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Phospholipid Methylation

  • Fusao Hirata

Abstract

Phospholipid methylation is a reaction in which phosphatidylethanolamine (PtdEth) is converted to phosphatidylcholine (PtdCho). This reaction was first described by Bremer et al.1 However, the enzyme activity of phospholipid methylation is quite low compared with CDP-choline transferese activity in PdtCho synthesis. For long time, this enzyme activity had not been detected in tissues other than lung and liver. Recently, many laboratories have reported the existence of PtdEth methyltransferase activity in a variety of organs and tissues of mammals. This enzyme activity in many tissues if not all, has now been connected to certain biological functions such as receptor-mediated signal transduction.2 In this chapter, recent studies on phospholipid methylation and its role in biological functions are described.

Keywords

Nerve Growth Factor Adenylate Cyclase Membrane Fluidity Cytoplasmic Side Eicosatrienoic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bremer, K., and Greenberg, D. M., 1961, Biochem. Biophys. Acta 46:205–216.CrossRefGoogle Scholar
  2. 2.
    Hirata, F., and Axelrod, J., 1980, Science 209:1082–1090.PubMedCrossRefGoogle Scholar
  3. 3.
    Hirata, F., Viveros, H. O., Deliverto, E. J., Jr., and Axelrod, J., 1979, Proc. Natl. Acad. Sci. U.S.A. 75:1718–1721.CrossRefGoogle Scholar
  4. 4.
    Mozzi, R., Andreoli, V., and Porcellati, G., 1980, FEBS Lett. 131:115–118.CrossRefGoogle Scholar
  5. 5.
    Crews, F. T., Hirata, F., and Axelrod, J., 1980, J. Neurochem. 34:1491–1498.PubMedCrossRefGoogle Scholar
  6. 6.
    Sastry, R. B. V., Satham, C. M., Axelrod, J., and Hirata, F., 1981, Arch. Biochem. Biophys. 211:762–773.PubMedCrossRefGoogle Scholar
  7. 7.
    Schneider, W. J., and Vance, D. E., 1979, J. Biol. Chem. 254:3886–3891.PubMedGoogle Scholar
  8. 8.
    Tanaka, Y., Doi, O., and Akamatsu, Y., 1979, Biochem. Biophys. Res. Commun. 87:1109–1115.PubMedCrossRefGoogle Scholar
  9. 9.
    Scarborough, G. A., and Nyc, J. F., 1967, J. Biol. Chem. 242:238–342.PubMedGoogle Scholar
  10. 10.
    McGivney, A., Crews, F. T., Hirata, F., Axelrod, J., and Siraganian, R. P., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:6176–6180.PubMedCrossRefGoogle Scholar
  11. 11.
    Op Den Kamp, A. F., 1979, Annu. Rev. Biochem. 48:47–71.CrossRefGoogle Scholar
  12. 12.
    Bergelson, L. D., and Barsucov, L. I., 1977, Science 197:224–230.PubMedCrossRefGoogle Scholar
  13. 13.
    Hirata, F., and Axelrod, J., 1978, Proc. Natl. Acad. Sci. U.S.A. 75:2348–2352.PubMedCrossRefGoogle Scholar
  14. 14.
    Crews, F. T., Hirata, F., and Axelrod, J., 1980, Neurochem. Res. 5:983–991.PubMedCrossRefGoogle Scholar
  15. 15.
    Higgins, J. A., 1981, Biochim. Biophys. Acta 640:1–15.PubMedCrossRefGoogle Scholar
  16. 16.
    Wakil, S. J., 1970, Lipid Metabolism ,Academic Press, New York.Google Scholar
  17. 17.
    Trewhella, M. A., and Collins, F. D., 1973, Biochim. Biophys. Acta 296:51–61.PubMedCrossRefGoogle Scholar
  18. 18.
    Klauser, R. D., Kleinfeld, A. M., Hoover, R. J., and Karnovsky, M. J., 1980, J. Biol. Chem. 255:1286–1295.Google Scholar
  19. 19.
    Akesson, S., 1978, FEBS Lett. 92:177–180.PubMedCrossRefGoogle Scholar
  20. 20.
    Schneider, W. J., and Vance, D. E., 1979, Eur. J. Biochem. 85:181–187.CrossRefGoogle Scholar
  21. 21.
    Pritchard, P. H., Chiang, P. K., Cantoni, G. L., and Vance, D. K., 1982, J. Biol. Chem. 237:6362–6367.Google Scholar
  22. 22.
    Sugiura, T., Onuma, Y., Sekiguchi, N., and Waku, K., 1982, Biochim. Biophys. Acta 712:515–522.PubMedCrossRefGoogle Scholar
