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Circulating Immune Complexes

  • Dinesh Kumar

Abstract

Antigens, self or foreign, induce an immune response leading to production of specific antibodies that interact with the inciting antigens and may form antigen—antibody (immune) complexes. An immune response is normally developed as a defense mechanism which eliminates and neutralizes the undesirable antigens. In addition, immune complexes have a regulatory role in both the cellular and humoral immune responses by virtue of their capacity to interreact with Fc and complement receptor-bearing lymphocytes and macrophages. The formation of the immune complexes under certain circumstances could be pathogenic, resulting in disease states.

Keywords

Immune Complex Raji Cell Islet Cell Antibody Insulin Antibody Immune Complex Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Andersen, O. O., 1976, Anti-insulin antibodies and late diabetic complications, Acta Endocrinol. (Kbh.) 83: 329–340.Google Scholar
  2. Anderson, J. H., Blackard, W. G., Goldman, J., and Rubenstein, A. H., 1978, Diabetes and hypoglycemia due to insulin antibodies, Am. J. Med. 64: 868–873.PubMedCrossRefGoogle Scholar
  3. Andreani, D., Di Mario, U., Galfo, C., Ventriglia, L., and Iavicoli, M., 1982, Circulating immune complexes in diabetics with severe microangiopathy, evaluation by two different methods, Acta Endocrinol. (Kbh.) 99: 239–244.Google Scholar
  4. Arend, W. P., Teller, D. C., and Mannik, M., 1972, Molecular composition and sedimentation characteristics of soluble antigen-antibody complexes, Biochemistry 11: 4063–4072.PubMedCrossRefGoogle Scholar
  5. Austen, K. F., 1974, Symposium on the immunobiology of complement, Transplant. Proc. 6: 1–88.Google Scholar
  6. Baldwin, R. W., and Robins, R. A., 1976, Factors interfering with immunological rejection of tumors, Br. Med. Bull. 32: 118–123.PubMedGoogle Scholar
  7. Barnett, E. V., Knutson, D. W., Abrass, C. K., Chia, D. S., Young, L. S., and Liebling, M. R., 1979, Circulating immune complexes, their immunochemistry, detection and importance, Ann. Intern. Med. 91: 430–440.Google Scholar
  8. Bartolotti, S. R., 1981, Defective Fc-receptor functions with the HLA-b8/DRw3 haplotype, N. Engl. J. Med. 305: 346.PubMedCrossRefGoogle Scholar
  9. Bauer, M., and Levan, N. E., 1970, Diabetic dermangiopathy, a spectrum including pigmented pretibial patches and necrobiosis lipoidica diabeticorum, Br. J. Dermatol. 83: 528–535.PubMedCrossRefGoogle Scholar
  10. Beregi, E., 1973, Immunopathologic study of renal changes of diabetic individuals, Int. Urol. Nephro. 5: 179–186.CrossRefGoogle Scholar
  11. Berson, S. A., Yalow, R. S., Bauman, A., Rothchild, A., and Newerly, K., 1956, Insulin-I131 metabolism in human subjects, demonstration of insulin binding globulin in circulation of insulin treated subjects, J. Clin. Invest. 35: 170–190.PubMedCrossRefGoogle Scholar
  12. Bodansky, H. J., Wolf, E., Cudworth, A. G., Dean, B. M., Nineham, L. J., Buttazzo, G. F., Mathews, J. A., Kurtz, A. B., and Kohner, E. M., 1982, Genetic and immunologic factors in microvascular disease in type 1 insulin-dependent diabetes, Diabetes 31: 70–74.PubMedCrossRefGoogle Scholar
  13. Casali, P., Bossus, A., Carpentier, N. A., and Lambert, P. H., 1977, Solid phase enzyme immunoassay or radioimmunoassay for the detection of immune complexes based on their recognition by conglutinin:conglutinin-binding test. A comparative study with125I labelled Clq binding and Raji-cell RIA tests, Clin. Exp. Immunol 29: 342–354.PubMedGoogle Scholar
