Advertisement

GABA Receptors

  • G. A. R. Johnston
  • R. D. Allan
  • J. H. Skerritt

Abstract

The simple amino acid GABA (γ-amin0butyric acid, 4-aminobutanoic acid) is a transmitter of major significance in the mammalian central nervous system. Receptors for GABA are found at both presynaptic (“axoaxonic7”) and postsynaptic (“axosomatic” and “axodendritic”) sites and also on nerve fibers (“nonsynaptic” or “fiber” receptors). There is strong evidence for a multi plicity of GABA receptors. Activation of GABA receptors may be studied in vivo using electrophysiological or behavioral methods and in vitro using isolated tissue preparations. Such studies of receptor activation are complemented by neurochemical investigation of the binding of GABA and related ligands to a variety of CNS membrane preparations. These studies provide direct information on the kinetics of binding interactions but only rather indirect information on the relevance of these interactions to physiological processes. Binding to the recognition sites on GABA receptors is merely the initial stage in producing the changes in ionic permeability that influence membrane potential and neuronal excitability. GABA agonist binding is considered to change receptor conformation with the activated receptor influencing an associated ionophore.

Keywords

Gaba Receptor Brain Membrane Quaternary Salt Detergent Extraction Gaba Agonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Krogsgaard-Larsen, P., and Falch, E., 1981, Mol. Cell. Biochem. 38:129–146.PubMedGoogle Scholar
  2. 2.
    Johnston, G. A. R., Allan, R. D., Kennedy, S. M. E., and Twitchin, B., 1979, GABA-Neu rotransmiîters (P. Krogsgaard-Larsen, J. Scheel-Kruger, and H. Kofod, eds.), Munksgaard, Copenhagen, pp. 149–164.Google Scholar
  3. 3.
    Enna, S. J., 1981, Biochem. Pharmacol. 30:907–913.PubMedGoogle Scholar
  4. 4.
    Bowery, N. G., Hill, D. R., Hudson, A. L., Doble, A., Middlemiss, D. N., Shaw, J., and Turnbull, M., 1980, Nature 283:92–94.PubMedGoogle Scholar
  5. 5.
    Atkinson, J. G., Girard, Y., Rokack, J., Rooney, C. S., McFarlane, C. S., Rackham, A., and Share, N. N., 1979, J. Med. Chem. 22:99–106.PubMedGoogle Scholar
  6. 6.
    Lloyd, K. G., Worms, P., Deportere, H., and Bartholini, G., 1979, GABA-Neurotransmitters (P. Krogsgaard-Larsen, J. Scheel-Kruger, and H. Kofod, eds.), Munksgaard, Copenhagen, pp. 308–325.Google Scholar
  7. 7.
    Sytinsky, I. A., Soldatenkov, A. T., and Lajtha, A., 1978, Prog. Neurobiol. 10:89–133.PubMedGoogle Scholar
  8. 8.
    Gakzigna, L., Garbin, L., Bianchi, M., and Marzotto, A., 1978, Arch. Int. Pharmacodyn. Ther. 235:73–85.Google Scholar
  9. 9.
    Perkins, M. N., Bowery, N. G., Hill, D. R., and Stone, T. W., 1981, Neurosci. Lett. 23:325–327.PubMedGoogle Scholar
  10. 10.
    Desarmenien, M., Feltz, P., Headley, P. M., and Santangelo, F., 1981, Br. J. Pharm. 72:355–364.Google Scholar
  11. 11.
    Nicoll, R. A., and Wojtowicz, J. M., 1980, Brain Res. 191:225–237.PubMedGoogle Scholar
  12. 12.
    Willow, M., and Johnston, G. A. R., 1981, J. Neurochem. 37:1291–1294.PubMedGoogle Scholar
  13. 13.
    Curtis, D. R., and Johnston, G. A. R., 1974, Neuropoisons, Their Pathophysiological Actions ,Volume 2 (L. L. Simpson and D. R. Curtis, eds.), Plenum Press, New York, pp. 207–248.Google Scholar
  14. 14.
    Johnston, G. A. R., 1978, Annu. Rev. Pharmacol. Toxicol. 18:269–289.PubMedGoogle Scholar
  15. 15.
    Simmonds, M. A., 1978, Br. J. Pharm. 63:495–502.Google Scholar
  16. 16.
    Andrews, P. R., and Johnston, G. A. R., 1979, Biochem. Pharmacol. 28:2697–2702.PubMedGoogle Scholar
  17. 17.
