Adenosine Receptors on Human Inflammatory Cells
Adenosine, a naturally occurring purine nucleoside, plays an important role in controlling a variety of biological activities. Adenosine is formed within cells from AMP or from the degradation of S-adenosylhomocysteine and can be removed from cells by release into the extracellular fluid, by deamination to inosine, or by reutilization to form AMP (1). Adenosine is present in human blood and in post of the extracellular fluid at levels (3 × 10−7 M to 3 × 10−6 M) which in vitro modulate several biochemical and biological functions (2).
KeywordsAdenosine Receptor Histamine Release Human Lymphocyte Adenosine Deaminase cAMP Accumulation
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