  14. Charlesworth, J. A., Campbell, L. V., Quin, J., Lazarus, L., and Macdonald, G. J., 1979, Immune complexes in diabetes mellitus, Aust. N.Z. J. Med. 9: 370–373.PubMedCrossRefGoogle Scholar
  15. Clagett, J. H., Wilson, C. B., and Weigle, W. O., 1974, Intersitial immune complex thyroiditis in mice, the role of autoantibody to thyroglobulin, J. Exp. Med. 140: 1439–1456.PubMedCrossRefGoogle Scholar
  16. Cochrane, C. G., and Koffler, D., 1973, Immune complex disease in experimental animals and man, Adv. Immunol. 16: 186–264.Google Scholar
  17. Delespesse, G., Gausset, P. H., Sarfati, M., Dubi-Rucquoy, M., Dibesschop, M. J., and Van Haelst, L., 1980, Circulating immune complexes in old and in diabetics: correlation with autoantibodies, Clin. Exp. Immunol. 40: 96–102.PubMedGoogle Scholar
  18. Digeon, M., Laver, M., Rixa, J., and Bach, J. F., 1977, Detection of circulating immune complexes in human sera by simplified assays with polyethylene glycol, J. Immunol. Methods 16: 165–183.PubMedCrossRefGoogle Scholar
  19. Di Mario, U., Iavicoli, M., and Andreani, D., 1980, Circulating immune complexes in diabetes, Diabetologia 19: 89–92.PubMedCrossRefGoogle Scholar
  20. Dixon, K., Exon, P. D., and Malins, J M, 1975, Insulin antibodies and control of diabetes, Q. J. Med. 44: 543–553.PubMedGoogle Scholar
  21. Farrant, P. C., and Sheddon, W. I. H., 1965, Observations on the uptake of insulin conjugated with fluorescein isothiocyanate by diabetic kidney tissue, Diabetes 14: 274–278.PubMedGoogle Scholar
  22. Foiling, I., 1976, Insulin-anti-insulin complexes, Acta Endocrinol. (Kbh.) 83 (Suppl. 205): 199–209.Google Scholar
  23. Frikke, M. J., Gingerich, R. L., Stranahan, P. D., Carter, G., Bauman, A. K., Greider, M. H., Wright, P. H., and Lacy, P. E., 1974, Distribution of injected insulin and insulin-antibody complexes in normal and insulin-immunized animals, Diabetologia 10: 345–351.PubMedGoogle Scholar
  24. Fust, G., Szekley, J., and Gero, S., 1977, Circulating immune complexes in vascular diseases, Lancet 1: 193–194.PubMedCrossRefGoogle Scholar
  25. Gallo, G. R., 1970, Elution studies in kidneys with linear deposition of immunoglobulin in glomeruli, Am. J. Pathol. 61: 377–385.PubMedGoogle Scholar
  26. Gigli, I., 1976, Immunochemistry and immunobiology of complement system, J. Invest. Dermatol. 67: 346–353.PubMedCrossRefGoogle Scholar
  27. Gotze, O., and Muller-Eberhard, H. J., 1976, The alternative pathway of complement activation, Adv. Immunol. 24: 1–35.PubMedCrossRefGoogle Scholar
  28. Haakenstad, A. O., and Mannik, M., 1974, Saturation of the reticuloendothelial system with soluble immune complexes, J. Immunol. 112: 1939–1948.PubMedGoogle Scholar
  29. Hay, F. C., Nineham, L J., and Roitt, I. M., 1976, Routine assay for the detection of immune complexes of known immunoglobulin class using a solid phase Clq, Clin. Exp. Immunol. 24: 396–400.PubMedGoogle Scholar
  30. Hellstrom, K. E., and Hellstrom, I., 1974, Lymphocyte mediated cytotoxicity and blocking serum activity to tumor antigens, Adv. Immunol. 18: 209–277.PubMedCrossRefGoogle Scholar
  31. Henson, P. M., and Cochrane, C. G., 1971, Acute immune complex disease in rabbits. The role of complement and of a leukocyte-dependent release of vasoactive amines from platelets, J. Exp. Med. 133: 54–571.CrossRefGoogle Scholar
  32. Henson, P. M., and Oades, Z. G., 1976, Activation of platelets by platelets-activating factor (PAF) derived from IgE-sensitized basophils. II The role of serine proteases, cyclic nucleotides, and contractile elements in PAF-induced secretion, J. Exp. Med. 143: 953–968.PubMedCrossRefGoogle Scholar
