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Animal Models of Human Type I Diabetes

  • Ali Naji
  • Clyde F. Barker

Abstract

Experimental and clinical evidence indicates that human diabetes is not a single disease, but a heterogeneous group of syndromes having hyperglycemia as the common denominator (Fajans et al., 1978; Rotter and Rimoin., 1981; Nerup and Lernmark, 1981; Rizza et al., 1981). The diabetic syndromes in animals are similarly complex and include a broad spectrum of pathophysiology. Since hyperglyemic states in animals may or may not parallel the human diseases, (which are themselves ill-defined), animal syndromes should not be expected to serve as exact “models” of various types of diabetes in humans. However, they can be used to simulate certain genotypic or phenotypic expressions that may have a role in human diabetes. The availability of nondiabetic animals of genetic makeup similar or identical to their diabetic counterparts constitutes an important resource for diabetes research because these nondiabetic control animals can be used for physiological comparisons as well as tissue transplantation studies.

Keywords

Beta Cell Pancreatic Islet Islet Transplantation Human Type Islet Cell Antibody 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Ali Naji
    • 1
  • Clyde F. Barker
    • 1
  1. 1.Department of Surgery, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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