  23. 23.
    Albert, D. H., and Snyder, F., 1983, J. Biol. Chem. 258:97–102.PubMedGoogle Scholar
  24. 24.
    Vargatfig, B. B., Chignard, M., Benvenite, J., Lefort, J., and Wal, F., 1981, Ann. N.Y. Acad. Sci. 77:119–136.Google Scholar
  25. 25.
    Cantoni, G. L., Richard, H. H., and Chiang, P. K., 1979, Transmethylation E. Usdin, R. T. Borchardt, and C. R. Creveling, Elsevier, Amsterdam, pp. 155–165. .Google Scholar
  26. 26.
    Zimmerman, T. P., Schmitges, C. J., Wolberg, G., Deeprose, R. D., Duncan, G. S., Cuatre-casas, P., and Elion, G. B., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:5639–5643.PubMedCrossRefGoogle Scholar
  27. 27.
    Hirata, F., and Axelrod, J., 1980, Nature 275:219–220.CrossRefGoogle Scholar
  28. 28.
    Nakajima, M., Tamura, E., Irimura, T., Toyoshima, S., Hirano, H., and Osawa, T., 1981, J. Biochem. 89:665–675.PubMedGoogle Scholar
  29. 29.
    Strittmatter, W. J., Hirata, F., and Axelrod, J., 1979, Biochem. Biophys. Res. Com/nun. 88:147–153.CrossRefGoogle Scholar
  30. 30.
    Strittmatter, W. J., Hirata, F., and Axelrod, J., 1979, Science 204:1207–1209.CrossRefGoogle Scholar
  31. 31.
    Bhattacharya, A., and Vonderhaar, B. K., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:4487–4492.Google Scholar
  32. 32.
    Pike, M. C., and Snyderman, R., 1982, Cell 28:107–114.PubMedCrossRefGoogle Scholar
  33. 33.
    Hirata, F., 1982, Biochemistry of S-Adenosylmethionine and Related Compounds. (E. Usdin, R. T. Borchardt, and C. R. Creveling, eds.), Macmillan, London, pp. 109–118.Google Scholar
  34. 34.
    Tallman, J. F., Henneberry, R. C., Hirata, F., and Axelrod, J., 1979, Catecholamines: Basic and Clinical Frontiers ,Volume 1. (E. Usdin, I. J. Kopin, and J. Barchas, eds.), Pergamon Press, New York, pp. 489–491.Google Scholar
  35. 35.
    Hirata, F., Corcoran, B., Venkatasubramanian, K., Schiffmann, E., and Axelrod, J., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:2640–2643.PubMedCrossRefGoogle Scholar
  36. 36.
    Pfenniger, K. H., and Johnson, M. P., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:7797–7800.CrossRefGoogle Scholar
  37. 37.
    Strittmatter, W. J., Hirata, F., Axelrod, J., Mallorga, P., Tallman, J. F., and Henneberry, R. C., 1979, Nature 282:857–859.PubMedCrossRefGoogle Scholar
  38. 38.
    Crews, F. T., Morita, Y., McGivney, A., Hirata, F., Siraganian, R. P., and Axelrod, J., 1981, Arch. Biochem. Biophys. 212:561–571.PubMedCrossRefGoogle Scholar
  39. 39.
    Randon, J., Lecompte, T., Chignard, M., Siess, W., Marias, G., Dray, F., and Vargraftig, B. B., 1981, Nature 293:660–662.PubMedCrossRefGoogle Scholar
  40. 40.
    Kannagi, R., Koizumi, K., and Masuda, T., 1981, J. Biol. Chem. 256:1177–1184.PubMedGoogle Scholar
  41. 41.
    Rittenhouse-Simmons, S., 1979, J. Clin. Invest. 63:580–587.PubMedCrossRefGoogle Scholar
  42. 42.
    Ishizaka, T., Hirata, F., Sterk, A. R., Ishizaka, K., and Axelrod, J., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:6167–6180.CrossRefGoogle Scholar
  43. 43.
    Ross, E. M., and Gillman, A. G., 1980, Annu. Rev. Biochem. 49:533–564.PubMedCrossRefGoogle Scholar
  44. 44.
    Hirata, F., Strittmatter, W. J., and Axelrod, J., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:368–372.PubMedCrossRefGoogle Scholar
  45. 45.
    Rimmon, G., Hanski, E., Braum, S., and Levitzke, A., 1978, Nature 276:394–397.CrossRefGoogle Scholar
  46. 46.
    Klein, I., Moore, L., and Pastan, I., 1978, Biochem. Biophys. Acta 506:42–53.PubMedCrossRefGoogle Scholar
  47. 47.