  33. Henson, P. M., and Spiegelberg, H. L., 1973, Release of serotinin from human platelets induced by aggregated immunoglobulins of different classes and subclasses J. Clin. Invest. 52: 1282–1288.PubMedCrossRefGoogle Scholar
  34. Howes, E. L., and McKay, D. G., 1975, Circulating immune complexes. Effects on ocular vascular permeability in the rabbit, Arch. Ophthaimoi. 93: 365–370.CrossRefGoogle Scholar
  35. Hultquist, G. T., and Olding, L. B., 1981, Endocrine pathology of infants of diabetic mothers, Acta Endocrinol. (Kbh.) 97 (Suppl. 241): 1–202.Google Scholar
  36. Iavicoli, M., Di Mario, U., Pozzilli, P., Canalese, J., Vetrigfia, L., Galfo, C., and Andreani, D., 1982, Impaired phagocytic function and increased immune complexes in diabetics with severe microangiopathy, Diabetes 31: 7–11.PubMedCrossRefGoogle Scholar
  37. Inman, R. D., and Day, N. K., 1981, Immunologic and clinical aspects of immune complex diseases, Am. J. Med. 70: 1097–1106.PubMedCrossRefGoogle Scholar
  38. Irvine, W. J., Al-Khateeb, S. F., Di Mario, U., Feek, C. M., Gray, R. S., Edmond, B., and Duncan, L. J. P., 1977, Soluble immune complexes in the sera of newly diagnosed insulin-dependent diabetics and in treated diabetics, Clin. Exp. Immunol. 30: 16–21.PubMedGoogle Scholar
  39. Irvine, W. J., Di Mario, U., Guy, K., Feek, C. M., Gray, R. S., and Duncan, L. J. P., 1978a, Immune complexes in newly diagnosed insulin dependent (type 1) diabetics, J. Clin. Lab. Immunol. 1: 183–186.PubMedGoogle Scholar
  40. Irvine, W. J., Di Mario, U., Guy, K., Iavicoli, M., Pozzilli, P., Lumbroso, B., and Andreani, D., 1978b, Immune complexes and diabetic microangiopathy, J. Clin. Lab. Immunol. 1: 187–191.PubMedGoogle Scholar
  41. Jayarao, K., Faulk, W. P., Karam, J. H., Grodsky, G. M., and Forsham, P. H., 1974, Evidence in support of the concept of immune-complex disease in insulin-treated diabetics, in: Immunity and Autoimmunity in Diabetes Mellitus ( P. A. Bastenie and W. Gepts, eds.), pp. 255–263, Excerpta Medica, Amsterdam.Google Scholar
  42. Jerne, N. K., 1974, Towards a network theory of immune system, Ann. Immunol. 125: 373–389.Google Scholar
  43. Kahn, C. R., and Rosenthal, A. J., 1979, Immunolgoic reactions to insulin: Insulin allergy, insulin resistance, and autoimmune insulin syndrome, Diabetes Care 2: 283–295.PubMedGoogle Scholar
  44. Kahn, C. R., Baird, K. L., Jarret, D. B., and Flier, J., 1978, Direct demonstration that receptor crosslinking or aggregation is important in insulin action, Proc. Natl. Acad. Sci. USA 75: 4209–4213.PubMedCrossRefGoogle Scholar
  45. Kanatsuna, T., Freedman, Z. R., Rubenstein, A. H., and Lernmark, A., 1982, Effects of islet cell surface antibodies and complement on the release of insulin and chromium from perifused B cells, Clin. Exp. Immunol. 47: 85–92.PubMedGoogle Scholar
  46. Kilpatrick, J. M., and Virella, G., 1980, Isolation and characterization of soluble insulin-anti-insulin immune complexes formed in vitro and in vivo in sera from patients with diabetes mellitus, Clin. Exp. Immunol. 40: 445–452.PubMedGoogle Scholar
  47. Klein, V. G., 1973, Quantitative immunological determination of plasma proteins in diabetic microangiopathy. Wein. Klin. Wochenschr. 85: 192–194.Google Scholar
  48. Kloppel, G., Altenahn, E., and Freytag, G., 1971, Electronemicroskopische untersuchugen zur experimentellen insulitis nach injection von anti-insulin serum, Virchows Arch. Pathol. Anat. 354: 324–335.CrossRefGoogle Scholar
  49. Kumar, D., 1977, Anti-insulin IgE in diabetics, J. Clin. Endocrinol. Metab. 45: 1159–1164.PubMedCrossRefGoogle Scholar
  50. Kumar, D., and Miller, L., 1973, Proinsulin specific antibodies in huamn sera, Diabetes 22: 361–366.PubMedGoogle Scholar
