Immunopathology of Parasitic Diseases: A Conceptual Approach

  • S. Michael Phillips
  • Edward G. Fox
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 12)


The pathology caused by parasites, the most prevalant infectious diseases of humankind, can be divided into two major aspects: the first relates to the effects of the parasite per se, e.g., iron deficiency anemia, secondary to blood loss caused by intestinal nematodes; hemolytic anemia, secondary to intracellular protozoans; or hepatobiliary fibrosis, secondary to toxic products produced by intraductal trematodes. However, in many parasitic conditions there is limited pathology directly attributable to the parasite. Most host morbidity is related to the immunoinflammatory response of the host to the parasite. This reaction is the principal subject of this chapter.


Parasitic Disease Granuloma Formation Schistosoma Mansoni Schistosoma Japonicum Filarial Infection 


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  1. Abdel-Hafez, S. K., Phillips, S. M., and Zodda, D. M., 1983, Schistosoma mansoni: Detection and characterization of antigens and antigenemia in inhibition enzyme-linked immunosorbent assay (IELISA), Exp. Parasitol 55: 219.PubMedGoogle Scholar
  2. Abdel-Salam, E., Ishaac, S., and Mahmoud, A. A. F., 1979, Histocompatibility-linked susceptibility for hepatosplenomegaly in human schistosomiasis mansoni, J. Immunol 123: 1829.Google Scholar
  3. Ackerman, S. J., Gleich, G. J., Weller, P. F., and Ottesen, E. A., 1981, Eosinophilia and elevated serum levels of eosinophil major basic protein and Charcot-Leyden crystal protein (lysophospholipase) after treatment of patients with Bancroft’s filariasis, J. Immunol 127: 1093.PubMedGoogle Scholar
  4. Andrade, Z. A., and Andrade, S. G., 1970, Pathogenesis of schistosomal pulmonary arteritis, Am. J. Trop. Med. Hyg 19: 305.PubMedGoogle Scholar
  5. Andrade, Z. A., and Warren, K. S., 1964, Mild prolonged schistosomiasis in mice: Alterations in host response with time and the development of portal fibrosis, Trans, R. Soc. Trop. Med. Hyg 58: 53.Google Scholar
  6. Askenase, F. W., Hayden, B., and Higashi, G. I., 1976, Cutaneous basophil hypersensitivity and inhibited macrophage migration in guinea pigs with schistosomiasis, Clin. Exp. Immunol 23: 318.Google Scholar
  7. Barrett-Connor, E., 1982, Concise clinical studies: Parasite pulmonary disease, Am. Rev. Respir. Dis 126: 558.PubMedGoogle Scholar
  8. Benjamin, D., and Soulsby, E. J. L., 1976, Homocytotropic and hemagglutinating antibody responses to Brugia pahangi infection in the multimmate rat (Mastomys natalensis), Am. J. Trop. Med. Hyg 25: 266.PubMedGoogle Scholar
  9. Bentley, A. G., Doughty, B. L., and Phillips, S. M., 1982, Ultrastructural analysis of the cellular response to Schistosoma mansoni: III. The in vitro granuloma, Am. J. Trop. Med. Hyg 316: 1168.Google Scholar
  10. Billings, F. T., Winkenwerder, W. L., and Huninen, A. V., 1946, Studies of acute schistosomiasis japonica in the Philippine Islands: I. A clinical study of 337 cases with a preliminary report on the results of treatment with Faudin in 110 cases, Bull. John Hopkins Hosp 78: 21.PubMedGoogle Scholar
  11. Bloch, E. H., Abdel-Wahab, M. F., and Warren, K. S., 1972, In vivo microscopic observations of the pathogenesis and pathophysiology of hepatosplenic schistosomiasis in the mouse liver, Am. J. Trop. Med. Hyg 21: 546.Google Scholar
  12. Boros, D. L., and Warren, K. S., 1970, Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma monsoni eggs, J. Exp. Med 132: 488.PubMedGoogle Scholar
  13. Bosworth, W., Ewert, A., and Bray, J., 1973, The interaction of Brugia malayi and streptococcus in an animal model, Am. J. Trop. Med. Hyg 22: 714.PubMedGoogle Scholar
  14. Bout, D., Santoro, F., Carlier, Y., Bina, J. C., and Capron, A., 1977, Circulating immune complexes in schistosomiasis, Immunology 33: 17.PubMedGoogle Scholar
  15. Buchanan, R. D., Fine, D. P., and Colley, D. G., 1973, Schistosoma mansoni infection in mice depleted of thymus-dependent lymphocytes. II. Pathology and altered pathogenesis, Am. J. Pathol 71: 207.Google Scholar
  16. Butterworth, A. E., Sturrock, R. S., Houba, V., and Reese, P. H., 1974, Antibody- dependent cell-mediated damage to schistosomula in vitro, Nature (Lond.) 252: 503.Google Scholar
  17. Butterworth, A. E., Sturrock, R. S., Houba, V., Mahmoud, A. A. F., Sher, A., and Reese, P. H., 1975, Eosinophils as mediators of antibody-dependent cell-mediated damage to schistosomula, Nature (Land) 256: 727.Google Scholar
  18. Butterworth, A. E., Wassom, D. L., Gleich, G. J., and Loegering, D. A., and David, J. R., 1979a, Damage of schistosomula of Schistosoma mansoni induced directly by eosinophil major basic protein, J. Immunol 122: 221.PubMedGoogle Scholar
  19. Butterworth, A. E., Vadas, M. A., Martz, E., and Sher, A., 1979b, Cytolytic T lymphocytes recognize alloantigens of schistosomula of Schistosoma mansoni but fail to induce damage, J. Immunol 122: 1314.PubMedGoogle Scholar
  20. Byram, J. E., and von Lichtenberg, F., 1981, Altered schistosome granuloma formation in nude mice, Am. J. Trop. Med. Hyg 26: 944.Google Scholar
  21. Canto, A. L., Sesso, A., and de Brito, T., 1977, Human chronic mansonian schistosomiasiscell proliferation and fibre formation in the hepatic sinusoidal wall: A morphometric, light and electron-microscopy study, J. Pathol 123: 35.PubMedGoogle Scholar
