Selectivity of Antiviral Effectiveness Derived from Differences of Herpes Simplex Virus-Coded Thymidine Kinases
Herpes simplex viruses are human pathogens that cause oral and ocular lesions (HSV-1) or genital lesions (HSV-2). These viruses code for enzymes with substrate specificities different from those of the host cell. The pyrimidine metabolism of the cell is augmented by a virus-coded deoxythymidine (dThd) kinase (TK). This enzyme has a relatively broad phosphate acceptor specificity which permits the phosphorylation of several antiviral nucleoside analogs, the first step in their activation. These analogs are selective inhibitors of DNA synthesis in virus-infected cells, in part, because they are phosphorylated to their triphosphate derivatives only in infected cells.
KeywordsHerpes Simplex Herpes Simplex Virus Type Thymidine Kinase Pyrimidine Metabolism Genital Lesion
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- 5.J. A. Fyfe, Differential phosphorylation of (E)-5-(2-bromo- vinyl)-2’-deoxyuridine monophosphate by thymidylate kinases from herpes simplex viruses Type I and II and varicella zoster virus, Mol. Pharmacol. 21: 432 (1982).Google Scholar