Excitatory Amino Acid Receptors

  • Najam A. Sharif


Despite limitations imposed by their ubiquitous occurrence, universal neuronal excitant properties, and involvement in metabolic functions, glutamic (Glu) and aspartic (Asp) acids now satisfy many of the basic criteria employed to assess and ascribe a transmitter role to neuroactive substances.1-4 The dicarboxylate amino acids (AAs) exhibit a heterogeneous distribution in the mam malian central nervous system (CNS), being enriched, together with their synthetic enzymes, within synaptosomal fractions. Release of endogenous and exogenous AAs from CNS preparations by depolarizing stimuli has been demonstrated. Iontophoresed Glu, Asp, and their analogs produce neuronal excitation, mimicking the responses evoked by stimulation of excitatory pathways, and their actions are terminated by specific uptake mechanisms. Furthermore, specific synaptic binding proteins and receptor-mediated ionic fluxes and cyclic nucleotide generation associated with Glu and Asp have been detected and extensively evaluated.2-4


Kainic Acid Excitatory Amino Acid Receptor Pharmacological Specificity Cysteine Sulfinate Cerebellar Membrane 
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  1. 1.
    Werman, R., 1966, Comp. Biochem. Physiol. 18:745–766.PubMedCrossRefGoogle Scholar
  2. 2.
    Curtis, D. R., and Johnston, G. A. R., 1974, Ergeb. Physiol. 69:97–188.PubMedGoogle Scholar
  3. 3.
    Johnson, J. L., 1978, Prog. Neurobiol. 10:155–202.PubMedCrossRefGoogle Scholar
  4. 4.
    Watkins, J. C., and Evans, R. H., 1981, Annu. Rev. Pharmacol. Toxicol. 21:165–204.PubMedCrossRefGoogle Scholar
  5. 5.
    Burt, D. R., 1978, Neurotransmitter Receptor Binding (H. I. Yamamura, S. J., Enna, and M. J. Kuhar, eds.), Raven Press, New York, pp. 41–55.Google Scholar
  6. 6.
    Weiland, G. A., and Molinoff, P. B., 1981, Life Sci. 29:313–330.PubMedCrossRefGoogle Scholar
  7. 7.
    Molinoff, P. B., Wolfe, B. B., and Weiland, G. A., 1981, Life Sci. 29:427–443.PubMedCrossRefGoogle Scholar
  8. 8.
    Cuatracasas, P., and Hollenberg, M. D., 1975, Biochem. Biophys. Res. Commun. 62:31–41.CrossRefGoogle Scholar
  9. 9.
    Evans, R. H., and Watkins, J. C., 1981, Life Sci. 28:1303–1308.PubMedCrossRefGoogle Scholar
  10. 10.
    Logan, W. J., and Snyder, S. H., 1972, Brain Res. 11:199–212.Google Scholar
  11. 11.
    Palacios, J. M., Niehoff, D. L., and Kuhar, M. J., 1981, Neurosci. Lett. 25:101–105.PubMedCrossRefGoogle Scholar
  12. 12.
    Enna, S. J., and Snyder, S. H., 1975, Brain Res. 100:81–97.PubMedCrossRefGoogle Scholar
  13. 13.
    Cotman, C. W., Foster, A. C., and Lanthorn, T., 1981, Glutamate as a Neurotransmitter (G. DiChiara and G. L. Gessa, eds.), Raven Press, New York, pp. 1–27.Google Scholar
  14. 14.
    Matus, A., Pehling, G., and Wilkinson, D., 1981, J. Neurobiol. 12:67–73.PubMedCrossRefGoogle Scholar
  15. 15.
    Horag, J. S., and Wong, D. T., 1979, J. Neurochem. 32:1379–1386.CrossRefGoogle Scholar
  16. 16.
    Toffano, G., Guidotti, A., and Costa, E., 1978, Proc. Natl. Acad. Sci. U.S.A. 75:4024–4028.PubMedCrossRefGoogle Scholar
  17. 17.
    Napias, C., Bergmann, M. O., Van Ness, P. C., Greenlee, D. V., and Olsen, R. W., 1980, Life Sci. 27:1001–1011.PubMedCrossRefGoogle Scholar
  18. 18.
