Evidence of Abnormal Renal Handling of Uric Acid in Patients with Nephrolithiasis and Hyperuricosuria

  • F. Mateos
  • J. G. Puig
  • E. Ma. Martínez
  • G. Gaspar
  • E. Herrero
  • J. A. Martínez Piñeiro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

A group of patients forming calcium oxalate stones are hyperuricosuric and it is thought that their excessive urate excretion contributes to calcium-stones formation1. The pathomechanisms invoked are dietary purine excess and endogenous uric acid overproduction, being defective tubular reabsorption of urate “unattractive” because uricemia was found to be normal in patients with recurrent calcium nephrolithiasis (RCN) and hyperuricosuria. Current studies were undertaken to define the incidence, role of diet, abnormalities of the renal handling of urate, and associated metabolic disturbances in patients with RCN and hyperuricosuria.

Keywords

Oxalate Purine Gout Allo Probenecid 

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References

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    F. L. Coe, Nephrolithiasis: pathogenesis and treatment. Year book of Medicine. Year book Publishers Inc. Chigago, London. (1978).Google Scholar
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    C. Y. C. Pak, F. Briton, R. Peterson, P. P. Ward, C. Northcurtt, M. A. Breslau, J. McQuire, K. Sakhace, S. Bush, M. Nicar, D. Norman, and P. Peters, Valoración ambulatoria de la nefrolitiasis: Clasificación, formas de presentación clinica y criterios diagnósticos, Am. J. Med. (spanish edition) 12: 11 (1980).Google Scholar
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    A. de Vries, and O. Sperling, Inborn hypouricemia due to isolated renal tubular defect, Biomedicine, 30: 75 (1979).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • F. Mateos
    • 1
  • J. G. Puig
    • 1
  • E. Ma. Martínez
    • 1
  • G. Gaspar
    • 1
  • E. Herrero
    • 1
  • J. A. Martínez Piñeiro
    • 1
  1. 1.Departments of Internal Medicine and Clinical BiopathologyCiudad Sanitaria La PazMadridSpain

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