Pulse Radiolysis Study of Hypoxanthine and Xanthine Oxidation

  • J. Santamaria
  • C. Pasquier
  • C. Ferradini
  • J. Pucheault
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


The oxidation of hypoxanthine (Hyx) into xanthine (X) and xanthine into uric acid (U) plays an important role in diseases like gout and xanthinuria.A good knowledge of this oxidation would allow to understand the mechanism of action of drugs like pyrazolopyrimidines (allopurinol and thiopurinol) which reduce uric acid synthesis.


Electron Paramagnetic Resonance Uric Acid Electron Paramagnetic Resonance Spectrum Second Order Reaction Reverse Phase HPLC Method 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. Santamaria
    • 1
  • C. Pasquier
    • 2
  • C. Ferradini
    • 3
  • J. Pucheault
  1. 1.Laboratoire de Recherches Organiques de l’ESPCIUniversité P.& M. CurieParisFrance
  2. 2.Institut de RhumatologieHopital CochinParisFrance
  3. 3.Laboratoire de Chimie PhysiqueUniversité R. DescartesParisFrance

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