Abstract
We have recently shown that adenosine and some of its analogs decrease phosphoribosylpyrophosphate (PP-ribose-P) availability in rat liver cells (unpublished results). Tubercidin (7-deazaadenosine), 3′-deoxyadenosine, and 6-methylmercaptopurine ribonucleoside are the analogs which cause the greatest decrease of PP-ribose-P availability. They are three- to eight-times more potent than adenosine. This action could possibly result from the inhibition of PP-ribose-P synthesis by these compounds or one of their metabolites.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D.G. Roth, E. Shelton, and T.F. Deuel, Purification and properties of phosphoribosyl pyrophosphate synthetase from rat liver, J. Biol. Chem. 249: 291–296 (1974).
D.G. Roth and T.F. Deuel, Stability and regulation of phosphoribosyl pyrophosphate synthetase from rat liver, J. Biol. Chem. 249: 297–301 (1974).
M. Lalanne and F. Lafleur, Inosine synthesis and phosphoribosylpyrophosphate availability in rat liver cells in the presence of allopurinol, Can. J. Biochem. 58: 607–613 (1980).
A. Abrams and H. Klenow, On the action of surface forces on phosphoribomutase, Arch. Biochem. Biophys. 34: 285–292 (1951).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Lalanne, M. (1984). Optimal Conditions for Phosphoribosylpyrophosphate Synthesis in a Crude Extract of Liver Cells. In: De Bruyn, C.H.M.M., Simmonds, H.A., Müller, M.M. (eds) Purine Metabolism in Man-IV. Advances in Experimental Medicine and Biology, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4553-4_51
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4553-4_51
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4555-8
Online ISBN: 978-1-4684-4553-4
eBook Packages: Springer Book Archive