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Turnover and Distribution of 14C-Uric Acid in Psoriatic Patients

  • Giuliano Mariani
  • Mario Tuoni
  • Roberto Gianfaldoni
  • Nicola Molea
  • Luca Giubbolini
  • Lucio Fusani
  • Eneo Mian
  • Romano Bianchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

Psoriatic patients frequently present with altered serum urate levels, a disturbance which is commonly attributed to some changes in nucleoprotein metabolism directly linked to the pathological process of the skin lesions; in fact, it is well known that an increased turnover rate of the epidermal cells (from the normal value of 27 days to 3–4 days only) is responsible for the psoriatic skin changes (Fitzpatrick and Haynes, 1980). To date, no tracer turnover studies with labelled uric acid have been reported in patients affected by psoriasis. We present here the metabolic results obtained with the aid of 14C-uric acid in a group of psoriatic patients with various degrees of severity of the disease. The aim of the study was to elucidate some pathophysiologic aspects of uric acid turnover in such clinical conditions.

Keywords

Uric Acid Psoriatic Patient Total Pool Metabolic Result Metabolic Clearance Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bianchi, R., Vitali, C., Clerico, A., Pilo, A., Fusani, L., and Mariani, G., 1979, Uric acid metabolism in normal subjects and in gouty patients by chromatographic measurement of 14C-uric acid in plasma and urine, Metabolism, 28: 1105.PubMedCrossRefGoogle Scholar
  2. Bianchi, R., Vitali, C., Clerico, A., Pilo, A., Fusani, L., Riente, L., and Mariani, G., 1978, A chromatographic method for the determination of uric acid turnover in man, J. Nucl. Med. All. Sci., 22: 37.Google Scholar
  3. Fitzpatrick, T.B., and Haynes, H.A., 1980, Skin lesions of general medical significance, in: “Principles of Internal Medicine”, K.J. Isselbacher, R.D. Adams, E. Braunwald, R.G. Petersdorf, and J.D. Wilson, eds., McGraw-Hill Kogakusha, Tokio.Google Scholar
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Giuliano Mariani
    • 1
  • Mario Tuoni
    • 1
  • Roberto Gianfaldoni
    • 1
  • Nicola Molea
    • 1
  • Luca Giubbolini
    • 1
  • Lucio Fusani
    • 1
  • Eneo Mian
    • 1
  • Romano Bianchi
    • 1
  1. 1.5th Medical Pathology, and Institute of Dermatology of the University of PisaCNR Institute of Clinical PhysiologyPisaItaly

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