Biochemical Mechanisms for Sex Specific Differences of Rat Liver Xanthine Oxidase
Xanthine oxidase (EC 188.8.131.52) catalyzes the irreversible oxidation of hypoxanthine and xanthine to uric acid. Recently, we have shown that rat liver xanthine oxidase enzyme activity is, in part, dependent on both age-and sex-specific differences.1 Immaturity in both sexes, adult females and pubertal male castrates demonstrate a basal or feminine pattern of enzyme activity. Androgen is required in the pubescent period for the full expression of hepatic xanthine oxidase activity in the adult male. The effect of androgen exposure on hepatic enzyme activity, however, remains speculative.
KeywordsXanthine Oxidase Xanthine Oxidase Activity Androgen Exposure Hepatic Enzyme Activity Chick Liver
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- 2.E. Della Corte and F. Stirpe, The regulation of rat liver xanthine oxidase: Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (Type D) into oxidase (Type 0) and purification of the enzyme, Biochem. J. 126: 739 (1972).Google Scholar