Phagocytic Cell Functions in Diabetes Mellitus

  • Michael E. Miller


The mechanisms by which the patient with diabetes mellitus demonstrates increased susceptibility to infections have aroused much interest. Consideration of possible de fects has been divided into two major areas. In the first, potential abnormalities of the T- and/or B-cell system and their effects upon immunological functions in the diabetic patient have been probed. These studies are extensive and are reviewed elsewhere in this text (Chapter 11). The second group of studies has concerned a different component of the host defense system; the phagocytic cell lines. Although more contemporary in terms of active investigation, a sizable literature now exists through which investigators have implicated primary granulocyte dysfunctions as (a) major contributing factor(s) to infection in the diabetic host (Bagade, 1976). In this chapter, I will review the evidence for possible phagocytic dysfunction as a primary or major secondary cause of infections in the diabetic patient. These studies will then be summarized with reference to the limitations of in vitro assays of phagocyte function.


Diabetic Patient Diabetic Subject Polymorphonuclear Leukocyte Chronic Granulomatous Disease Neurogenic Bladder 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Michael E. Miller
    • 1
  1. 1.Department of PediatricsUniversity of California at DavisSacramentoUSA

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