Biochemical Mechanisms for Sex Specific Differences of Rat Liver Xanthine Oxidase

  • Dennis J. Levinson
  • Douglas E. Decker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Xanthine oxidase (EC catalyzes the irreversible oxidation of hypoxanthine and xanthine to uric acid. Recently, we have shown that rat liver xanthine oxidase enzyme activity is, in part, dependent on both age-and sex-specific differences.1 Immaturity in both sexes, adult females and pubertal male castrates demonstrate a basal or feminine pattern of enzyme activity. Androgen is required in the pubescent period for the full expression of hepatic xanthine oxidase activity in the adult male. The effect of androgen exposure on hepatic enzyme activity, however, remains speculative.


Xanthine Oxidase Xanthine Oxidase Activity Androgen Exposure Hepatic Enzyme Activity Chick Liver 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D. J. Levinson and D. Chalker, Rat hepatic xanthine oxidase: Age and sex specific differences, Arthritis Rheum. 23: 77 (1980).PubMedCrossRefGoogle Scholar
  2. 2.
    E. Della Corte and F. Stirpe, The regulation of rat liver xanthine oxidase: Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (Type D) into oxidase (Type 0) and purification of the enzyme, Biochem. J. 126: 739 (1972).Google Scholar
  3. 3.
    J. M. Thompson, J. S. Nickels, and J. R. Fisher, Synthesis and degradation of xanthine dehydrogenase in chick liver, Biochim. Biophys. Acta. 568: 157 (1979).CrossRefGoogle Scholar
  4. 4.
    P. B. Rowe and J. B. Wyngaarden, The mechanism of dietary alterations in rat hepatic xanthine oxidase levels, J. Biol. Chem. 241: 5571 (1966).PubMedGoogle Scholar
  5. 5.
    E. G. McQuarrie and A. T. Venosa, The effect of dietary protein intake on the xanthine oxidase activity in rat liver, Science. 101: 493 (1945).PubMedCrossRefGoogle Scholar
  6. 6.
    J. L. Johnson, W. R. Wand, H. J. Cohen, and K. V. Rajagopalan, Molecular basis of the biological function of molybdenum: Molybdenum-free xanthine oxidase from liver of tungsten-treated rats, J. Biol. Chem. 249: 5056 (1974).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Dennis J. Levinson
    • 1
  • Douglas E. Decker
    • 1
  1. 1.Division of RheumatologyMichael Reese Hospital and Medical CenterChicagoUSA

Personalised recommendations