    Sharif, N. A., and Roberts, P. J., 1980, J. Neurochem. 34:779–784.PubMedCrossRefGoogle Scholar
  19. 19.
    Sharif, N. A., and Roberts, P. J., 1981, Brain Res. 211:293–303.PubMedCrossRefGoogle Scholar
  20. 20.
    Sharif, N. A., and Roberts, P. J., 1981, Biochem. Pharm. 30:3019–3022.PubMedCrossRefGoogle Scholar
  21. 21.
    Roberts, P. J., and Sharif, N. A., 1983, Methods Neurobiol. (P. J. Marangos, I. Campbell, and R. M. Cohen, eds.), Academic Press, New York (in press).Google Scholar
  22. 22.
    Baudry, M., and Lynch, G., 1981, J. Neurochem. 36:811–820.PubMedCrossRefGoogle Scholar
  23. 23.
    Iwata, H., Yamagami, S., and Baba, A., 1982, J. Neurochem. 38:1275–1279.PubMedCrossRefGoogle Scholar
  24. 24.
    Hosli, J. S., Andres, P. F., and Hosli, E., 1976, Pflugers Arch. 363:43–48.PubMedCrossRefGoogle Scholar
  25. 25.
    Greengard, P., 1979, Fed. Proc. 38:2208–2217.PubMedGoogle Scholar
  26. 26.
    Foster, G. A., and Roberts, P. J., 1980, Life Sci. 27:215–221.PubMedCrossRefGoogle Scholar
  27. 27.
    Garthwaite, J., and Balázs, R., 1978, Nature 275:328–329.PubMedCrossRefGoogle Scholar
  28. 28.
    Curtis, D. R., and Watkins, J. C., 1963, J. Physiol. (Lond.) 166:1–14.Google Scholar
  29. 29.
    Roberts, P. J., 1974, Nature 252:399–401.PubMedCrossRefGoogle Scholar
  30. 30.
    Michaelis, E. K., Michaelis, M. K., and Boyarsky, L. L., 1974, Biochim. Biophys. Acta 367:338–348.PubMedCrossRefGoogle Scholar
  31. 31.
    Michaelis, E. K., 1975, Biochem. Biophys. Res. Commun. 87:106–112.CrossRefGoogle Scholar
  32. 32.
    DeRobertis, E., and Fiszer de Plazas, S., 1976, J. Neurochem. 26:1237–1243.CrossRefGoogle Scholar
  33. 33.
    Foster, A. C., and Roberts, P. J., 1978, J. Neurochem. 31:1467–1477.PubMedCrossRefGoogle Scholar
  34. 34.
    Biziere, K., Thompson, H., and Coyle, J. T., 1980, Brain Res. 183:421–433.PubMedCrossRefGoogle Scholar
  35. 35.
    Vincent, S. R., and McGeer, E. G., 1980, Brain Res. 184:99–108.PubMedCrossRefGoogle Scholar
  36. 36.
    Baudry, M., and Lynch, G., 1979, Eur. J. Pharmacol. 57:283–285.PubMedCrossRefGoogle Scholar
  37. 37.
    Werling, L. L., and Nadler, J. V., 1982, J. Neurochem. 38:1050–1062.PubMedCrossRefGoogle Scholar
  38. 38.
    Shinozaki, H., and Konishi, S., 1970, Brain Res. 24:368–371.PubMedCrossRefGoogle Scholar
  39. 39.
    Baudry, M., Oliver, M., Creager, R., Wieraszko, A., and Lynch, G., 1980, Life Sci. 27:325–330.PubMedCrossRefGoogle Scholar
  40. 40.
    Baudry, M., Arst, D., Oliver, M., and Lynch, G., 1981, Dev. Brain Res. 1:37–48.CrossRefGoogle Scholar
  41. 41.
    Mitchell, C. K., and Redburn, D. A., 1982, Neurosci. Lett. 28:241–246.PubMedCrossRefGoogle Scholar
  42. 42.
    Head, R. A., Tunnicliff, G., and Matheson, G. K., 1980, Can. J. Biochem. 58:534–538.PubMedCrossRefGoogle Scholar
  43. 43.
