Bovine Papillomavirus Shuttle Vectors

  • N. Sarver
  • S. Mitrani-Rosenbaum
  • M.-F. Law
  • W. T. McAllister
  • J. C. Byrne
  • P. M. Howley
Part of the Genetic Engineering book series (GEPM, volume 8)


The papillomaviruses are widespread in nature and induce benign squamous epithelial tumors in a wide variety of higher vertebrates. The proliferative lesions induced by most papillomaviruses are limited to the squamous epithelium. There is a subgroup of papillomaviruses, however, which includes the bovine papillomaviruses types 1 and 2 (BPV-1 and BPV-2), the ovine papillomavirus, and the deer papillomavirus which induce fibropapillomas consisting both of a proliferative dermal fibroblastic component as well as a proliferative squamous epithelial component. The full vegetative cycle of the papillomaviruses is expressed only in terminally differentiating squamous epithelial cells comprising the papilloma. Although these self-limiting tumors generally regress, some papillomas may undergo malignant progression.


Transformation Efficiency Mouse Cell Globin Gene Shuttle Vector Hybrid Plasmid 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • N. Sarver
    • 1
  • S. Mitrani-Rosenbaum
    • 1
  • M.-F. Law
    • 1
  • W. T. McAllister
    • 1
  • J. C. Byrne
    • 1
  • P. M. Howley
    • 1
  1. 1.Laboratory of PathologyNational Cancer InstituteBethesdaUSA

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