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Excitatory Amino Acid Receptors

  • Najam A. Sharif

Abstract

Despite limitations imposed by their ubiquitous occurrence, universal neuronal excitant properties, and involvement in metabolic functions, glutamic (Glu) and aspartic (Asp) acids now satisfy many of the basic criteria employed to assess and ascribe a transmitter role to neuroactive substances.1-4 The dicarboxylate amino acids (AAs) exhibit a heterogeneous distribution in the mam malian central nervous system (CNS), being enriched, together with their synthetic enzymes, within synaptosomal fractions. Release of endogenous and exogenous AAs from CNS preparations by depolarizing stimuli has been demonstrated. Iontophoresed Glu, Asp, and their analogs produce neuronal excitation, mimicking the responses evoked by stimulation of excitatory pathways, and their actions are terminated by specific uptake mechanisms. Furthermore, specific synaptic binding proteins and receptor-mediated ionic fluxes and cyclic nucleotide generation associated with Glu and Asp have been detected and extensively evaluated.2-4

Keywords

Kainic Acid Excitatory Amino Acid Receptor Pharmacological Specificity Cysteine Sulfinate Cerebellar Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Najam A. Sharif
    • 1
  1. 1.Department of Pharmacology and Experimental TherapeuticsUniversity of Maryland School of MedicineBaltimoreUSA

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