Advertisement

Genetic Variability of Purine Nucleoside Phosphorylase in the Mouse

  • Floyd F. Snyder
  • Fred G. Biddle
  • Trevor Lukey
  • Marcia J. Sparling
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

The inherited human deficiency of purine nucleoside phosphorylase is associated primarily with cellular immune dysfunction1. We have begun to screen for quantitative activity variants of purine nucleoside phosphorylase in Mus musculus in attempts to establish an animal model for the enzyme deficiencies associated with immunodeficiency disease. A preliminary survey of feral and inbred mouse strains revealed a 4-fold range in erythrocyte purine nucleoside phosphorylase activity. We have examined some of the biochemical and genetic aspects of this variability.

Keywords

Inbred Mouse Strain Purine Nucleoside Purine Nucleoside Phosphorylase Quantitative Variability Human Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    E.R. Giblett, A.J. Ammann, R. Sandman, D.W. Wara, and L.K. Diamond, Lancet 2: 1010 (1975).CrossRefGoogle Scholar
  2. 2.
    T. Lukey and F.F. Snyder, Can. J. Biochem. 58: 677 (1980).PubMedGoogle Scholar
  3. 3.
    F.F. Snyder, J. Mendelsohn, and J.E. Seegmiller, J. Clin. Invest. 58: 654 (1976).PubMedCrossRefGoogle Scholar
  4. 4.
    J.E. Womack, M.T. Davisson, E.M. Eicher, and D.A. Kendall, Biochem. Genet. 15: 347 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    T.A. Bremner, E. Premkumer-Reddy, K. Nayar, and R.E. Kouri, Biochem. Genet. 16: 1143 (1978).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Floyd F. Snyder
    • 1
  • Fred G. Biddle
    • 1
  • Trevor Lukey
    • 1
  • Marcia J. Sparling
    • 1
  1. 1.Departments of Medical Biochemistry and Paediatrics Faculty of MedicineUniversity of Calgary CalgaryAlbertaCanada

Personalised recommendations