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Renal Handling of Uric Acid in Gout by Means of the Pyrazinamide and Probenecid Tests

  • J. G. Puig
  • F. Mateos
  • A. Muñoz
  • G. Gaspar
  • T. Ramos
  • J. Gijón Baños
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

The protagonism of the kidney in the pathogenesis of primary gout is essential because at least three-fourths of all patients have normal urate production and require an elevated plasma urate concentration to obtain a normal uric acid excretion1,2. Recent investigations of the urate transport system in the human kidney have provided evidence for a 4-component model: glomerular filtration, proximal or presecretory reabsorption, tubular secretion, and postsecretory reabsorption3. According to this model, renal hypouricemia might result from diminished glomerular filtration rate (GFR), augmented either presecretory or postsecretory reabsorption, or diminished tubular secretion of uric acid. In an attempt to determine the site of the renal abnormality resulting in decreased clearance of urate, we examined the tubular phases that govern uric acid excretion in a gouty population in the states of hyperuricemia and hypouricemia.

Keywords

Uric Acid Glomerular Filtration Rate Tubular Secretion Renal Handling Uric Acid Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    P. A. Simkin, Uric acid excretion in patients with gout, Ann. Intern. Med. 92: 98 (1980).Google Scholar
  2. 2.
    D. J. Levinson, and L. B. Sorensen, Renal handling of uric acid in normal and gouty subjects: evidence for a 4-component system, Ann. Rheum. Dis. 39: 173 (1980).Google Scholar
  3. 3.
    H. S. Diamond, and J. S. Paolino, Evidence for a postsecretory reabsortive site for uric acid in man. J. Clin. Invest. 52: 1491 (1973)Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. G. Puig
    • 1
  • F. Mateos
    • 1
  • A. Muñoz
    • 1
  • G. Gaspar
    • 1
  • T. Ramos
    • 1
  • J. Gijón Baños
    • 1
  1. 1.Departments of Internal Medicine and Clinical BiopathologyCiudad Sanitaria La PazMadridSpain

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