    Foster, A. C., Mena, E. E., Fagg, G. E., and Cotman, C. W., 1981, J. Neurosci. 1:620–625.PubMedGoogle Scholar
  44. 44.
    Sanderson, C., and Murphy, S., 1982, Dev. Brain Res. 2:329–339.CrossRefGoogle Scholar
  45. 45.
    Roberts, P. J., McBean, G. J., Sharif, N. A., and Thomas, E. M., 1982, Brain Res. 235:83–91.PubMedCrossRefGoogle Scholar
  46. 46.
    Johnston, G. A. R., Curtis, D. R., Davies, J., and McCulloch, R. M., 1974, Nature 248:804.PubMedCrossRefGoogle Scholar
  47. 47.
    Cull-Candy, S. G., Donnellan, J. F., James, R. W., and Lunt, G. G., 1976, Nature 262:408–409.PubMedCrossRefGoogle Scholar
  48. 48.
    Roberts, P. J., Foster, G. A., Sharif, N. A., and Collins, J. F., 1982, Brain Res. 238:475–479.PubMedCrossRefGoogle Scholar
  49. 49.
    Koerner, J. F., and Cotman, C. W., 1981, Brain Res. 216:192–198.PubMedCrossRefGoogle Scholar
  50. 50.
    Fagg, G. E., Foster, A. C., Mena, E. E., Koerner, J. F., and Cotman, C. W., 1981, Trans. Am. Soc. Neurochem. 12:21.Google Scholar
  51. 51.
    Cheung, W. Y., 1982, Sci. Am. 246:62–71.PubMedCrossRefGoogle Scholar
  52. 52.
    Roberts, P. J., and Watkins, J. C., 1975, Brain Res. 85:120–125.PubMedCrossRefGoogle Scholar
  53. 53.
    Krogsgaard-Larsen, P., and Honoré, T., 1983, TIPS 1:31–33.Google Scholar
  54. 54.
    Honoré, T., Lauridsen, J., and Krogsgaard-Larsen, P., 1981, J. Neurochem. 36:1302–1304.PubMedCrossRefGoogle Scholar
  55. 55.
    Watkins, J. C., 1981, Glutamate: Transmitter in the CNS (P. J. Roberts, J. Storm-Mathisen, and G. A. R. Johnston, eds.), John Wiley & Sons, New York, pp. 1–24.Google Scholar
  56. 56.
    McLennan, H., Hicks, T. P., and Liu, J. R., 1982, Neuropharmacology 21:549–554.PubMedCrossRefGoogle Scholar
  57. 57.
    Baudry, M., Bundman, M. C., Smith, E. K., and Lynch, G., 1981, Science 212:937–938.PubMedCrossRefGoogle Scholar
  58. 58.
    Vargas, F., Greenbaum, L., and Costa, E., 1981, Neuropharmacology 19:791–794.CrossRefGoogle Scholar
  59. 59.
    Baudry, M., Smith, E., and Lynch, G., 1981, Mol. Pharmacol. 20:280–286.PubMedGoogle Scholar
  60. 60.
    Michaelis, E. K., Michaelis, M. L., Chang, H. H., Grubbs, R. D., and Kuonen, D. R. 1981, Mol. Cell. Biochem. 38:163–179.PubMedCrossRefGoogle Scholar
  61. 61.
    Foster, A. C., Fagg, G. E., Harris, E. W., and Cotman, C. W., 1982, Brain Res. 242:374–377.PubMedCrossRefGoogle Scholar
  62. 62.
    Rodbell, M., 1980, Nature 284:17–22.PubMedCrossRefGoogle Scholar
  63. 63.
    Sharif, N. A., and Roberts, P. J., 1980, Eur. J. Pharmacol. 61:213–214.PubMedCrossRefGoogle Scholar
  64. 64.
    Foster, G. A., and Roberts, P. J., 1981, Br. J. Pharm. 74:723–729.CrossRefGoogle Scholar
  65. 65.
    Baudry, M., and Lynch, G., 1980, Exp. Neurol. 68:202–204.PubMedCrossRefGoogle Scholar
  66. 66.
