Optimal Conditions for Phosphoribosylpyrophosphate Synthesis in a Crude Extract of Liver Cells
We have recently shown that adenosine and some of its analogs decrease phosphoribosylpyrophosphate (PP-ribose-P) availability in rat liver cells (unpublished results). Tubercidin (7-deazaadenosine), 3′-deoxyadenosine, and 6-methylmercaptopurine ribonucleoside are the analogs which cause the greatest decrease of PP-ribose-P availability. They are three- to eight-times more potent than adenosine. This action could possibly result from the inhibition of PP-ribose-P synthesis by these compounds or one of their metabolites.
KeywordsIncubation Medium Pyruvate Kinase Pentose Phosphate Liver Extract Nucleoside Triphosphate
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