Genetic Variability of Purine Nucleoside Phosphorylase in the Mouse
The inherited human deficiency of purine nucleoside phosphorylase is associated primarily with cellular immune dysfunction1. We have begun to screen for quantitative activity variants of purine nucleoside phosphorylase in Mus musculus in attempts to establish an animal model for the enzyme deficiencies associated with immunodeficiency disease. A preliminary survey of feral and inbred mouse strains revealed a 4-fold range in erythrocyte purine nucleoside phosphorylase activity. We have examined some of the biochemical and genetic aspects of this variability.
KeywordsInbred Mouse Strain Purine Nucleoside Purine Nucleoside Phosphorylase Quantitative Variability Human Deficiency
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