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The Effect of Dipyridamole on Plasma Adenosine Levels and Skin Micro-Circulation in Man

  • A. Sollevi
  • J. Östergren
  • P. Hjemdahl
  • B. B. Fredholm
  • B. Fagrell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

Dipyridamole (Dip) is a vasodilator, which probably acts by elevating endogenous adenosine. We have studied the influence of Dip on plasma levels of adenosine and on finger skin circulation. Thirteen healthy males were given Dip (0.4 mg/kg i.v.); 5 of them received the drug and saline double-blind. Heart rate, blood pressure, digital pulse amplitude, skin temperature and capillary blood cell velocity (CBV, measured by videophotometric capillaroscopy) were recorded continuously. Reactive hyperemia in the capillaries following arterial occlusion for 15 and 60 sec was measured. The plasma concentrations of noradrenaline, adrenaline, Dip and adenosine were determined by HPLC methods.

Keywords

Skin Temperature HPLC Method Arterial Occlusion Healthy Male Reactive Hyperemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. Sollevi
    • 1
  • J. Östergren
    • 1
  • P. Hjemdahl
    • 1
  • B. B. Fredholm
    • 1
  • B. Fagrell
    • 1
  1. 1.Dept. of Pharmacology, Karolinska Institutet and Dept. of MedicineDanderyds HospitalStockholmSweden

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