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Immunopathology of Parasitic Diseases: A Conceptual Approach

  • Chapter
Immunobiology of Parasites and Parasitic Infections

Part of the book series: Contemporary Topics in Immunobiology ((CTI,volume 12))

Abstract

The pathology caused by parasites, the most prevalant infectious diseases of humankind, can be divided into two major aspects: the first relates to the effects of the parasite per se, e.g., iron deficiency anemia, secondary to blood loss caused by intestinal nematodes; hemolytic anemia, secondary to intracellular protozoans; or hepatobiliary fibrosis, secondary to toxic products produced by intraductal trematodes. However, in many parasitic conditions there is limited pathology directly attributable to the parasite. Most host morbidity is related to the immunoinflammatory response of the host to the parasite. This reaction is the principal subject of this chapter.

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References

  • Abdel-Hafez, S. K., Phillips, S. M., and Zodda, D. M., 1983, Schistosoma mansoni: Detection and characterization of antigens and antigenemia in inhibition enzyme-linked immunosorbent assay (IELISA), Exp. Parasitol 55: 219.

    PubMed  CAS  Google Scholar 

  • Abdel-Salam, E., Ishaac, S., and Mahmoud, A. A. F., 1979, Histocompatibility-linked susceptibility for hepatosplenomegaly in human schistosomiasis mansoni, J. Immunol 123: 1829.

    Google Scholar 

  • Ackerman, S. J., Gleich, G. J., Weller, P. F., and Ottesen, E. A., 1981, Eosinophilia and elevated serum levels of eosinophil major basic protein and Charcot-Leyden crystal protein (lysophospholipase) after treatment of patients with Bancroft’s filariasis, J. Immunol 127: 1093.

    PubMed  CAS  Google Scholar 

  • Andrade, Z. A., and Andrade, S. G., 1970, Pathogenesis of schistosomal pulmonary arteritis, Am. J. Trop. Med. Hyg 19: 305.

    PubMed  CAS  Google Scholar 

  • Andrade, Z. A., and Warren, K. S., 1964, Mild prolonged schistosomiasis in mice: Alterations in host response with time and the development of portal fibrosis, Trans, R. Soc. Trop. Med. Hyg 58: 53.

    CAS  Google Scholar 

  • Askenase, F. W., Hayden, B., and Higashi, G. I., 1976, Cutaneous basophil hypersensitivity and inhibited macrophage migration in guinea pigs with schistosomiasis, Clin. Exp. Immunol 23: 318.

    Google Scholar 

  • Barrett-Connor, E., 1982, Concise clinical studies: Parasite pulmonary disease, Am. Rev. Respir. Dis 126: 558.

    PubMed  CAS  Google Scholar 

  • Benjamin, D., and Soulsby, E. J. L., 1976, Homocytotropic and hemagglutinating antibody responses to Brugia pahangi infection in the multimmate rat (Mastomys natalensis), Am. J. Trop. Med. Hyg 25: 266.

    PubMed  CAS  Google Scholar 

  • Bentley, A. G., Doughty, B. L., and Phillips, S. M., 1982, Ultrastructural analysis of the cellular response to Schistosoma mansoni: III. The in vitro granuloma, Am. J. Trop. Med. Hyg 316: 1168.

    Google Scholar 

  • Billings, F. T., Winkenwerder, W. L., and Huninen, A. V., 1946, Studies of acute schistosomiasis japonica in the Philippine Islands: I. A clinical study of 337 cases with a preliminary report on the results of treatment with Faudin in 110 cases, Bull. John Hopkins Hosp 78: 21.

    PubMed  CAS  Google Scholar 

  • Bloch, E. H., Abdel-Wahab, M. F., and Warren, K. S., 1972, In vivo microscopic observations of the pathogenesis and pathophysiology of hepatosplenic schistosomiasis in the mouse liver, Am. J. Trop. Med. Hyg 21: 546.

    CAS  Google Scholar 

  • Boros, D. L., and Warren, K. S., 1970, Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma monsoni eggs, J. Exp. Med 132: 488.

    PubMed  CAS  Google Scholar 

  • Bosworth, W., Ewert, A., and Bray, J., 1973, The interaction of Brugia malayi and streptococcus in an animal model, Am. J. Trop. Med. Hyg 22: 714.

    PubMed  CAS  Google Scholar 

  • Bout, D., Santoro, F., Carlier, Y., Bina, J. C., and Capron, A., 1977, Circulating immune complexes in schistosomiasis, Immunology 33: 17.

    PubMed  CAS  Google Scholar 

  • Buchanan, R. D., Fine, D. P., and Colley, D. G., 1973, Schistosoma mansoni infection in mice depleted of thymus-dependent lymphocytes. II. Pathology and altered pathogenesis, Am. J. Pathol 71: 207.

    CAS  Google Scholar 

  • Butterworth, A. E., Sturrock, R. S., Houba, V., and Reese, P. H., 1974, Antibody- dependent cell-mediated damage to schistosomula in vitro, Nature (Lond.) 252: 503.

    CAS  Google Scholar 

  • Butterworth, A. E., Sturrock, R. S., Houba, V., Mahmoud, A. A. F., Sher, A., and Reese, P. H., 1975, Eosinophils as mediators of antibody-dependent cell-mediated damage to schistosomula, Nature (Land) 256: 727.

    CAS  Google Scholar 

  • Butterworth, A. E., Wassom, D. L., Gleich, G. J., and Loegering, D. A., and David, J. R., 1979a, Damage of schistosomula of Schistosoma mansoni induced directly by eosinophil major basic protein, J. Immunol 122: 221.

    PubMed  CAS  Google Scholar 

  • Butterworth, A. E., Vadas, M. A., Martz, E., and Sher, A., 1979b, Cytolytic T lymphocytes recognize alloantigens of schistosomula of Schistosoma mansoni but fail to induce damage, J. Immunol 122: 1314.

    PubMed  CAS  Google Scholar 

  • Byram, J. E., and von Lichtenberg, F., 1981, Altered schistosome granuloma formation in nude mice, Am. J. Trop. Med. Hyg 26: 944.

    Google Scholar 

  • Canto, A. L., Sesso, A., and de Brito, T., 1977, Human chronic mansonian schistosomiasiscell proliferation and fibre formation in the hepatic sinusoidal wall: A morphometric, light and electron-microscopy study, J. Pathol 123: 35.

    PubMed  CAS  Google Scholar 

  • Capron, A. R. G., and Dessaint, J. P., 1982, Schistosome as a potential source of immunological pharmocologic agents, in: Clinics in Immunology and Allergy, Vol. 2: Immunopharmocology (A. Capron, ed.), No. 3., p. 613, W. B. Saunders, London.

    Google Scholar 

  • Capron, A., Dessaint, J. P., Capron, M., and Bazin, H., 1975, Specific IgE antibodies in immune adherence of normal macrophages to Schistosoma mansoni schistosomules, Nature (London). 253: 474.

