The Excretion of 14C-Hypoxanthine and Its Metabolites in Rats Following Administration of Uricostatic Drugs
In vivo xanthine oxidase inhibition results in a reduction of uric acid (and allantoin) in urine and in an increase in the urinary excretion of hypoxanthine and xanthine as described by Elionl for allopurinol. The dose-dependence of the excreted amounts of hypoxanthine and xanthine is a relevant consideration when using these parameters to measure the action of uricostatics in the rat. The purpose of our studies was to obtain a simple and rapid method to detect the uricostatic quality of hypouricemic compounds.
KeywordsUric Acid Xanthine Oxidase Total Radioactivity Potassium Dihydrogen Xanthine Oxidase Inhibition
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