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Influence of Dietary Purines on Allopurinol Metabolism and Allopurinol Induced Oroticaciduria

  • S. Reiter
  • W. Löffler
  • W. Gröbner
  • N. Zöllner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

The allopurinol induced oroticaciduria is markedly diminished by oral administration of purines.1 The underlying mechanism is still unknown. We performed nutrition experiments to determine whether this effect could be due to an influence of dietary purines on either absorption or metabolism of allopurinol. A change of allopurinol metabolism by intravenous administration of adenine in the pig was previously reported.2

Keywords

Uric Acid Urinary Excretion Healthy Male Subject Orotic Acid Excretion Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. 1.
    N. Zöllner and W. Gröbner. Dietary feedback regulation of purine and pyrimidine biosynthesis in man. Ciba Found. Symp. 48: 165 (1977)PubMedGoogle Scholar
  2. 2.
    J.S. Cameron, H.A. Simmonds, A. Cadenhead and D. Farebrother. Metabolism of intravenous adenine in the pig. Adv. Exp. Med. Biol. 76A: 196 (1977)PubMedGoogle Scholar
  3. 3.
    D.R. Webster, H.A. Simmonds, D.M.J. Barry and D.M.O. Becroft. Pyrimidine and Purine Metabolites in Orni-thine Carbamoyl Transferase Deficiency. J. Inher. Metab. Dis. 4: 27 (1981)CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • S. Reiter
    • 1
  • W. Löffler
    • 1
  • W. Gröbner
    • 1
  • N. Zöllner
    • 1
  1. 1.Medizinische PoliklinikUniversität MünchenGermany

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