Properties of a Novel PEG Derivative of Calf Adenosine Deaminase
Human adenosine deaminase (ADA) deficiency has been causally associated with severe combined immunodeficiency diseasel. Some success has been achieved in restoring immune function in these patients by administering the enzyme via red blood cell transfusions2. A derivative of ADA which retains enzymatic activity and which has a long circulation time and minimal immunogenicity when injected intravenously could be useful as an alternate means of enzyme replacement therapy.
KeywordsEnzyme Replacement Therapy Adenosine Deaminase Blood Clearance Severe Combine Immunodeficiency Severe Combine Immunodeficiency Disease
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