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Induction and Expression of Mucosal Immune Responses and Inflammation to Parasitic Infections

  • Chapter
Immunobiology of Parasites and Parasitic Infections

Part of the book series: Contemporary Topics in Immunobiology ((CTI,volume 12))

Abstract

At least five million people die annually of gastrointestinal infection (Holmgren, 1981), and the morbidity level from such infections must be several-fold greater. In the veterinary field, an estimated 20% of pigs born in North America and Britain die before weaning of diarrheal disease caused by Escherichia coli and transmissible gastroenteritis (TGE) virus (Porter, 1979). The human and economic losses resulting from gastrointestinal infections are thus of staggering proportions; e.g., in Kenya, Ascaris lumbricoides infection, generally considered to be relatively nonpathogenic and unimportant, results in economic losses in excess of $5 million per year (Latham et al., 1977). Similarly depressing figures could be provided for the mortality and morbidity statistics of respiratory infections in the international community (e.g., World Health Organization Technical Report, 1980). The magnitude of the problem of mucosal infection has stimulated research directed at its solution and, given the success of vaccination programs with various infectious diseases, the potential for immunoprophylaxis is being vigorously explored.

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  1. Department of Pathology, Host Resistance Programme, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada, L8N 3Z5

    Dean Befus & John Bienenstock

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  1. Medical University of South Carolina, Charleston, South Carolina, USA

    John J. Marchalonis

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Befus, D., Bienenstock, J. (1984). Induction and Expression of Mucosal Immune Responses and Inflammation to Parasitic Infections. In: Marchalonis, J.J. (eds) Immunobiology of Parasites and Parasitic Infections. Contemporary Topics in Immunobiology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4571-8_3

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