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Selectivity of Antiviral Effectiveness Derived from Differences of Herpes Simplex Virus-Coded Thymidine Kinases

  • James A. Fyfe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

Herpes simplex viruses are human pathogens that cause oral and ocular lesions (HSV-1) or genital lesions (HSV-2). These viruses code for enzymes with substrate specificities different from those of the host cell. The pyrimidine metabolism of the cell is augmented by a virus-coded deoxythymidine (dThd) kinase (TK). This enzyme has a relatively broad phosphate acceptor specificity which permits the phosphorylation of several antiviral nucleoside analogs, the first step in their activation. These analogs are selective inhibitors of DNA synthesis in virus-infected cells, in part, because they are phosphorylated to their triphosphate derivatives only in infected cells.

Keywords

Herpes Simplex Herpes Simplex Virus Type Thymidine Kinase Pyrimidine Metabolism Genital Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • James A. Fyfe
    • 1
  1. 1.Wellcome Research LaboratoriesUSA

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