  22. Capron, A. R. G., and Dessaint, J. P., 1982, Schistosome as a potential source of immunological pharmocologic agents, in: Clinics in Immunology and Allergy, Vol. 2: Immunopharmocology (A. Capron, ed.), No. 3., p. 613, W. B. Saunders, London.Google Scholar
  23. Capron, A., Dessaint, J. P., Capron, M., and Bazin, H., 1975, Specific IgE antibodies in immune adherence of normal macrophages to Schistosoma mansoni schistosomules, Nature (London). 253: 474.Google Scholar
  24. Capron, A., Dessaint, J. P., Joseph, M., Torpier, G., Capron, M., Rousseaux, R., Santoro, F., and Bazin, H., 1977, IgE and cells in schistosomiasis, Am. J. Trop. Med. Hyg 26 (Suppl.): 39.PubMedGoogle Scholar
  25. Capron, A., Dessaint, J. P., Capron, M., et al., 1980, Role of anaphylactic antibodies in immunity to schistosomes, Am. J. Trop. Med. Hyg. 29: 849.PubMedGoogle Scholar
  26. Capron, A., Dessaint, J. P., and Capron, M., 1982, Effector mechanisms and their regulation, Immunol. Rev 61: 41.PubMedGoogle Scholar
  27. Capron, M., Capron, A., and Torpier, G., 1978, Eosinophil-dependent cytotoxicity in rat schistosomiasis. Involvement of IgG2a antibody and role of mast cells, Eur. J. Immunol 8: 127.PubMedGoogle Scholar
  28. Capron, M., Capron, A., Dessaint, J. P., et al., 198la, Fc receptors on human and rat eosinophils, J. Immunol 126: 2087.Google Scholar
  29. Capron, M., Capron, A., Goetzl, E. J., and Austen, K. F., 1981b, Tetrapeptides of the eosinophil chemotactic factor of anaphylaxis (ECF-A) enhance eosinophil Fc receptor, Nature (bond.) 289: 71.Google Scholar
  30. Carme, B., and Laigret, J., 1979, Longevity of Wuchereria bancrofti var. pacifica and mosquito infection acquired from a patient with low level parasitemia, Am. J. Trop. Med. Hyg 28: 53.PubMedGoogle Scholar
  31. Cheever, A. W., 1968, A quantitative post-mortem study of schistosomiasis mansoni in man, Am. J. Trop. Med. Hyg 17: 38.PubMedGoogle Scholar
  32. Cheever, A. W., 1972, Pipe-stem fibrosis of the liver, Trans. R. Soc. Trop. Med. Hyg. 66: 946.Google Scholar
  33. Cheever, A. W., and Warren, K. S., 1964, Hepatic blood flow in mice with acute hepatosplenic schistosomiasis mansoni, Trans. R. Soc. Trop. Med. Hyg 58: 406.PubMedGoogle Scholar
  34. Chensue, S. W., and Boros, D. L., 1979a, Population dynamics of T- and B-lymphocytes in the lymphoid organs, circulation and granulomas of mice infected with Schistosoma mansoni, Am. J. Trop. Med. Hyg 28: 291.PubMedGoogle Scholar
  35. Chensue, S. W., and Boros, D. L., 1979b, Modulation of granulomatous hypersensitivity. I. Characterization of T-lymphocytes involved in the adoptive suppression of granuloma formation of in Schistosoma mansoni-infected mice, J. Immunol 123: 1409.PubMedGoogle Scholar
  36. Chensue, S. W., Boros, D. L., and David, C. S., 1980, Regulation of granulomatous inflammation in murine schistosomiasis. In vitro characterization of T lymphocyte subsets involved in the production and suppression of migration inhibition factor, J. Exp. Med. 151: 1398.Google Scholar
  37. Chensue, S. W., Wellhausen, S. R., and Boros, D. L., 1981, Modulation of granulomatous hypersensitivity. II. Participation of Ly-1* and Ly-2* T lymphocytes in the suppression of granuloma formation and lymphokine production in Schistosoma mansoni-infected mice, J. Immunol 127: 363.PubMedGoogle Scholar
  38. Chensue, S. W., Boros, D. L., and David, C. S., 1983, Regulation of granulomatous inflammation in murine schistomiasis. II. T-suppressor cell-derived, I-C subregion-coded soluble suppressor factor mediates regulation of lymphokine production, J. Exp. Med 157: 219.PubMedGoogle Scholar
  39. Colley, D. G., 1976, Adoptive suppression of granuloma formation, J. Exp. Med 143: 696PubMedGoogle Scholar
  40. Colley, D. G., 1981, Immune responses and immunoregulation in experimental and clinical schistosomiasis, in: The Immunology of Parasitic Diseases, Vol. 1 (J. M. Mansfield, ed.), pp. 1–83, Marcel Dekker, New York.Google Scholar
  41. Colley, D. G., Megalhaes-Filho, Barros-Coelho, R., 1972, Immunopathology of dermal reactions induced by Schistosoma mansoni cercariae and cercarial extract, Am. J. Trop. Med. Hyg 21: 558.Google Scholar
  42. Colley, D. G., Savage, A. M., and Lewis, F. A., 1977, Host responses induced and elicited by cercariae, schistosomula and cercarial antigenic preparations, Am. J. Trop. Med. Hyg 26 (Suppl.): 88.PubMedGoogle Scholar
  43. Colley, D. G., Lewis, F. A., and Todd, C. W., 1979, Adoptive suppression of granuloma formation by T lymphocytes by lymphoid cells sensitive to cyclophosphamide, Cell Immunol. 45: 192.Google Scholar
  44. Coulis, P. A., Lewert, R. M., and Fitch, T. W., 1978, Splenic suppressor cells and cell-mediated immunity in murine schistosomiasis, J. Immunol 120: 1074.PubMedGoogle Scholar
  45. Crandall, R. B., McGreevey, P. B., Connor, D. H., Crandall, C. A., Neilson, J. T., and McCall, J. W., 1982, The ferret (Mustela putorius furo) as an experimental host for Brugia malay i and Brugia pahangi, Am. J. Trop. Med. Hyg 31: 752.PubMedGoogle Scholar
  46. Crowell, W. A., Malone, J. B., Chapman, W. L., and Thompson, P. E., 1973, Amyloidosis in mongolian gerbils infected with Litomosoides carinii, J. Am. Vet. Med. Assoc 163: 596Google Scholar
  47. Danaraj, T. J., 1951, Eosinophilic lung, in: A study of 150 cases seen in Singapore, p. 57, Papineau Studios, Singapore.Google Scholar
  48. Date, A., Shastry, J. C. M., and Johny, K. V., 1979, Ultrastructural glomerular changes in filarial chyluria, J. Trop. Med. Hyg 82: 150.PubMedGoogle Scholar
  49. Date, A., Pandandatti, T., Vaska, P. H., and Shastry, J. C. M., 1980, Lymphocytopenia in chyluria, Trans. R. Soc. Trop. Med. Hyg 74: 137.PubMedGoogle Scholar