    Baudry, M., and Lynch, G., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:2298–2302.PubMedCrossRefGoogle Scholar
  67. 67.
    Altman, J., 1972, J. Comp. Neurol. 145:353–514.PubMedCrossRefGoogle Scholar
  68. 68.
    Rosenblatt, J. E., Shore, D., Neckers, L. M., Perlow, M. J., Freed, W. J., and Wyatt, R. J., 1979, Eur. J. Pharmacol. 60:387–388.PubMedCrossRefGoogle Scholar
  69. 69.
    Møller Nielsen, I., Christensen, A. V., and Hyttel, J., 1978, Advances in Biochemical Psychopharmacology ,Volume 19, Dopamine ,(P. J. Roberts, G. N. Woodruff, and L. L. Iversen, eds.) Raven Press, New York, pp. 267–274.Google Scholar
  70. 70.
    Foster, G. A., Roberts, P. J., Rowlands, G. J., and Sharif, N. A., 1981, Br. J. Pharm. 73:235.Google Scholar
  71. 71.
    Sharif, N. A., and Roberts, P. J., 1980 Brain Res. 194:594–597.PubMedCrossRefGoogle Scholar
  72. 72.
    Sharif, N. A., and Roberts, P. J., 1980, Neurotransmitters and their Receptors (U. Z. Littauer, Y. Dudai, I. Silman, V. I. Teichberg, and Z. Vogel, eds.), John Wiley & Sons, pp. 369–372.Google Scholar
  73. 73.
    Sharif, N. A., and Roberts, P. J., 1983, Neurochem. Res. (in press).Google Scholar
  74. 74.
    Hedlund, B., and Bartfai, T., 1979, Mol. Pharmacol. 15:531–544.PubMedGoogle Scholar
  75. 75.
    Hamblin, M. W., and Creese, I., 1981, Mol. Pharmacol. 21:44–51.Google Scholar
  76. 76.
    Michaelis, E. K., 1979, Biochem. Biophys. Res. Commun. 87:106–112.PubMedCrossRefGoogle Scholar
  77. 77.
    Grubbs, R. D., and Michaelis, E. K., 1979, Soc. Neurosci Abstr. 5:304.Google Scholar
  78. 78.
    McLennan, H., and Lodge, D., 1979, Brain Res. 169:83–90.PubMedCrossRefGoogle Scholar
  79. 79.
    McLennan, H., and Wheal, H. V., 1976, Nueropharmacology 15:709–712.CrossRefGoogle Scholar
  80. 80.
    Shinozaki, H., and Shibuya, I., 1974, Neuropharmacology 13:1057–1065.PubMedCrossRefGoogle Scholar
  81. 81.
    Roberts, P. J., and Sharif, N. A., 1978, Brain Res. 157:391–395.PubMedCrossRefGoogle Scholar
  82. 82.
    Slevin, J. T., and Coyle, J. T., 1981, J. Neurochem. 37:531–533.PubMedCrossRefGoogle Scholar
  83. 83.
    Simon, J. R., Contrera, J. F., and Kuhar, M. J., 1976, J. Neurochem. 26:141–147.PubMedGoogle Scholar
  84. 84.
    London, E. D., and Coyle, J. T., 1979, Eur. J. Pharmacol. 56:287–290.PubMedCrossRefGoogle Scholar
  85. 85.
    London, E. D., and Coyle, J. T., 1979, Mol. Pharmacol. 15:492–505.PubMedGoogle Scholar
  86. 86.
    Henke, H., 1980, Amino Acid Transmitters (F. V. DeFeudis and P. Mandel, eds.), Raven Press, New York, pp. 30–38.Google Scholar
  87. 87.
    Schwarcz, R., and Fuxe, K., 1979, Life Sci. 24:1471–1480.PubMedCrossRefGoogle Scholar
  88. 88.
    Foster, A. C., Mena, E. E., Monaghan, D. T., and Cotman, C. W., 1981, Nature 289:73–75.PubMedCrossRefGoogle Scholar
  89. 89.
    Campochiaro, P., and Coyle, J. T., 1978, Proc. Natl. Acad. Sci. U.S.A. 75:2025–2029.PubMedCrossRefGoogle Scholar
  90. 90.