  51. Kumar, D., and Quismorio, Jr., F. P., 1978, Immune complexes in diabetic patients, Diabetes 27: 222.Google Scholar
  52. Kumar, D., Miller, L. V., and Mehtalia, S. D., 1977, Use of dexamethasone in treatment of insulin lipoatrophy, Diabetes 26: 296–299.PubMedCrossRefGoogle Scholar
  53. Kumar, D., Rhodes, J., and Miller, A., 1981, Idiotypic antibodies against insulin antibodies in circulating immune complexes, Diabetes 30 (Suppl. 1): 94A.Google Scholar
  54. Kumar, D., Zeidler, A., and Quismorio, Jr., F. P., 1979, Circulating immune complexes, islet-cell and insulin antibodies, Diabetes 28: 378.Google Scholar
  55. Kurtz, A. B., Mustaffa, B. E., Dagget, P. R., and Nabarro, J. D. N., 1977, Effects of insulin antibodies on free and total plasma insulin, Lancet 2: 56–58.PubMedCrossRefGoogle Scholar
  56. Lacy, P. E., and Wright, P. H., 1965, Allergic interstitial pancreatitis in rats injected with guinea pig anti-insulin serum, Diabetes 14: 634–642.PubMedGoogle Scholar
  57. Lambert, P. H., Dixon, F. J., Zubler, R. H., Agnello, V., Cambiaso, C., Casali, P., Clarke, J., Cowdery, J. S., McDuffie, F. C., Hay, F. C., Maclennan, I. C. M., Masson, P., Muller-Eberhard, H. J., Penthinen, K., Smith, M., Tappeiner, G., Theofilopoulos, A. N., and Verroust, P., 1978, A WHO collaborative study for the evaluation of eighteen methods for detecting immune complexes in serum, J. Clin. Lab. Immunol. 1: 1–15.Google Scholar
  58. Larsson, O., 1967, Studies of small vessels in patients with diabetes. A clinical histological and immunohistochemical study of diabetic and non-diabetic subjects with special reference to the occurrence of various plasma proteins in the dermal vessel walls, Acta Med. Scand. [Suppl.] 480: 5–65.Google Scholar
  59. Lattime, E. C., and Strausser, H. R., 1977, Atherosclerosis. Is stress-induced immune suppression a risk factor? Science 198: 302–303.PubMedCrossRefGoogle Scholar
  60. Lawley, T. J., Hall, R. P., Fauci, A. S., Katz, S. I., Hamberger, M. I., and Frank, M. M., 1981, Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotypes: Studies in patients with dermatitis herpetiformis and normal subjects, N. Engl. J. Med. 304: 185–192.PubMedCrossRefGoogle Scholar
  61. Mathews, J. D., Whittingham, S., and Mackay, I. R., 1974, Autoimmune mechanisms in human vascular disease, Lancet 2: 1423–1427.PubMedCrossRefGoogle Scholar
  62. Meade, C. J., Brandon, D. R., Smith, W., Simmonds, R. G., Harris, S., and Sowter, C., 1981, the relationship between hyperglycemia and renal immune complex deposition in mice with inherited diabetes, Clin. Exp. Immunol 43: 109–120.PubMedGoogle Scholar
  63. Muller-Eberhard, H. J., 1975, Complement, Annu. Rev. Biochem. 44: 697–724.PubMedCrossRefGoogle Scholar
  64. Oldstone, M., and Dixon, F., 1971, Immune complex disease in chronic viral infections, J. Exp. Med. (Suppl) 134: 32s - 39s.Google Scholar
  65. Osier, A. G., and Sandberg, A. L., 1973, Alternate complement pathways, Prog. Allergy 17: 51–92.Google Scholar
  66. Porter, R. R., and Reid, K. B. M., 1978, The biochemistry of complement, Nature 275: 699–704.PubMedCrossRefGoogle Scholar
  67. Reeves, W. G., Allen, B. R., and Tattersall, R. B., 1980, Insulin-induced lipoatrophy, evidence for an immune pathogenesis, Br. Med. J. 280: 1500–1503.PubMedCrossRefGoogle Scholar
  68. Revoltella, R., Pediconi, M., Bertolini, L., and Bosman, C., 1975, In vitro immune response by murine bone marrow cells stimulated against soluble immune complexes, Cell. Immunol. 20: 117–132.PubMedCrossRefGoogle Scholar