    Johnston, G. A. R., 1978, Receptors in Pharmacology (J. R. Smythies and R. J. Bradley, eds.), Marcel Dekker, New York, pp. 295–333.Google Scholar
  18. 18.
    Simmonds, M. A., 1980, Neuropharmacology 19:39–45.PubMedGoogle Scholar
  19. 19.
    Olsen, R. W., 1981, J. Neurochem. 37:1–13.PubMedGoogle Scholar
  20. 20.
    Segal, M., 1976, Brain Res. 103:161–166.PubMedGoogle Scholar
  21. 21.
    Pickles, H. G., and Simmonds, M. A., 1980, Neuropharmacology 19:35–38.PubMedGoogle Scholar
  22. 22.
    Schlosser W., and Franco, S., 1979, J. Pharmacol. Exp. Ther. 211:290–295.PubMedGoogle Scholar
  23. 23.
    Gruol, D. L., Barker, J. L., and Smith, T. G., 1980, Brain Res. 198:323–332.PubMedGoogle Scholar
  24. 24.
    Antonaccio, M. J., Asaad, M., and Boccagno, J., 1981, Eur. J. Pharmacol. 72:369–372.PubMedGoogle Scholar
  25. 25.
    Gent, J. P., and Normanton, J. R., 1978, Br. J. Pharmacol. 64:383P–384P.PubMedGoogle Scholar
  26. 26.
    Johnston, G. A. R., 1978, Proc. Aust. Physiol. Pharmacol. Soc. 9:94–98.Google Scholar
  27. 27.
    Krause, D. N., Ikeda, K., and Roberts, E., 1981, Brain Res. 255:319–332.Google Scholar
  28. 28.
    Krogsgaard-Larsen, P., Johnston, G. A. R., Lodge, D., and Curtis, D. R., 1977, Nature 268:53–55.PubMedGoogle Scholar
  29. 29.
    Pickles, H. G., 1979, Br. J. Pharmacol. 65:223–228.PubMedGoogle Scholar
  30. 30.
    Curtis, D. R., Bornstein, J. C., and Lodge, D., 1980, Brain Res. 194:255–258.PubMedGoogle Scholar
  31. 31.
    Mathison, R. D., and Dreifuss, J. J., 1980, Brain Res. 187:476–480.PubMedGoogle Scholar
  32. 32.
    Curtis, D. R., Duggan, A. W., Felix, D., Johnston, G. A. R., and McLennan, H., 1971, Brain Res. 70:493–499.Google Scholar
  33. 33.
    Biscoe, T. J., Duggan, A. W., and Lodge, D., 1972, Comp. Gen. Pharmacol. 3:423–433.PubMedGoogle Scholar
  34. 34.
    Martin, M. R., McHanwell, S., and Biscoe, T. J., 1978, Brain Res. 151:225–233.PubMedGoogle Scholar
  35. 35.
    Frederickson, R. C. A., Neuss, M., Morzorati, S. L., and McBride, W. J., 1978, Brain Res. 145:117–126.PubMedGoogle Scholar
  36. 36.
    Brown, D. A., 1979, Trends Neurosci. 2:271–273.Google Scholar
  37. 37.
    Allan, R. D., Evans, R. H., and Johnston, G. A. R., 1980, Br. J. Pharmacol. 70:609–615.PubMedGoogle Scholar
  38. 38.
    Alger, B. E., and Nicoll, R. A., 1982, J. Physiol. (Lond.) 328:125–141.Google Scholar
  39. 39.
    Barker, J. L., McBurney, R. N., and MacDonald, J. F., 1982, J. Physiol. 322:365–387.PubMedGoogle Scholar
  40. 40.
    Barker, J. L., and Mathers, D. A., 1981, Science 212:358–361.PubMedGoogle Scholar
  41. 41.
    Cull-Candy, S. G., and Parker, I., 1982, Nature 295:410–412.PubMedGoogle Scholar
  42. 42.
    Mathers, D. A., and Barker, J. L., 1981, Proc. Soc. Neurosci. 6:726.Google Scholar
  43. 43.
    Perkins, M. N., and Stone, T. W., 1982, Br. J. Pharmacol. 75:93–99.PubMedGoogle Scholar
  44. 44.
    Davies, L. P., Hambley, J. W., and Johnston, G. A. R., 1982, Neurosci. Lett. 29:57–61.PubMedGoogle Scholar
  45. 45.
    Barker, J. L., and Mathers, D. A., 1981, Trends Neurosci. 4:10–13.Google Scholar
  46. 46.