  50. Date, A., John, T. J., Chandy, K. G., Rajapopalan, M. S., Vaska, P. H., Pundey, A. P., and Shastry, J. C. M., 1981, Abnormalities of the immune system in patients with chyluria, Br. J. Urol 53: 384.PubMedGoogle Scholar
  51. Date, A., Shastry, J. C. M., Vaska, P. H., Pundey, A. P., Sridaran, G., and Koshi, G., 1982, Complement in chyluria, Trans. R. Soc. Trop. Med. Hyg 76: 238.PubMedGoogle Scholar
  52. Davis, B. H., Mahmoud, A. A. F., and Warren, K. S., 1974, Granulomatous hypersensitivity to Schistosoma mansoni eggs in thymectomized and bursectomized chickens, J. Immunol 113: 1064.PubMedGoogle Scholar
  53. des Moutis, I., Ouaisse, R., Grzych, J. M., Yarzabal, L., Hague, A., and Capron, A., 1982, Onchocerca vovulus: Detection of circulating antigen by monoclonal antibodies in human onchocerciasis,Am. J. Trop. Med. Hyg 32: 533.Google Scholar
  54. Desowitz, R. S., Barnwell, J. W., Palumbo, N. E., Una, S. R., and Perri, S. F., 1978, Rapid increase of precipitating and reagenic antibodies in Dirofilaria immitis infected dogs which develop severe adverse reactions following treatment with diethylcarbamazine, Am. J. Trop. Med. Hyg 27: 1148.PubMedGoogle Scholar
  55. Dessaint, J. P., 1982, Anaphylactic antibodies and their significance, in: Clinics in Immunology and Allergy, Vol. 2, no. 3: Immunoparasitology ( A. Capron, ed.), p. 621, W. B. Saunders, London.Google Scholar
  56. Dessaint, J. P., Capron, M., Bout, D., and Capron, A., 1975, Quantitative determination of specific IgE antibodies to schistosome antigens and serum IgE level in patients with schistosomiasis (S. mansoni or S. haematobium), Clin. Exp. Immunol 20: 427.Google Scholar
  57. Dessaint, J. P., Torpier, G., Capron, M., and Bazin, H., 1979, Cytophilic binding of IgE to the macrophage. I. Binding characteristics of IgE on the surface of macrophages in the rat, Cell. Immunol 46: 12.PubMedGoogle Scholar
  58. Diaz-Rivera, R. S., Ramos-Morales, F., Koppisch, E., Garcia-Palmieri, M. R., CintronRivera, A. A., Marchand, E. J., Gonzalez, O., and Torregrosa, M. V., 1956, Acute Manson’s schistosomiasis, Am. J. Med 21: 918.PubMedGoogle Scholar
  59. Doenhoff, M., Musallan, R., Bain, J., and McGregor, A., 1979, Schistosoma mansoni infections in T-cell deprived mice, and the ameliorating effect of administering homologous chronic infection serum. I. Pathogenesis, Am. J. Trop. Med. Hyg 28: 260.Google Scholar
  60. Domingo, E. O., and Warren, K. S., 1967, The inhibition of granuloma formation around Schistosoma mansoni eggs. II. Thymectomy, Am. J. Pathol 51: 757.PubMedGoogle Scholar
  61. Domingo, E. O., and Warren, K. S., 1968, Endogeneous densitization: Changing host granulomatous response to schistosome eggs at different stages of infection with Schistosoma mansoni; Am. J. Pathol. 52: 369.PubMedGoogle Scholar
  62. Doughty, B. L., and Phillips, S. M., 1982a, Delayed hypersensitivity granuloma formation around Schistosoma mansoni eggs in vitro. I. Definition of the model, J. Immunol 128: 30.PubMedGoogle Scholar
  63. Doughty, B. L., and Phillips, S. M., 1982b, Delayed hypersensitivity granuloma formation around Schistosoma mansoni eggs in vitro. II. Regulatory T-cell subsets, J. Immunol 128: 37.PubMedGoogle Scholar
  64. Elmer, J. J., Olds, G. R., Kamel, R., Osman, G. S., El Kholy, A., Mahmoud, A. A. F., 1980, Suppressor splenic T lymphocytes in human hepatosplenic schistosomiasis mansoni, J. Immunol 125: 308.Google Scholar
  65. Ellner, J. J., Olds, G. R., Lee, C. W., and Clinhenz, M. E., 1982, Destruction of multi-cellular parasite Schistosoma mansoni by T-lymphocytes, J. Clin. Invest 70: 369.PubMedGoogle Scholar
  66. Epstein, W. L., Fukuyama, K., Danno, K., and Kwan-Wong, E., 1979, Granulomatous hypersensitivity inflammation in normal and athymic mouse infected with S. mansoni: An ultrastructural study, J. Pathol 127: 207.PubMedGoogle Scholar
  67. Fox, E. G., 1979, The pathology, immunology and immunogenetics of Brugia infection in syngeneic rats, Doctoral dissertation, University of California, Los Angeles.Google Scholar
  68. Fuglsang, H., Anderson, J., and de Marshall, T. F., 1979, Studies on onchocerciasis in the United Cameroon Republic. V. A four year follow-up of 6 rain-forest and 6 Sudan savanna villages. Some changes in skin and lymph nodes, Trans. R. Soc. Trop. Med. Hyg. 73: 118.Google Scholar
  69. Galvao-Castro, B., Bina, J., Prata, A., and Lambert, P. H., 1981, Correlation of circulating immune complexes and complement breakdown products with the severity of the disease in human schistosomiasis mansoni, Am. J. Trop. Med. Hyg 30 (6): 1238.PubMedGoogle Scholar
  70. Garb, K. S., Stavitsky, A. B., and Mahmoud, A. A. F., 1981, Dynamics of antigen and mitogen-induced responses in schistosomiasis japonica: In vitro comparison between hepatic granulomas and splenic cells, J. Immunol 127: 115.PubMedGoogle Scholar
  71. Garb, K. S., Stavitsky, A. B., Olds, G. R., Tracy, J. W., and Mahmoud, A. A. F., 1982, Immune regulation in murine schistosomiasis japonica: Inhibition of in vivo antigen-and mitogen-induced cellular responses by splenocyte culture supernatants and by purified fractions from serum of chronically infected mice, J. Immunol 129 (6): 2752.PubMedGoogle Scholar
  72. Gazzinelli, G., Ramalho-Pinto, F. J., and Dias da Silva, W., 1969, Schistosoma mansoni generation of anaphylatoxin by cercarial extracts, Exp. Parasitol 28: 86.Google Scholar
  73. Goodwin, L. G., Green, D. G., Guy, M. W., and Voller, A., 1972, Immunosuppression during trypanosomiasis, Br. J. Exp. Pathol 53: 40–43.PubMedGoogle Scholar
