Influence of Ethanol on the Production of Allantoin by the Perfused Rat Liver

  • G. Van den Berghe
  • F. Bontemps
  • H. G. Hers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Ingestion of alcohol is traditionally considered a predisposing or precipitating factor in the gouty attack. Studies performed in man by Lieber et al. (1962) have shown that the administration of ethanol provokes an increase in the serum concentration of uric acid, which was attributed to a decrease in its renal excretion. More recently, ethanol infusion has been shown to enhance the production of uric acid by the liver, as measured from arteriovenous concentration differences during hepatic catheterisation in human volunteers (Grunst et al., 1973).


Uric Acid Adenine Nucleotide Adenosine Deaminase Perfuse Liver Perfusion Medium 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • G. Van den Berghe
    • 1
  • F. Bontemps
    • 1
  • H. G. Hers
    • 1
  1. 1.Laboratoire de Chimie PhysiologiqueUniversité de Louvain and International Institute of Cellular and Molecular PathologyBrusselsBelgium

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