    Davies, J., and Watkins, J. C., 1974, Brain Res. 70:501–505.PubMedGoogle Scholar
  47. 47.
    Curtis, D. R., Game, C. J. A., Johnston, G. A. R., and McCulloch, R. M., 1974, Brain Res. 70:493–499.PubMedGoogle Scholar
  48. 48.
    Johnston, G. A. R., Curtis, D. R., Beart, P. M., Game, C. G. A., McCulloch, R. M., and Twitchin, B., 1975, J. Neurochem. 24:157–160.PubMedGoogle Scholar
  49. 49.
    Johnston, G. A. R., 1976, GAB A in Nervous System Function (E. Roberts, T. N. Chase, and D. B. Tower, eds.), Raven Press, New York, pp. 395–411.Google Scholar
  50. 50.
    Allan, R. D., Curtis, D. R., Headley, P. M., Johnston, G. A. R., Lodge, D., and Twitchin, B., 1980, J. Neurochem. 34:652–654.PubMedGoogle Scholar
  51. 51.
    Ryall, R. W., 1975, Handbook Psychopharmacol. 4:83–128.Google Scholar
  52. 52.
    Bowery, N. G. Doble, A., Hill, D. R., Hudson, A. L., Shaw, J. S., Turnbull, M. G., and Warrington, R., 1981, Eur. J. Pharmacol. 71:53–70.PubMedGoogle Scholar
  53. 53.
    Dunlap, K., 1981, Br. J. Pharmacol. 74:579–585.PubMedGoogle Scholar
  54. 54.
    Ault, B., and Evans, R. H., 1981, Eur. J. Pharmacol. 71:357–364.PubMedGoogle Scholar
  55. 55.
    Curtis, D. R., Lodge, D., Bornstein, J. C., and Peet, M. J., 1981, Exp. Brain Res. 42:158–170.PubMedGoogle Scholar
  56. 56.
    Davies, J., 1981, Br. J. Pharmacol. 72:373–384.PubMedGoogle Scholar
  57. 57.
    Lanthorn, T. H., and Cotman, C. W., 1981, Brain Res. 225:171–178.PubMedGoogle Scholar
  58. 58.
    Allan, R. D., Tran, H., and Skerritt, J. H., 1982, Neurosci. Lett. S8:30.Google Scholar
  59. 59.
    Ransom, B. R., and Barker, J. L., 1976, Brain Res. 114:530–535.PubMedGoogle Scholar
  60. 60.
    Polc, P., and Haefely, W., 1976, Naunyn Schmiedebergs Arch. Pharmacol. 294:121–131.PubMedGoogle Scholar
  61. 61.
    Nicoll, R. A., 1978, Psychopharmacology: A Generation of Progress (M. A. Lipton, A. Dimascio, and K. F. Killiam, eds.), Raven Press, New York, pp. 1337–1348.Google Scholar
  62. 62.
    MacDonald, R. L., and Barker, J. L., 1978, Nature 271:563–564.PubMedGoogle Scholar
  63. 63.
    Evans, R. H., 1979, Brain Res. 171:113–120.PubMedGoogle Scholar
  64. 64.
    Johnston, G. A. R., and Willow, M., 1982, Trends Pharmacol. 3:328–833.Google Scholar
  65. 65.
    Polc, P., Mohler, H., and Haefely, W., 1974, Naunyn Schmiedebergs Arch. Pharmacol. 284:319–337.PubMedGoogle Scholar
  66. 66.
    Curtis, D. R., Lodge, D., Johnston, G. A. R., and Brand, S. J., 1976, Brain Res. 118:344–347.PubMedGoogle Scholar
  67. 67.
    Jiang, Z.-G., 1981, Can. J. Physiol. Pharmacol. 59:595–598.PubMedGoogle Scholar
  68. 68.
    Lodge, D., and Curtis, D. R., 1978, Neurosci. Lett. 8:125–129.Google Scholar
  69. 69.
    Simmonds, M. A., 1980, Nature 284:558–560.PubMedGoogle Scholar
  70. 70.
    Study, R. E., and Barker, J. L., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:7180–7184.PubMedGoogle Scholar
  71. 71.
    Nutt, D. J., and Cowen, P. J., 1982, Nature 295:436–438.PubMedGoogle Scholar
  72. 72.
    Deisz, R. A., and Lux, H. D., 1977, Neurosci. Lett. 5:199–203.PubMedGoogle Scholar
  73. 73.