    CAS  Google Scholar 

  • Capron, A., Dessaint, J. P., Joseph, M., Torpier, G., Capron, M., Rousseaux, R., Santoro, F., and Bazin, H., 1977, IgE and cells in schistosomiasis, Am. J. Trop. Med. Hyg 26 (Suppl.): 39.

    PubMed  CAS  Google Scholar 

  • Capron, A., Dessaint, J. P., Capron, M., et al., 1980, Role of anaphylactic antibodies in immunity to schistosomes, Am. J. Trop. Med. Hyg. 29: 849.

    PubMed  CAS  Google Scholar 

  • Capron, A., Dessaint, J. P., and Capron, M., 1982, Effector mechanisms and their regulation, Immunol. Rev 61: 41.

    PubMed  CAS  Google Scholar 

  • Capron, M., Capron, A., and Torpier, G., 1978, Eosinophil-dependent cytotoxicity in rat schistosomiasis. Involvement of IgG2a antibody and role of mast cells, Eur. J. Immunol 8: 127.

    PubMed  CAS  Google Scholar 

  • Capron, M., Capron, A., Dessaint, J. P., et al., 198la, Fc receptors on human and rat eosinophils, J. Immunol 126: 2087.

    Google Scholar 

  • Capron, M., Capron, A., Goetzl, E. J., and Austen, K. F., 1981b, Tetrapeptides of the eosinophil chemotactic factor of anaphylaxis (ECF-A) enhance eosinophil Fc receptor, Nature (bond.) 289: 71.

    CAS  Google Scholar 

  • Carme, B., and Laigret, J., 1979, Longevity of Wuchereria bancrofti var. pacifica and mosquito infection acquired from a patient with low level parasitemia, Am. J. Trop. Med. Hyg 28: 53.

    PubMed  CAS  Google Scholar 

  • Cheever, A. W., 1968, A quantitative post-mortem study of schistosomiasis mansoni in man, Am. J. Trop. Med. Hyg 17: 38.

    PubMed  CAS  Google Scholar 

  • Cheever, A. W., 1972, Pipe-stem fibrosis of the liver, Trans. R. Soc. Trop. Med. Hyg. 66: 946.

    Google Scholar 

  • Cheever, A. W., and Warren, K. S., 1964, Hepatic blood flow in mice with acute hepatosplenic schistosomiasis mansoni, Trans. R. Soc. Trop. Med. Hyg 58: 406.

    PubMed  CAS  Google Scholar 

  • Chensue, S. W., and Boros, D. L., 1979a, Population dynamics of T- and B-lymphocytes in the lymphoid organs, circulation and granulomas of mice infected with Schistosoma mansoni, Am. J. Trop. Med. Hyg 28: 291.

    PubMed  CAS  Google Scholar 

  • Chensue, S. W., and Boros, D. L., 1979b, Modulation of granulomatous hypersensitivity. I. Characterization of T-lymphocytes involved in the adoptive suppression of granuloma formation of in Schistosoma mansoni-infected mice, J. Immunol 123: 1409.

    PubMed  CAS  Google Scholar 

  • Chensue, S. W., Boros, D. L., and David, C. S., 1980, Regulation of granulomatous inflammation in murine schistosomiasis. In vitro characterization of T lymphocyte subsets involved in the production and suppression of migration inhibition factor, J. Exp. Med. 151: 1398.

    Google Scholar 

  • Chensue, S. W., Wellhausen, S. R., and Boros, D. L., 1981, Modulation of granulomatous hypersensitivity. II. Participation of Ly-1* and Ly-2* T lymphocytes in the suppression of granuloma formation and lymphokine production in Schistosoma mansoni-infected mice, J. Immunol 127: 363.

    PubMed  CAS  Google Scholar 

  • Chensue, S. W., Boros, D. L., and David, C. S., 1983, Regulation of granulomatous inflammation in murine schistomiasis. II. T-suppressor cell-derived, I-C subregion-coded soluble suppressor factor mediates regulation of lymphokine production, J. Exp. Med 157: 219.

    PubMed  CAS  Google Scholar 

  • Colley, D. G., 1976, Adoptive suppression of granuloma formation, J. Exp. Med 143: 696

    PubMed  CAS  Google Scholar 

  • Colley, D. G., 1981, Immune responses and immunoregulation in experimental and clinical schistosomiasis, in: The Immunology of Parasitic Diseases, Vol. 1 (J. M. Mansfield, ed.), pp. 1–83, Marcel Dekker, New York.

    Google Scholar 

  • Colley, D. G., Megalhaes-Filho, Barros-Coelho, R., 1972, Immunopathology of dermal reactions induced by Schistosoma mansoni cercariae and cercarial extract, Am. J. Trop. Med. Hyg 21: 558.

    Google Scholar 

  • Colley, D. G., Savage, A. M., and Lewis, F. A., 1977, Host responses induced and elicited by cercariae, schistosomula and cercarial antigenic preparations, Am. J. Trop. Med. Hyg 26 (Suppl.): 88.

    PubMed  CAS  Google Scholar 

  • Colley, D. G., Lewis, F. A., and Todd, C. W., 1979, Adoptive suppression of granuloma formation by T lymphocytes by lymphoid cells sensitive to cyclophosphamide, Cell Immunol. 45: 192.

    Google Scholar 

  • Coulis, P. A., Lewert, R. M., and Fitch, T. W., 1978, Splenic suppressor cells and cell-mediated immunity in murine schistosomiasis, J. Immunol 120: 1074.

    PubMed  CAS  Google Scholar 

  • Crandall, R. B., McGreevey, P. B., Connor, D. H., Crandall, C. A., Neilson, J. T., and McCall, J. W., 1982, The ferret (Mustela putorius furo) as an experimental host for Brugia malay i and Brugia pahangi, Am. J. Trop. Med. Hyg 31: 752.

    PubMed  CAS  Google Scholar 

  • Crowell, W. A., Malone, J. B., Chapman, W. L., and Thompson, P. E., 1973, Amyloidosis in mongolian gerbils infected with Litomosoides carinii, J. Am. Vet. Med. Assoc 163: 596

    Google Scholar 

  • Danaraj, T. J., 1951, Eosinophilic lung, in: A study of 150 cases seen in Singapore, p. 57, Papineau Studios, Singapore.

    Google Scholar 

  • Date, A., Shastry, J. C. M., and Johny, K. V., 1979, Ultrastructural glomerular changes in filarial chyluria, J. Trop. Med. Hyg 82: 150.

    PubMed  CAS  Google Scholar 

  • Date, A., Pandandatti, T., Vaska, P. H., and Shastry, J. C. M., 1980, Lymphocytopenia in chyluria, Trans. R. Soc. Trop. Med. Hyg 74: 137.

    PubMed  CAS  Google Scholar 

  • Date, A., John, T. J., Chandy, K. G., Rajapopalan, M. S., Vaska, P. H., Pundey, A. P., and Shastry, J. C. M., 1981, Abnormalities of the immune system in patients with chyluria, Br. J. Urol 53: 384.

