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T Cell Activation in Typhoid Fever Detected by Increased Levels of Adenosine Deaminase

  • Michele Russo
  • Teresa Pizzella
  • Salvatore Nardiello
  • Flavio Fiorentino
  • Bruno Galanti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

The demonstration of an inherited adenosine deaminase (ADA) deficiency in patients with combined immunodeficiency (Giblett et al., 1972) suggests a causal association between lymphocyte ADA levels and immune function. ADA activity is greatly increased in in vitro stimulated lymphocytes (Hovi et al., 1976) and in peripheral mononuclear cells from subjects developing an active immune response (Galanti et al., 1981). Recent data indicate that mechanisms of cell-mediated immunity play the major role in recovery from typhoid fever (Rajagopalan et al., 1982). The aim of this study is to assess the value of lymphocyte ADA assay in detecting T cell activation during typhoid fever.

Keywords

Typhoid Fever Adenosine Deaminase Peripheral Mononuclear Cell Active Immune Response Adenosine Deaminase Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Michele Russo
    • 1
  • Teresa Pizzella
    • 1
  • Salvatore Nardiello
    • 1
  • Flavio Fiorentino
    • 1
  • Bruno Galanti
    • 1
  1. 1.Clinic of Infectious Diseases1st Medical SchoolNaplesItaly

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