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Increases in Methylated Nucleosides during Human Pregnancy

  • Roger J. Simmonds
  • R. A. Harkness
  • S. B. Coade
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

In growing tissues there is an increased turnover of tRNA and consequent increases in tRNA breakdown. The methylated bases and pseudouridine characteristic of tRNA are not ‘salvaged’ unlike the majority of the constituent bases of tRNA. There is therefore an increased concentration of methylated purine nucleosides and pseudouridine in extracellular fluids in many cancer patients (Mrochek et al., 1974). We have shown such an increase in human pregnancy and in children.

Keywords

Urinary Excretion Amniotic Fluid Newborn Infant Extracellular Fluid Late Pregnancy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Mrochek, J.E., Dinsmore, S.R., and Waalkes, T.P., 1974, Analytic techniques in the separation and identification of specific purine and pyrimidine degradation products of tRNA: Application to urine samples from cancer patients. J. Nat. Cancer Inst., 53: 1553.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Roger J. Simmonds
    • 1
  • R. A. Harkness
    • 1
  • S. B. Coade
    • 1
  1. 1.Division of Perinatal MedicineMRC Clinical Research CentreHarrowUK

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