    PubMed  CAS  Google Scholar 

  • Date, A., Shastry, J. C. M., Vaska, P. H., Pundey, A. P., Sridaran, G., and Koshi, G., 1982, Complement in chyluria, Trans. R. Soc. Trop. Med. Hyg 76: 238.

    PubMed  CAS  Google Scholar 

  • Davis, B. H., Mahmoud, A. A. F., and Warren, K. S., 1974, Granulomatous hypersensitivity to Schistosoma mansoni eggs in thymectomized and bursectomized chickens, J. Immunol 113: 1064.

    PubMed  CAS  Google Scholar 

  • des Moutis, I., Ouaisse, R., Grzych, J. M., Yarzabal, L., Hague, A., and Capron, A., 1982, Onchocerca vovulus: Detection of circulating antigen by monoclonal antibodies in human onchocerciasis,Am. J. Trop. Med. Hyg 32: 533.

    Google Scholar 

  • Desowitz, R. S., Barnwell, J. W., Palumbo, N. E., Una, S. R., and Perri, S. F., 1978, Rapid increase of precipitating and reagenic antibodies in Dirofilaria immitis infected dogs which develop severe adverse reactions following treatment with diethylcarbamazine, Am. J. Trop. Med. Hyg 27: 1148.

    PubMed  CAS  Google Scholar 

  • Dessaint, J. P., 1982, Anaphylactic antibodies and their significance, in: Clinics in Immunology and Allergy, Vol. 2, no. 3: Immunoparasitology ( A. Capron, ed.), p. 621, W. B. Saunders, London.

    Google Scholar 

  • Dessaint, J. P., Capron, M., Bout, D., and Capron, A., 1975, Quantitative determination of specific IgE antibodies to schistosome antigens and serum IgE level in patients with schistosomiasis (S. mansoni or S. haematobium), Clin. Exp. Immunol 20: 427.

    Google Scholar 

  • Dessaint, J. P., Torpier, G., Capron, M., and Bazin, H., 1979, Cytophilic binding of IgE to the macrophage. I. Binding characteristics of IgE on the surface of macrophages in the rat, Cell. Immunol 46: 12.

    PubMed  CAS  Google Scholar 

  • Diaz-Rivera, R. S., Ramos-Morales, F., Koppisch, E., Garcia-Palmieri, M. R., CintronRivera, A. A., Marchand, E. J., Gonzalez, O., and Torregrosa, M. V., 1956, Acute Manson’s schistosomiasis, Am. J. Med 21: 918.

    PubMed  Google Scholar 

  • Doenhoff, M., Musallan, R., Bain, J., and McGregor, A., 1979, Schistosoma mansoni infections in T-cell deprived mice, and the ameliorating effect of administering homologous chronic infection serum. I. Pathogenesis, Am. J. Trop. Med. Hyg 28: 260.

    CAS  Google Scholar 

  • Domingo, E. O., and Warren, K. S., 1967, The inhibition of granuloma formation around Schistosoma mansoni eggs. II. Thymectomy, Am. J. Pathol 51: 757.

    PubMed  CAS  Google Scholar 

  • Domingo, E. O., and Warren, K. S., 1968, Endogeneous densitization: Changing host granulomatous response to schistosome eggs at different stages of infection with Schistosoma mansoni; Am. J. Pathol. 52: 369.

    PubMed  CAS  Google Scholar 

  • Doughty, B. L., and Phillips, S. M., 1982a, Delayed hypersensitivity granuloma formation around Schistosoma mansoni eggs in vitro. I. Definition of the model, J. Immunol 128: 30.

    PubMed  CAS  Google Scholar 

  • Doughty, B. L., and Phillips, S. M., 1982b, Delayed hypersensitivity granuloma formation around Schistosoma mansoni eggs in vitro. II. Regulatory T-cell subsets, J. Immunol 128: 37.

    PubMed  CAS  Google Scholar 

  • Elmer, J. J., Olds, G. R., Kamel, R., Osman, G. S., El Kholy, A., Mahmoud, A. A. F., 1980, Suppressor splenic T lymphocytes in human hepatosplenic schistosomiasis mansoni, J. Immunol 125: 308.

    Google Scholar 

  • Ellner, J. J., Olds, G. R., Lee, C. W., and Clinhenz, M. E., 1982, Destruction of multi-cellular parasite Schistosoma mansoni by T-lymphocytes, J. Clin. Invest 70: 369.

    PubMed  CAS  Google Scholar 

  • Epstein, W. L., Fukuyama, K., Danno, K., and Kwan-Wong, E., 1979, Granulomatous hypersensitivity inflammation in normal and athymic mouse infected with S. mansoni: An ultrastructural study, J. Pathol 127: 207.

    PubMed  CAS  Google Scholar 

  • Fox, E. G., 1979, The pathology, immunology and immunogenetics of Brugia infection in syngeneic rats, Doctoral dissertation, University of California, Los Angeles.

    Google Scholar 

  • Fuglsang, H., Anderson, J., and de Marshall, T. F., 1979, Studies on onchocerciasis in the United Cameroon Republic. V. A four year follow-up of 6 rain-forest and 6 Sudan savanna villages. Some changes in skin and lymph nodes, Trans. R. Soc. Trop. Med. Hyg. 73: 118.

    CAS  Google Scholar 

  • Galvao-Castro, B., Bina, J., Prata, A., and Lambert, P. H., 1981, Correlation of circulating immune complexes and complement breakdown products with the severity of the disease in human schistosomiasis mansoni, Am. J. Trop. Med. Hyg 30 (6): 1238.

    PubMed  CAS  Google Scholar 

  • Garb, K. S., Stavitsky, A. B., and Mahmoud, A. A. F., 1981, Dynamics of antigen and mitogen-induced responses in schistosomiasis japonica: In vitro comparison between hepatic granulomas and splenic cells, J. Immunol 127: 115.

    PubMed  CAS  Google Scholar 

  • Garb, K. S., Stavitsky, A. B., Olds, G. R., Tracy, J. W., and Mahmoud, A. A. F., 1982, Immune regulation in murine schistosomiasis japonica: Inhibition of in vivo antigen-and mitogen-induced cellular responses by splenocyte culture supernatants and by purified fractions from serum of chronically infected mice, J. Immunol 129 (6): 2752.

    PubMed  CAS  Google Scholar 

  • Gazzinelli, G., Ramalho-Pinto, F. J., and Dias da Silva, W., 1969, Schistosoma mansoni generation of anaphylatoxin by cercarial extracts, Exp. Parasitol 28: 86.

    Google Scholar 

  • Goodwin, L. G., Green, D. G., Guy, M. W., and Voller, A., 1972, Immunosuppression during trypanosomiasis, Br. J. Exp. Pathol 53: 40–43.

    PubMed  CAS  Google Scholar 

  • Green, W. F., and Colley, D. G., 1981, Modulation of Schistosoma mansoni egg-induced granuloma formation: I-J restriction of T-cell-mediated suppression in a chronic parasitic infection, Proc. Natl. Acad. Sci. USA 78: 1152.

