Effect of Hormones on Adenine and Adenosine Metabolism in Mammary Gland in Vitro

  • J. Barankiewicz
  • P. Tysarowski
  • P. Chomczynski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Little is known regarding the effect of hormones on purine metabolism. It has been shown that injection of some hormones, such as insulin, glucagon, increase PRPP concentration in mouse liver1. Also integrative action of insulin in purine metabolism has been reported2. According to these authors, hepatic PRPP amidotransferase activity in diabetic rats decreased 50%, and hepatic concentrations of ATP and GTP decreased markedly. Injection of insulin restored enzyme activity and ribonucleotide level increased. Insulin treatment of rat hepatocytes also increased adenine nucleotide pool3.


Mammary Gland Adenosine Deaminase Purine Metabolism Nucleotide Synthesis Hepatic Concentration 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. Barankiewicz
    • 1
  • P. Tysarowski
    • 1
  • P. Chomczynski
    • 1
  1. 1.Department of Biochemistry Institute of Animal PhysiologyWarsaw University of AgricultureWarsawPoland

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