Peptide Receptors

  • David R. Burt
  • Najam A. Sharif


The general area of peptide neurotransmission/neuromodulation has been re viewed extensively in recent years1-5 and is covered elsewhere in the present series. Neuropeptide receptors have also been reviewed previously.6,7 This chapter concentrates on the modest progress that has been made towards identifying receptors for nonopioid peptides in the vertebrate central nervous system (CNS) by binding and other biochemical measurements. Only limited reference is made to results of anatomic, electrophysiological, or behavioral experiments in the CNS or to results in various peripheral systems. Peptides are included because they are present in the CNS and have effects there. In most cases, additional criteria for neurotransmitter identification have been met as well. Many of the peptides discussed here have prominent hormonal or other peripheral roles so that their receptors have been best studied outside the CNS. These receptors may or may not be the same as CNS receptors. In some cases, there are questions about the exact identities of the peptides exciting CNS receptors, since the peptides’ presence has been established by radioimmunoassay or immunohistochemistry-methods that can be detecting families of structurally related peptides. In other cases, there are questions about the sources of peptides exciting these receptors, i.e., whether they are of central or peripheral origin.


Receptor Binding Olfactory Bulb Vasoactive Intestinal Peptide Peptide Receptor Amylase Release 


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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • David R. Burt
    • 1
  • Najam A. Sharif
    • 1
  1. 1.Department of Pharmacology and Experimental TherapeuticsUniversity of Maryland School of MedicineBaltimoreUSA

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