Lymphocyte Ecto 5′-Nucleotidase in Immunodeficiency and Leukaemia
Circulating blood lymphocytes have relatively high activity of ecto 5′-nucleotidase (EC 126.96.36.199-5′N) as compared to monocytes of neutrophils (Webster et al 1978). This activity varies between different subpopulations; B lymphocytes having about four times the activity of ‘E’ rosetting T lymphocytes (Rowe et al 1980). 5′N activity also varies between T cell subpopulations, OKT8 (suppressor) T cells having about half the activity of OKT4 (helper) cells (Boss et al 1980, Massaia et al 1982). Pro-thymocytes and cortical thymocytes have very low 5′N activity, medullary thymocytes and cord blood T cells having about half the activity of circulating T cells (Fig.1). The 5′-N activity in cortical thymocytes can be increased by incubation with either thymic epithelial cells or thymosin (Cohen et al (1981).
KeywordsSevere Combine Immunodeficiency Purine Metabolism Thymic Epithelial Cell Nucleotidase Activity Obligate Heterozygote
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