    PubMed  CAS  Google Scholar 

  • Greenwood, B. M., and Whittle, H. C., 1981, Immunology of medicine, in: Current Topics in Immunology Series, Vol. 14 (J. Turk, ed.), Edward Arnold, London.

    Google Scholar 

  • Greenwood, B. M., Bradley-Moore, A. M., Poalit, A., and Bryceson, A. D. M., 1972, Immunosuppression in children with malaria, Lancet 1: 169.

    PubMed  CAS  Google Scholar 

  • Grove, D. I., and Forbes, I. J., 1979, Immunosuppression in Bancroftian filariasis, Trans. R. Soc. Trop. Med. Hyg. 73: 23.

    PubMed  CAS  Google Scholar 

  • Gutekunst, R. R., Browne, H. G., and Meyers, D. M., 1965, Influence of Schistosoma mansoni eggs on growth of monkey heart cells, Exp. Parasitol. 17: 194.

    PubMed  CAS  Google Scholar 

  • Hang, L. M., Warren, K. S., and Boros, D. L., 1974, Schistosoma mansoni: Antigenic secretions and the etiology of egg granulomas in mice, Exp. Parasitol. 35: 288.

    PubMed  CAS  Google Scholar 

  • Hague, A., Camus, D., Ogilvie, B. M., Capron, M., Bazin, H., and Capron, A., 1981, Dipetalonema viteae infective larvae reach reproductive maturity in rats immunodepressed by prior exposure to Schistosoma mansoni or its products and in congenitally athymic rats, Clin. Exp. Immunol 143: 1.

    Google Scholar 

  • Henson, P. M., Mackenzie, C. D., and Spector, W. G., 1979, Inflammatory reactions in onchocerciasis: A report on current knowledge and recommendations for further study, Bull. WHO 57: 667.

    PubMed  CAS  Google Scholar 

  • Hiatt, R. A., Sotomayor, Z. R., Sanchez, G., Zambrana, M., Knight, W. B., 1979, Factors in the pathogenesis of acute schistosomiasis mansoni, J. Infect. Dis. 139: 659.

    PubMed  CAS  Google Scholar 

  • Hillyer, G. V., 1969, Immunoprecipitins in Schistosoma mansoni infections. IV. Human infections, Exp. Parasitol 25: 376.

    PubMed  CAS  Google Scholar 

  • Hillyer, G. V., 1973, Schistosome deoxyribonucleic acid (DNA), antibodies to DNA in schistosome infections, and their possible role in renal pathology, Boletin Asociancion Medica de Puerto Rica, 65 (Suppl.): 1.

    Google Scholar 

  • Hillyer, G. V., Hernandez-Almenas, N., Knight, W. B., and Cline, B., 1976, Circulating antigens, antibodies and immunoglobulins in the serum of humans with schistosomiasis mansoni, Biol. Assoc. Med. P. R 68: 128.

    CAS  Google Scholar 

  • Houba, F. Sturrock, R. F., and Butterworth, A. E., 1977, Kidney lesions in baboons infected with Schistosoma mansoni, Clin. Exp. Immunol 30: 439.

    CAS  Google Scholar 

  • Houba, V., 1979, Experimental renal disease due to schistosomiasis, Kidney Int. 16: 30.

    PubMed  CAS  Google Scholar 

  • Hsü, H. F., Davis, J. R., Hsü, S. Y. L., and Osborne, J. W., 1963, Histopathology in albino mice and Rhesus monkeys infected with irradiated cercariae of Schistosoma japonicum, Z. Tropenmed. Parasitol 14: 240.

    Google Scholar 

  • Hsü, S. Y. L., Davis, J. R., and Hsü, H. F., 1965, Histopathology in rhesus monkeys infected four times with the Formosan strain of Schistosoma japonicum, Z. Tropenmed. Parasitol 16: 297.

    Google Scholar 

  • Hsü, C. K., Hsü, S. H., Whitney, R. A., Jr., and Hansen, C. T., 1976, Immunology of schistosomiasis in athymic mice, Nature (Lond.) 262: 397.

    Google Scholar 

  • Ishizaka, T., Urban, J., Jr., Tatatsu, K., and Ishizaka, K., 1976, Immunoglobulin E synthesis in parasite infection, J. Allergy Clin. Immunol. 58: 523.

    CAS  Google Scholar 

  • Jarrett, E. E. E., 1978, Stimuli for the production and control of IgE in rats, Immunol. Rev 41: 52.

    PubMed  CAS  Google Scholar 

  • Kane, C. A., and Most, H., 1948, Schistosomiasis of the central nervous system: Experiences in World War II and a review of the literature, Arch. Neurol. Psychol 59: 141.

    CAS  Google Scholar 

  • Karavodin, L. M., and Ash, L. R., 1980, Circulating immune complexes in experimental filariasis, Clin. Exp. Immunol 40: 312.

    PubMed  CAS  Google Scholar 

  • Kasukawa, R., Okada, M., and Igari, S., 1980, Receptors for IgG, Fc and complement in the mammalian aorta, Int. Arch. Allergy Appl. Immunol 61: 175.

    PubMed  CAS  Google Scholar 

  • Kazura, J. W., Fauning, M. M., Blumer, J. L., and Mahmoud, A. A. F., 1981, Role of cell generated hydrogen peroxide in granulocyte mediated killing of schistosomula of Schistosoma mansoni in vitro, J. Clin. Invest 67: 93.

    PubMed  CAS  Google Scholar 

  • Klei, T. R., McCall, J. W., and Malone, J. B., 1980, Evidence for increased susceptibility of Brugia pahangi-infected jirds (Meriones unguiculatus) to subsequent homologous infections, J. Helminthol 54: 161.

    PubMed  CAS  Google Scholar 

  • Klei, T. R., Enright, F. M., Blanchard, D. P., and Uhl, S. A., 1981, Specific hypo-responsive granulomatous tissue reactions in Brugia pahangi infected jirds,Acta Trop. 38: 267.

    CAS  Google Scholar 

  • Klei, T. R., Enright, F.M., Blanchard, D. P., and Uhl, S. A., 1982, Effects of presensitization of the development of lymphatic lesions in Brugia pahangi infected jirds, Am. J. Trop. Med. Hyg 31: 280.

    PubMed  CAS  Google Scholar 

  • Knight, D. A., 1979, Pathophysiology of canine dirofilariasis, Am. Coll. Vet. Inst. Med. Sci. Proc. p. 41.

    Google Scholar 

  • Lambert, P. H., 1978, A WHO collaborative study for the evaluation of eighteen methods for detecting immune complexes in serum, J. Clin. Lab. Immunol 1: 1.

    Google Scholar 

  • Lawley, T. J., Ottesen, R. A., Hiatt, R. A., and Gazze, L. A., 1979, Circulating immune complexes in acute schistosomiasis, Clin. Exp. Immunol 37: 221.

