Mitchell, G. F., Curtis, J. M., Handman, E., and MacKenzie, I. F., 1980, Cutaneous leishmaniasis in mice: Disease patterns in reconstituted nude mice of several genotypes infected with Leishmania tropica, Aust. J. Exp. Biol. Med. Sci 58: 521.
Mitchell, G. F., Curtis, J. M., Scollay, R. G., and Handman, E., 1981, Resistance and abrogation of resistance to cutaneous leishmaniasis in reconstituted Balb/c nude mice, Aust. J. Exp. Biol. Med. Sci 59: 539.
Nacy, C. A., Meltzer, M. S., Leonard, E. J., and Wyler, D. J., 1981, Intracellular replication and lymphokine-induced destruction of Leishmania tropica in C3H/HeN mouse macrophages, J. Immunol 127: 2381.
Nasseri, M., and Modabber, F. Z., 1979, Generalized infection and lack of delayed hypersensitivity in Balb/c mice infected with Leishmania tropica major, Infect. Immun 26: 611.
Nguyen, T. V., Mauel, J., Etges, R., and Bordier, C., 1982, Identification of immunogenic proteins during the infection of different strains of mice by Leishmania tropica, Fed. Proc 41: 582.
Paul, W. E., Shevach, E. M., Pickeral, S., Thomas, D. W., and Rosenthal, A. S., 1977, Independent populations of primed Fi guinea-pig T lymphocytes respond to antigen pulsed parental peritoneal exudate cells, J. Exp. Med 145: 618.
Ramalho-Pinto, F. J., Goldring, O. L., Playfair, J. H. L., and Smithers, S. R., 1976, T cell response to surface components of Schistosoma mansoni, in: Biochemistry of Parasites and Host-Parasite Relationships ( H. Van den Bossche, ed.), pp. 291 - 298, North-Holland, Amsterdam.
Rittenberg, M. B., and Pratt, K. L., 1969, Anti-TNP plaque assay: Primary response of Balb/c mice to soluble and particulate immunogen, Proc. Soc. Exp. Biol. Med 132: 575.
Ryser, J. E., Cerottini, J. C., and Brunner, K. T., 1978, Generation of cytolytic T lymphocytes in vitro. IX. Induction of secondary CTL responses in primary long term MLC by supernatants from secondary MLC, J. Immunol 120: 370.
Sher, A., Jaimes, S., Simpson, A. J. G., Lazdins, J. K., and Meltzer, M. S., 1982, Macrophages as effector cells of protective immunity in murine schistosomiasis. III. Loss of susceptibility to macrophage-mediated killing during maturation of S. mansoni schistosomula from the skin to the lung stage, J. Immunol 128: 1876.
Thomas, D. W., and Shevach, E. M., 1978, Nature of the antigenic complex recognized by T lymphocytes. V. Genetic predisposition of independent F1 T cell subpopulations responsive to antigen pulsed parental macrophages, J. Immunol 120: 638.
Weintraub, J., and Weinbaum, F. I., 1977, The effect of BCG on experimental cutaneous leishmaniasis in mice, J. Immunol 118: 2288.
Ziegler, K., and Unanue, E. R., 1979, The specific binding of Listeria monocytogenes-immune T lymphocytes to macrophages. I. Quantitation and role of H-2 gene products, J. Exp. Med 150: 1143.
Zubler, R. H., and Louis, J. A., 1981, Clonal assay for T helper-cells (Tn) and conditions for H-2 restricted linked cooperation between Th and hapten-primed B cells. Application to the quantitation of hemocyanin or Leishmania tropica-specific Th in primed mice, J. Immunol 127: 1924.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Louis, J.A., Lima, G., Pestel, J., Titus, R., Engers, H.D. (1984). Murine T-Cell Responses to Protozoan and Metazoan Parasites: Functional Analysis of T-Cell Lines and Clones Specific for Leishmania tropica and Schistosoma mansoni. In: Marchalonis, J.J. (eds) Immunobiology of Parasites and Parasitic Infections. Contemporary Topics in Immunobiology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4571-8_6
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4571-8_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4573-2
Online ISBN: 978-1-4684-4571-8
eBook Packages: Springer Book Archive