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Bovine Papillomavirus Shuttle Vectors

  • N. Sarver
  • S. Mitrani-Rosenbaum
  • M.-F. Law
  • W. T. McAllister
  • J. C. Byrne
  • P. M. Howley
Part of the Genetic Engineering book series (GEPM, volume 8)

Abstract

The papillomaviruses are widespread in nature and induce benign squamous epithelial tumors in a wide variety of higher vertebrates. The proliferative lesions induced by most papillomaviruses are limited to the squamous epithelium. There is a subgroup of papillomaviruses, however, which includes the bovine papillomaviruses types 1 and 2 (BPV-1 and BPV-2), the ovine papillomavirus, and the deer papillomavirus which induce fibropapillomas consisting both of a proliferative dermal fibroblastic component as well as a proliferative squamous epithelial component. The full vegetative cycle of the papillomaviruses is expressed only in terminally differentiating squamous epithelial cells comprising the papilloma. Although these self-limiting tumors generally regress, some papillomas may undergo malignant progression.

Keywords

Transformation Efficiency Mouse Cell Globin Gene Shuttle Vector Hybrid Plasmid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • N. Sarver
    • 1
  • S. Mitrani-Rosenbaum
    • 1
  • M.-F. Law
    • 1
  • W. T. McAllister
    • 1
  • J. C. Byrne
    • 1
  • P. M. Howley
    • 1
  1. 1.Laboratory of PathologyNational Cancer InstituteBethesdaUSA

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