    PubMed  CAS  Google Scholar 

  • Lehman, J. S., 1973, Urinary schistosomiasis in Egypt: Clinical and parasitological correlation, Trans. R. Soc. Trop. Med. Hyg 67: 385.

    Google Scholar 

  • Lehman, J. S., Farid, Z., Haxton, S., Jr. Abdel-Wahab, M. F., and Kent, D. C., 1970, In- testinal protein loss in schistosomal polyposis of the colon, Gastroenterology 59: 433.

    Google Scholar 

  • MacFarlane, W. V., 1949, Schistosome dermatitis in New Zealand. Part II. Pathology and immunology of cercarial lesions, Am. J. Hyg 50: 152.

    PubMed  CAS  Google Scholar 

  • Machado, A. J., Gazzinelli, G., Pellegrino, J., and Dias da Silva, W., 1975, Schistosoma mansoni: The role of the complement C3-activating system in the cercaricidal action of normal serum, Exp. Parasitol. 38: 20.

    PubMed  CAS  Google Scholar 

  • McCully, R. M., Barron, C. N., and Cheever, A. W., 1976, Schistosomiasis (bilharziasis), in: Pathology of Tropical and Extraordinary Diseases, Vol. 2 ( C. H. Binford and D. H. Connor, eds.), p. 482, Armed Forces Institute of Pathology, Washington, D.C.

    Google Scholar 

  • Magalhaes-Filho, A., 1959, Pulmonary lesions in mice experimentally infected with Schistosoma mansoni, Am. J. Trop. Med. Hyg 8: 527.

    PubMed  CAS  Google Scholar 

  • Magalhaes-Filho, A., Krupp, I. M., and Malek, E. A., 1965, Localization of antigen and presence of antibody in tissues of mice infected with Schistosoma mansoni, as indicated by fluorescent antibody techniques, Am. J. Trop. Med. Hyg 14: 84.

    Google Scholar 

  • Mahmoud, A. A. F., Peters, P. A., Sevil, R., and Remington, J. S., 1979, In vitro killing of schistosomula of Schistosoma mansoni by BCG and C. paruum-activated macrophages, J. Immunol 122: 1655.

    PubMed  CAS  Google Scholar 

  • Martial-Rojas, R. A., and Fial, R. E., 1963, Neurologic complications of the literature and report of two cases of transverse myelitis due to Schistosoma mansoni, Ann. Intern. Med 59: 215.

    Google Scholar 

  • Manson-Bahr, P. E. C. and Apted, F.I.C., 1982, in: Manson’s Tropical Diseases, 18th edition, p. 206, Guilliere Tindall, London.

    Google Scholar 

  • Meyers, F. J., and Kouwenaar, W., 1939, Over hypereosinophile en over en merkwaaridgen vorm van filariasis, Geneesk. Tidscher. Med. Ind 79: 853.

    Google Scholar 

  • Mitchell, G. F., Garcia, E. G., Cruise, K. M., Tiu, W. U., and Hawking, R. E., 1983, Lung granulomatous hypersensitivity to eggs of Schistosoma japonicum in mice analyzed by a radioisotopic assay and effects of hybridoma (idiotype sensitization), Aust. J. Exp. Biol. Med. Sci 60: 401.

    Google Scholar 

  • Morbidity and Mortality Weekly Report Katayama Syndrome, Ethiopia 1982, Morbidity Mortality Weekly Rep. 31 (32): 436.

    Google Scholar 

  • Nash, T. E., Cheever, A. W., Ottesen, E. A., and Cook, J. A., 1982, Schistosome infections in humans: Perspectives and recent findings, Ann. Intern. Med 97: 740.

    PubMed  CAS  Google Scholar 

  • Nelson, G. S., 1966, The pathology of filarial infections, Helminthol. Abstr 35: 311

    Google Scholar 

  • Nelson, G. S., 1979, Current concepts in parasitology: Filariasis, N. Engl. J. Med. 300: 1136.

    PubMed  CAS  Google Scholar 

  • Neva, F. A., and Ottesen, E. A., 1978, Tropical (Filarial) Eosinophilia, N. Engl. J. Med 298: 1129.

    PubMed  CAS  Google Scholar 

  • Ogilvie, B. M., and Jones, V. E., 1973, Immunity in the parasitic relationship between helminths and hosts, Prog. Allergy 17: 93.

    PubMed  CAS  Google Scholar 

  • Olds, G. R., Ellner, J. J., Kearse, L. A., Jr., Kazura, J. W., and Mahmoud, A. A. F., 1980, Role of agrinase in killing of schistosomula of Schistosoma mansoni, J. Exp. Med 151: 1551.

    Google Scholar 

  • Olds, G. R., Olveda, R., Tracy, J. W., and Mahmoud, A. A. F., 1982, Adoptive transfer of modulation of granuloma formation and hepatosplenic disease in murine schistosomiasis japonica by serum from chronically infected animals, J. Immunol 128: 1393.

    Google Scholar 

  • Olivier, L., 1949, Schistosome dermatitis: A sensitization phenomenon, Am. J. Hyg 49: 290.

    PubMed  CAS  Google Scholar 

  • Olivier, L., and Weinstein, 1953, Experimental schistosome dermatitis in rabbits, J. Parastiol 38: 280.

    Google Scholar 

  • Oliveira, C. A., Bicalho, D. M., Pimenta-Filho, R., Katz, H., Ferreira, H. Bittencourt, D., Dias, R. P., Alvarenga, R. J., and Dias, C. B., 1969, A fase aguda da equistossomose mansoni. Estude laparoscopico disseminacao equistossomoticos, GEN 23: 369.

    Google Scholar 

  • Orange, R. G., Valentine, M. D., and Austen, K. F., 1968, Inhibition of the release of slow-reacting substance of amphylaxis in the rat with diethylcarbamazine, Proc. Soc. Exp. Biol. Med 127: 127–132.

    PubMed  CAS  Google Scholar 

  • Ottesen, E. A., 1979, Modulation of the host response in human schistosomiasis mansoni. I. Adherent suppressor cells which inhibit blastogenesis, J. Immunol 123: 1639.

    PubMed  CAS  Google Scholar 

  • Ottesen, E. A., 1980, Immunopathology of lymphatic filariasis in man, Springer Sem. Immunopathol 2: 373.

    Google Scholar 

  • Ottesen, E. A., and Poindexter, R. W., 1980, Modulation of the host response in human schistosomiasis. II. Humoral factors which inhibit lymphocyte proliferative responses to parasite antigens, Am. J. Trop. Med. Hyg 29: 592.

    PubMed  CAS  Google Scholar 

  • Ottesen, E. A., and Weller, P. F., 1979, Eosinophilia following treatment of patients with schistosomiasis mansoni and Bancroft’s filariasis, J. Infect. Dis 139: 343.

    PubMed  CAS  Google Scholar 

  • Ottesen, E. A., Weller, P. F. and Heck, L., 1977, Specific cellular unresponsiveness in human filariasis, Immunology 33: 413.

