Pulse Radiolysis Study of Hypoxanthine and Xanthine Oxidation
The oxidation of hypoxanthine (Hyx) into xanthine (X) and xanthine into uric acid (U) plays an important role in diseases like gout and xanthinuria.A good knowledge of this oxidation would allow to understand the mechanism of action of drugs like pyrazolopyrimidines (allopurinol and thiopurinol) which reduce uric acid synthesis.
KeywordsElectron Paramagnetic Resonance Uric Acid Electron Paramagnetic Resonance Spectrum Second Order Reaction Reverse Phase HPLC Method
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