  69. Rodrick, M., Allan, R., and Isliker, H., 1978, Activation of the classical and alternative pathways of complement fixation by immune complexes containing normal and tryptophan-modified immunoglobulin G, J. Immunol. Methods 22: 211–218.PubMedCrossRefGoogle Scholar
  70. Root, M., Chance, R. E., and Galloway, J. A., 1972, Immunogenicity of insulin, Diabetes, 21: 657–660.PubMedGoogle Scholar
  71. Rose, L. M., and Lambert, P. H., 1980, The natural occurrence of circulating idiotype anti-idiotype complexes during a secondary immune response to phosphorylcholine, Clin. Immunol. Immunopathol. 15: 481–492.PubMedCrossRefGoogle Scholar
  72. Rothberger, H., Zimmerman, T. S., Spiegelberg, H. L., and Vaughn, J. H., 1977, Leukocyte procoagulant activity. Enhancement of production in vitro by IgG and antigen-antibody complexes, J. Clin. Invest. 59: 549–557.PubMedCrossRefGoogle Scholar
  73. Sabesin, S. M., 1963, A function of the eosinophil: Phagocytosis of antigen-antibody complexes, Proc. Soc. Exp. Biol. Med. 112: 667–670.PubMedGoogle Scholar
  74. Schernthaner, G., Ludwig, H., Tappeiner, G., Mayr, W. R., 1979, Circulating immune complexes (CIC), IgG-insulin antibodies (I-ab), islet-cell antibodies (ICA) and HLA antigens in insulin-dependent diabetics, Diabetes 28: 378.Google Scholar
  75. Shechter, Y., Chang, K-J, Jacobs, S., and Cuatrecasas, P., 1979, Modulation of binding and bioactivity of insulin by anti-insulin antibody: Relation to possible role of receptor self-aggregation in hormone action, Proc. Natl. Acad. Sci. USA 76: 2720–2724.PubMedCrossRefGoogle Scholar
  76. Spiegelberg, H. L., 1974, Biological activities of immunoglobulins of different classes and subclasses,o Adv. Immunol. 19: 259–294.PubMedCrossRefGoogle Scholar
  77. Theofilopoulos, A. N., and Dixon, F. J., 1979, The biology and detection of immune complexes, Adv. Immunol. 28: 89–220.PubMedCrossRefGoogle Scholar
  78. Theofilopoulos, A. N., Wilson, C. B., and Dixon, F. J., 1976, The Raaji cell radioimmune assay for detecting immune complexes in human sera, J. Clin. Invest. 57: 169–182.PubMedCrossRefGoogle Scholar
  79. Ullman, S., and Dahl, M., 1977, Necrobiosis lipoidica, An immunofluorescence study. Arch. Dermatol. 113: 1671–1673.PubMedCrossRefGoogle Scholar
  80. Urizer, R. E., Schwartz, A., Top, F., and Vernier, R. L., 1969, The nephrotic syndrome in children with diabetes mellitus of recent onset, N. Engl. J. Med. 281: 173–181.CrossRefGoogle Scholar
  81. Virella, G., Wohltmann, H., Sagel, J., Lopes-Virella, M. F. L., Kilpatrick, M. Phillips, C., and Colwell, J., 1981, Soluble immune complexes in patients with diabetes mellitus, detection and pathological significance, Diabetologia 21: 184–191.PubMedCrossRefGoogle Scholar
  82. Wehner, H., 1976, The influence of insulin and insulin antibodies on the glomerular structure, Acta Endocrinol. (Kbh) 83 (Suppl. 205): 241–253.Google Scholar
  83. Werner, A. U., and Larsen, H. W,, 1969, Immunohistological studies on human diabetic and non-diabetic eyes. I Fluorescent labelling of insulin and insulin-antibodies, Acta. Ophthalmol. (Kbh.) 47: 935–937.Google Scholar
  84. Wiggins, R. C., and Cochrane, C. G., 1981, Immune-complex-mediated biologic effects, N. Engl. J. Med. 304: 518–520.PubMedCrossRefGoogle Scholar
  85. Williams, R. C., 1981, Immune complexes in huamn diseases, Annu. Rev. Med. 32: 13–28.PubMedCrossRefGoogle Scholar
  86. Wilson, C. B., and Dixon, F. J., 1974, Diagnosis of immunopathologic renal disease, Kidney Int. 5: 389–401.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Dinesh Kumar
    • 1
  1. 1.Division of Diabetes and Clinical NutritionUniversity of Southern California School of MedicineLos AngelesUSA

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