The Chronologically Synchronous Elevation of Phosphoribosyl — Pyrophosphate and Cyclic AMP in Regenerating Rat Liver
Glucagon increases DNA synthesis in regenerating rat liverl or even in nonoperated rat liver2 and an elevated level of plasma glucagon has been documented after hepatectomy.3 Other investigations have demonstrated that the concentration of 5-phosphoribosyl l-pyrophosphate(PP-ribose-P), which is an important regulator of purine biosynthesis de novo, and the rate of purine biosynthesis de novo itself are increased by glucagon administered in mice4 and in isolated rat hepatocytes.5,6
KeywordsPlasma Glucagon Purine Biosynthesis Phosphoribosyl Pyrophosphate Adenine Phosphoribosyltransferase Plasma Glucagon Concentration
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