Orotate Uptake and Metabolism by Human Erythrocytes

  • Peter Berman
  • Eric Harley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

The uptake of the pyrimidine nucleotide precursor, orotate, by non-nucleated human erythrocytes is not immediately explicable, (1). During the course of an investigation into the origin of the increased erythrocyte nucleotides seen in hereditary ythrocyte pyrimidine 5′nucleotidase deficiency, rapid uptake of 14C orotate and its conversion to uridine nucleotides by normal red cells was observed (Figure 1(a) A). Moreover, free uridine was present within the cells and accumulated in significant quantities in the medium (Figure 2).

Keywords

HPLC Tate Benzyl Pyrimidine Dine 

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Reference

  1. 1.
    E.H. Harley, A. Heaton and W. Wicomb, Pyrimidine metabolism in hereditary erythrocyte pyrimidine 5′nucleotidase deficiency, Metabolism 27: 1743 (1978).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Peter Berman
    • 1
  • Eric Harley
    • 1
  1. 1.Department of Chemical PathologyUniversity of Cape TownCape TownRepublic of South Africa

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