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The Excretion of 14C-Hypoxanthine and Its Metabolites in Rats Following Administration of Uricostatic Drugs

  • Béla v. Kerékjártó
  • Max Hropot
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

In vivo xanthine oxidase inhibition results in a reduction of uric acid (and allantoin) in urine and in an increase in the urinary excretion of hypoxanthine and xanthine as described by Elionl for allopurinol. The dose-dependence of the excreted amounts of hypoxanthine and xanthine is a relevant consideration when using these parameters to measure the action of uricostatics in the rat. The purpose of our studies was to obtain a simple and rapid method to detect the uricostatic quality of hypouricemic compounds.

Keywords

Uric Acid Xanthine Oxidase Total Radioactivity Potassium Dihydrogen Xanthine Oxidase Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    G. B. Elion, Allopurinol and other inhibitors of urate synthesis, in: Uric acid, W. N. Kelley, I. M. Weiner, ed. Springer-Verlag, Berlin (1978)Google Scholar
  2. 2.
    R. Greger, Purine excretion by the rat kidney, in: Amino acid transport and uric acid transport, S. Silbernagl, F. Lang, R. Greger, ed. Georg Thieme Publishers Stuttgart (1976)Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Béla v. Kerékjártó
    • 1
  • Max Hropot
    • 1
  1. 1.Hoechst AGFrankfurt (M) 80Germany

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