Adenosine Deaminase in Malaria Infection: Effect of 2′-Deoxycoformycin in Vivo

  • Horace K. Webster
  • William P. Wiesmann
  • Charles S. Pavia
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


We have observed a dramatic increase in erythrocyte (RBC) adenosine deam;nase (ADA: E.C. activity during malaria infection of the rhesus monkey. Previous studies in our laboratory using P. knowlesi infected rhesus monkeys showed cyclic changes in RBC purine metabolites-particularly ATP and GTP-that were associated with the stage of parasite schizogony (1).


Malaria Parasite Malaria Infection Adenosine Deaminase Purine Nucleotide Severe Combine Immunodeficiency Disease 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Horace K. Webster
    • 1
  • William P. Wiesmann
    • 2
  • Charles S. Pavia
    • 2
  1. 1.Department of ImmunobiologyArmed Forces Research Institute of Medical SciencesBangkokThailand
  2. 2.Department of HematologyWalter Reed Army Institute of ResearchUSA

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