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Regulation of De Novo Purine Biosynthesis in Chinese Hamster Cells

  • Milton W. Taylor
  • Suman Olivelle
  • Kathy Coy
  • Roy A. Levine
  • Howard Hershey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

It has been proposed that in mammalian cells (1), as in the case of E. coli (2), de novo purine biosynthesis is controlled by both feedback inhibition by the end products of the pathway and by repression. In procaryotes, repression appears to involve an interaction between a specific nucleotide (ATP or GTP) and a repressor protein binding to the operator region of the early purine genes (2). We have recently isolated a series of PurR mutants in E. coli, in which repression of the de novo pathway is abolished (3). However such mutants are still subject to feedback inhibition.

Keywords

Feedback Inhibition CHINESE Hamster Cell Nucleotide Pool Purine Biosynthesis Ehrlich Ascites Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Milton W. Taylor
    • 1
  • Suman Olivelle
    • 1
  • Kathy Coy
    • 1
  • Roy A. Levine
    • 1
  • Howard Hershey
    • 1
  1. 1.Department of BiologyIndiana UniversityBloomingtonUSA

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