  74. Green, W. F., and Colley, D. G., 1981, Modulation of Schistosoma mansoni egg-induced granuloma formation: I-J restriction of T-cell-mediated suppression in a chronic parasitic infection, Proc. Natl. Acad. Sci. USA 78: 1152.PubMedGoogle Scholar
  75. Greenwood, B. M., and Whittle, H. C., 1981, Immunology of medicine, in: Current Topics in Immunology Series, Vol. 14 (J. Turk, ed.), Edward Arnold, London.Google Scholar
  76. Greenwood, B. M., Bradley-Moore, A. M., Poalit, A., and Bryceson, A. D. M., 1972, Immunosuppression in children with malaria, Lancet 1: 169.PubMedGoogle Scholar
  77. Grove, D. I., and Forbes, I. J., 1979, Immunosuppression in Bancroftian filariasis, Trans. R. Soc. Trop. Med. Hyg. 73: 23.PubMedGoogle Scholar
  78. Gutekunst, R. R., Browne, H. G., and Meyers, D. M., 1965, Influence of Schistosoma mansoni eggs on growth of monkey heart cells, Exp. Parasitol. 17: 194.PubMedGoogle Scholar
  79. Hang, L. M., Warren, K. S., and Boros, D. L., 1974, Schistosoma mansoni: Antigenic secretions and the etiology of egg granulomas in mice, Exp. Parasitol. 35: 288.PubMedGoogle Scholar
  80. Hague, A., Camus, D., Ogilvie, B. M., Capron, M., Bazin, H., and Capron, A., 1981, Dipetalonema viteae infective larvae reach reproductive maturity in rats immunodepressed by prior exposure to Schistosoma mansoni or its products and in congenitally athymic rats, Clin. Exp. Immunol 143: 1.Google Scholar
  81. Henson, P. M., Mackenzie, C. D., and Spector, W. G., 1979, Inflammatory reactions in onchocerciasis: A report on current knowledge and recommendations for further study, Bull. WHO 57: 667.PubMedGoogle Scholar
  82. Hiatt, R. A., Sotomayor, Z. R., Sanchez, G., Zambrana, M., Knight, W. B., 1979, Factors in the pathogenesis of acute schistosomiasis mansoni, J. Infect. Dis. 139: 659.PubMedGoogle Scholar
  83. Hillyer, G. V., 1969, Immunoprecipitins in Schistosoma mansoni infections. IV. Human infections, Exp. Parasitol 25: 376.PubMedGoogle Scholar
  84. Hillyer, G. V., 1973, Schistosome deoxyribonucleic acid (DNA), antibodies to DNA in schistosome infections, and their possible role in renal pathology, Boletin Asociancion Medica de Puerto Rica, 65 (Suppl.): 1.Google Scholar
  85. Hillyer, G. V., Hernandez-Almenas, N., Knight, W. B., and Cline, B., 1976, Circulating antigens, antibodies and immunoglobulins in the serum of humans with schistosomiasis mansoni, Biol. Assoc. Med. P. R 68: 128.Google Scholar
  86. Houba, F. Sturrock, R. F., and Butterworth, A. E., 1977, Kidney lesions in baboons infected with Schistosoma mansoni, Clin. Exp. Immunol 30: 439.Google Scholar
  87. Houba, V., 1979, Experimental renal disease due to schistosomiasis, Kidney Int. 16: 30.PubMedGoogle Scholar
  88. Hsü, H. F., Davis, J. R., Hsü, S. Y. L., and Osborne, J. W., 1963, Histopathology in albino mice and Rhesus monkeys infected with irradiated cercariae of Schistosoma japonicum, Z. Tropenmed. Parasitol 14: 240.Google Scholar
  89. Hsü, S. Y. L., Davis, J. R., and Hsü, H. F., 1965, Histopathology in rhesus monkeys infected four times with the Formosan strain of Schistosoma japonicum, Z. Tropenmed. Parasitol 16: 297.Google Scholar
  90. Hsü, C. K., Hsü, S. H., Whitney, R. A., Jr., and Hansen, C. T., 1976, Immunology of schistosomiasis in athymic mice, Nature (Lond.) 262: 397.Google Scholar
  91. Ishizaka, T., Urban, J., Jr., Tatatsu, K., and Ishizaka, K., 1976, Immunoglobulin E synthesis in parasite infection, J. Allergy Clin. Immunol. 58: 523.Google Scholar
  92. Jarrett, E. E. E., 1978, Stimuli for the production and control of IgE in rats, Immunol. Rev 41: 52.PubMedGoogle Scholar
  93. Kane, C. A., and Most, H., 1948, Schistosomiasis of the central nervous system: Experiences in World War II and a review of the literature, Arch. Neurol. Psychol 59: 141.Google Scholar
  94. Karavodin, L. M., and Ash, L. R., 1980, Circulating immune complexes in experimental filariasis, Clin. Exp. Immunol 40: 312.PubMedGoogle Scholar
  95. Kasukawa, R., Okada, M., and Igari, S., 1980, Receptors for IgG, Fc and complement in the mammalian aorta, Int. Arch. Allergy Appl. Immunol 61: 175.PubMedGoogle Scholar
  96. Kazura, J. W., Fauning, M. M., Blumer, J. L., and Mahmoud, A. A. F., 1981, Role of cell generated hydrogen peroxide in granulocyte mediated killing of schistosomula of Schistosoma mansoni in vitro, J. Clin. Invest 67: 93.PubMedGoogle Scholar
  97. Klei, T. R., McCall, J. W., and Malone, J. B., 1980, Evidence for increased susceptibility of Brugia pahangi-infected jirds (Meriones unguiculatus) to subsequent homologous infections, J. Helminthol 54: 161.PubMedGoogle Scholar
  98. Klei, T. R., Enright, F. M., Blanchard, D. P., and Uhl, S. A., 1981, Specific hypo-responsive granulomatous tissue reactions in Brugia pahangi infected jirds,Acta Trop. 38: 267.Google Scholar
  99. Klei, T. R., Enright, F.M., Blanchard, D. P., and Uhl, S. A., 1982, Effects of presensitization of the development of lymphatic lesions in Brugia pahangi infected jirds, Am. J. Trop. Med. Hyg 31: 280.PubMedGoogle Scholar
  100. Knight, D. A., 1979, Pathophysiology of canine dirofilariasis, Am. Coll. Vet. Inst. Med. Sci. Proc. p. 41.Google Scholar
  101. Lambert, P. H., 1978, A WHO collaborative study for the evaluation of eighteen methods for detecting immune complexes in serum, J. Clin. Lab. Immunol 1: 1.Google Scholar
  102. Lawley, T. J., Ottesen, R. A., Hiatt, R. A., and Gazze, L. A., 1979, Circulating immune complexes in acute schistosomiasis, Clin. Exp. Immunol 37: 221.PubMedGoogle Scholar
