Ethanol Induced Alterations of Uric Acid Metabolism
Early studies by Lieber and MacLachlan presented evidence suggesting that ethanol led to hyperlactic acidemia and decreased the excretion of uric acid.1,2 Delbarre indicated the possibility of increased urate production3 and a study by Grunst, et al. suggested that ethanol infusion lead to increased release of uric acid from the liver.4 We have reexamined whether ethanol-induced hyperuricemia may be related to decreased renal excretion of uric acid, increased urate production by either accelerated degradation of nucleotides or increased de novo synthesis or both mechanisms together.
KeywordsUric Acid Serum Urate Ethanol Administration Uric Acid Excretion Urine Uric Acid
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- 6.J. Grunst, G. Dietze and M. Wickimayr, Leber. Verh. Dt. Ges. inn Med. 79: 941–917 (1973).Google Scholar