The Excretion of 14C-Hypoxanthine and Its Metabolites in Rats Following Administration of Uricostatic Drugs

  • Béla v. Kerékjártó
  • Max Hropot
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)


In vivo xanthine oxidase inhibition results in a reduction of uric acid (and allantoin) in urine and in an increase in the urinary excretion of hypoxanthine and xanthine as described by Elionl for allopurinol. The dose-dependence of the excreted amounts of hypoxanthine and xanthine is a relevant consideration when using these parameters to measure the action of uricostatics in the rat. The purpose of our studies was to obtain a simple and rapid method to detect the uricostatic quality of hypouricemic compounds.


Uric Acid Xanthine Oxidase Total Radioactivity Potassium Dihydrogen Xanthine Oxidase Inhibition 
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  1. 1.
    G. B. Elion, Allopurinol and other inhibitors of urate synthesis, in: Uric acid, W. N. Kelley, I. M. Weiner, ed. Springer-Verlag, Berlin (1978)Google Scholar
  2. 2.
    R. Greger, Purine excretion by the rat kidney, in: Amino acid transport and uric acid transport, S. Silbernagl, F. Lang, R. Greger, ed. Georg Thieme Publishers Stuttgart (1976)Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Béla v. Kerékjártó
    • 1
  • Max Hropot
    • 1
  1. 1.Hoechst AGFrankfurt (M) 80Germany

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