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Gout Resistant to Allopurinol: Poor Compliance or Non-Response

  • H. A. Simmonds
  • T. Gibson
  • G. J. Huston
  • D. R. Webster
  • A. V. Rodgers
  • J. Munro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

Patients with chronic gouty arthritis unresponsive to allopurinol are generally dismissed as poor compliers. This paper presents studies in a middle-aged male with a 20-year history of gout in whom allopurinol in varying doses and combinations had proved ineffective in controlling either plasma uric acid levels or the gouty arthritis. The patient was studied on two separate occasions under Metabolic Ward conditions because the initial study on low dose allopurinol had failed to reduce plasma uric acid levels — they had in fact increased.

Keywords

Uric Acid Uric Acid Level Gouty Arthritis Gout Patient Plasma Uric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    H. A. Simmonds. Urinary excretion of purines, pyrimidines and pyrazolopyrimidines in patients treated with allopurinol and oxipurinol. Clin.Chim.Acta. 23: 353 (1969).PubMedCrossRefGoogle Scholar
  2. 2.
    H. A. Simmonds, D. J. Warren, J. S. Cameron, C. F. Potter and D. A. Farebrother. Familial gout and renal failure in young women. Clin.Nephrol. 14: 176 (1980).PubMedGoogle Scholar
  3. 3.
    T. Gibson, J. Highton, H. A. Simmonds and C. F. Potter. Hypertension, renal function and gout. Postgrad.Med.J. 55: 21 (1979).PubMedGoogle Scholar
  4. 4.
    S. Sved and L. Wilson. Analysis of allopurinol and oxipurinol in plasma and its application to metabolic studies. Biopharmaceutics and Drug Disposition, 1: 111 (1980).CrossRefGoogle Scholar
  5. 5.
    H. A. Simmonds, J. S. Cameron, M. J. Dillon, T. M. Barratt and K. J. Van Acker. ‘Uric acid’ stones in children: problems of diagnosis and treatment in a new defect - adenine phosphoribosyltransferase deficiency. Fortschritte der Urol und Nephrol. 16: 52 (1981).Google Scholar
  6. 6.
    J. B. Wyngaarden and W. N. Kelley. Gout and Hyperuricaemia. Grune and Stratton, New York (1976).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • H. A. Simmonds
    • 1
  • T. Gibson
    • 1
  • G. J. Huston
    • 1
  • D. R. Webster
    • 1
  • A. V. Rodgers
    • 1
  • J. Munro
    • 1
  1. 1.Purine Laboratory, Department of Rheumatology and Metabolic Ward, Department of MedicineGuy’s HospitalLondonUK

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