The Effect of Dipyridamole on Plasma Adenosine Levels and Skin Micro-Circulation in Man
Dipyridamole (Dip) is a vasodilator, which probably acts by elevating endogenous adenosine. We have studied the influence of Dip on plasma levels of adenosine and on finger skin circulation. Thirteen healthy males were given Dip (0.4 mg/kg i.v.); 5 of them received the drug and saline double-blind. Heart rate, blood pressure, digital pulse amplitude, skin temperature and capillary blood cell velocity (CBV, measured by videophotometric capillaroscopy) were recorded continuously. Reactive hyperemia in the capillaries following arterial occlusion for 15 and 60 sec was measured. The plasma concentrations of noradrenaline, adrenaline, Dip and adenosine were determined by HPLC methods.