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The Effect of Dipyridamole on Plasma Adenosine Levels and Skin Micro-Circulation in Man

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Purine Metabolism in Man-IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 165))

Abstract

Dipyridamole (Dip) is a vasodilator, which probably acts by elevating endogenous adenosine. We have studied the influence of Dip on plasma levels of adenosine and on finger skin circulation. Thirteen healthy males were given Dip (0.4 mg/kg i.v.); 5 of them received the drug and saline double-blind. Heart rate, blood pressure, digital pulse amplitude, skin temperature and capillary blood cell velocity (CBV, measured by videophotometric capillaroscopy) were recorded continuously. Reactive hyperemia in the capillaries following arterial occlusion for 15 and 60 sec was measured. The plasma concentrations of noradrenaline, adrenaline, Dip and adenosine were determined by HPLC methods.

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© 1984 Plenum Press, New York

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Sollevi, A., Östergren, J., Hjemdahl, P., Fredholm, B.B., Fagrell, B. (1984). The Effect of Dipyridamole on Plasma Adenosine Levels and Skin Micro-Circulation in Man. In: De Bruyn, C.H.M.M., Simmonds, H.A., Müller, M.M. (eds) Purine Metabolism in Man-IV. Advances in Experimental Medicine and Biology, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4553-4_105

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  • DOI: https://doi.org/10.1007/978-1-4684-4553-4_105

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4555-8

  • Online ISBN: 978-1-4684-4553-4

  • eBook Packages: Springer Book Archive

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