Increases in Methylated Nucleosides during Human Pregnancy
In growing tissues there is an increased turnover of tRNA and consequent increases in tRNA breakdown. The methylated bases and pseudouridine characteristic of tRNA are not ‘salvaged’ unlike the majority of the constituent bases of tRNA. There is therefore an increased concentration of methylated purine nucleosides and pseudouridine in extracellular fluids in many cancer patients (Mrochek et al., 1974). We have shown such an increase in human pregnancy and in children.
KeywordsUrinary Excretion Amniotic Fluid Newborn Infant Extracellular Fluid Late Pregnancy
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- Mrochek, J.E., Dinsmore, S.R., and Waalkes, T.P., 1974, Analytic techniques in the separation and identification of specific purine and pyrimidine degradation products of tRNA: Application to urine samples from cancer patients. J. Nat. Cancer Inst., 53: 1553.Google Scholar