    PubMed  CAS  Google Scholar 

  • Ottesen, E. A., Hiatt, R. A., Cheever, A. W., Sotomayor, Z. R., and Neva, F. A., 1978, The acquisition and loss of antigen-specific cellular immune responsiveness in acute and chronic schistosomiasis in man, Clin. Exp. Immunol 33: 38.

    Google Scholar 

  • Ottesen, E. A., Neva, F. A., Paranjape, R. S., Tripathy, S. P., Thiruvengadam, V., and Beaver, M. A., 1979, Specific allergic sensitization to filarial antigens in tropical eosinophilia syndrome, Lancet 1: 1158.

    PubMed  CAS  Google Scholar 

  • Ottesen, E. A., Poindexter, R. W., and Hussain, R., 1981e, Detection, quantitation and specificity of anti-parasite IgE in schistosomiasis mansoni, Am. J. Trop. Med. Hyg 30: 1225.

    Google Scholar 

  • Ottesen, E. A., Mandell, N. R., MacQueen, J. M., Weller, P. F., Amos, D. B., and Ward, F. E., 1981b, Familial predisposition to filarial infection—not linked to HLA-A or -B locus specificities, Acta. Trop. 38: 205.

    PubMed  CAS  Google Scholar 

  • Palmieri, J., Purnomo, R., Dennis, D. T., Marwoto, H. A., 1980, Filariid parasites of South Kalimantan (Borneo) Indonesia. Wuchereria kalimantani Sp. N. (Nematoda: Filarioidea) from the silvered leaf monkey, Presbytis crisatus Eshscholtz 1921, J. Parasitol 66: 645.

    CAS  Google Scholar 

  • Palmieri, J. R., Connor, D. H., Purnomo, D. T., Dennis, D. T., and Marwoto, H., 1982, Experimental infection of Wuchereria bancrofti in the silvered leaf monkey Presbytis cristatus Eschcholz, J. Helminthol 56: 243.

    PubMed  CAS  Google Scholar 

  • Peck, C. A., Carpenter, M. D., and Mahmoud, A. A. F., 1983, Species-related innate resistance to Schistosoma mansoni: Role of mononuclear phagocytes in schistosomula killing in vitro, J. Clin. Invest 71: 66.

    PubMed  CAS  Google Scholar 

  • Pereira, D. M., and Da, S. M., 1979, Sistemas HLA, ABO e Rh e características raciasis em pacientes corn hepatoesplenomegalia equistossomótica, Brasilia, Brazil, thesis, p. 152, University of Brasilia.

    Google Scholar 

  • Phillips, S. M., and Colley, D. G., 1978, Immunologic aspects of host responses to schistosomiasis: Resistance, immunopathology, and eosinophil involvement, Prog. Allergy 24: 49.

    PubMed  CAS  Google Scholar 

  • Phillips. S. M., and Fox, E. G., 1982, The immunopathology of parasitic disease, in: Clinics of Immunology and Allergy, Vol. 2, no. 3, Immunoparasitology (A. Capron, ed.), p. 667, Fig. 1, W. B. Saunders, London.

    Google Scholar 

  • Phillips, S. M., and Zodda, D. M., 1983, Monoclonal Antibodies and Immunoparasitology in Monoclonal Antibodies, 2nd ed. (R. H. Kennett, T. J. McKearn, and K. B. Bechtol, eds.), Plenum Press, New York (in press).

    Google Scholar 

  • Phillips, S. M., DiConza, J. J., Gold, J. A., and Reid, W. A., 1977, Schistosomiasis in the congenitally athymic (nude) mouse. I. Thymic dependence of eosinophilia, granuloma formation and host morbidity, J. lmmunol 118: 594.

    CAS  Google Scholar 

  • Phillips, S. M., Reid, W. A., Doughty, B. L., and Bentley, A. G., 1980, The immunologic modulation of morbidity in schistosomiasis studies in athymic mice and in vitro granuloma formation, Am. J. Trop. Med. Hyg 29: 8.

    Google Scholar 

  • Piessens, W. F., 1981, Lymphatic filariasis in human: An immunologic maze, Ann. Intern. Med 95: 778.

    PubMed  CAS  Google Scholar 

  • Piessens, W. F., McGreevy, P. B., Piessens, P. W., McGreevy, M., Kaman, I., Karoso, J. S., and Dennis, D. T., 1980a, Immune responses in human infections with Brugia malayi. Specific cellular unresponsiveness to filarial antigen, J. Clin. Invest 65: 172.

    PubMed  CAS  Google Scholar 

  • Piessens, W. F., Ratiwayanto, S., Tuti, S., Palmieri, J. H., Piessens, P. W., Koiman, I., and Dennis, D. T., 1980b, Antigen-specific suppressor cells and suppressor factors in human filariasis with Brugia malayi, N. Engl. J. Med 302: 833.

    PubMed  CAS  Google Scholar 

  • Piessens, W. F., Partono, F., Hoffman, S. L., Ratiwayanto, S., Piessens, P. W., Palmieri, J. R., Koiman, I., Dennis, D. T., and Carney, W. P., 1982, Antigen-specific suppressor T-lymphocyte in human lymphatic filariasis, N. Engl. J. Med 307: 144.

    PubMed  CAS  Google Scholar 

  • Portaro, J., Britton, S., and Ash, L. R., 1976, Brugia pahangi: Depressed mitogen reactivity in filarial infection in the jird, Meriones unguiculatus, Exp. Parasitol 40: 438.

    PubMed  CAS  Google Scholar 

  • Powell, M. R., and Damian, R. T., 1982, Schistosomiasis mansoni in baboons. VI. Plastic adherent cell suppression of the primary in vitro antibody response of peripheral blood mononuclear cells to a heterologous antigen (SRBC) during chronic infection, Am. J. Trop. Med. Hyg 31: 790.

    PubMed  CAS  Google Scholar 

  • Reis, A. P., Katz, N., and Pellegrino, J., 1970, Immunodiffusion tests in patients with Schistosoma mansoni infection, Rev. Inst. Med. Trop. Sao Paulo 12: 245.

    PubMed  CAS  Google Scholar 

  • Rocklin, R. E., Brown, A., Warren, K. S., Pelley, R. P., Houba, V., and Butterworth, A. E., 1977, Immunologic modulation in children with schistosomiasis, Clin. Res 25: 486A

    Google Scholar 

  • Rocklin, R. E., Tracy, J. W., and El Kholy, A. E., 1981, Activation of antigen-specific suppressor cells in human schistosomiasis mansoni by fractions of soluble egg antigens nonadherent to Con A sepharose, J. Immunol 127: 2314.

    PubMed  CAS  Google Scholar 

  • Rogers, R., Denham, D. A., Nelson, G. S., Guy, F., and Ponnudurai, T., 1975, Studies with Brugia pahangi. III. Histological changes in the affected lymph nodes of infected cats, Am. J. Trop. Med. Parasitol 69: 77.

    CAS  Google Scholar 

  • Sadun, E. H., 1963, Immunization in schistosomiasis by previous exposure to homologous and heterologous cercariae by inoculation of preparations from schistosomes and by exposure to irradiated cercariae, Ann. NYAcad. Sci 113: 418.