  103. Lehman, J. S., 1973, Urinary schistosomiasis in Egypt: Clinical and parasitological correlation, Trans. R. Soc. Trop. Med. Hyg 67: 385.Google Scholar
  104. Lehman, J. S., Farid, Z., Haxton, S., Jr. Abdel-Wahab, M. F., and Kent, D. C., 1970, In- testinal protein loss in schistosomal polyposis of the colon, Gastroenterology 59: 433.Google Scholar
  105. MacFarlane, W. V., 1949, Schistosome dermatitis in New Zealand. Part II. Pathology and immunology of cercarial lesions, Am. J. Hyg 50: 152.PubMedGoogle Scholar
  106. Machado, A. J., Gazzinelli, G., Pellegrino, J., and Dias da Silva, W., 1975, Schistosoma mansoni: The role of the complement C3-activating system in the cercaricidal action of normal serum, Exp. Parasitol. 38: 20.PubMedGoogle Scholar
  107. McCully, R. M., Barron, C. N., and Cheever, A. W., 1976, Schistosomiasis (bilharziasis), in: Pathology of Tropical and Extraordinary Diseases, Vol. 2 ( C. H. Binford and D. H. Connor, eds.), p. 482, Armed Forces Institute of Pathology, Washington, D.C.Google Scholar
  108. Magalhaes-Filho, A., 1959, Pulmonary lesions in mice experimentally infected with Schistosoma mansoni, Am. J. Trop. Med. Hyg 8: 527.PubMedGoogle Scholar
  109. Magalhaes-Filho, A., Krupp, I. M., and Malek, E. A., 1965, Localization of antigen and presence of antibody in tissues of mice infected with Schistosoma mansoni, as indicated by fluorescent antibody techniques, Am. J. Trop. Med. Hyg 14: 84.Google Scholar
  110. Mahmoud, A. A. F., Peters, P. A., Sevil, R., and Remington, J. S., 1979, In vitro killing of schistosomula of Schistosoma mansoni by BCG and C. paruum-activated macrophages, J. Immunol 122: 1655.PubMedGoogle Scholar
  111. Martial-Rojas, R. A., and Fial, R. E., 1963, Neurologic complications of the literature and report of two cases of transverse myelitis due to Schistosoma mansoni, Ann. Intern. Med 59: 215.Google Scholar
  112. Manson-Bahr, P. E. C. and Apted, F.I.C., 1982, in: Manson’s Tropical Diseases, 18th edition, p. 206, Guilliere Tindall, London.Google Scholar
  113. Meyers, F. J., and Kouwenaar, W., 1939, Over hypereosinophile en over en merkwaaridgen vorm van filariasis, Geneesk. Tidscher. Med. Ind 79: 853.Google Scholar
  114. Mitchell, G. F., Garcia, E. G., Cruise, K. M., Tiu, W. U., and Hawking, R. E., 1983, Lung granulomatous hypersensitivity to eggs of Schistosoma japonicum in mice analyzed by a radioisotopic assay and effects of hybridoma (idiotype sensitization), Aust. J. Exp. Biol. Med. Sci 60: 401.Google Scholar
  115. Morbidity and Mortality Weekly Report Katayama Syndrome, Ethiopia 1982, Morbidity Mortality Weekly Rep. 31 (32): 436.Google Scholar
  116. Nash, T. E., Cheever, A. W., Ottesen, E. A., and Cook, J. A., 1982, Schistosome infections in humans: Perspectives and recent findings, Ann. Intern. Med 97: 740.PubMedGoogle Scholar
  117. Nelson, G. S., 1966, The pathology of filarial infections, Helminthol. Abstr 35: 311Google Scholar
  118. Nelson, G. S., 1979, Current concepts in parasitology: Filariasis, N. Engl. J. Med. 300: 1136.PubMedGoogle Scholar
  119. Neva, F. A., and Ottesen, E. A., 1978, Tropical (Filarial) Eosinophilia, N. Engl. J. Med 298: 1129.PubMedGoogle Scholar
  120. Ogilvie, B. M., and Jones, V. E., 1973, Immunity in the parasitic relationship between helminths and hosts, Prog. Allergy 17: 93.PubMedGoogle Scholar
  121. Olds, G. R., Ellner, J. J., Kearse, L. A., Jr., Kazura, J. W., and Mahmoud, A. A. F., 1980, Role of agrinase in killing of schistosomula of Schistosoma mansoni, J. Exp. Med 151: 1551.Google Scholar
  122. Olds, G. R., Olveda, R., Tracy, J. W., and Mahmoud, A. A. F., 1982, Adoptive transfer of modulation of granuloma formation and hepatosplenic disease in murine schistosomiasis japonica by serum from chronically infected animals, J. Immunol 128: 1393.Google Scholar
  123. Olivier, L., 1949, Schistosome dermatitis: A sensitization phenomenon, Am. J. Hyg 49: 290.PubMedGoogle Scholar
  124. Olivier, L., and Weinstein, 1953, Experimental schistosome dermatitis in rabbits, J. Parastiol 38: 280.Google Scholar
  125. Oliveira, C. A., Bicalho, D. M., Pimenta-Filho, R., Katz, H., Ferreira, H. Bittencourt, D., Dias, R. P., Alvarenga, R. J., and Dias, C. B., 1969, A fase aguda da equistossomose mansoni. Estude laparoscopico disseminacao equistossomoticos, GEN 23: 369.Google Scholar
  126. Orange, R. G., Valentine, M. D., and Austen, K. F., 1968, Inhibition of the release of slow-reacting substance of amphylaxis in the rat with diethylcarbamazine, Proc. Soc. Exp. Biol. Med 127: 127–132.PubMedGoogle Scholar
  127. Ottesen, E. A., 1979, Modulation of the host response in human schistosomiasis mansoni. I. Adherent suppressor cells which inhibit blastogenesis, J. Immunol 123: 1639.PubMedGoogle Scholar
  128. Ottesen, E. A., 1980, Immunopathology of lymphatic filariasis in man, Springer Sem. Immunopathol 2: 373.Google Scholar
  129. Ottesen, E. A., and Poindexter, R. W., 1980, Modulation of the host response in human schistosomiasis. II. Humoral factors which inhibit lymphocyte proliferative responses to parasite antigens, Am. J. Trop. Med. Hyg 29: 592.PubMedGoogle Scholar
  130. Ottesen, E. A., and Weller, P. F., 1979, Eosinophilia following treatment of patients with schistosomiasis mansoni and Bancroft’s filariasis, J. Infect. Dis 139: 343.PubMedGoogle Scholar
  131. Ottesen, E. A., Weller, P. F. and Heck, L., 1977, Specific cellular unresponsiveness in human filariasis, Immunology 33: 413.PubMedGoogle Scholar
