Induction and Expression of Mucosal Immune Responses and Inflammation to Parasitic Infections

  • Dean Befus
  • John Bienenstock
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 12)


At least five million people die annually of gastrointestinal infection (Holmgren, 1981), and the morbidity level from such infections must be several-fold greater. In the veterinary field, an estimated 20% of pigs born in North America and Britain die before weaning of diarrheal disease caused by Escherichia coli and transmissible gastroenteritis (TGE) virus (Porter, 1979). The human and economic losses resulting from gastrointestinal infections are thus of staggering proportions; e.g., in Kenya, Ascaris lumbricoides infection, generally considered to be relatively nonpathogenic and unimportant, results in economic losses in excess of $5 million per year (Latham et al., 1977). Similarly depressing figures could be provided for the mortality and morbidity statistics of respiratory infections in the international community (e.g., World Health Organization Technical Report, 1980). The magnitude of the problem of mucosal infection has stimulated research directed at its solution and, given the success of vaccination programs with various infectious diseases, the potential for immunoprophylaxis is being vigorously explored.


Mast Cell Lamina Propria Goblet Cell Parasitic Infection Mucosal Immune Response 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Dean Befus
    • 1
  • John Bienenstock
    • 1
  1. 1.Department of Pathology, Host Resistance ProgrammeMcMaster University Health Sciences CentreHamiltonCanada

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