    CAS  Google Scholar 

  • Sadun, E. H., 1972, Homocytophilic antibody response to parasitic infections, in: Immunity to Animal Parasites ( E. J. L. Soulsby, ed.), p. 97, Academic Press, New York.

    Google Scholar 

  • Sadun, E. H., von Lichtenberg, F., Cheever, A. W., and Erickson, D. G., 1970, Schistosomiasis mansoni in the chimpanzee. The natural history of chronic infections after single and multiple exposures, Am. J. Trop. Med. Hyg 29: 258.

    Google Scholar 

  • Sasazuki, T., Ohuta, N., Kanoeoka, R., and Kojima, S., 1980, Association between an HLA haplotype and low responsiveness to schistosomal worm antigen in man, J. Exp. Med 152: 314s.

    PubMed  CAS  Google Scholar 

  • Scaglia, M., Tinelli, M., and Revoltella, L., 1979, Relationship between serum IgE levels and intestinal parasite load in African populations, Intl. Arch. Allergy 59: 465.

    CAS  Google Scholar 

  • Schacher, J. F., and Sayhoun, P. F., 1967, A chronological study of the histopathology of filariid disease in cats caused by Brugia pahangi (Buckley and Edeson, 1950), Trans. R. Soc. Trop. Med. Hyg. 61: 234.

    Google Scholar 

  • Schacher, J. F., Edesen, J. F. B., Salahian, A. and Rizk, G., 1973, An 18-month longitudinal lymphographie study of filarial disease in dogs infected with Brugia pahangi (Buckley and Edeson, 1956), Ann. Trop. Med. Parasitol 67: 81.

    PubMed  CAS  Google Scholar 

  • Sher, A., and Scott, P. A., 1982, Genetic factors influencing the interactions of parasites with the immune system, in: Clinics in Immunology and Allergy, Vol. 2, no. 21, Immunoparasitology ( A. Capron, ed.), W. B. Saunders, London p. 489.

    Google Scholar 

  • Simpson, C. F., and Neilson, J. T. M., 1976, The pathology associated with single and quadruple infections of hamsters with Dipetalonema viteae, Tropenmed. Parasitol 27: 349.

    PubMed  CAS  Google Scholar 

  • Smith, M. D., 1977, The ultrastructural development of the schistosome egg granuloma in mice, Parasitology 75: 119.

    PubMed  CAS  Google Scholar 

  • Smithers, S. R., and Terry, R. J., 1969, The immunology of schistosomiasis,Adv. Parasitol. 7: 41.

    CAS  Google Scholar 

  • Smithers, S. R., and Terry, R. J., 1976, The immunology of schistosomiasis, in: Advances in Parasitology, ( B. Dawes, ed.), Vol. 14, p. 399, Academic Press, New York.

    Google Scholar 

  • Spry, C. J. F., 1981, Alterations in blood eosinophil morphology, binding capacity for cornplexed IgE and kinetitics in patients with tropical (filarial) eosinophilia, Parasite ImmunoL 3: 1.

    PubMed  CAS  Google Scholar 

  • Staninuas, R. J., and Hammerberg, B., 1982, Diethylcarbamazine enhanced activation of complement by intact microfilariae of Dirofilaria immitis and their in vitro products, J. Parasitol 68: 809.

    Google Scholar 

  • Stenger, R. J., Warren, K. S., and Johnson, E. A., 1967, An ultrastructural study of hepatic granulomas and schistosome egg shells in murine hepatosplenic schistosomiasis mansoni, Exp. Mol. Pathol 8: 116.

    Google Scholar 

  • Suemura, M., Yodoi, J. Hirashima, M., and Ishizaka, K., 1980, Regulatory role of IgEbinding factors from rat T-lymphocytes. I. Mechanism of enhancement of IgE response by IgE-potentiating factor, J. Immunol 125: 148.

    CAS  Google Scholar 

  • Suzuki, T., and Damian, R. T., 1981, Schistosomiasis mansoni in baboons. IV. The development of antibodies to Schistosoma mansoni adult worm, egg, and cercarial antigens during acute and chronic infections, Am. J. Trop. Med. Hyg 30: 825.

    PubMed  CAS  Google Scholar 

  • Symmers, W., St. C., 1903, Note on a new form of liver cirrhosis due to the presence of the ova of Bilharzia haematobia, J. Pathol. Bacteriol 9: 237.

    Google Scholar 

  • Tada, T., Kondo, Y., Okumura, K., Sano, M., and Yokogawa, M., 1975, Schistosoma japon- icum: Immunopathology of nephritis inMacaca fascicularis, Exp. Parasitol 38: 291.

    CAS  Google Scholar 

  • Todd, C.W., Goodgame, R. W., and Colley, D.G., 1979, Immune responses during human schistosomiasis mansoni. V. Suppression of schistosome antigen-specific lymphocyte blastogenesis by adherent phagocytic cells, J. Immunol 122: 1440.

    PubMed  CAS  Google Scholar 

  • Tsang, V. C. W., Hubbard, W. J., and Damian, R. T., 1977, Coagulation Factor XIIa (Activated Hageman Factor) inhibitor from adult Schistosoma mansoni, Am. J. Trop. Med. Hyg 26: 243.

    PubMed  CAS  Google Scholar 

  • Tsutsumi, H., and Nakashima, T., 1972, Pathology of liver cirrhosis due to Schistosoma japonicum, in: Research in Filariasis and Schistosomiasis ( M. Yokogawa, ed.), p. 133, University Park Press, Baltimore.

    Google Scholar 

  • Urban, J. F., Jr., and Ishizaka, K., Jr., 1977, IgE formation in the rat following infection with Nippostrongylus brasiliensis. III. Soluble factor for the generation of IgE bearing lymphocytes, J. Immunol 119: 583.

    PubMed  CAS  Google Scholar 

  • Vadas, M. A., David, J. R., Butterworth, A. E., Pisari, N. T., and Siogok, T. A., 1979, A new method for the purification of human eosinophils and neutrophils, and comparison of the ability of these cells to damage schistosomula of Schistosoma mansoni, J. Immunol 122: 1228.

    PubMed  CAS  Google Scholar 

  • Verwaede, C., Grzych, J. M., Bazin, H., Capron, M., and Capron, A., 1979, Production d’anticorps monoclonaux anti-Schistosoma mansoni. Etude préliminaire de leurs activités biologiques, Comptes Rendus de l’Academic des Sciences, Paris (D) 289: 725.

    Google Scholar 

  • Vincent, A. L., Ash, L. R., Rodrick, G. E., and Sodeman, W. A., 1980, The lymphatic pathology of Brugia pahangi in the mongolian jird, J. Parasitol 66: 613.

    PubMed  CAS  Google Scholar 

  • von Lichtenberg, F., 1964, Studies on granuloma formation. III. Antigen sequestration and destruction in the schistosome pseudotubercle, Am. J. Pathol. 45: 75.

