The Effect of Beer Ingestion on Plasma and Urine Uric Acid in Gout and Normouricaemic Subjects

  • A. V. Rodgers
  • T. Gibson
  • H. A. Simmonds
  • P. Toseland
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

A relationship between hyperuricaemia, gout and excessive alcohol consumption is well established. The increase of serum lactate which follows alcohol ingestion may impair renal urate excretion and is claimed to be the principal mechanism.1 Such an effect has been shown in studies using alcohol in amounts which have exceeded those commonly consumed by gout patients in our experience.2 Furthermore, previous experiments have usually involved fasting subjects so that the role of lactate on urate clearance has not been clearly distinguishable from that of fasting alone.3

Keywords

Arthritis Lactate Purine Colchicine Gout 

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References

  1. 1.
    D.S. Newcombe, Ethanol metabolism and uric acid. Metabolism 21: 1193 (1972)PubMedCrossRefGoogle Scholar
  2. 2.
    C.S. Lieber, D.P. Jones, M.S. Losowsky, C.S. Davidson, Interrelation of uric acid and ethanol methabolism in man. J. Clin. Invest. 41: 1863 (1962)PubMedCrossRefGoogle Scholar
  3. 3.
    M.J. Maclachlan and G.P. Rodnan, Effects of food, fast and alcohol on serum uric acid and acute attacks of gout. Am. J. Med. 42: 38 (1967)PubMedCrossRefGoogle Scholar
  4. 4.
    T. Gibson, V. Rodgers, F. Court-Brown, H.A. Simmonds, Dietary intake of gout patients, Ann. Rheum. Dis. 40: 515 (1981)CrossRefGoogle Scholar
  5. 5.
    T.S.F. Yu, J.H. Sirota, L. Berger, M. Halpern, A.B. Gutman, Effect of sodium lactate infusion on urate clearance in man, Proc. Soc. Exp. Biol. Med. 96: 809 (1957)PubMedGoogle Scholar
  6. 6.
    F. Delbarre, C. Auscher, H. Brouilhet, A. de Géry, A.tion de l’ethanol dans la goutte et sur le métabolisme de l’acide urique, Sem. H6p. Paris, 43: 659 (1967)Google Scholar
  7. 7.
    J. Grunst, J. Dietze, M. Wicklmayr, Effect of metabolic changes on uric acid production of human liver in: “Urolithiasis Research”, H. Fleisch, W.G. Robertson, L.H. Smith, W. Vahlinsiek, ed., Plenum Press, N. York (1976)Google Scholar
  8. 8.
    H.S. Diamond, R. Lazarus, D. Kaplan, D. Halbersam, Effect of urine flow rate on uric acid excretion in man, Arthritis Rheum. 15: 338 (1972)PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. V. Rodgers
    • 1
  • T. Gibson
    • 1
  • H. A. Simmonds
    • 1
  • P. Toseland
    • 1
  1. 1.Guy’s HospitalLondonUK

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