  132. Ottesen, E. A., Hiatt, R. A., Cheever, A. W., Sotomayor, Z. R., and Neva, F. A., 1978, The acquisition and loss of antigen-specific cellular immune responsiveness in acute and chronic schistosomiasis in man, Clin. Exp. Immunol 33: 38.Google Scholar
  133. Ottesen, E. A., Neva, F. A., Paranjape, R. S., Tripathy, S. P., Thiruvengadam, V., and Beaver, M. A., 1979, Specific allergic sensitization to filarial antigens in tropical eosinophilia syndrome, Lancet 1: 1158.PubMedGoogle Scholar
  134. Ottesen, E. A., Poindexter, R. W., and Hussain, R., 1981e, Detection, quantitation and specificity of anti-parasite IgE in schistosomiasis mansoni, Am. J. Trop. Med. Hyg 30: 1225.Google Scholar
  135. Ottesen, E. A., Mandell, N. R., MacQueen, J. M., Weller, P. F., Amos, D. B., and Ward, F. E., 1981b, Familial predisposition to filarial infection—not linked to HLA-A or -B locus specificities, Acta. Trop. 38: 205.PubMedGoogle Scholar
  136. Palmieri, J., Purnomo, R., Dennis, D. T., Marwoto, H. A., 1980, Filariid parasites of South Kalimantan (Borneo) Indonesia. Wuchereria kalimantani Sp. N. (Nematoda: Filarioidea) from the silvered leaf monkey, Presbytis crisatus Eshscholtz 1921, J. Parasitol 66: 645.Google Scholar
  137. Palmieri, J. R., Connor, D. H., Purnomo, D. T., Dennis, D. T., and Marwoto, H., 1982, Experimental infection of Wuchereria bancrofti in the silvered leaf monkey Presbytis cristatus Eschcholz, J. Helminthol 56: 243.PubMedGoogle Scholar
  138. Peck, C. A., Carpenter, M. D., and Mahmoud, A. A. F., 1983, Species-related innate resistance to Schistosoma mansoni: Role of mononuclear phagocytes in schistosomula killing in vitro, J. Clin. Invest 71: 66.PubMedGoogle Scholar
  139. Pereira, D. M., and Da, S. M., 1979, Sistemas HLA, ABO e Rh e características raciasis em pacientes corn hepatoesplenomegalia equistossomótica, Brasilia, Brazil, thesis, p. 152, University of Brasilia.Google Scholar
  140. Phillips, S. M., and Colley, D. G., 1978, Immunologic aspects of host responses to schistosomiasis: Resistance, immunopathology, and eosinophil involvement, Prog. Allergy 24: 49.PubMedGoogle Scholar
  141. Phillips. S. M., and Fox, E. G., 1982, The immunopathology of parasitic disease, in: Clinics of Immunology and Allergy, Vol. 2, no. 3, Immunoparasitology (A. Capron, ed.), p. 667, Fig. 1, W. B. Saunders, London.Google Scholar
  142. Phillips, S. M., and Zodda, D. M., 1983, Monoclonal Antibodies and Immunoparasitology in Monoclonal Antibodies, 2nd ed. (R. H. Kennett, T. J. McKearn, and K. B. Bechtol, eds.), Plenum Press, New York (in press).Google Scholar
  143. Phillips, S. M., DiConza, J. J., Gold, J. A., and Reid, W. A., 1977, Schistosomiasis in the congenitally athymic (nude) mouse. I. Thymic dependence of eosinophilia, granuloma formation and host morbidity, J. lmmunol 118: 594.Google Scholar
  144. Phillips, S. M., Reid, W. A., Doughty, B. L., and Bentley, A. G., 1980, The immunologic modulation of morbidity in schistosomiasis studies in athymic mice and in vitro granuloma formation, Am. J. Trop. Med. Hyg 29: 8.Google Scholar
  145. Piessens, W. F., 1981, Lymphatic filariasis in human: An immunologic maze, Ann. Intern. Med 95: 778.PubMedGoogle Scholar
  146. Piessens, W. F., McGreevy, P. B., Piessens, P. W., McGreevy, M., Kaman, I., Karoso, J. S., and Dennis, D. T., 1980a, Immune responses in human infections with Brugia malayi. Specific cellular unresponsiveness to filarial antigen, J. Clin. Invest 65: 172.PubMedGoogle Scholar
  147. Piessens, W. F., Ratiwayanto, S., Tuti, S., Palmieri, J. H., Piessens, P. W., Koiman, I., and Dennis, D. T., 1980b, Antigen-specific suppressor cells and suppressor factors in human filariasis with Brugia malayi, N. Engl. J. Med 302: 833.PubMedGoogle Scholar
  148. Piessens, W. F., Partono, F., Hoffman, S. L., Ratiwayanto, S., Piessens, P. W., Palmieri, J. R., Koiman, I., Dennis, D. T., and Carney, W. P., 1982, Antigen-specific suppressor T-lymphocyte in human lymphatic filariasis, N. Engl. J. Med 307: 144.PubMedGoogle Scholar
  149. Portaro, J., Britton, S., and Ash, L. R., 1976, Brugia pahangi: Depressed mitogen reactivity in filarial infection in the jird, Meriones unguiculatus, Exp. Parasitol 40: 438.PubMedGoogle Scholar
  150. Powell, M. R., and Damian, R. T., 1982, Schistosomiasis mansoni in baboons. VI. Plastic adherent cell suppression of the primary in vitro antibody response of peripheral blood mononuclear cells to a heterologous antigen (SRBC) during chronic infection, Am. J. Trop. Med. Hyg 31: 790.PubMedGoogle Scholar
  151. Reis, A. P., Katz, N., and Pellegrino, J., 1970, Immunodiffusion tests in patients with Schistosoma mansoni infection, Rev. Inst. Med. Trop. Sao Paulo 12: 245.PubMedGoogle Scholar
  152. Rocklin, R. E., Brown, A., Warren, K. S., Pelley, R. P., Houba, V., and Butterworth, A. E., 1977, Immunologic modulation in children with schistosomiasis, Clin. Res 25: 486AGoogle Scholar
  153. Rocklin, R. E., Tracy, J. W., and El Kholy, A. E., 1981, Activation of antigen-specific suppressor cells in human schistosomiasis mansoni by fractions of soluble egg antigens nonadherent to Con A sepharose, J. Immunol 127: 2314.PubMedGoogle Scholar
  154. Rogers, R., Denham, D. A., Nelson, G. S., Guy, F., and Ponnudurai, T., 1975, Studies with Brugia pahangi. III. Histological changes in the affected lymph nodes of infected cats, Am. J. Trop. Med. Parasitol 69: 77.Google Scholar
  155. Sadun, E. H., 1963, Immunization in schistosomiasis by previous exposure to homologous and heterologous cercariae by inoculation of preparations from schistosomes and by exposure to irradiated cercariae, Ann. NYAcad. Sci 113: 418.Google Scholar
