Turnover and Distribution of 14C-Uric Acid in Psoriatic Patients
Psoriatic patients frequently present with altered serum urate levels, a disturbance which is commonly attributed to some changes in nucleoprotein metabolism directly linked to the pathological process of the skin lesions; in fact, it is well known that an increased turnover rate of the epidermal cells (from the normal value of 27 days to 3–4 days only) is responsible for the psoriatic skin changes (Fitzpatrick and Haynes, 1980). To date, no tracer turnover studies with labelled uric acid have been reported in patients affected by psoriasis. We present here the metabolic results obtained with the aid of 14C-uric acid in a group of psoriatic patients with various degrees of severity of the disease. The aim of the study was to elucidate some pathophysiologic aspects of uric acid turnover in such clinical conditions.
KeywordsUric Acid Psoriatic Patient Total Pool Metabolic Result Metabolic Clearance Rate
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