Pyrazolopyrimidine Metabolism in Leishmania: An Overview

  • J. Joseph Marr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


The hemoflagellates that infect man have proven recalcitrant to effective chemotherapy. The specificity of antimicrobial therapy, so useful in the treatment of diseases caused by bacteria, is lacking in diseases caused by these protozoans which have adapted themselves to survival within mammalian cells. This is evinced by the significant toxicity of the agents used in their treatment. A high therapeutic index for a given antimicrobial usually requires a specific difference in metabolism between the host and the parasite. Such a difference appears to exist in the ability of organisms of the genera Leishmania and Trypanosoma to metabolize the pyrazolopyrimidine nucleus as though it were a purine base.


High Performance Liquid Chromatography Cutaneous Leishmaniasis Purine Metabolism Purine Analogue Cellular Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. Joseph Marr
    • 1
  1. 1.Department of MedicineUniversity of Colorado Health Sciences CenterDenverUSA

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