Lymphocyte Adenosine Deaminase Levels in Active and in Inactive Forms of HBsAg-Positive Chronic Liver Disease
Patients with congenital adenosine deaminase (ADA) deficiency show an impairment of both cell-mediated and humoral immunity (Giblett et al., 1972); exogenous ADA added to lymphocytes from these patients partially restores their in vitro response to mitogens (Polmar et al., 1975). On the other hand, ADA inhibitors in association with deoxynucleosides inhibit lymphocyte proliferation and T suppressor cell activity, while T helper cell function and differentiation of B cells are unaffected (Gelfand et al., 1979).
KeywordsChronic Liver Disease Adenosine Deaminase Chronic Active Hepatitis Severe Combine Immunodeficiency Purine Nucleoside Phosphorylase
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