    Coyle, J. T., McGeer, E. G., McGeer, P. L., and Schwarcz, R., 1978, Kainic Acid as a Tool in Neurobiology (E. G. McGeer, J. W. Olney, and P. L. McGeer, eds.), Raven Press, New York, pp. 139–159.Google Scholar
  91. 91.
    Beaumont, K., Maurin, Y., Reisine, T. D., Fields, J. Z., Spokes, E., Bird, E. D., and Yamamura, H. I., 1979, Life Sci. 24:809–816.PubMedCrossRefGoogle Scholar
  92. 92.
    Coyle, J. T., Zaczek, R., Slevin, J., and Collins, J., 1981, Glutamate as a Neurotransmitter (G. Di Chiara and G. L. Gessa, eds.), Raven Press, New York, pp. 337–346.Google Scholar
  93. 93.
    Luini, A., Goldberg, O., and Teichberg, V. I., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:3250–3254.PubMedCrossRefGoogle Scholar
  94. 94.
    Tal, N., Goldberg, O., Luini, A., and Teichberg, V. I., 1982, J. Neurochem. 39:574–576.PubMedCrossRefGoogle Scholar
  95. 95.
    Riveros, N., and Orrego, F., 1982, Brain Res. 236:492–496.PubMedCrossRefGoogle Scholar
  96. 96.
    Duggan, A. W., 1974, Exp. Brain Res. 19:522–525.PubMedCrossRefGoogle Scholar
  97. 97.
    Biscoe, T. J., Evans, R. H., Headley, P. M. Martin, P. M., and Watkins, J. C., 1976, Br. J. Pharmacol. 58:373–383.PubMedCrossRefGoogle Scholar
  98. 98.
    Dostrovsky, J. O., and Pomeranz, B., 1977, Neurosci. Lett. 4:315–319.PubMedCrossRefGoogle Scholar
  99. 99.
    Fiszer de Plazas, S., and De Robertis, E., 1976, J. Neurochem. 27:889–894.CrossRefGoogle Scholar
  100. 100.
    Snodgrass, S. R., 1979, Soc. Neurosci. Abstr. 5:572.Google Scholar
  101. 101.
    Foster, A. C., Fagg, G. E., Mena, E. E., and Cotman, C. W., 1981, Brain Res. 229:246–250.PubMedCrossRefGoogle Scholar
  102. 102.
    Di Lauro, A., Meek, J. L., and Costa, E., 1982, J. Neurochem. 38:1261–1267.PubMedCrossRefGoogle Scholar
  103. 103.
    Scatton, B., and Leymann, J., 1982, Nature 297:422–424.PubMedCrossRefGoogle Scholar
  104. 104.
    Olney, J. W., Degubareff, T., and Labruyere, J., 1979, Life Sci. 25:537–540.PubMedCrossRefGoogle Scholar
  105. 105.
    Recasen, M., Varga, V., Nanopoulous, D., Saadoun, F., Vincendon, G., and Benavides, J., 1982, Brain Res. 239:153–173.CrossRefGoogle Scholar
  106. 106.
    Sharif, N. A., and Roberts, P. J., 1983, J. Neurosci. Methods submitted.Google Scholar
  107. 107.
    De Barry, J., Vincendon, G., and Gombos, G., 1980, FEBS. Lett. 109:175–179.PubMedCrossRefGoogle Scholar
  108. 108.
    Skrede, K. K., and Malthe-Sørenssen, D., 1981, Brain Res. 208:436–441.PubMedCrossRefGoogle Scholar
  109. 109.
    Chujo, T., Yamada, Y., and Yamamoto, C., 1975, Exp. Brain Res. 23:293–300.PubMedCrossRefGoogle Scholar
  110. 110.
    Nadler, J. V., Evensen, D. A., and Smith, E. M., 1981, Brain Res. 205:405–410.PubMedCrossRefGoogle Scholar
  111. 111.
    Kim, J. S., Kornhuber, H. H., Schmid-Burgk, and Holzmuller, B., 1980,Neuroscience 20:379.Google Scholar
  112. 112.