    Gallagher, D. W., Mallorga, P., and Tallman, J. F., 1980, Brain Res. 189:209–220.Google Scholar
  74. 74.
    Kerwin, R. W., Olpe, H.-R., and Schmutz, M., 1980, Br. J. Pharmacol. 71:545–551.PubMedGoogle Scholar
  75. 75.
    MacDonald, R. L., and Bergey, K. B., 1979, Brain Res. 170:558–562.PubMedGoogle Scholar
  76. 76.
    Scheel-Kruger, J., Arnt, J., Braestrup, C., Christensen, A. V., and Magelund, G., 1979, GABA-Neurotransmitters (P. Krogsgaard-Larsen, J. Scheel-Kruger, and H. Kofod, eds.), Munksgaard, Copenhagen, pp. 447–464.Google Scholar
  77. 77.
    Waddington, J. L., and Cross, A. J., 1979, Naunyn Schmiedebergs Arch. Pharmacol. 306:275–280.PubMedGoogle Scholar
  78. 78.
    Delini-Stula, A., 1979, GABA-Neurotransmitters (P. Krogsgaard-Larsen, J. Scheel-Kruger, and H. Kofod, eds.), Munksgaard, Copenhagen, pp. 482–499.Google Scholar
  79. 79.
    Waddington, J. L., 1978, Eur. J. Pharmacol. 51:417–422.PubMedGoogle Scholar
  80. 80.
    Hill, R. C., Maurer, R., Buescher, H.-H., and Roemer, D., 1981, Eur. J. Pharmacol. 69:221–224.PubMedGoogle Scholar
  81. 81.
    Johnston, G. A. R., Skerritt, J. H., and Willow, M., 1982, Problems in GAB A Research (Y. Okada and E. Roberts, eds.), Excerpta Medica, Amsterdam, pp. 293–301.Google Scholar
  82. 82.
    DeFeudis, F. V., 1981, Neurochem. Int. 3:113–122.PubMedGoogle Scholar
  83. 83.
    Krogsgaard-Larsen, P., Hjeds, H., Curtis, D. R., Lodge, D., and Johnston, G. A. R., 1979, J. Neurochem. 32:1717–1724.PubMedGoogle Scholar
  84. 84.
    Spano, P. F., Riccardi, F., Kobayashi, H., Memo, M., and Trabucchi, M., 1981, Abstracts, Eighth International Congress of Pharmacology, Japanese Pharmacological Society, Tokyo, p. 307.Google Scholar
  85. 85.
    Matus, A., Pehling, G., and Wilkinson, D., 1981, J. Neurobiol. 12:67–73.PubMedGoogle Scholar
  86. 86.
    DeFeudis, F. V., 1980, Neuroscience 5:675–688.PubMedGoogle Scholar
  87. 87.
    Palacios, J. M., Wamsley, J. K., and Kuhar, M. J., 1981, Brain Res. 222:285–307.PubMedGoogle Scholar
  88. 88.
    Morin, A. M., and Wasterlain, C. G., 1980, Life Sci. 26:1239–1245.PubMedGoogle Scholar
  89. 89.
    Krogsgaard-Larsen, P., Snowman, A., Lummis, S. C., and Olsen, R. W., 1981,J. Neurochem. 37:401–409.PubMedGoogle Scholar
  90. 90.
    Falch, E., and Krogsgaard-Larsen, P., 1982, J. Neurochem. 38:1123–1129.PubMedGoogle Scholar
  91. 91.
    Hill, D. R., and Bowery, N. G., 1981, Nature 290:149–152.PubMedGoogle Scholar
  92. 92.
    Molher, H., and Okada, T., 1978, Mol. Pharmacol. 14:256–265.Google Scholar
  93. 93.
    Bhatacharyya, A., Madyastha, K. M., Bhattacharyya, P. K., and Devanandan, M. S., 1981, Biochim. Biophys. Acta 98:520–526.Google Scholar
  94. 94.
    Olsen, R. W., Ticku, M. K., Greenlee, D., and Van Ness, P., 1979, GABA-Neurotransmitters (P. Krogsgaard-Larsen, J. Scheel-Kruger, and H. Kofod, eds.), Munksgaard, Copenhagen, pp. 165–178.Google Scholar
  95. 95.
    Olsen, R. W., and Leep-Lundberg, F. L., 1980, Eur. J. Pharmacol. 65:101–104.PubMedGoogle Scholar
  96. 96.
    Johnston, G. A. R., Kennedy, S. M. E., and Lodge, D., 1978, J. Neurochem. 31:1519–1523.PubMedGoogle Scholar
  97. 97.
