Ethanol Induced Alterations of Uric Acid Metabolism

  • Jason Faller
  • Irving H. Fox
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Early studies by Lieber and MacLachlan presented evidence suggesting that ethanol led to hyperlactic acidemia and decreased the excretion of uric acid.1,2 Delbarre indicated the possibility of increased urate production3 and a study by Grunst, et al. suggested that ethanol infusion lead to increased release of uric acid from the liver.4 We have reexamined whether ethanol-induced hyperuricemia may be related to decreased renal excretion of uric acid, increased urate production by either accelerated degradation of nucleotides or increased de novo synthesis or both mechanisms together.


Uric Acid Serum Urate Ethanol Administration Uric Acid Excretion Urine Uric Acid 
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  1. 1.
    C.S. Lieber, D.P. Jones, M.S. Losowsky and C.S. Davidson, J. Clin. Invest. 41: 1863 (1962).PubMedCrossRefGoogle Scholar
  2. 2.
    M.J. MacLachlan, G.P. Rodnan, Am. J. Med. 42: 38 (1967).PubMedCrossRefGoogle Scholar
  3. 3.
    F. Delbarre, C. Auscher, H. Brouilhet and A. deGery, Sem. Hop. Paris 43: 659–664 (1967).PubMedGoogle Scholar
  4. 4.
    J. Grunst, G. Dietze and M. Wicklmayr, Nutr. Metab. 21 (Suppl. 1) 138 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    R.L. Veech, R. Guyinn and D. Veloso, Biochem. J. 127: 387 (1972).PubMedGoogle Scholar
  6. 6.
    J. Grunst, G. Dietze and M. Wickimayr, Leber. Verh. Dt. Ges. inn Med. 79: 941–917 (1973).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Jason Faller
    • 1
  • Irving H. Fox
    • 1
  1. 1.The Human Purine Research Center Departments of Internal Medicine and Biological ChemistryUniversity HospitalsAnn ArborUSA

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