Influence of Dietary Purines on Allopurinol Metabolism and Allopurinol Induced Oroticaciduria
The allopurinol induced oroticaciduria is markedly diminished by oral administration of purines.1 The underlying mechanism is still unknown. We performed nutrition experiments to determine whether this effect could be due to an influence of dietary purines on either absorption or metabolism of allopurinol. A change of allopurinol metabolism by intravenous administration of adenine in the pig was previously reported.2
KeywordsUric Acid Urinary Excretion Healthy Male Subject Orotic Acid Excretion Pattern
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