    Enna, S. J., and Snyder, S. H., 1975, Brain Res. 100:81–97.PubMedGoogle Scholar
  98. 98.
    Enna, S. J., and Snyder, S. H., 1977, Mol. Pharmac. 13:442–453.Google Scholar
  99. 99.
    Horng, J. S., and Wong, D. T., 1979, J. Neurochem. 32:1379–1386.PubMedGoogle Scholar
  100. 100.
    Johnston, G. A. R., and Kennedy, S. M. E., 1978, Amino Acids as Chemical Transmitters (F. Fonnum, ed.), Plenum Press, New York, pp. 507–516.Google Scholar
  101. 101.
    Fiszer, S., and DeRobertis, E., 1967, Brain Res. 5:31–44.PubMedGoogle Scholar
  102. 102.
    Lester, B. R., Miller, A. L., and Peck, E. J., 1981, J. Neurochem. 36:154–164.PubMedGoogle Scholar
  103. 103.
    Redburn, D. A., and Mitchell, C. K., 1981, Life Sci. 28:541–549.PubMedGoogle Scholar
  104. 104.
    Mazzari, S., Massotti, A., Guidotti, A., and Costa, E., 1981, GABA and Benzodiazepine Receptors (E. Costa, G. DiChiara, and G. L. Gessa, eds.), Raven Press, New York, pp. 1–8.Google Scholar
  105. 105.
    Greenlee, D. V., and Olsen, R. W., 1979, Biochem. Biophys, Res. Commun. 88:380–387.Google Scholar
  106. 106.
    DeFeudis, F. V., and Somoza, E., 1977, Gen. Pharmacol. 8:181–187.PubMedGoogle Scholar
  107. 107.
    Bowery, N. G., Hill, D. R., Hudson, A. L., Perkins, M. N., and Stone, T. W., 1982, Br. J. Pharmacol. 75:47P.Google Scholar
  108. 108.
    Tunnicliff, G., and Smith, J. A., 1981, J. Neurochem. 36:1122–1126.PubMedGoogle Scholar
  109. 109.
    Gardner, C. R., Klein, J., and Grove, J., 1981, Eur. J. Pharmacol. 75:83–92.PubMedGoogle Scholar
  110. 110.
    Olsen, R. W., Bergman, M. O., Van Ness, P. C., Lummis, S. C., Watkins, A. E., Napias, C., and Greenlee, D. V., 1981, Mol. Pharmacol. 19:217–227.PubMedGoogle Scholar
  111. 111.
    Browner, M., Ferkany, J. W., and Enna, S. J., 1981, J. Neurosci. 1:514–518.PubMedGoogle Scholar
  112. 112.
    Skerritt, J. H., Willow, M., and Johnston, G. A. R., 1982, Neurosci. Lett. 29:63–66.PubMedGoogle Scholar
  113. 113.
    Waddington, J. L., and Cross, A. J., 1978, Nature 276:618–620.PubMedGoogle Scholar
  114. 114.
    Napias, C., Bergman, M. O., Van Ness, P. C., Greenlee, D. V., and Olsen, R. W., 1980, Life Sci. 27:1001–1011.PubMedGoogle Scholar
  115. 115.
    Elliott, K. A. C., and Van Gelder, N. M., 1958, J. Neurochem. 3:28–40.PubMedGoogle Scholar
  116. 116.
    Skerritt, J. H., Trisdikoon, P., and Johnston, G. A. R., 1981, Brain Res. 215:398–401.PubMedGoogle Scholar
  117. 117.
    Loh, H. H., and Low, P. Y., 1980, Annu. Rev. Pharmacol. 20:201–234.Google Scholar
  118. 118.
    Watkins, J. C., 1965, J. Theor. Biol. 9:37–50.PubMedGoogle Scholar
  119. 119.
    Giambalvo, C., and Rosenberg, P., 1976, Biochim. Biophys. Acta 436:741–756.PubMedGoogle Scholar
  120. 120.
    Lloyd, K. G., and Davidson, L., 1979, Science 205:1147–1149.PubMedGoogle Scholar
  121. 121.
    Olsen, R. W., Van Ness, P., Napias, C., Bergman, M., and Tourtellotte, W. W., 1980, Re ceptors for Neurotransmitters and Peptide Hormones (G. Pepeu, M. J. Kuhar, and S. J. Enna, eds.), Raven Press, New York, pp. 451–460.Google Scholar
  122. 122.
