The Chronologically Synchronous Elevation of Phosphoribosyl — Pyrophosphate and Cyclic AMP in Regenerating Rat Liver

  • Mitsuo Itakura
  • Kamejiro Yamashita
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


Glucagon increases DNA synthesis in regenerating rat liverl or even in nonoperated rat liver2 and an elevated level of plasma glucagon has been documented after hepatectomy.3 Other investigations have demonstrated that the concentration of 5-phosphoribosyl l-pyrophosphate(PP-ribose-P), which is an important regulator of purine biosynthesis de novo, and the rate of purine biosynthesis de novo itself are increased by glucagon administered in mice4 and in isolated rat hepatocytes.5,6


Plasma Glucagon Purine Biosynthesis Phosphoribosyl Pyrophosphate Adenine Phosphoribosyltransferase Plasma Glucagon Concentration 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Mitsuo Itakura
    • 1
  • Kamejiro Yamashita
    • 1
  1. 1.Institute of Clinical MedicineThe University of TsukubaIbaraki, 305Japan

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