    Google Scholar 

  • von Lichtenberg, F., and Byram, J. C., 1980, Pulmonary cell reactions and resistance to Schistosoma mansoni, in: The Host-Invader Interplay ( H. van Den Bossche, ed.), p. 405, Elsevier-North Holland, Amsterdam.

    Google Scholar 

  • von Lichtenberg, F., Erickson, D. G., and Sadun, E. H., 1973, Comparative histopathology of schistosome granulomas in the hamster, Am. J. Pathol 72: 149.

    Google Scholar 

  • von Lichtenberg, F., Bawden, M.P., and Shealey, S. H., 1974, Origin of circulating antigen in the schistosome gut. An immunofluorescent study, Am. J. Trop. Med. Hyg 23: 1088

    Google Scholar 

  • von Lichtenberg, F., Sher, A., and Maclntyre, S., 1977, A lung model of schistosome im-munity in mice, Am. J. Pathol 87: 105.

    Google Scholar 

  • Walker, L., Hay, F. C., and Roitt, I. M., 1979, Characteristics of complexes for arming and inhibiting effector cells for antibody-dependent cell-mediated cytotoxicity, Clin. Exp. Immunol. 36: 397.

    CAS  Google Scholar 

  • Waltzing, P. and Bloch-Michel, H., 1971, Le phénomène des rosettes filarennes: Intérêt pour le diagnostic des arthrites filarennes, 30: 2061.

    Google Scholar 

  • Warren, K. S., 1971, Worms, in: Immunological Diseases, 2nd ed. ( M. Samter, ed.), p. 668, Boston, Little, Brown.

    Google Scholar 

  • Warren, K. S., 1972a, The immunopathogenesis of schistosomiasis: A multidisciplinary approach, Trans. R. Soc. Trop. Med. Hyg. 66: 417.

    PubMed  CAS  Google Scholar 

  • Warren, K. S., 1972b, Pipe-stem fibrosis of the liver, Trans. R. Soc. Trop. Med. Hyg 66: 946

    Google Scholar 

  • Warren, K. S., 1973, The pathology of schistosome infections, Helminthol. Abstr. (A) 42: 591.

    Google Scholar 

  • Warren, D. S., 1974, Modulation of immunopathology in schistosomiasis, in: Parasites in the Immunized Host: Mechenisms of Survival, Ciba Foundation Symposium No. 25, p. 243, Elsevier North-Holland, Amsterdam.

    Google Scholar 

  • Warren, K. S., 1982, The secret of immunopathogenesis of schistosomiasis in vivo models, Immunol. Rev 61: 189.

    PubMed  CAS  Google Scholar 

  • Warren, K. S., Reboucas, G., and Baptista, A. G., 1965, Ammonia metabolism and hepatic coma in hepatosplenic schistosomiasis. Patients studied before and after portacaval shunt, Ann. Intern. Med 62: 1113.

    PubMed  CAS  Google Scholar 

  • Warren, K. S., Domingo, E. O., and Cowan, R. B. T., 1967, Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity, Am. J. Pathol 51: 735

    PubMed  CAS  Google Scholar 

  • Warren, K. S., Boros, D. L., Hang, L. M., and Mahmoud, A. A. F., 1975, Schistosoma japonicum egg granuloma, Am. J. Pathol 80: 279.

    PubMed  CAS  Google Scholar 

  • Warren, K. S.,, Grove, K. I., and Pelley, R. P., 1978; Schistosoma japonicum egg granuloma. II. Cellular composition, granuloma size, and immunologic concomitants, Am. J. Trop. Med. Hyg 27: 271.

    CAS  Google Scholar 

  • Webb, J. K. G., Job, C. K., and Gault, E. W., 1960, Tropical eosinophilia: Demonstration of microfilariae in lung, liver, and lymph nodes, Lancet 7129: 835.

    Google Scholar 

  • Webster, E. H., 1946, Filariasis among white immigrants in Samoa, U.S. Nay. Med. Bull 46: 186.

    CAS  Google Scholar 

  • Wei-Hsin, C., 1958, Acute schistosomiasis. Clinical manifestations of 96 cases, Chinese Med. J 76: 1.

    Google Scholar 

  • Weinstock, J. V., and Boros, D. L., 1981, Heterogeneity of the granulomatous response in the liver, colon, ileum, and ileal Peyer’s patches to schistosome eggs in murine schistosomiasis mansoni, J. Immunol 127: 1906.

    PubMed  CAS  Google Scholar 

  • Weinstock, J. V., Boros, D. L., Gee, J. B., and Ehrinpreis, M. N., 1981, The effect of SQ14225, an inhibitor of angiotensin I converting enzyme on the granulomatous response to Schistosoma mansoni eggs in mice, J. Clin. Invest 67: 931.

    PubMed  CAS  Google Scholar 

  • Weiss, N., Sturchler, D., and Dietrich, F. M., 1978, Radioallosorbent and indirect fluorescent antibody tests in immunodiagnosis of schistosomiasis, Lancet 2: 1231.

    PubMed  CAS  Google Scholar 

  • Wellhausen, S. R., Chensue, S. W., and Boros, D. L., 1980, Modulation of granulomatous hypersensitivity. Analysis by adoptive transfer of effect and suppressor T lymphocytes involved in granulomatous inflammation in murine schistosomiasis, in: Basic and Clinical Aspects of Granulomatous Diseases ( D. L. Boros and T. Yoshida, eds.), p. 219, Elsevier North-Holland, Amsterdam.

    Google Scholar 

  • World Health Organization, 1976, Epidemiology of onchocerceriasis, Tech. Rep. Ser 597: 94.

    Google Scholar 

  • World Health Organization, 1981, Immunology of filariasis, Bull. WHO 59: 1.

    Google Scholar 

  • Wyler, D. H., and Postlethwaite, A. E., 1983, Fibroblast stimulation in schistosomiasis, 130: 1371.

    CAS  Google Scholar 

  • Wyler, D. H., Wahl, S. M., and Wahl., L. M., 1978, Hepatic fibrosis in schistosomiasis: Egg granulomas secrete fibroblast stimulating factor in vitro, Science 202: 438.

    PubMed  CAS  Google Scholar 

  • Wyler, D. H., Weinbaum, F. I., and Herrod, H. R., 1979, Characterization of in vitro proliferative responses of human lymphocytes to leishmanial antigens, J. Infect. Dis 140: 215.

    PubMed  CAS  Google Scholar 

  • Zvaifler, N. J., Sadun, E. H., Becker, E. L., and Schoenbechler, M. J., 1967, Demonstration of homologous anaphylactic antibody in rabbits infected with Schistosoma mansoni, Ex. Parasitol 20: 278.

    Google Scholar 

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Phillips, S.M., Fox, E.G. (1984). Immunopathology of Parasitic Diseases: A Conceptual Approach. In: Marchalonis, J.J. (eds) Immunobiology of Parasites and Parasitic Infections. Contemporary Topics in Immunobiology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4571-8_11

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