    Toffano, G., Aldino, C., Balzano, M., Leon, A., and Savoini, G., 1981, Brain Res. 222:95–102.PubMedGoogle Scholar
  123. 123.
    Ebadi, M., and Chweh, A., 1980, Neuropharmacology 19:1105–1111.PubMedGoogle Scholar
  124. 124.
    Guidotti, A., Toffano, G., and Costa, E., 1978, Nature 275:553–555.PubMedGoogle Scholar
  125. 125.
    Ebstein, B., Guidotti, A., and Costa, E., 1982, Problems in GABA Research (Y. Okada and E. Roberts, eds.), Excerpta Medica, Amsterdam, pp. 348–354.Google Scholar
  126. 126.
    Nagy, J., Kardos, J., Maksay, G., and Simonyi, M., 1981, Neuropharmacology 20:529–533.PubMedGoogle Scholar
  127. 127.
    Johnston, G. A. R., and Kennedy, S. M. E., 1978, Clin. Exp. Pharmacol. Physiol. 6:686–687.Google Scholar
  128. 128.
    Yoneda, Y., and Kuriyama, K., 1980, Nature 285:670–673.PubMedGoogle Scholar
  129. 129.
    Ticku, M. K., and Burch, T., 1980, Biochem. Pharmacol. 29:1217–1220.PubMedGoogle Scholar
  130. 130.
    Skerritt, J. H., and Johnston, G. A. R., 1982, Dev. Neurosci. 5:189–197.PubMedGoogle Scholar
  131. 131.
    Aldinio, C., Balzano, M. A., and Toffano, G., 1980, Pharmacol. Res. Commun. 12:495–500.PubMedGoogle Scholar
  132. 132.
    Candy, J. M., and Martin, I. L., 1979, J. Neurochem. 32:655–658.PubMedGoogle Scholar
  133. 133.
    Mallorga, P., Hamburg, M., Tallman, J. F., and Gallager, D. W., 1980, Neuropharmacology 19:405–408.PubMedGoogle Scholar
  134. 134.
    Mann, E., and Enna, S. J., 1980, Brain Res. 184:367–373.PubMedGoogle Scholar
  135. 135.
    Braestrup, C., and Nielsen, M., 1978, Brain Res. 147:170–173.PubMedGoogle Scholar
  136. 136.
    Ticku, M. J., 1980, Br. J. Pharmacol. 70:403–410.PubMedGoogle Scholar
  137. 137.
    Enna, S. J., Ferkany, J. W., and Strong, R., 1980, Receptors for Neurotransmitters and Peptide Hormones (G. Pepeu, M. J., Kuhar, and S. J. Enna, ed.), Raven Press, New York, pp. 253–263.Google Scholar
  138. 138.
    Ticku, M. J., and Huffman, R. D., 1980, Eur. J. Pharmacol. 68:97–106.PubMedGoogle Scholar
  139. 139.
    Mohler, H., Okada, T., and Enna, S. J., 1978, Brain Res. 156:391–395.PubMedGoogle Scholar
  140. 140.
    Willow, M., and Johnston, G. A. R., 1981, J. Neurosci. 1:364–367.PubMedGoogle Scholar
  141. 141.
    Willow, M., and Johnston, G. A. R., 1981, Neurosci. Lett. 23:71–74.PubMedGoogle Scholar
  142. 142.
    Willow, M., and Johnston, G. A. R., 1981, J. Neurochem. 37:1291–1294.PubMedGoogle Scholar
  143. 143.
    Willow, M., Morgan, I. G., and Johnston, G. A. R., 1981, Neurosci. Lett. 24:301–306.PubMedGoogle Scholar
  144. 144.
    Tallman, J. F., Thomas, J. W., and Gallager, D. W., 1978, Nature 274:383–385.PubMedGoogle Scholar
  145. 145.
    Braestrup, C., Neilson, M., Krogsgaard-Larsen, P., and Falch, E., 1980, Nature 280:331–333.Google Scholar
  146. 146.
    Garvish, M., and Snyder, S. H., 1979, Life Sci. 26:579–582.Google Scholar
  147. 147.
    Massotti, M., and Guidotti, A., 1980, Life Sci. 27:847–854.PubMedGoogle Scholar
  148. 148.
    Mohler, H., 1981, Trends Pharmacol. Sci. 2:116–119.Google Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • G. A. R. Johnston
    • 1
  • R. D. Allan
    • 1
  • J. H. Skerritt
    • 1
  1. 1.Department of PharmacologyUniversity of SydneySydneyAustralia

Personalised recommendations