Evidence for an Adenosine Receptor in Human Tissues

  • Laureen Kurpis
  • David John
  • Irving H. Fox
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Adenosine is an intermediate of the pathway of purine nucleotide degradation. Many biological properties of adenosine have been identified: It is toxic to mammalian and bacterial cells, and its presence is associated with inhibition of the immune response, coronary vasodilation, delayed neurotransmission, sedation, inhibition or stimulation of hormone secretion and changes in the metabolism of a number of tissues.1


Adenylate Cyclase Adenosine Receptor Coronary Vasodilation Adenosine Receptor Antagonist Adenosine Receptor Agonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    I.H. Fox and W.N. Kelley, Ann. Rev. Biochem. 47: 655 (1978).PubMedCrossRefGoogle Scholar
  2. 2.
    C. Londos and J. Wolff, Proc. Nat. Acad. Sci., USA, 74: 5482 (1977)CrossRefGoogle Scholar
  3. 3.
    C. Londos, D.M.F. Cooper, W. Schlegel and M. Rodbell, Proc. Nat. Acad. Sci., USA, 75: 5362 (1978).CrossRefGoogle Scholar
  4. 4.
    C. Londos, D.M.F. Cooper and J. Wolff, Proc. Nat. Acad. Sci., USA, 77: 2551 (1980).CrossRefGoogle Scholar
  5. 5.
    R.F. Bruns, J.W. Daly and S.H. Snyder, Proc. Nat. Acad. Sci., USA, 77: 5547 (1980).CrossRefGoogle Scholar
  6. 6.
    T. Trost and U. Schwabe, Mol. Pharmacol., 19: 228 (1981).PubMedGoogle Scholar
  7. 7.
    L. Kurpis and I.H. Fox, Clin. Res. 29:7O5A (1981).Google Scholar
  8. 8.
    P.H. Wu, J.W. Phillis, K. Bulls and B. Rinaldi, Can. J. Physiol. Pharmacol., 58: 576 (1980).CrossRefGoogle Scholar
  9. 9.
    U. Schwabe and T. Trost, Arch. Pharmacol., 313: 179 (1980).CrossRefGoogle Scholar
  10. 10.
    Y. Salomon, C. Londos and M. Rodbell, Anal. Biochem., 58: 541, (1974).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Laureen Kurpis
    • 1
    • 2
  • David John
    • 1
    • 2
  • Irving H. Fox
    • 1
    • 2
  1. 1.Departments of Internal MedicineThe Human Purine Research CenterAnn ArborUSA
  2. 2.Biological ChemistryUniversity HospitalsAnn ArborUSA

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