  156. Sadun, E. H., 1972, Homocytophilic antibody response to parasitic infections, in: Immunity to Animal Parasites ( E. J. L. Soulsby, ed.), p. 97, Academic Press, New York.Google Scholar
  157. Sadun, E. H., von Lichtenberg, F., Cheever, A. W., and Erickson, D. G., 1970, Schistosomiasis mansoni in the chimpanzee. The natural history of chronic infections after single and multiple exposures, Am. J. Trop. Med. Hyg 29: 258.Google Scholar
  158. Sasazuki, T., Ohuta, N., Kanoeoka, R., and Kojima, S., 1980, Association between an HLA haplotype and low responsiveness to schistosomal worm antigen in man, J. Exp. Med 152: 314s.PubMedGoogle Scholar
  159. Scaglia, M., Tinelli, M., and Revoltella, L., 1979, Relationship between serum IgE levels and intestinal parasite load in African populations, Intl. Arch. Allergy 59: 465.Google Scholar
  160. Schacher, J. F., and Sayhoun, P. F., 1967, A chronological study of the histopathology of filariid disease in cats caused by Brugia pahangi (Buckley and Edeson, 1950), Trans. R. Soc. Trop. Med. Hyg. 61: 234.Google Scholar
  161. Schacher, J. F., Edesen, J. F. B., Salahian, A. and Rizk, G., 1973, An 18-month longitudinal lymphographie study of filarial disease in dogs infected with Brugia pahangi (Buckley and Edeson, 1956), Ann. Trop. Med. Parasitol 67: 81.PubMedGoogle Scholar
  162. Sher, A., and Scott, P. A., 1982, Genetic factors influencing the interactions of parasites with the immune system, in: Clinics in Immunology and Allergy, Vol. 2, no. 21, Immunoparasitology ( A. Capron, ed.), W. B. Saunders, London p. 489.Google Scholar
  163. Simpson, C. F., and Neilson, J. T. M., 1976, The pathology associated with single and quadruple infections of hamsters with Dipetalonema viteae, Tropenmed. Parasitol 27: 349.PubMedGoogle Scholar
  164. Smith, M. D., 1977, The ultrastructural development of the schistosome egg granuloma in mice, Parasitology 75: 119.PubMedGoogle Scholar
  165. Smithers, S. R., and Terry, R. J., 1969, The immunology of schistosomiasis,Adv. Parasitol. 7: 41.Google Scholar
  166. Smithers, S. R., and Terry, R. J., 1976, The immunology of schistosomiasis, in: Advances in Parasitology, ( B. Dawes, ed.), Vol. 14, p. 399, Academic Press, New York.Google Scholar
  167. Spry, C. J. F., 1981, Alterations in blood eosinophil morphology, binding capacity for cornplexed IgE and kinetitics in patients with tropical (filarial) eosinophilia, Parasite ImmunoL 3: 1.PubMedGoogle Scholar
  168. Staninuas, R. J., and Hammerberg, B., 1982, Diethylcarbamazine enhanced activation of complement by intact microfilariae of Dirofilaria immitis and their in vitro products, J. Parasitol 68: 809.Google Scholar
  169. Stenger, R. J., Warren, K. S., and Johnson, E. A., 1967, An ultrastructural study of hepatic granulomas and schistosome egg shells in murine hepatosplenic schistosomiasis mansoni, Exp. Mol. Pathol 8: 116.Google Scholar
  170. Suemura, M., Yodoi, J. Hirashima, M., and Ishizaka, K., 1980, Regulatory role of IgEbinding factors from rat T-lymphocytes. I. Mechanism of enhancement of IgE response by IgE-potentiating factor, J. Immunol 125: 148.Google Scholar
  171. Suzuki, T., and Damian, R. T., 1981, Schistosomiasis mansoni in baboons. IV. The development of antibodies to Schistosoma mansoni adult worm, egg, and cercarial antigens during acute and chronic infections, Am. J. Trop. Med. Hyg 30: 825.PubMedGoogle Scholar
  172. Symmers, W., St. C., 1903, Note on a new form of liver cirrhosis due to the presence of the ova of Bilharzia haematobia, J. Pathol. Bacteriol 9: 237.Google Scholar
  173. Tada, T., Kondo, Y., Okumura, K., Sano, M., and Yokogawa, M., 1975, Schistosoma japon- icum: Immunopathology of nephritis inMacaca fascicularis, Exp. Parasitol 38: 291.Google Scholar
  174. Todd, C.W., Goodgame, R. W., and Colley, D.G., 1979, Immune responses during human schistosomiasis mansoni. V. Suppression of schistosome antigen-specific lymphocyte blastogenesis by adherent phagocytic cells, J. Immunol 122: 1440.PubMedGoogle Scholar
  175. Tsang, V. C. W., Hubbard, W. J., and Damian, R. T., 1977, Coagulation Factor XIIa (Activated Hageman Factor) inhibitor from adult Schistosoma mansoni, Am. J. Trop. Med. Hyg 26: 243.PubMedGoogle Scholar
  176. Tsutsumi, H., and Nakashima, T., 1972, Pathology of liver cirrhosis due to Schistosoma japonicum, in: Research in Filariasis and Schistosomiasis ( M. Yokogawa, ed.), p. 133, University Park Press, Baltimore.Google Scholar
  177. Urban, J. F., Jr., and Ishizaka, K., Jr., 1977, IgE formation in the rat following infection with Nippostrongylus brasiliensis. III. Soluble factor for the generation of IgE bearing lymphocytes, J. Immunol 119: 583.PubMedGoogle Scholar
  178. Vadas, M. A., David, J. R., Butterworth, A. E., Pisari, N. T., and Siogok, T. A., 1979, A new method for the purification of human eosinophils and neutrophils, and comparison of the ability of these cells to damage schistosomula of Schistosoma mansoni, J. Immunol 122: 1228.PubMedGoogle Scholar
  179. Verwaede, C., Grzych, J. M., Bazin, H., Capron, M., and Capron, A., 1979, Production d’anticorps monoclonaux anti-Schistosoma mansoni. Etude préliminaire de leurs activités biologiques, Comptes Rendus de l’Academic des Sciences, Paris (D) 289: 725.Google Scholar
  180. Vincent, A. L., Ash, L. R., Rodrick, G. E., and Sodeman, W. A., 1980, The lymphatic pathology of Brugia pahangi in the mongolian jird, J. Parasitol 66: 613.PubMedGoogle Scholar
  181. von Lichtenberg, F., 1964, Studies on granuloma formation. III. Antigen sequestration and destruction in the schistosome pseudotubercle, Am. J. Pathol. 45: 75.Google Scholar