    Ross, E. M., 1982, J. Biol. Chem. 257:10751–10758.PubMedGoogle Scholar
  48. 48.
    Münzel, P., and Kosehel, K., 1982, Proc. Natl. Acad. Sci. U.S.A. 79:3692–3696.PubMedCrossRefGoogle Scholar
  49. 49.
    Edelman, G., 1976, Science 192:218–226.PubMedCrossRefGoogle Scholar
  50. 50.
    Soifer, D., and Czosnek, H., 1980, Microtubules andMicrotuble Inhibitors ,(M. DeBrabander, and J. DeMey, eds.), Elsevier/North-Holland, Biomedical Press, Amsterdam, pp. 429–447.Google Scholar
  51. 51.
    Kumar, N., Blumenthal, R., Henkart, M., Weinstein, J. N., and Klausner, R. D., 1982, J. Biol. Chem. 257:15137–15144.PubMedGoogle Scholar
  52. 52.
    Marchese, S. L., Steers, E., Marchesi, V. T., and Tillalk, T. W., 1969, Biochemistry 9:50–57.CrossRefGoogle Scholar
  53. 53.
    Hargraves, W. R., Giedd, K. N., Verkleji, A., and Branton, D., 1980, J. Biol. Chem. 256:11965–11972.Google Scholar
  54. 54.
    Pike, M., Kredich, N. M., and Snyderman, R., 1980, Cell 20:373–379.PubMedCrossRefGoogle Scholar
  55. 55.
    Sahyoun, N. E., Levine, H. III, Devis, J., Hobdon, G. E., and Cuatrecasas, P., 1981, Proc. Natl. Acad. Sci. U.S.A 78:6158–6162.PubMedCrossRefGoogle Scholar
  56. 56.
    Hoffman, T., Hirata, F., Bongnonx, P., Fraser, B. A., Goldfarb, R. H., Herberman, R. B., and Axelrod, J., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:3839–3843.PubMedCrossRefGoogle Scholar
  57. 57.
    Rasmussen, H., and Goodman, D. B. P., 1977, Physiol. Rev. 57:421–509.PubMedGoogle Scholar
  58. 58.
    Ishizaka, T., Hirata, F., Ishizaka, K., and Axelrod, J., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:1903–1909.PubMedCrossRefGoogle Scholar
  59. 59.
    Toyoshima, S., Hirata, F., Axelrod, J., Beppu, M., Osawa, T., and Waxdal, M. J., 1982, Mol. Immunol. 19:229–234.PubMedCrossRefGoogle Scholar
  60. 60.
    Bareis, D. L., Hirata, F., Schiffmann, E., and Axelrod, J., 1982, J. Cell Biol. 93:690–697.PubMedCrossRefGoogle Scholar
  61. 61.
    Mallorga, P., Tallman, J. F., Henneberry, R. C., Hirata, F., Strittmatter, W. J., and Axelrod, J., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:1341–1345.PubMedCrossRefGoogle Scholar
  62. 62.
    Shítara, N., McKeever, P. E., Cummins, C., Smith, B. H., Kornblith, P. L., and Hirata, F., 1982, Biochem. Biophys. Res. Commun. 109:753–761.PubMedCrossRefGoogle Scholar
  63. 63.
    Cimazierre, C., Maziere, J. C., Mora, L., and Polonovski, J., 1981, FEBS Lett. 129:67–69.CrossRefGoogle Scholar
  64. 64.
    Honma, Y., Kasukabe, T., and Hozumi, M., 1981, Biochim. Biophys. Acta 664:441–444.PubMedCrossRefGoogle Scholar
  65. 65.
    Chiang, P. K., 1980, Science 211:1164–1166.CrossRefGoogle Scholar
  66. 66.
    Hitzemann, R., 1982, Life Sci. 30:1297–1303.PubMedCrossRefGoogle Scholar
  67. 67.
    Blusztajn, J. K., Ziesel, S. H., and Wurtman, R. J., 1982, Biochemistry of S-Adenosylme-thionine and Related Compounds. (E. Usdin, R. T. Borchardt, and C. R. Creveling, eds.), Macmillan, London, pp. 155–164.Google Scholar
  68. 68.
    Limas, C. J., 1980, Circ. Res. 47:536–541.PubMedCrossRefGoogle Scholar
  69. 69.
    Schanche, J. S., Sanche, T., and Ueland, P. M., 1982, Biochim. Biophys. Acta 721:399–407.PubMedCrossRefGoogle Scholar
  70. 70.
    Yamashita, S., Oshima, A., Nikawa, J., and Hosaka, K., 1982, Eur. J. Biochem. 128:589–595.PubMedCrossRefGoogle Scholar
  71. 71.
    Michel, R. H., 1975, Biochim. Biophys. Acta 415:81–147.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Fusao Hirata
    • 1
  1. 1.Laboratory of Cell BiologyNational Institute of Mental HealthBethesdaUSA

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