Purine Salvage Enzymes in Leishmania Donovani and Trichomonas Vaginalis

  • Thomas A. Krenitsky
  • Richard L. Miller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


The purine salvage pathways of pathogenic protozoa are of special interest because most of these organisms lack the ability to synthesize purines de novo. This absence of an alternative to salvage is the basis for the view that these pathogens might be particularly susceptible to selective chemotherapy with purine analogues and their nucleosides. The preceding paper provides some examples to illustrate the validity of this view. The central point of this paper is the comparison of purine salvage enzymes of two not so distantly related pathogenic protozoa. The basic lesson is that not only do pathogenic protozoa differ from mammals in their purine salvage enzymes, but dramatic diversity among the protozoa themselves can be found.


Liver Extract Purine Nucleoside Purine Analogue PHOSPHORIBOSYL Transferase Dramatic Diversity 
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  1. 1.
    J.V. Tuttle and T.A. Krenitsky, Purine Phosphoribosyltrans- ferases from Leishmania donovani, J. Bíol. Chem. 255: 909 (1980).PubMedGoogle Scholar
  2. 2.
    G.W. Koszalka and T.A. Krenitsky, Nucleosidases from Leishmania donovani, J. Biol. Chem. 254: 8185 (1979).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Thomas A. Krenitsky
    • 1
  • Richard L. Miller
    • 1
  1. 1.Wellcome Research LaboratoriesUSA

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