Use of Adenine in Blood Banking
The use of an acid-citrate-glucose mixture as a preservative/anticoagulant for the cold storage of human blood for purposes of transfusion developed out of research carried out during World War II in the United States and England. With this preservative it was possible to hold blood for three weeks with at least 70% post-transfusion survival of the red cells, longer storage leading to rapidly decreasing viability. The so-called ACD, and CPD (a slight variant), preservatives have been in use since the mid 1940’s until last year when supplementation with adenine has allowed extension of the storage outdating time from 3 to 5 weeks. The purpose of the present communication is to summarize key events leading to this use of adenine.1
KeywordsXanthine Oxidase Cold Storage Adenosine Deaminase Blood Banking Organic Phosphate
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