Impaired Metabolism of Deoxyadenosine in Uremic Erythrocytes

  • William P. Wiesmann
  • Horace K. Webster
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


The metabolism of adenylates and guanylates by mammalian cells is tightly controlled through a series of enzymatic reactions (7, 9). Adenosine (deoxyadenosine) is metabolized by erythrocytes (RBC) to either adenylates via adenylate kinase (AK) or to inosine by adenosine deaminase (ADA). Inosine, guanosine and their deoxy forms are converted to the purine base hypoxanthine by purine nucleoside phosphorylase (PNP).


High Performance Liquid Chromatographic High Performance Liquid Chromatographic Adenosine Deaminase Adenylate Kinase Uremic Patient 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • William P. Wiesmann
    • 1
  • Horace K. Webster
    • 1
  1. 1.Dept. of Nephrology and HematologyWalter Reed Army Institute of ResearchUSA

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