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Lymphocyte Adenosine Deaminase Levels in Active and in Inactive Forms of HBsAg-Positive Chronic Liver Disease

  • Salvatore Nardiello
  • Teresa Pizzella
  • Luciano Tarantino
  • Michele Russo
  • Bruno Galanti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

Patients with congenital adenosine deaminase (ADA) deficiency show an impairment of both cell-mediated and humoral immunity (Giblett et al., 1972); exogenous ADA added to lymphocytes from these patients partially restores their in vitro response to mitogens (Polmar et al., 1975). On the other hand, ADA inhibitors in association with deoxynucleosides inhibit lymphocyte proliferation and T suppressor cell activity, while T helper cell function and differentiation of B cells are unaffected (Gelfand et al., 1979).

Keywords

Chronic Liver Disease Adenosine Deaminase Chronic Active Hepatitis Severe Combine Immunodeficiency Purine Nucleoside Phosphorylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Salvatore Nardiello
    • 1
  • Teresa Pizzella
    • 1
  • Luciano Tarantino
    • 1
  • Michele Russo
    • 1
  • Bruno Galanti
    • 1
  1. 1.Clinic of Infectious Diseases1st Medical SchoolNaplesItaly

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