  182. von Lichtenberg, F., and Byram, J. C., 1980, Pulmonary cell reactions and resistance to Schistosoma mansoni, in: The Host-Invader Interplay ( H. van Den Bossche, ed.), p. 405, Elsevier-North Holland, Amsterdam.Google Scholar
  183. von Lichtenberg, F., Erickson, D. G., and Sadun, E. H., 1973, Comparative histopathology of schistosome granulomas in the hamster, Am. J. Pathol 72: 149.Google Scholar
  184. von Lichtenberg, F., Bawden, M.P., and Shealey, S. H., 1974, Origin of circulating antigen in the schistosome gut. An immunofluorescent study, Am. J. Trop. Med. Hyg 23: 1088Google Scholar
  185. von Lichtenberg, F., Sher, A., and Maclntyre, S., 1977, A lung model of schistosome im-munity in mice, Am. J. Pathol 87: 105.Google Scholar
  186. Walker, L., Hay, F. C., and Roitt, I. M., 1979, Characteristics of complexes for arming and inhibiting effector cells for antibody-dependent cell-mediated cytotoxicity, Clin. Exp. Immunol. 36: 397.Google Scholar
  187. Waltzing, P. and Bloch-Michel, H., 1971, Le phénomène des rosettes filarennes: Intérêt pour le diagnostic des arthrites filarennes, 30: 2061.Google Scholar
  188. Warren, K. S., 1971, Worms, in: Immunological Diseases, 2nd ed. ( M. Samter, ed.), p. 668, Boston, Little, Brown.Google Scholar
  189. Warren, K. S., 1972a, The immunopathogenesis of schistosomiasis: A multidisciplinary approach, Trans. R. Soc. Trop. Med. Hyg. 66: 417.PubMedGoogle Scholar
  190. Warren, K. S., 1972b, Pipe-stem fibrosis of the liver, Trans. R. Soc. Trop. Med. Hyg 66: 946Google Scholar
  191. Warren, K. S., 1973, The pathology of schistosome infections, Helminthol. Abstr. (A) 42: 591.Google Scholar
  192. Warren, D. S., 1974, Modulation of immunopathology in schistosomiasis, in: Parasites in the Immunized Host: Mechenisms of Survival, Ciba Foundation Symposium No. 25, p. 243, Elsevier North-Holland, Amsterdam.Google Scholar
  193. Warren, K. S., 1982, The secret of immunopathogenesis of schistosomiasis in vivo models, Immunol. Rev 61: 189.PubMedGoogle Scholar
  194. Warren, K. S., Reboucas, G., and Baptista, A. G., 1965, Ammonia metabolism and hepatic coma in hepatosplenic schistosomiasis. Patients studied before and after portacaval shunt, Ann. Intern. Med 62: 1113.PubMedGoogle Scholar
  195. Warren, K. S., Domingo, E. O., and Cowan, R. B. T., 1967, Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity, Am. J. Pathol 51: 735PubMedGoogle Scholar
  196. Warren, K. S., Boros, D. L., Hang, L. M., and Mahmoud, A. A. F., 1975, Schistosoma japonicum egg granuloma, Am. J. Pathol 80: 279.PubMedGoogle Scholar
  197. Warren, K. S.,, Grove, K. I., and Pelley, R. P., 1978; Schistosoma japonicum egg granuloma. II. Cellular composition, granuloma size, and immunologic concomitants, Am. J. Trop. Med. Hyg 27: 271.Google Scholar
  198. Webb, J. K. G., Job, C. K., and Gault, E. W., 1960, Tropical eosinophilia: Demonstration of microfilariae in lung, liver, and lymph nodes, Lancet 7129: 835.Google Scholar
  199. Webster, E. H., 1946, Filariasis among white immigrants in Samoa, U.S. Nay. Med. Bull 46: 186.Google Scholar
  200. Wei-Hsin, C., 1958, Acute schistosomiasis. Clinical manifestations of 96 cases, Chinese Med. J 76: 1.Google Scholar
  201. Weinstock, J. V., and Boros, D. L., 1981, Heterogeneity of the granulomatous response in the liver, colon, ileum, and ileal Peyer’s patches to schistosome eggs in murine schistosomiasis mansoni, J. Immunol 127: 1906.PubMedGoogle Scholar
  202. Weinstock, J. V., Boros, D. L., Gee, J. B., and Ehrinpreis, M. N., 1981, The effect of SQ14225, an inhibitor of angiotensin I converting enzyme on the granulomatous response to Schistosoma mansoni eggs in mice, J. Clin. Invest 67: 931.PubMedGoogle Scholar
  203. Weiss, N., Sturchler, D., and Dietrich, F. M., 1978, Radioallosorbent and indirect fluorescent antibody tests in immunodiagnosis of schistosomiasis, Lancet 2: 1231.PubMedGoogle Scholar
  204. Wellhausen, S. R., Chensue, S. W., and Boros, D. L., 1980, Modulation of granulomatous hypersensitivity. Analysis by adoptive transfer of effect and suppressor T lymphocytes involved in granulomatous inflammation in murine schistosomiasis, in: Basic and Clinical Aspects of Granulomatous Diseases ( D. L. Boros and T. Yoshida, eds.), p. 219, Elsevier North-Holland, Amsterdam.Google Scholar
  205. World Health Organization, 1976, Epidemiology of onchocerceriasis, Tech. Rep. Ser 597: 94.Google Scholar
  206. World Health Organization, 1981, Immunology of filariasis, Bull. WHO 59: 1.Google Scholar
  207. Wyler, D. H., and Postlethwaite, A. E., 1983, Fibroblast stimulation in schistosomiasis, 130: 1371.Google Scholar
  208. Wyler, D. H., Wahl, S. M., and Wahl., L. M., 1978, Hepatic fibrosis in schistosomiasis: Egg granulomas secrete fibroblast stimulating factor in vitro, Science 202: 438.PubMedGoogle Scholar
  209. Wyler, D. H., Weinbaum, F. I., and Herrod, H. R., 1979, Characterization of in vitro proliferative responses of human lymphocytes to leishmanial antigens, J. Infect. Dis 140: 215.PubMedGoogle Scholar
  210. Zvaifler, N. J., Sadun, E. H., Becker, E. L., and Schoenbechler, M. J., 1967, Demonstration of homologous anaphylactic antibody in rabbits infected with Schistosoma mansoni, Ex. Parasitol 20: 278.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • S. Michael Phillips
    • 1
  • Edward G. Fox
    • 1
  1. 1.Allergy and Immunology SectionUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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