Gout Resistant to Allopurinol: Poor Compliance or Non-Response
Patients with chronic gouty arthritis unresponsive to allopurinol are generally dismissed as poor compliers. This paper presents studies in a middle-aged male with a 20-year history of gout in whom allopurinol in varying doses and combinations had proved ineffective in controlling either plasma uric acid levels or the gouty arthritis. The patient was studied on two separate occasions under Metabolic Ward conditions because the initial study on low dose allopurinol had failed to reduce plasma uric acid levels — they had in fact increased.
KeywordsUric Acid Uric Acid Level Gouty Arthritis Gout Patient Plasma Uric Acid
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