Optimal Conditions for Phosphoribosylpyrophosphate Synthesis in a Crude Extract of Liver Cells
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 165)
We have recently shown that adenosine and some of its analogs decrease phosphoribosylpyrophosphate (PP-ribose-P) availability in rat liver cells (unpublished results). Tubercidin (7-deazaadenosine), 3′-deoxyadenosine, and 6-methylmercaptopurine ribonucleoside are the analogs which cause the greatest decrease of PP-ribose-P availability. They are three- to eight-times more potent than adenosine. This action could possibly result from the inhibition of PP-ribose-P synthesis by these compounds or one of their metabolites.
KeywordsIncubation Medium Pyruvate Kinase Pentose Phosphate Liver Extract Nucleoside Triphosphate
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© Plenum Press, New York 1984