    Olney, J. W., Fuller, T. W., and Degubareff, T., 1979, Brain Res. 176:91–100.PubMedCrossRefGoogle Scholar
  113. 113.
    Barrow, M. V., Simpson, C. F., and Miller, E. J., 1974, Q. Rev. Biol. 49:101–128.PubMedCrossRefGoogle Scholar
  114. 114.
    Prasad, K. N., Nayak, M., Prasad, E. J., Cummings, S., and Pattisapu, K., 1980, Life Sci. 27:2251–2259.PubMedCrossRefGoogle Scholar
  115. 115.
    Chang, L. R., Barnard, E. A., Lo, M. M. S., and Dolly, J. O., 1981, FEBS Lett. 126:309–312.PubMedCrossRefGoogle Scholar
  116. 116.
    Heidmann, T., and Changeaux, J.-P., 1978, Annu. Rev. Biochem. 47:317–357.PubMedCrossRefGoogle Scholar
  117. 117.
    Clark, R. B., Donaldson, P. L., Gration, K. A. F., Lambert, J. J., Piek, T., Ramsey, R., Spanuer, W., and Usherwood, P. N. R., 1982, Brain Res. 241:105–114.PubMedCrossRefGoogle Scholar
  118. 118.
    Brown, C. E., 1981, J. Neurosci. Methods 3:339–363.PubMedCrossRefGoogle Scholar
  119. 119.
    Ferkany, J. W., Zaczek, R., and Coyle, J. T., 1982, Nature ,298:757–759.PubMedCrossRefGoogle Scholar
  120. 120.
    Potashner, S. J., and Gerard, D., 1983, J. Neurochem. 40:1548–1557.PubMedCrossRefGoogle Scholar
  121. 121.
    Collins, G. S., Anson, J., and Suites, L., 1983, Brain Res. 265:157–159.PubMedCrossRefGoogle Scholar
  122. 122.
    Berdichevsky, E., Riveros, N., Sanchez-Armass, S., and Orrego, F., 1983, Neurosci. Lett. 36:75–80.PubMedCrossRefGoogle Scholar
  123. 123.
    Schwarcz, R., Collins, J. F., and Parks, D. A., 1982, Neurosci. Lett. 33:85–90.PubMedCrossRefGoogle Scholar
  124. 124.
    Croucher, R., Collins, J. F., and Meldrum, B. S. 1982, Science ,216:899–901.PubMedCrossRefGoogle Scholar
  125. 125.
    Schwarcz, R., Whetsell, W. O., and Mangano, R. M., 1983, Science ,219:316–318.PubMedCrossRefGoogle Scholar
  126. 126.
    Monaghan, D. T., and Cotman, C. W., 1982, Brain Res. 252:91–100.PubMedCrossRefGoogle Scholar
  127. 127.
    Halpain, S., Parsons, B., and Rainbow, T. C., 1983, Eur. J. Pharmacol. 86:313–314.CrossRefGoogle Scholar
  128. 128.
    Greenamyre, J. T., Young, A. B., and Penney, J. B., 1983, Neurosci. Lett. 37:155–160.PubMedCrossRefGoogle Scholar
  129. 129.
    Zaczek, R., Koller, K., Cotter, R., Heller, D., and Coyle, J. T., 1983, Proc. Natl. Acad. Sci. U.S.A. 80:1116–1119.PubMedCrossRefGoogle Scholar
  130. 130.
    Butcher, S. P., Roberts, P. J., and Collins, J. F., 1983, IRCS Med. Sci. 11:42–43.Google Scholar
  131. 131.
    Jones, A. W. Olverman, H. J., and Watkins, J. C., 1983, J. Physiol 340:45P.Google Scholar
  132. 132.
    Slevin, J., Collins, J., Lindsley, K., and Coyle, J. T., 1982, Brain Res. 249:353–360.PubMedCrossRefGoogle Scholar
  133. 133.
    Michaelis, E. K., Michaelis, M. L., Stormann, T. M., Chittenden, W. L., and Grubbs, R. D., 1983 7. Neurochem. 40:1742–1753.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Najam A. Sharif
    • 1
  1. 1.Department of Pharmacology and Experimental TherapeuticsUniversity of Maryland School of MedicineBaltimoreUSA

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