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Recognition Sites for Antidepressant Drugs

  • De-Maw Chuang
  • E. Costa

Abstract

It has been almost two decades since the discovery that tricyclic antidepressants and monoamine oxidase (MAO) inhibitors were clinically effective in the treatment of depression. In spite of intensive investigations, neither the mo lecular mechanisms whereby antidepressants operate nor the etiology of this disease is well understood. The knowledge that reserpine, which depletes monoamine stores,1,2 can induce a depressed mood 3 has stimulated speculation on a causal relationship between a defect in monoaminergic transmission and endogenous depression.

Keywords

Adenylate Cyclase Recognition Site Antidepressant Drug Daily Injection Endogenous Modulator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • De-Maw Chuang
    • 1
  • E. Costa
    • 1
  1. 1.Laboratory of Preclinical Pharmacology, National Institute of Mental HealthSaint Elizabeths HospitalUSA

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