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Optimal Conditions for Phosphoribosylpyrophosphate Synthesis in a Crude Extract of Liver Cells

  • Marcel Lalanne
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

We have recently shown that adenosine and some of its analogs decrease phosphoribosylpyrophosphate (PP-ribose-P) availability in rat liver cells (unpublished results). Tubercidin (7-deazaadenosine), 3′-deoxyadenosine, and 6-methylmercaptopurine ribonucleoside are the analogs which cause the greatest decrease of PP-ribose-P availability. They are three- to eight-times more potent than adenosine. This action could possibly result from the inhibition of PP-ribose-P synthesis by these compounds or one of their metabolites.

Keywords

Incubation Medium Pyruvate Kinase Pentose Phosphate Liver Extract Nucleoside Triphosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    D.G. Roth and T.F. Deuel, Stability and regulation of phosphoribosyl pyrophosphate synthetase from rat liver, J. Biol. Chem. 249: 297–301 (1974).PubMedGoogle Scholar
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    M. Lalanne and F. Lafleur, Inosine synthesis and phosphoribosylpyrophosphate availability in rat liver cells in the presence of allopurinol, Can. J. Biochem. 58: 607–613 (1980).PubMedCrossRefGoogle Scholar
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    A. Abrams and H. Klenow, On the action of surface forces on phosphoribomutase, Arch. Biochem. Biophys. 34: 285–292 (1951).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Marcel Lalanne
    • 1
  1. 1.Département de Biochimie, Faculté de MédecineUniversité LavalCanada

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